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242 results on '"Wartolowska, Karolina"'

1. Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial

Author

Kopczak, Anna, Stringer, Michael S., van den Brink, Hilde, Kerkhofs, Danielle, Blair, Gordon W., van Dinther, Maud, Arteaga Reyes, Carmen, Jaime Garcia, Daniela, Onkenhout, Laurien, Wartolowska, Karolina A., Thrippleton, Michael J., Kampaite, Agniete, Duering, Marco, Staals, Julie, Lesnik-Oberstein, Saskia, Muir, Keith, Middeke, Martin, Norrving, Bo, Bousser, Marie-Germaine, Mansmann, Ulrich, Rothwell, Peter M., Doubal, Fergus N., van Oostenbrugge, Robert, Biessels, Geert Jan, Webb, Alastair J.S., Wardlaw, Joanna, Dichgans, Martin, André, Elisabeth, Kääb, Stefan, Anders, Hans-Joachim, Hack, Remco, Kaffe, Maria, Dewenter, Anna, Malik, Rainer, Stringer, Michael S, Blair, Gordon W, Reyes, Carmen Arteaga, Garcia, Daniela Jaime, Wartolowska, Karolina A, Thrippleton, Michael J, Muir, Keith W, Rothwell, Peter M, Doubal, Fergus N, Webb, Alastair J S, and Wardlaw, Joanna M

Published
2023
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4. The QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation

Author

Rogers, Chris A., Andrews, Robert, Blazeby, Jane M., Byrne, James, Donovan, Jenny L., Kelly, Jamie, Mazza, Graziella, Mahon, David, Noble, Hamish, Reeves, Barnaby C., Thompson, Janice L., Wordsworth, Sarah, Welbourn, Richard, Beard, David, Carr, Andrew, Cook, Jonathan, Cooper, Cushla, Dean, Benjamin, Gray, Alastair, Gwilym, Stephen, Judge, Andrew, Merritt, Naomi, Moser, Jane, Rees, Jonathan, Rombach, Ines, Savulescu, Julian, Tracey, Irene, Wartolowska, Karolina, Harrison, Eleanor, Tan, Wei, Mills, Nicola, Karantana, Alexia, Sprange, Kirsty, Duley, Lelia, Elliott, Daisy, Hollingworth, William, Montgomery, Alan A., Davis, Tim, Stein, Rob, Bartlett, John, Cameron, David, Campbell, Amy, Canney, Peter, Dunn, Janet, Earl, Helena, Falzon, Mary, Francis, Adele, Hall, Peter, Harmer, Victoria, Higgins, Helen, Hiller, Louise, Hughes-Davies, Luke, Hulme, Claire, Macpherson, Iain, Makris, Andreas, Marshall, Andrea, McCabe, Christopher, Morgan, Adrienne, Pinder, Sarah, Poole, Christopher, Provenzano, Elena, Rea, Daniel, Stallard, Nigel, Avery, Kerry N.L., Barham, C. Paul, Berrisford, Richard, Elliott, Jackie, Falk, Stephen J., Goldin, Rob, Hanna, George, Hollowood, Andrew A., Krysztopik, Richard, Metcalfe, Chris, Noble, Sian, Sanders, Grant, Streets, Christopher G., Titcomb, Dan R., Wheatley, Tim, Rooshenas, Leila, Scott, Lauren J., Tilling, Kate M., Husbands, Samantha, Conefrey, Carmel, Stein, Robert C., Carr, Andrew J., Beard, David J., Paramasivan, Sangeetha, Jepson, Marcus, Avery, Kerry, and Wilson, Caroline

Published
2019
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5. An observational study showed that explaining randomization using gambling-related metaphors and computer-agency descriptions impeded randomized clinical trial recruitment

