234 results on '"Warren Reed"'
Search Results
2. Exploring software navigation tools for liver tumour angiography: a scoping review
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Nathan Brunskill, John Robinson, Don Nocum, and Warren Reed
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3D imaging ,angiography ,cancer ,cone‐beam computed tomography ,interventional oncology ,Interventional radiology ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Introduction Liver cancer presents a growing global health concern, necessitating advanced approaches for intervention. This review investigates the use and effectiveness of software navigation in interventional radiology for liver tumour procedures. Methods In accordance with Preferred Reporting Items for Systematic reviews and Meta‐Analyses extension for Scoping Reviews (PRISMA‐ScR) guidelines, a scoping review was conducted of the literature published between 2013 and 2023 sourcing articles through MEDLINE, Scopus, CINAHL and Embase. Eligible studies focused on liver cancer, utilised cone‐beam computed tomography (CBCT), and employed software for intervention. Twenty‐one articles were deemed eligible for data extraction and analysis. Results Categorised by type, software applications yielded diverse benefits. Feeder detection software significantly enhanced vessel identification, reducing non‐target embolisation by up to 43%. Motion correction software demonstrated a 20% enhancement in image quality, effectively mitigating breathing‐induced motion artefacts. Liver perfusion software facilitated efficient tumour targeting while simultaneously reducing the occurrence of side effects. Needle guide software enabled precise radiofrequency ablation needle placement. Additionally, these software applications provided detailed anatomical simulations. Overall, software integration resulted in shorter procedures, reduced radiation exposure and decreased contrast media usage. Conclusion This scoping review highlights the innovative yet relatively underexplored role of software navigation for liver tumour procedures. The integration of software applications not only enhances procedural efficiency but also bolsters operator confidence, and contributes to improved patient outcomes. Despite the current lack of uniformity and standardisation, these software‐driven advancements hold significant promise for transforming liver tumour interventions. To realise these benefits, further research is needed to explore the clinical impact and optimal utilisation of software navigation tools in interventional radiology.
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- 2024
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3. The use of radiomics in magnetic resonance imaging for the pre‐treatment characterisation of breast cancers: A scoping review
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Annalise Campana, Ziba Gandomkar, Nicola Giannotti, and Warren Reed
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biomarkers ,breast cancer ,MRI ,radiomics ,texture analysis ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Radiomics is an emerging field that aims to extract and analyse a comprehensive set of quantitative features from medical images. This scoping review is focused on MRI‐based radiomic features for the molecular profiling of breast tumours and the implications of this work for predicting patient outcomes. A thorough systematic literature search and outcome extraction were performed to identify relevant studies published in MEDLINE/PubMed (National Centre for Biotechnology Information), EMBASE and Scopus from 2015 onwards. The following information was retrieved from each article: study purpose, study design, extracted radiomic features, machine learning technique(s), sample size/characteristics, statistical result(s) and implications on patient outcomes. Based on the study purpose, four key themes were identified in the included 63 studies: tumour subtype classification (n = 35), pathologically complete response (pCR) prediction (n = 15), lymph node metastasis (LNM) detection (n = 7) and recurrence rate prediction (n = 6). In all four themes, reported accuracies widely varied among the studies, for example, area under receiver characteristics curve (AUC) for detecting LNM ranged from 0.72 to 0.91 and the AUC for predicting pCR ranged from 0.71 to 0.99. In all four themes, combining radiomic features with clinical data improved the predictive models. Preliminary results of this study showed radiomics potential to characterise the whole tumour heterogeneity, with clear implications for individual‐targeted treatment. However, radiomics is still in the pre‐clinical phase, currently with an insufficient number of large multicentre studies and those existing studies are often limited by insufficient methodological transparency and standardised workflow. Consequently, the clinical translation of existing studies is currently limited.
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- 2023
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4. COVID‐19 and its enduring influence on medical imaging
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Peter O'Reilly, Warren Reed, and Sarah Lewis
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Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Published
- 2022
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5. Reliability of radiologists’ first impression when interpreting a screening mammogram
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Ziba Gandomkar, Somphone Siviengphanom, Mo’ayyad Suleiman, Dennis Wong, Warren Reed, Ernest U. Ekpo, Dong Xu, Sarah J. Lewis, Karla K. Evans, Jeremy M. Wolfe, and Patrick C. Brennan
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Medicine ,Science - Abstract
Previous studies showed that radiologists can detect the gist of an abnormality in a mammogram based on a half-second image presentation through global processing of screening mammograms. This study investigated the intra- and inter-observer reliability of the radiologists’ initial impressions about the abnormality (or "gist signal"). It also examined if a subset of radiologists produced more reliable and accurate gist signals. Thirty-nine radiologists provided their initial impressions on two separate occasions, viewing each mammogram for half a second each time. The intra-class correlation (ICC) values showed poor to moderate intra-reader reliability. Only 13 radiologists had an ICC of 0.6 or above, which is considered the minimum standard for reliability, and only three radiologists had an ICC exceeding 0.7. The median value for the weighted Cohen’s Kappa was 0.478 (interquartile range = 0.419–0.555). The Mann-Whitney U-test showed that the "Gist Experts", defined as those who outperformed others, had significantly higher ICC values (p = 0.002) and weighted Cohen’s Kappa scores (p = 0.026). However, even for these experts, the intra-radiologist agreements were not strong, as an ICC of at least 0.75 indicates good reliability and the signal from none of the readers reached this level of reliability as determined by ICC values. The inter-reader reliability of the gist signal was poor, with an ICC score of 0.31 (CI = 0.26–0.37). The Fleiss Kappa score of 0.106 (CI = 0.105–0.106), indicating only slight inter-reader agreement, confirms the findings from the ICC analysis. The intra- and inter-reader reliability analysis showed that the radiologists’ initial impressions are not reliable signals. In particular, the absence of an abnormal gist does not reliably signal a normal case, so radiologists should keep searching. This highlights the importance of "discovery scanning," or coarse screening to detect potential targets before ending the visual search.
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- 2023
6. Magnetic Resonance Imaging for the diagnosis and management of acute colonic diverticulitis: a review of current and future use
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Franziska Jerjen, Tooba Zaidi, Shannon Chan, Ajay Sharma, Reuel Mudliar, Khadija Soomro, Yobelli Jimenez, and Warren Reed
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Colon ,computed tomography ,diagnosis ,diverticular disease ,magnetic resonance imaging ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Diverticular disease is one of the most common causes of outpatient visits and hospitalisations across Australia, North America and Europe. According to the Gastroenterological Society of Australia (GESA, 2010), approximately 33% of Australians over 45 years of age and 66% over 85 years of age have some form of colonic diverticulosis. Patients with colonic diverticulosis are known to develop subsequent complications such as acute colonic diverticulitis (ACD), and when more than one attack of diverticulitis occurs, there is a 70‐90% chance that the individual will experience ongoing problems and recurring infections throughout their lifetime. Medical imaging is fundamental in the diagnosis, treatment and ongoing management of ACD and its complications, with Computed Tomography (CT) identified as the prevailing gold standard in the last few decades. Cross‐database searching highlighted a large gap in the literature regarding the effectiveness of Magnetic Resonance Imaging (MRI) as a non‐ionising radiation alternative imaging tool for ACD imaging after the mid‐2000s, despite ongoing technological advancements in this modality. This narrative review identified 13 key publications (11 primary prospective cohort studies, 1 systematic review and 1 meta‐analysis) that evaluate MRI for ACD imaging, of which five were published within the last decade. Several existing MRI protocols are deemed suitable for ACD imaging, and it is recommended they be re‐evaluated in larger cohorts. Future studies should consider the rapidly growing technological improvements of MRI, its cost efficiency and its applicability in modern day healthcare settings when addressing ACD management. This is especially important considering the gradual rise in radiation dose among the Australian population attributable to increased CT referrals, alongside increased reporting of ACD cases in younger individuals.
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- 2021
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7. Identifying predictors of patient radiation dose during uterine artery embolisation
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Don J. Nocum, John Robinson, Mark Halaki, Eisen Liang, Nadine Thompson, Michelle Moscova, and Warren Reed
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dose optimisation ,interventional radiology ,radiation dose ,regression analysis ,uterine artery embolisation ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Introduction Uterine artery embolisation (UAE) is regarded as a safe and effective treatment for symptomatic uterine fibroids and/or adenomyosis. Dose reduction during UAE is critical for this reproductive‐age patient population to minimise the risks of radiation‐induced effects. The aim of this study was to identify the predictors of radiation dose which can be controlled and optimised for patients during UAE. Methods A total of 150 patients between June 2018 and August 2019 were included in this study. Demographic and clinical information such as age, body mass index (BMI), total number of fibroids, total fibroid volume, total uterus volume and dosimetric measurements on Dose Area Product (DAP), Air Kerma (AK) and fluoroscopy time were recorded. Total digital subtraction angiography (DSA), total conventional roadmap (CRM), total last‐image hold (LIH) and total fluoroscopy were calculated from the dose report. Multiple linear regression analysis was used to identify the independent predictor variables of total dose (DAP) using a regression model. Results Total DSA, total CRM and total LIH were identified as the determinants of dose for UAE (P
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- 2021
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8. The role of quality improvement in radiography
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Don J. Nocum, John Robinson, and Warren Reed
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Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Published
- 2021
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9. Evaluation of an integrated 3D‐printed phantom for coronary CT angiography using iterative reconstruction algorithm
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Kamarul A. Abdullah, Mark F. McEntee, Warren Reed, and Peter L. Kench
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reconstruction settings ,coronary CTA ,dose optimisation ,phantom ,image quality ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Introduction 3D‐printed imaging phantoms are now increasingly available and used for computed tomography (CT) dose optimisation study and image quality analysis. The aim of this study was to evaluate the integrated 3D‐printed cardiac insert phantom when evaluating iterative reconstruction (IR) algorithm in coronary CT angiography (CCTA) protocols. Methods The 3D‐printed cardiac insert phantom was positioned into a chest phantom and scanned with a 16‐slice CT scanner. Acquisitions were performed with CCTA protocols using 120 kVp at four different tube currents, 300, 200, 100 and 50 mA (protocols A, B, C and D, respectively). The image data sets were reconstructed with a filtered back projection (FBP) and three different IR algorithm strengths. The image quality metrics of image noise, signal–noise ratio (SNR) and contrast–noise ratio (CNR) were calculated for each protocol. Results Decrease in dose levels has significantly increased the image noise, compared to FBP of protocol A (P
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- 2020
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10. Artificial intelligence and convolution neural networks assessing mammographic images: a narrative literature review
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Dennis Jay Wong, Ziba Gandomkar, Wan‐Jing Wu, Guijing Zhang, Wushuang Gao, Xiaoying He, Yunuo Wang, and Warren Reed
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Artificial intelligence ,breast cancer ,breast density ,convolutional neural network ,mammography ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Studies have shown that the use of artificial intelligence can reduce errors in medical image assessment. The diagnosis of breast cancer is an essential task; however, diagnosis can include ‘detection’ and ‘interpretation’ errors. Studies to reduce these errors have shown the feasibility of using convolution neural networks (CNNs). This narrative review presents recent studies in diagnosing mammographic malignancy investigating the accuracy and reliability of these CNNs. Databases including ScienceDirect, PubMed, MEDLINE, British Medical Journal and Medscape were searched using the terms ‘convolutional neural network or artificial intelligence’, ‘breast neoplasms [MeSH] or breast cancer or breast carcinoma’ and ‘mammography [MeSH Terms]’. Articles collected were screened under the inclusion and exclusion criteria, accounting for the publication date and exclusive use of mammography images, and included only literature in English. After extracting data, results were compared and discussed. This review included 33 studies and identified four recurring categories of studies: the differentiation of benign and malignant masses, the localisation of masses, cancer‐containing and cancer‐free breast tissue differentiation and breast classification based on breast density. CNN's application in detecting malignancy in mammography appears promising but requires further standardised investigations before potentially becoming an integral part of the diagnostic routine in mammography.