Author

Beard, David, Carr, Andrew, Cook, Jonathan, Cooper, Cushla, Dean, Benjamin, Donovan, Jenny L., Gray, Alastair, Gwilym, Stephen, Judge, Andrew, Merritt, Naomi, Moser, Jane, Rees, Jonathan, Rombach, Ines, Savulescu, Julian, Tracey, Irene, Wartolowska, Karolina, Blazeby, Jane M., Barham, Paul, Brookes, Sara T., Crosby, Tom, Falk, Stephen J., Griffin, S. Michael, Hollingworth, William, Hollowood, Andrew D., Krysztopik, Richard, Lewis, Wyn, Nicklin, Jo, Streets, Christopher, Strong, Sean, Titcomb, Dan, Williams, Geraint, Birtle, Alison, Bryan, Rik, Catto, James, Chester, John, French, Ann, Hall, Emma, Harris, Chris, Johnson, Mark, Jones, Rob, Keeley, Francis, Kirkbank, Tony, Kockelbergh, Roger, Lewis, Rebecca, Newton, Michelle, Powles, Thomas, Waters, Rachel, Winterbottom, Andrew, Halliday, Alison, Becquemin, Jean-Pierre, Belli, Anna, Bosiers, Marc, Cao, Piergiorgio, Davies, Christina, Gough, Michael, Hayter, Elizabeth, Leopold, Peter, McDonald, Sumaira, Michaels, Jonathan, Mihaylova, Borislava, Peto, Richard, Robertson, Steven, Rothwell, Peter, Scott, Rachael, Thomas, Dafydd, Vermassen, Frank, Stein, Rob, Bartlett, John, Cameron, David, Campbell, Amy, Canney, Peter, Dunn, Janet, Earl, Helena, Falzon, Mary, Francis, Adele, Hall, Peter, Harmer, Victoria, Higgins, Helen, Hiller, Louise, Hughes-Davies, Luke, Hulme, Claire, Macpherson, Iain, Makris, Andreas, Marshall, Andrea, McCabe, Christopher, Morgan, Adrienne, Pinder, Sarah, Poole, Christopher, Rea, Daniel, Stallard, Nigel, Jepson, Marcus, Elliott, Daisy, Conefrey, Carmel, Wade, Julia, Rooshenas, Leila, and Wilson, Caroline

Published
2018
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6. Arthroscopic subacromial decompression for subacromial shoulder pain (CSAW): a multicentre, pragmatic, parallel group, placebo-controlled, three-group, randomised surgical trial

Author

Ahrens, Philip, Baldwick, Cheryl, Brinsden, Mark, Brownlow, Harry, Burton, David, Butt, Muhammad Sohail, Carr, Andrew, Charalambous, Charalambos P, Conboy, Veronica, Dennell, Lucy, Donaldson, Oliver, Drew, Steven, Dwyer, Amitabh, Gidden, David, Hallam, Peter, Kalogrianitis, Socrates, Kelly, Cormac, Kulkarni, Rohit, Matthews, Tim, McBirnie, Julie, Patel, Vipul, Peach, Chris, Roberts, Chris, Robinson, David, Rosell, Philip, Rossouw, Dan, Senior, Colin, Singh, Bijayendra, Sjolin, Soren, Taylor, Geoffrey, Venkateswaran, Balachandran, Woods, David, Beard, David J, Rees, Jonathan L, Cook, Jonathan A, Rombach, Ines, Cooper, Cushla, Merritt, Naomi, Shirkey, Beverly A, Donovan, Jenny L, Gwilym, Stephen, Savulescu, Julian, Moser, Jane, Gray, Alastair, Jepson, Marcus, Tracey, Irene, Judge, Andrew, Wartolowska, Karolina, and Carr, Andrew J

Published
2018
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9. Recommendations for the development, implementation, and reporting of control interventions in efficacy and mechanistic trials of physical, psychological, and self-management therapies: the CoPPS Statement

Author

Hohenschurz-Schmidt, David, primary, Vase, Lene, additional, Scott, Whitney, additional, Annoni, Marco, additional, Ajayi, Oluwafemi K, additional, Barth, Jürgen, additional, Bennell, Kim, additional, Berna, Chantal, additional, Bialosky, Joel, additional, Braithwaite, Felicity, additional, Finnerup, Nanna B, additional, Williams, Amanda C de C, additional, Carlino, Elisa, additional, Cerritelli, Francesco, additional, Chaibi, Aleksander, additional, Cherkin, Dan, additional, Colloca, Luana, additional, Côté, Pierre, additional, Darnall, Beth D, additional, Evans, Roni, additional, Fabre, Laurent, additional, Faria, Vanda, additional, French, Simon, additional, Gerger, Heike, additional, Häuser, Winfried, additional, Hinman, Rana S, additional, Ho, Dien, additional, Janssens, Thomas, additional, Jensen, Karin, additional, Johnston, Chris, additional, Juhl Lunde, Sigrid, additional, Keefe, Francis, additional, Kerns, Robert D, additional, Koechlin, Helen, additional, Kongsted, Alice, additional, Michener, Lori A, additional, Moerman, Daniel E, additional, Musial, Frauke, additional, Newell, David, additional, Nicholas, Michael, additional, Palermo, Tonya M, additional, Palermo, Sara, additional, Peerdeman, Kaya J, additional, Pogatzki-Zahn, Esther M, additional, Puhl, Aaron A, additional, Roberts, Lisa, additional, Rossettini, Giacomo, additional, Tomczak Matthiesen, Susan, additional, Underwood, Martin, additional, Vaucher, Paul, additional, Vollert, Jan, additional, Wartolowska, Karolina, additional, Weimer, Katja, additional, Werner, Christoph Patrick, additional, Rice, Andrew S C, additional, and Draper-Rodi, Jerry, additional