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- 2020
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11. The factors contributing to the total radiation exposure of patients during uterine artery embolisation
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Don J. Nocum, John Robinson, Eisen Liang, Nadine Thompson, and Warren Reed
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Angiography ,dose ,radiation effects ,radiology ,vascular interventional ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Uterine artery embolisation (UAE) is an interventional angiography procedure for the treatment of symptomatic fibroids and/or adenomyosis in women. UAE is a less invasive and non‐surgical alternative to hysterectomy or myomectomy. However, ionising radiation is used for both fluoroscopic and angiographic image guidance to visualise and access the uterine arteries for embolisation and treatment of these benign conditions. Identifying the contributors and implementing dose reduction techniques are particularly important as UAE patients are usually of child‐bearing age. The purpose of this review was to examine the progression of literature on radiation exposure measurements and identifying the factors contributing to the total radiation exposure of female patients undergoing UAE. A Medline, ProQuest Central, ScienceDirect and Scopus database search from 2000 to 2018 was performed and forty articles were deemed acceptable for review following the inclusion and exclusion criteria set. UAE is a viable alternative to hysterectomy and myomectomy, as the reviewed literature demonstrated that the reported radiation exposure doses appear to be below the threshold for any deterministic radiation risks. The total radiation exposure of UAE patients is affected independently by multiple patient, operator expertise and technique, angiographic imaging and x‐ray unit variables. Uterus preservation can be attained post‐UAE with dose reduction and optimisation, however, a longitudinal study on UAE patients and their risk of radiation‐induced deterministic and/or stochastic effects is recommended.
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- 2019
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12. Dose reduction in CT imaging for facial bone trauma in adults: A narrative literature review
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Tayla Hooper, Grace Eccles, Talia Milliken, Josephine R. Mathieu‐Burry, and Warren Reed
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Computed tomography ,cone‐beam ,dose reduction ,dual‐source ,facial bone trauma ,intraoperative ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Trauma to the facial area accounts for a significant number of admissions to the emergency department. Diagnostic imaging is almost always required, and is critical in determining patient management. Multi‐detector computed tomography (MDCT) appears consistently in the literature as the gold‐standard imaging modality for facial bones, but results in a high radiation dose to the patient. This makes the application and advancement of dose reduction and dose optimisation methods vital. This narrative review presents a critical analysis of the literature concerning diagnostic imaging of facial bone trauma, with an emphasis on dose reduction methods for MDCT. Databases including Pubmed, Medline, Web of Science and Scopus were used to investigate this topic, with the key words: facial bone trauma, computed tomography (CT) imaging and dose reduction. Exclusion criteria included studies on nasal bone fracturing, dental imaging, elective surgeries and paediatric imaging. The literature shows overwhelming support for MDCT, given its accuracy, efficiency and ease of operation. Noise reducing reconstruction algorithms show promise as a successful method of dose reduction in facial bone imaging. Investigations of more innovative techniques also appear within the literature, including diagnostic cone‐beam CT (CBCT), intraoperative CBCT and dual‐source CT (DSCT), but further research is required to confirm their clinical value.
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- 2019
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13. Susquehanna Shale Hills Critical Zone Observatory: Shale Hills in the Context of Shaver’s Creek Watershed
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Susan L. Brantley, Tim White, Nicole West, Jennifer Z. Williams, Brandon Forsythe, Dan Shapich, Jason Kaye, Henry Lin, Yuning Shi, Margot Kaye, Elizabeth Herndon, Kenneth J. Davis, Yuting He, David Eissenstat, Julie Weitzman, Roman DiBiase, Li Li, Warren Reed, Kristen Brubaker, and Xin Gu
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Environmental sciences ,GE1-350 ,Geology ,QE1-996.5 - Abstract
The Susquehanna Shale Hills Critical Zone Observatory (SSHCZO) was established to investigate the form, function, and dynamics of the critical zone developed on sedimentary rocks in the Appalachian Mountains in central Pennsylvania. When first established, the SSHCZO encompassed only the Shale Hills catchment, a 0.08-km subcatchment within Shaver’s Creek watershed. The SSHCZO has now grown to include 120 km of the Shaver’s Creek watershed. With that growth, the science team designed a strategy to measure a parsimonious set of data to characterize the critical zone in such a large watershed. This parsimonious design includes three targeted subcatchments (including the original Shale Hills), observations along the main stem of Shaver’s Creek, and broad topographic and geophysical observations. Here we describe the goals, the implementation of measurements, and the major findings of the SSHCZO by emphasizing measurements of the main stem of Shaver’s Creek as well as the original Shale Hills subcatchment.
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- 2018
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14. Terminology describing medical imaging professionals
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Warren Reed
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Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Published
- 2019
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15. Do Reader Characteristics Affect Diagnostic Efficacy in Screening Mammography? A Systematic Review
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Dennis Jay Wong, Ziba Gandomkar, Sarah Lewis, Warren Reed, Mo'ayyad Suleiman, Somphone Siviengphanom, and Ernest Ekpo
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Cancer Research ,Oncology - Published
- 2023
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16. Teaching evidence-based practice: Case study of an integrated assessment task for diagnostic radiography students
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Yobelli A. Jimenez, Amanda Punch, Sarah J. Lewis, and Warren Reed
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Radiography ,Radiological and Ultrasound Technology ,Evidence-Based Practice ,Australia ,Humans ,Radiology, Nuclear Medicine and imaging ,Curriculum ,Students - Abstract
A core competency for all health care professionals is evidence-based practice (EBP). An understanding of research skills are key to diagnostic radiographers adopting EBP, and should be taught and assessed in curricula leading to eligibility to register and practice. This paper focuses on the design, implementation and initial evaluation of an assessment task in the Diagnostic Radiography (DR) curriculum at an Australian university, which aimed to facilitate students' skills to identify and interpret research methods and output as a foundation for EBP by combining with EBP and DR theoretical content.An integrated assessment task was introduced across two units of study, requiring student groups to produce a single literature review incorporating learning objectives from each distinct unit of study. This approach recognised and incorporated themes of student choice, negotiation of group membership, and scholarly writing as inherent components.Student feedback showed that students valued the integration of content knowledge and research principles across two units of study to better reflect their depth and breadth of learning. Students also commented on the value of team or group work in developing their communication and cooperation skills, which are essential skills in the DR workplace.A literature review assessment task integrated across two previously separate units of study provided an innovative approach to assessment of EBP in the DR curricula.It is anticipated that DR graduates, who are prepared with knowledge and skills in EBP prior to graduation, will become leaders and drive future innovation in EBP.
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- 2022
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17. Investigating the error-making patterns in reading high-density screening mammograms between radiologists from two countries
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Xuetong Tao, Somphone Siviengphanom, Ziba Gandomkar, Tong Li, Warren Reed, and Patrick C. Brennan
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- 2023
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18. False-negative diagnosis might occur due to absence of the global radiomic signature of malignancy on screening mammograms
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Ziba Gandomkar, Sarah J. Lewis, Somphone Siviengphanom, Dennis Wong, Ernest Ekpo, Moayyad E. Suleiman, Xuetong Tao, Warren Reed, and Patrick C. Brennan
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- 2023
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19. Assessing the implementation of COVID-19 structured reporting templates for chest radiography: a scoping review
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Peter A O'Reilly, Sarah Lewis, and Warren Reed
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General Medicine - Abstract
Objective: One of the common modalities used in imaging COVID-19 positive patients is chest radiography (CXR), and serves as a valuable imaging method to diagnose and monitor a patients’ condition. Structured reporting templates are regularly used for the assessment of COVID-19 CXRs and are supported by international radiological societies. This review has investigated the use of structured templates for reporting COVID-19 CXRs. Methods: A scoping review was conducted on literature published between 2020 and 2022 using Medline, Embase, Scopus, Web of Science, and manual searches. An essential criterion for the inclusion of the articles was the use of reporting methods employing either a structured quantitative or qualitative reporting method. Thematic analyses of both reporting designs were then undertaken to evaluate utility and implementation. Results: Fifty articles were found with the quantitative reporting method used in 47 articles whilst 3 articles were found employing a qualitative design. Two quantitative reporting tools (Brixia and RALE) were used in 33 studies, with other studies using variations of these methods. Brixia and RALE both use a posteroanterior or supine CXR divided into sections, Brixia with six and RALE with four sections. Each section is scaled numerically depending on the level of infection. The qualitative templates relied on selecting the best descriptor of the presence of COVID-19 radiological appearances. Grey literature from 10 international professional radiology societies were also included in this review. The majority of the radiology societies recommend a qualitative template for reporting COVID-19 CXRs. Conclusion: Most studies employed quantitative reporting methods which contrasted with the structured qualitative reporting template advocated by most radiological societies. The reasons for this are not entirely clear. There is also a lack of research literature on both the implementation of the templates or comparing both template types, indicating that the use of structured radiology reporting types may be an underdeveloped clinical strategy and research methodology. Advances in knowledge: This scoping review is unique in that it has undertaken an examination of the utility of the quantitative and qualitative structured reporting templates for COVID-19 CXRs. Moreover, through this review, the material examined has allowed a comparison of both instruments, clearly showing the favoured style of structured reporting by clinicians. At the time of the database interrogation, there were no studies found had undertaken such examinations of both reporting instruments. Moreover, due to the enduring influence of COVID-19 on global health, this scoping review is timely in examining the most innovative structured reporting tools that could be used in the reporting of COVID-19 CXRs. This report could assist clinicians in decision-making regarding templated COVID-19 reports.
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- 2023
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20. SCREENING MAMMOGRAPHY: DIAGNOSTIC EFFICACY—ISSUES AND CONSIDERATIONS FOR THE 2020S
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Sahand Hooshmand, Warren Reed, Moayyad E. Suleiman, and Patrick C. Brennan
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medicine.medical_specialty ,Radiation ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Screening mammography ,Public Health, Environmental and Occupational Health ,Breast Neoplasms ,Cognition ,General Medicine ,Breast cancer screening ,Medical imaging ,Humans ,Medicine ,Female ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Narrative review ,Breast ,Diagnostic Errors ,business ,Early Detection of Cancer ,Mammography - Abstract
Diagnostic efficacy in medical imaging is ultimately a reflection of radiologist performance. This can be influenced by numerous factors, some of which are patient related, such as the physical size and density of the breast, and machine related, where some lesions are difficult to visualise on traditional imaging techniques. Other factors are human reader errors that occur during the diagnostic process, which relate to reader experience and their perceptual and cognitive oversights. Given the large-scale nature of breast cancer screening, even small increases in diagnostic performance equate to large numbers of women saved. It is important to identify the causes of diagnostic errors and how detection efficacy can be improved. This narrative review will therefore explore the various factors that influence mammographic performance and the potential solutions used in an attempt to ameliorate the errors made.
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- 2021
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21. UTERINE ARTERY EMBOLISATION: CONTINUOUS QUALITY IMPROVEMENT REDUCES RADIATION DOSE WHILE MAINTAINING IMAGE QUALITY
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Nejc Mekiš, Don J Nocum, Mark Halaki, Magnus Båth, Nadine Thompson, Michelle Moscova, John Robinson, Warren Reed, and Eisen Liang
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Radiation ,Quality management ,Radiological and Ultrasound Technology ,business.industry ,Image quality ,Significant difference ,Radiation dose ,Public Health, Environmental and Occupational Health ,Uterine artery embolisation ,General Medicine ,Uterine Artery Embolization ,Radiation Dosage ,Quality Improvement ,Visual grading ,Kerma ,Humans ,Medicine ,Female ,Radiology, Nuclear Medicine and imaging ,Dose reduction ,business ,Nuclear medicine - Abstract
The purpose of this study was to introduce a continuous quality improvement (CQI) program for radiation dose optimisation during uterine artery embolisation (UAE) and assess its impact on dose reduction and image quality. The CQI program investigated the effects of optimising radiation dose parameters on the kerma-area product (KAP) and image quality when comparing a ‘CQI intervention’ group (n = 50) and ‘Control’ group (n = 50). Visual grading characteristics (VGC) analysis was used to assess image quality, using the ‘Control’ group as a reference. A significant reduction in KAP by 17% (P = 0.041, d = 0.2) and reference air kerma (Ka, r) by 20% (P = 0.027, d = 0.2) was shown between the two groups. The VGC analysis resulted in an area under the VGC curve (AUCVGC) of 0.54, indicating no significant difference in image quality between the two groups (P = 0.670). The implementation of the CQI program and optimisation of radiation dose parameters improved the UAE radiation dose practices at our centre. The dose reduction demonstrated no detrimental effects on image quality.