Published
2023
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11. How do US orthopaedic surgeons view placebo-controlled surgical trials? A pilot online survey study

Author

Bernstein, Michael H, Rosenfield, Maayan N, Blease, Charlotte, Magill, Molly, Terek, Richard M, Savulescu, Julian, Beaudoin, Francesca L, Rich, Josiah D, and Wartolowska, Karolina

Abstract

Randomised placebo-controlled trials (RPCTs) are the gold standard for evaluating novel treatments. However, this design is rarely used in the context of orthopaedic interventions where participants are assigned to a real or placebo surgery. The present study examines attitudes towards RPCTs for orthopaedic surgery among 687 orthopaedic surgeons across the USA. When presented with a vignette describing an RPCT for orthopaedic surgery, 52.3% of participants viewed it as ‘completely’ or ‘mostly’ unethical. Participants were also asked to rank-order the value of five different types of evidence supporting the efficacy of a surgery, ranging from RPCT to an anecdotal report. Responses regarding RPCTs were polarised with 26.4% viewing it as the leastvaluable (even less valuable than an anecdote) and 35.7 .% viewing it as the mostvaluable. Where equipoise exists, if we want to subject orthopaedic surgeries to the highest standard of evidence (RPCTs) before they are implemented in clinical practice, it will be necessary to educate physicians on the value and ethics of placebo surgery control conditions. Otherwise, invasive procedures may be performed without any benefits beyond possible placebo effects.

Published
2024
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16. RECOMMENDATIONS FOR THE DEVELOPMENT, IMPLEMENTATION, AND REPORTING OF (SHAM) CONTROL INTERVENTIONS IN EFFICACY TRIALS OF PHYSICAL, PSYCHOLOGICAL, AND SELF-MANAGEMENT THERAPIES: THE CoPPS STATEMENT

Author

David Hohenschurz-Schmidt David, Vase, Lene, Scott, Whitney, Marco Annoni Marco, Ajayi Oluwafemi, K, Barth, Jürgen, Bennell, Kim, Berna, Chantal, Bialosky, Joel, Braithwaite, Felicity, Finnerup Nanna, B, C Williams Amanda C, De, Carlino, Elisa, Cerritelli, Francesco, Chaibi, Aleksander, Cherkin, Dan, Colloca, Luana, Côté, Pierre, Darnall Beth, D, Evans, Roni, Fabre, Laurent, Faria, Vanda, French, Simon, Gerger, Heike, Häuser, Winfried, Hinman Rana, S, Dien, Ho, Janssens, Thomas, Jensen, Karin, Lunde Sigrid Juhl, Keefe, Francis, Kerns Robert, D, Koechlin, Helen, Kongsted, Alice, Michener Lori, A, Moerman Daniel, E, Musial, Frauke, Newell, David, Nicholas, Michael, Palermo Tonya, M, Palermo, Sara, Peerdeman Kaya, J, Pogatzki-Zahn Esther, M, Puhl Aaron, A, Roberts, Lisa, Rossettini, Giacomo, Johnston, Chris, Tomczak Matthiesen Susan, Underwood, Martin, Vaucher, Paul, Vollert, Jan, Wartolowska, Karolina, Weimer, Katja, Werner Christoph Patrick, Rice Andrew SC, and Draper-Rodi, Jerry

Published
2023

17. Recommendations for the development, implementation, and reporting of control interventions in efficacy and mechanistic trials of physical, psychological, and self-management therapies: the CoPPS Statement