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- 2021
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22. Magnetic Resonance Imaging for the diagnosis and management of acute colonic diverticulitis: a review of current and future use
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Reuel Mudliar, Franziska Jerjen, Yobelli Jimenez, Warren Reed, Shannon Chan, Tooba Zaidi, Khadija Soomro, and Ajay Sharma
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medicine.medical_specialty ,Colon ,diagnosis ,diverticular disease ,R895-920 ,Computed tomography ,Review Article ,030218 nuclear medicine & medical imaging ,Diverticulitis, Colonic ,03 medical and health sciences ,Medical physics. Medical radiology. Nuclear medicine ,0302 clinical medicine ,Medical imaging ,medicine ,Humans ,magnetic resonance imaging ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Intensive care medicine ,Prospective cohort study ,Diverticulitis ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Gold standard ,Australia ,Magnetic resonance imaging ,computed tomography ,medicine.disease ,Diverticulosis ,030220 oncology & carcinogenesis ,Diverticular disease ,business - Abstract
Diverticular disease is one of the most common causes of outpatient visits and hospitalisations across Australia, North America and Europe. According to the Gastroenterological Society of Australia (GESA, 2010), approximately 33% of Australians over 45 years of age and 66% over 85 years of age have some form of colonic diverticulosis. Patients with colonic diverticulosis are known to develop subsequent complications such as acute colonic diverticulitis (ACD), and when more than one attack of diverticulitis occurs, there is a 70‐90% chance that the individual will experience ongoing problems and recurring infections throughout their lifetime. Medical imaging is fundamental in the diagnosis, treatment and ongoing management of ACD and its complications, with Computed Tomography (CT) identified as the prevailing gold standard in the last few decades. Cross‐database searching highlighted a large gap in the literature regarding the effectiveness of Magnetic Resonance Imaging (MRI) as a non‐ionising radiation alternative imaging tool for ACD imaging after the mid‐2000s, despite ongoing technological advancements in this modality. This narrative review identified 13 key publications (11 primary prospective cohort studies, 1 systematic review and 1 meta‐analysis) that evaluate MRI for ACD imaging, of which five were published within the last decade. Several existing MRI protocols are deemed suitable for ACD imaging, and it is recommended they be re‐evaluated in larger cohorts. Future studies should consider the rapidly growing technological improvements of MRI, its cost efficiency and its applicability in modern day healthcare settings when addressing ACD management. This is especially important considering the gradual rise in radiation dose among the Australian population attributable to increased CT referrals, alongside increased reporting of ACD cases in younger individuals., Diverticular disease is one of the most common causes of outpatient visits and hospitalisations. Cross‐database searching has highlighted a large gap in the literature: an absence of publications providing efficacy data on Magnetic Resonance Imaging (MRI) as a non‐ionising radiation alternative for ACD. This narrative review aims to explore available published data and provide an up‐to‐date evaluation of MRI as a tool for the diagnosis and ongoing management of ACD.
- Published
- 2021
23. The cognitive and perceptual processes that affect observer performance in lung cancer detection: a scoping review
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Warren Reed and Monica-Rose Van De Luecht
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medicine.medical_specialty ,Visual perception ,MEDLINE ,R895-920 ,visual perception ,Review Article ,lung neoplasms ,radiologic detection ,Cancer screening ,Medical physics. Medical radiology. Nuclear medicine ,Cognition ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Lung cancer ,Lung ,Review Articles ,Early Detection of Cancer ,Radiological and Ultrasound Technology ,eye‐tracking ,business.industry ,Solitary Pulmonary Nodule ,medicine.disease ,Visual field ,Eye tracking ,Radiology ,business ,Lung cancer screening - Abstract
Introduction Early detection of malignant pulmonary nodules through screening has been shown to reduce lung cancer‐related mortality by 20%. However, perceptual and cognitive factors that affect nodule detection are poorly understood. This review examines the cognitive and visual processes of various observers, with a particular focus on radiologists, during lung nodule detection. Methods Four databases (Medline, Embase, Scopus and PubMed) were searched to extract studies on eye‐tracking in pulmonary nodule detection. Studies were included if they used eye‐tracking to assess the search and detection of lung nodules in computed tomography or 2D radiographic imaging. Data were charted according to identified themes and synthesised using a thematic narrative approach. Results The literature search yielded 25 articles and five themes were discovered: 1 – functional visual field and satisfaction of search, 2 – expert search patterns, 3 – error classification through dwell time, 4 – the impact of the viewing environment and 5 – the effect of prevalence expectation on search. Functional visual field reduced to 2.7° in 3D imaging compared to 5° in 2D radiographs. Although greater visual coverage improved nodule detection, incomplete search was not responsible for missed nodules. Most radiological errors during lung nodule detection were decision‐making errors (30%–45%). Dwell times associated with false‐positive (FP) decisions informed feedback systems to improve diagnosis. Interruptions did not influence diagnostic performance; however, it increased viewing time by 8% and produced a 23.1% search continuation accuracy. Comparative scanning was found to increase the detection of low contrast nodules. Prevalence expectation did not directly affect diagnostic accuracy; however, decision‐making time increased by 2.32 seconds with high prevalence expectations. Conclusion Visual and cognitive factors influence pulmonary nodule detection. Insights gained from eye‐tracking can inform advancements in lung screening. Further exploration of eye‐tracking in lung screening, particularly with low‐dose computed tomography (LDCT), will benefit the future of lung cancer screening., Early detection of malignant pulmonary nodules through screening has been shown to reduce lung cancer‐related mortality by 20%. However, perceptual and cognitive factors that affect nodule detection are poorly understood. This review examines the cognitive and visual processes during lung nodule detection.
- Published
- 2021
24. Mining 911 Calls in New York City: Temporal Patterns, Detection, and Forecasting.
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Alex Chohlas-Wood, Aliya Merali, Warren Reed, and Theodoros Damoulas
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- 2015
25. Classification and reviewing of prior screening mammograms from screen-detected breast cancer cases
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Ziba Gandomkar, Sarah J. Lewis, Somphone Siviengphanom, Moayyad E. Suleiman, Dennis Wong, Warren Reed, Ernest U. Ekpo, and Patrick C. Brennan
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- 2022
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26. Student radiographers’ perceptions of evidence-based practice during clinical placements: implications for health professional education
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Laura Di Michele, Amani Bell, Kate Thomson, Mark McEntee, Belinda Kenny, and Warren Reed
- Abstract
Educating students to become evidence-based practitioners remains a significant challenge in health professional education. Clinical placements form a significant element of curriculum and the impact of students’ placement experiences on their ability and desire to practice in an evidence-based manner remains largely unexplored. Medical imaging students complete a variety of clinical placements and observe and participate in a range of clinical settings. This study utilised focus groups to explore students’ experiences of evidence-based practice (EBP) during clinical placements, the impact of these experiences on their education and their future tendencies within the profession. Reflexive thematic analysis was utilised to analyse data and three main overarching themes were identified. The first theme, “Education” explored participants’ understanding of the concept of EBP, the importance of sound pedagogy to enable students’ ability to practice in an evidence-based manner and explored the relationship between participants’ placement experiences and their future EBP tendencies. The second theme investigated, “Culture and responsibility” and was divided into three subthemes, professional, organisational, and individual. Focusing on where the responsibility for implementing EBP should lie and the impact of culture on individuals’ ability to implement evidence-based practice. The third theme, “Hopes, fears, and barriers” explored the participants’ sense of responsibility around implementing EBP and the barriers that they had experienced in doing so. It illuminated their fears around becoming apathetic as clinicians. Improving the teaching of EBP skills within health professional education has the potential to enhance the translation of knowledge into practice as graduates become clinicians within the profession.
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- 2022
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27. The Effect of Visual Hindsight Bias on Radiologist Perception
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Roger Bourne, Stephen Littlefair, Warren Reed, and Jacky Chen
- Subjects
medicine.medical_specialty ,Lung Neoplasms ,genetic structures ,media_common.quotation_subject ,education ,Audiology ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Bias ,Perception ,Radiologists ,Pulmonary nodule ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,media_common ,Observer Variation ,Visual search ,medicine.diagnostic_test ,Solitary Pulmonary Nodule ,030220 oncology & carcinogenesis ,Eye tracking ,Chest radiograph ,Psychology ,Hindsight bias - Abstract
Rationale and Objectives To measure the effect of visual hindsight bias on radiologists’ perception during chest radiograph pulmonary nodule detection. Materials and Methods This was a prospective multi-observer study to assess the effect of hindsight bias on radiologists’ perception. Sixteen radiologists were asked to interpret 15 postero-anterior chest images containing a solitary lung nodule each consisting of 25 incremental levels of blur. Participants were requested initially to detect the nodule by reducing the blur of the images (foresight). They were then asked to increase the blur until the identified nodule was undetectable (hindsight). Participants then repeated the experiment, after being informed of the potential effects of hindsight bias and asked to counteract these effects. Participants were divided into two groups (experienced and less experienced) and the nodules were given different conspicuity ratings to determine the effect of expertise and task difficulty. Eye tracking technology was also utilised to capture visual search. Results Wilcoxon analysis demonstrated significant differences between foresight and hindsight values of the radiologists (p = 0.02). However, after being informed of hindsight bias, these differences were no longer significant (p = 0.97). Friedman analysis also determined overall significance in the hindsight ratios between nodule conspicuities for both phases (phase 1: p = 0.02; phase 2: p = 0.02). There was no significance difference between the experienced and less experienced groups. Conclusion This study demonstrated that radiologists exhibit hindsight bias but appeared to be able to compensate for this phenomenon once its effects were considered. Also, visual hindsight bias appears to be affected by task difficulty with a greater effect occurring with less conspicuous nodules.
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- 2020
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28. Using Radiomics-Based Machine Learning to Create Targeted Test Sets to Improve Specific Mammography Reader Cohort Performance: A Feasibility Study
- Author
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Xuetong Tao, Ziba Gandomkar, Tong Li, Patrick C. Brennan, and Warren Reed
- Subjects
Medicine (miscellaneous) ,mammography ,mammography interpretation ,diagnostic errors ,radiomics ,machine learning - Abstract
Mammography interpretation is challenging with high error rates. This study aims to reduce the errors in mammography reading by mapping diagnostic errors against global mammographic characteristics using a radiomics-based machine learning approach. A total of 36 radiologists from cohort A (n = 20) and cohort B (n = 16) read 60 high-density mammographic cases. Radiomic features were extracted from three regions of interest (ROIs), and random forest models were trained to predict diagnostic errors for each cohort. Performance was evaluated using sensitivity, specificity, accuracy, and AUC. The impact of ROI placement and normalization on prediction was investigated. Our approach successfully predicted both the false positive and false negative errors of both cohorts but did not consistently predict location errors. The errors produced by radiologists from cohort B were less predictable compared to those in cohort A. The performance of the models did not show significant improvement after feature normalization, despite the mammograms being produced by different vendors. Our novel radiomics-based machine learning pipeline focusing on global radiomic features could predict false positive and false negative errors. The proposed method can be used to develop group-tailored mammographic educational strategies to help improve future mammography reader performance.
- Published
- 2023
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29. Brief Report: Immunoglobulin A Deficiency in a Subset of Autistic Subjects.
- Author
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Warren, Reed P.
- Abstract
A study of 40 individuals (ages 5-31) with autism investigated immune deficiency. Results found the subjects had significantly lower serum immunoglobulin A (IgA) levels than that of age- and sex-matched controls. Seventeen subjects had one of three haplotypes associated with IgA deficiency and seven of these had decreased IgA levels. (CR)
- Published
- 1997
30. Panoramic radiography and patients with disability: a new simple breathing technique to reduce common airspace error
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Antonia Scott and Warren Reed
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Radiological and Ultrasound Technology ,Child, Preschool ,Intellectual Disability ,Radiography, Panoramic ,Humans ,Radiology, Nuclear Medicine and imaging ,Child - Abstract
Patients with intellectual disabilities often fail to follow traditional tongue position instructions for panoramic radiographs resulting in missed pathology or unnecessary further radiation. This simple breathing technique is a new clinical instruction method for panoramic radiography developed to reduce the most common patient position error: patient failure to hold the tongue to the roof of the mouth. The technique is suitable for all patients including young patients and those with intellectual disabilities. The simple breathing technique uses 'tell-show-do' communication methods and does not mention the tongue but utilises the known tongue positions that occur during breathing and swallowing. This simple breathing technique instruction for panoramic radiography uses a demonstration of 'breathe-in, breathe-out, swallow, lips closed and hold still' to reduce the intensity of both the palatoglossal and pharyngeal airspaces on panoramic radiographs. This method, referred in this article as the simple breathing technique, can improve the diagnostic potential of panoramic radiographs and can be used with young children and patients with intellectual disabilities, and this slow breathing technique can help them further relax.