Author

Hohenschurz-Schmidt, David, Vase, Lene, Scott, Whitney, Annoni, Marco, Ajayi, Oluwafemi K, Barth, Jürgen, Bennell, Kim, Berna, Chantal, Bialosky, Joel, Braithwaite, Felicity, Finnerup, Nanna B, Williams, Amanda C de C, Carlino, Elisa, Cerritelli, Francesco, Chaibi, Aleksander, Cherkin, Dan, Colloca, Luana, Côté, Pierre, Darnall, Beth D, Evans, Roni, Fabre, Laurent, Faria, Vanda, French, Simon, Gerger, Heike, Häuser, Winfried, Hinman, Rana S, Ho, Dien, Janssens, Thomas, Jensen, Karin, Johnston, Chris, Juhl Linde, Sigrid, Keefe, Francis, Kern, Robert D, Koechlin, Helen, Kongsted, Alice, Michener, Lori A, Moerman, Daniel E, Musial, Frauke, Newell, David, Nicholas, Michael, Palermo, Tonya M, Peerdeman, Kaya J, Pogatzki-Zahn, Esther, Puhl, Aaron A, Roberts, Lisa, Rossettini, Giacomo, Tomczak Matthiesen, Susan, Underwood, Martin, Vaucher, Paul, Vollert, Jan, Wartolowska, Karolina, Weimer, Katja, Werner, Christoph Patrick, Rice, Andrew S C, Draper-Rodi, Jerry, and University of Zurich

Subjects
10034 Institute of Complementary Medicine, General Earth and Planetary Sciences, 610 Medicine & health, General Environmental Science
Published
2023
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18. The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial

Author

Kopczak, Anna, primary, S Stringer, Michael, additional, van den Brink, Hilde, additional, Kerkhofs, Danielle, additional, W Blair, Gordon, additional, van Dinther, Maud, additional, Onkenhout, Laurien, additional, A Wartolowska, Karolina, additional, Thrippleton, Michael J, additional, Duering, Marco, additional, Staals, Julie, additional, Middeke, Martin, additional, André, Elisabeth, additional, Norrving, Bo, additional, Bousser, Marie-Germaine, additional, Mansmann, Ulrich, additional, Rothwell, Peter M, additional, N Doubal, Fergus, additional, van Oostenbrugge, Robert, additional, Jan Biessels, Geert, additional, Webb, Alastair JS, additional, Wardlaw, Joanna M, additional, and Dichgans, Martin, additional

Published
2022
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26. The importance of using placebo controls in non-pharmacological randomised trials.

Author

Wartolowska, Karolina A., Hohenschurz-Schmidt, David, Vase, Lene, and Aronson, Jeffrey K.

Subjects
*YOGA techniques, *NEURAL stimulation, *PSYCHOTHERAPY, *PLACEBOS, *SHOULDER disorders
Abstract

Although a placebo comparator tends to be safer than an active treatment, and involves the same precautions and analgesics as the tested intervention,[46] patients may have misconceptions, eg, that placebo surgery means open surgery without any anaesthesia (personal communications after an IASP workshop). Treatment providers Related to both the ethical and practical challenges of placebo-controlled nonpharmacological trials is the role of a treatment provider. Placebo A placebo is a treatment that is indistinguishable from the tested treatment but does not involve the key element of treatment expected to be responsible for the therapeutic effect that is being tested. Novel pharmacological compounds must undergo a series of highly regulated steps and have their efficacy demonstrated under strict conditions of placebo-controlled trials before being approved for clinical use.[17] This is often not the case for treatments that do not involve a pharmacological element, such as surgery, physiotherapy, or psychological therapy. [Extracted from the article]

Published
2023
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28. Midlife blood pressure is associated with the severity of white matter hyperintensities: analysis of the UK Biobank cohort study

Author

Wartolowska, Karolina Agnieszka and Webb, Alastair John Stewart

Subjects
medicine.medical_specialty, Regression dilution, Population, 030204 cardiovascular system & hematology, Imaging, 03 medical and health sciences, Magnetic resonance imaging, 0302 clinical medicine, Diastolic blood pressure, Internal medicine, White matter hyperintensities, Medicine, AcademicSubjects/MED00200, education, education.field_of_study, business.industry, Clnical Research, Hyperintensity, Confidence interval, Small vessel disease, Blood pressure, Hypertension, Attributable risk, Cohort, Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery, Cohort study
Abstract

Aims White matter hyperintensities (WMH) progress with age and hypertension, but the key period of exposure to elevated blood pressure (BP), and the relative role of systolic BP (SBP) vs. diastolic BP (DBP), remains unclear. This study aims to determine the relationship between WMH and concurrent vs. past BP. Methods and results UK Biobank is a prospective community-based cohort of 40–69-year olds from 22 centres, with magnetic resonance imaging in a subgroup of over 40 000 people at 4–12 years after baseline assessment. Standardized associations between WMH load (WMH volume normalized by total white matter volume and logit-transformed) and concurrent vs. past BP were determined using linear models, adjusted for age, sex, cardiovascular risk factors, BP source, assessment centre, and time since baseline. Associations adjusted for regression dilution bias were determined between median WMH and usual SBP or DBP, stratified by age and baseline BP. In 37 041 eligible participants with WMH data and BP measures, WMH were more strongly associated with concurrent SBP [DBP: β = 0.064, 95% confidence interval (CI) 0.050–0.078; SBP: β = 0.076, 95% CI 0.062–0.090], but the strongest association was for past DBP (DBP: β = 0.087, 95% CI 0.064–0.109; SBP: β = 0.045, 95% CI 0.022–0.069), particularly under the age of 50 (DBP: β = 0.103, 95% CI 0.055–0.152; SBP: β = 0.012, 95% CI −0.044 to 0.069). Due to the higher prevalence of elevated SBP, median WMH increased 1.126 (95% CI 1.107–1.146) per 10 mmHg usual SBP and 1.106 (95% CI 1.090–1.122) per 5 mmHg usual DBP, whilst the population attributable fraction of WMH in the top decile was greater for elevated SBP (19.1% for concurrent SBP; 24.4% for past SBP). Any increase in BP, even below 140 for SBP and below 90 mmHg for DBP, and especially if requiring antihypertensive medication, was associated with increased WMH. Conclusions WMH were strongly associated with concurrent and past elevated BP with the population burden of severe WMH greatest for SBP. However, before the age of 50, DBP was more strongly associated with WMH. Long-term prevention of WMH may require control of even mildly elevated midlife DBP.

Published
2020

29. sj-pdf-2-jcb-10.1177_0271678X211058803 - Supplemental material for White matter damage due to pulsatile versus steady blood pressure differs by vascular territory: A cross-sectional analysis of the UK Biobank cohort study

Author

Wartolowska, Karolina A and Webb, Alastair JS

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-2-jcb-10.1177_0271678X211058803 for White matter damage due to pulsatile versus steady blood pressure differs by vascular territory: A cross-sectional analysis of the UK Biobank cohort study by Karolina A Wartolowska and Alastair JS Webb in Journal of Cerebral Blood Flow & Metabolism

Published
2022
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30. sj-pdf-1-jcb-10.1177_0271678X211058803 - Supplemental material for White matter damage due to pulsatile versus steady blood pressure differs by vascular territory: A cross-sectional analysis of the UK Biobank cohort study

Author

Wartolowska, Karolina A and Webb, Alastair JS

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X211058803 for White matter damage due to pulsatile versus steady blood pressure differs by vascular territory: A cross-sectional analysis of the UK Biobank cohort study by Karolina A Wartolowska and Alastair JS Webb in Journal of Cerebral Blood Flow & Metabolism

Published
2022
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31. sj-docx-1-eso-10.1177_23969873221143570 – Supplemental material for The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial

Author

Kopczak, Anna, S Stringer, Michael, van den Brink, Hilde, Kerkhofs, Danielle, W Blair, Gordon, van Dinther, Maud, Onkenhout, Laurien, A Wartolowska, Karolina, Thrippleton, Michael J, Duering, Marco, Staals, Julie, Middeke, Martin, André, Elisabeth, Norrving, Bo, Bousser, Marie-Germaine, Mansmann, Ulrich, Rothwell, Peter M, N Doubal, Fergus, van Oostenbrugge, Robert, Jan Biessels, Geert, Webb, Alastair JS, Wardlaw, Joanna M, and Dichgans, Martin

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-eso-10.1177_23969873221143570 for The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial by Anna Kopczak, Michael S Stringer, Hilde van den Brink, Danielle Kerkhofs, Gordon W Blair, Maud van Dinther, Laurien Onkenhout, Karolina A Wartolowska, Michael J Thrippleton, Marco Duering, Julie Staals, Martin Middeke, Elisabeth André, Bo Norrving, Marie-Germaine Bousser, Ulrich Mansmann, Peter M Rothwell, Fergus N Doubal, Robert van Oostenbrugge, Geert Jan Biessels, Alastair JS Webb, Joanna M Wardlaw and Martin Dichgans in European Stroke Journal

Published
2022
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32. Consistencies and Differences in Intermediate Physiological Phenotypes of Vascular Ageing between Ischaemic Stroke Aetiologies.