- Published
- 2021
31. The factors contributing to the total radiation exposure of patients during uterine artery embolisation
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Eisen Liang, Don J Nocum, Nadine Thompson, Warren Reed, and John Robinson
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lcsh:Medical physics. Medical radiology. Nuclear medicine ,Longitudinal study ,medicine.medical_specialty ,vascular interventional ,medicine.medical_treatment ,lcsh:R895-920 ,MEDLINE ,Uterus ,Uterine artery embolisation ,Review Article ,Radiation Dosage ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Adenomyosis ,Review Articles ,Hysterectomy ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Angiography ,dose ,Radiation Exposure ,Uterine Artery Embolization ,medicine.disease ,radiology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Inclusion and exclusion criteria ,radiation effects ,Female ,Radiology ,business - Abstract
Uterine artery embolisation (UAE) is an interventional angiography procedure for the treatment of symptomatic fibroids and/or adenomyosis in women. UAE is a less invasive and non‐surgical alternative to hysterectomy or myomectomy. However, ionising radiation is used for both fluoroscopic and angiographic image guidance to visualise and access the uterine arteries for embolisation and treatment of these benign conditions. Identifying the contributors and implementing dose reduction techniques are particularly important as UAE patients are usually of child‐bearing age. The purpose of this review was to examine the progression of literature on radiation exposure measurements and identifying the factors contributing to the total radiation exposure of female patients undergoing UAE. A Medline, ProQuest Central, ScienceDirect and Scopus database search from 2000 to 2018 was performed and forty articles were deemed acceptable for review following the inclusion and exclusion criteria set. UAE is a viable alternative to hysterectomy and myomectomy, as the reviewed literature demonstrated that the reported radiation exposure doses appear to be below the threshold for any deterministic radiation risks. The total radiation exposure of UAE patients is affected independently by multiple patient, operator expertise and technique, angiographic imaging and x‐ray unit variables. Uterus preservation can be attained post‐UAE with dose reduction and optimisation, however, a longitudinal study on UAE patients and their risk of radiation‐induced deterministic and/or stochastic effects is recommended.
- Published
- 2019
32. Dose reduction in CT imaging for facial bone trauma in adults: A narrative literature review
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Grace Eccles, Talia Milliken, Josephine R. Mathieu‐Burry, Tayla Hooper, and Warren Reed
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cone‐beam ,lcsh:Medical physics. Medical radiology. Nuclear medicine ,medicine.medical_specialty ,Facial bone ,lcsh:R895-920 ,MEDLINE ,Computed tomography ,Review Article ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Medical imaging ,Radiology, Nuclear Medicine and imaging ,Review Articles ,dual‐source ,facial bone trauma ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Emergency department ,Nasal bone ,dose reduction ,030220 oncology & carcinogenesis ,Dose reduction ,intraoperative ,Radiology ,Ct imaging ,business - Abstract
Trauma to the facial area accounts for a significant number of admissions to the emergency department. Diagnostic imaging is almost always required, and is critical in determining patient management. Multi‐detector computed tomography (MDCT) appears consistently in the literature as the gold‐standard imaging modality for facial bones, but results in a high radiation dose to the patient. This makes the application and advancement of dose reduction and dose optimisation methods vital. This narrative review presents a critical analysis of the literature concerning diagnostic imaging of facial bone trauma, with an emphasis on dose reduction methods for MDCT. Databases including Pubmed, Medline, Web of Science and Scopus were used to investigate this topic, with the key words: facial bone trauma, computed tomography (CT) imaging and dose reduction. Exclusion criteria included studies on nasal bone fracturing, dental imaging, elective surgeries and paediatric imaging. The literature shows overwhelming support for MDCT, given its accuracy, efficiency and ease of operation. Noise reducing reconstruction algorithms show promise as a successful method of dose reduction in facial bone imaging. Investigations of more innovative techniques also appear within the literature, including diagnostic cone‐beam CT (CBCT), intraoperative CBCT and dual‐source CT (DSCT), but further research is required to confirm their clinical value.
- Published
- 2019
33. Clinical History - New Analysis Methods Provide Extra Insight Into the Effect of Clinical History on Diagnostic Performance
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Warren Reed
- Subjects
medicine.medical_specialty ,Clinical history ,business.industry ,MEDLINE ,Medicine ,Radiology, Nuclear Medicine and imaging ,Medical physics ,business ,Analysis method - Published
- 2022
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34. Digital mammographic interpretation by UK radiographer mammographers: A JAFROC analysis of observer performance
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Warren Reed, S. Williams, L. Cielecki, Nick Woznitza, and U. Aksoy
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medicine.medical_specialty ,Breast Neoplasms ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Observer performance ,medicine ,Mammography ,Humans ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Breast ,Podiatry ,Observer Variation ,medicine.diagnostic_test ,business.industry ,medicine.disease ,United Kingdom ,Test (assessment) ,Clinical Practice ,030220 oncology & carcinogenesis ,Test set ,Female ,business - Abstract
Introduction Radiologists utilise mammography test sets to bench mark their performance against recognised standards. Using a validated test set, this study compares the performance of radiographer readers against previous test results for radiologists. Methods Under similar test conditions radiographer readers were given an established test set of 60 mammograms and tasked to identify breast cancer, they were measured against their ability to identify, locate and give a confidence level for cancer being present on a standard set of mammographic images. The results were then compared to previously published results for radiologists for similar or the same test sets. Results The 10 radiographer readers demonstrated similar results to radiologists and for lesion sensitivity were the highest scoring group. The study group score a sensitivity of 83; a specificity of 69.3 and lesion sensitivity of 74.8 with ROC and JAFROC scores of 0.86 and 0.74 respectively. Conclusion Under test conditions radiographers are able to identify and accurately locate breast cancer in a range of complex mammographic backgrounds. Implications for practice The study was performed under experimental conditions with results comparable to breast radiologists under similar conditions, translation of these findings into clinical practice will help address access and capacity issues in the timely identification and diagnosis of breast cancer.