Author

Webb, Alastair John Stewart, Wartolowska, Karolina A., Li, Linxin, Mazzucco, Sara, and Rothwell, Peter M.

Subjects
*ISCHEMIC stroke, *CEREBRAL circulation, *STROKE, *CARDIOVASCULAR diseases risk factors, *ARTERIAL diseases
Abstract

Objective: Arterial stiffness, cerebral pulsatility, and beat-to-beat blood pressure variability partly mediate the relationship between hypertension and stroke, but it is unknown if these intermediate phenotypes of vascular ageing differ between stroke aetiologies. We therefore aimed to characterize differences in these intermediate cardiovascular phenotypes between patients presenting with strokes of different aetiologies. Methods: In consecutive patients on best medical management 1 month after TIA or nondisabling stroke (Oxford Vascular Study), arterial stiffness (PWV) was measured by applanation tonometry (Sphygmocor), middle cerebral blood flow velocity, and pulsatility index (MCA-PI) were measured by transcranial ultrasound (TCD, DWL Doppler Box), and beat-to-beat BP variability was measured with a Finometer. Differences between patients with large artery (LAS), small vessel (SVD), cardioembolic (CE), or undetermined events were derived, including adjustment for cardiovascular risk factors. Relationships were characterized by mixed linear models. Results: In 909 eligible patients, MCA-PI, PWV, and SBPV were all positively skewed. Mean values were greatest in LAS than CE and lowest in SVD (p < 0.001). However, after adjustment for age, sex, and risk factors, PI was greatest in LAS and lowest in CE stroke, whilst PWV was greatest in SVD and undetermined stroke (p < 0.001). In multivariate linear models, age was more strongly associated with PWV and PI in patients with small vessel stroke than other aetiologies, particularly under the age of 65, but SBPV was only weakly associated with demographic indices in all stroke subtypes. Conclusions: Intermediate cardiovascular phenotypes of vascular ageing had similar demographic associations between stroke aetiologies, but these were particularly strong in patients with small vessel stroke under the age of 65, implying a potential role of these phenotypes in increasing stroke risk in this patient group. [ABSTRACT FROM AUTHOR]

Published
2023
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33. The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial.

Author

Kopczak, Anna, S Stringer, Michael, van den Brink, Hilde, Kerkhofs, Danielle, W Blair, Gordon, van Dinther, Maud, Onkenhout, Laurien, A Wartolowska, Karolina, Thrippleton, Michael J, Duering, Marco, Staals, Julie, Middeke, Martin, André, Elisabeth, Norrving, Bo, Bousser, Marie-Germaine, Mansmann, Ulrich, Rothwell, Peter M, N Doubal, Fergus, van Oostenbrugge, Robert, and Jan Biessels, Geert

Published
2023
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44. White matter damage due to pulsatile versus steady blood pressure differs by vascular territory: A cross-sectional analysis of the UK Biobank cohort study.

Author

Wartolowska, Karolina A and Webb, Alastair JS

Abstract

Small vessel disease is associated with age, mean blood pressure (MAP) and blood pressure pulsatility (PP). We used data from the UK Biobank cohort study to determine the relative importance of MAP versus PP driving white matter injury within individual white matter tracts, particularly in the anterior and posterior vascular territory. The associations between blood pressure and diffusion indices in 27 major tracts were analysed using unadjusted and fully-adjusted general linear models and mixed-effect linear models. Blood pressure and neuroimaging data were available for 37,041 participants (mean age 64+/−7.5 years, 53% female). In unadjusted analyses, MAP and PP were similarly associated with diffusion indices in the anterior circulation. In the posterior circulation, the associations were weaker, particularly for MAP. In fully-adjusted analyses, MAP remained associated with all diffusion indices in the anterior circulation, independently of age. In the posterior circulation, the effect of MAP became protective. PP remained associated with greater mean diffusivity and extracellular free water diffusion in the anterior circulation and all diffusion indices in the posterior circulation. There was a significant interaction between PP and age. This implies discordant mechanisms for chronic white matter injury in different brain regions and potentially in the associated stroke risks. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Reply to Banik

Author

Kjær, Sophie W., primary, Rice, Andrew S. C., additional, Wartolowska, Karolina, additional, and Vase, Lene, additional

Published
2020
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