- Published
- 2020
35. Knowledge translation: Radiographers compared to other healthcare professionals
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Kate Thomson, L. Di Michele, Belinda Kenny, Mark F. McEntee, and Warren Reed
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Evidence-based practice ,Health Personnel ,Allied Health Personnel ,Real evidence ,Diagnostic radiographer ,Knowledge translation ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Positive shift ,Medical education ,Health professionals ,Allied health professions ,Radiography ,030220 oncology & carcinogenesis ,Evidence-Based Practice ,Evidence-based radiography ,Implementation science ,Narrative review ,Psychology ,Delivery of Health Care - Abstract
Objectives This narrative review examines the current status of evidence-based practice and knowledge translation in diagnostic radiography. It explores knowledge translation efforts in the allied health professions aimed at systematically implementing evidence-based practice and suggests ways that these may be applied within diagnostic radiography. Key findings Knowledge translation in diagnostic radiography is in its infancy with numerous examples of key findings of rigorous studies not implemented in practice. Utilising frameworks, models and theories to systematically translate knowledge into evidence-based practice has been shown to be effective in other allied health professions. Whilst few studies in diagnostic radiography report utilising these systematic approaches to implementing evidence-based practice, those that do, show promising results. Attitudes towards evidence-based practice within diagnostic radiography are becoming more positive and it is important to use this positive shift in attitudes to create real evidence-based change in the profession. Conclusion The potential benefits of systematically translating knowledge into evidence-based practice in diagnostic radiography are wide reaching with positive implications for our patients, the profession and wider community. Leaders at all levels of radiography must work towards implementing evidence-based practice in their daily work. Implications for practice Systematic approaches to knowledge translation should be adopted and reported in diagnostic radiography in order to more effectively translate knowledge into evidence-based practice.
- Published
- 2020
36. Radiologists’ Performance at Reduced Recall Rates in Mammography: A Laboratory Study
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Norhashimah Mohd Norsuddin, Warren Reed, Sarah J. Lewis, and Claudia Mello-Thoms
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0301 basic medicine ,medicine.medical_specialty ,Breast imaging ,specificity ,Breast Neoplasms ,Sensitivity and Specificity ,Single test ,03 medical and health sciences ,0302 clinical medicine ,Informed consent ,Recall rates ,Radiologists ,Task Performance and Analysis ,medicine ,screening mammography ,Humans ,Mammography ,Breast ,Diagnostic Errors ,Early Detection of Cancer ,Observer Variation ,Recall ,medicine.diagnostic_test ,business.industry ,General Medicine ,sensitivity ,reader’s performance ,Radiographic Image Enhancement ,030104 developmental biology ,Free recall ,030220 oncology & carcinogenesis ,Anxiety ,Female ,Clinical Competence ,Radiology ,medicine.symptom ,business ,Over diagnosis ,Research Article - Abstract
Rationale and objectives: Target recall rates are often used as a performance indicator in mammography screening programs with the intention of reducing false positive decisions, over diagnosis and anxiety for participants. However, the relationship between target recall rates and cancer detection is unclear, especially when readers are directed to adhere to a predetermined rate. The purpose of this study was to explore the effect of setting different recall rates on radiologist’s performance. Materials and Methods: Institutional ethics approval was granted and informed consent was obtained from each participating radiologist. Five experienced breast imaging radiologists read a single test set of 200 mammographic cases (20 abnormal and 180 normal). The radiologists were asked to identify each case that they required to be recalled in three different recall conditions; free recall, 15% and 10% and mark the location of any suspicious lesions. Results: Wide variability in recall rates was observed when reading at free recall, ranging from 18.5% to 34.0%. Readers demonstrated significantly reduced performance when reading at prescribed recall rates, with lower sensitivity (H=12.891, P=0.002), case location sensitivity (H=12.512, P=0.002) and ROC AUC (H=11.601, P=0.003) albeit with an increased specificity (H=12.704, P=0.002). However, no significant changes were evident in lesion location sensitivity (H=1.982, P=0.371) and JAFROC FOM (H=1.820, P=0.403). Conclusion: In this laboratory study, reducing the number of recalled cases to 10% significantly reduced radiologists’ performance with lower detection sensitivity, although a significant improvement in specificity was observed.
- Published
- 2019
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37. Investigating Visual Hindsight Bias in Medical Imaging
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Warren Reed, Stephen Littlefair, and Jacky Chen
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medicine.medical_specialty ,business.industry ,Radiography ,MEDLINE ,Bias ,Radiologists ,Medical imaging ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Medical physics ,business ,Hindsight bias - Published
- 2020
38. Radiologist performance in the detection of lung cancer using CT
- Author
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Patrick C. Brennan, B. Al Mohammad, Stephen L. Hillis, Warren Reed, and Maram Alakhras
- Subjects
Adult ,Male ,medicine.medical_specialty ,Lung Neoplasms ,Computed tomography ,Cancer Care Facilities ,Sensitivity and Specificity ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Radiologists ,Cancer centre ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Lung cancer ,medicine.diagnostic_test ,Receiver operating characteristic ,business.industry ,Cancer ,General Medicine ,Middle Aged ,medicine.disease ,030220 oncology & carcinogenesis ,Female ,Radiography, Thoracic ,Clinical Competence ,Radiology ,Tomography, X-Ray Computed ,business - Abstract
AIM To measure the level of radiologists' performance in lung cancer detection, and to explore radiologists' performance in cancer specialised and non-specialised centres. MATERIALS AND METHODS Thirty radiologists read 60 chest computed tomography (CT) examinations. Thirty cases had surgically or biopsy-proven lung cancer and 30 were cancer-free cases. The cancer cases were validated by four expert radiologists who located the malignant lung nodules. Reader performance was evaluated by calculating sensitivity, location sensitivity, specificity, and area under the receiver operating characteristic (ROC) curve (AUC). In addition, sensitivity at fixed specificity (0.794) was computed from each reader's estimated ROC curve. RESULTS The radiologists had a mean sensitivity of 0.749, sensitivity at fixed specificity of 0.744, location sensitivity of 0.666, specificity of 0.81 and AUC of 0.846. Radiologists in the specialised and non-specialised cancer centres had the following (specialised, non-specialised) pairs of values: sensitivity=(0.80, 0.719); sensitivity for fixed 0.794 specificity=(0.752, 0.740); location sensitivity=(0.712, 0.637); specificity=(0.794, 0.82) and AUC=(0.846, 0.846). CONCLUSION The efficacy of radiologists was comparable to other studies. Furthermore, AUC outcomes were similar for specialised and non-specialised cancer centre radiologists, suggesting they have similar discriminatory ability and that the higher sensitivity and lower specificity for specialised-centre radiologists can be attributed to them being less conservative in interpreting case images.
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- 2019
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39. Increasing iterative reconstruction strength at low tube voltage in coronary CT angiography protocols using 3D-printed and Catphan
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Mark F. McEntee, Kamarul Amin Abdullah, Warren Reed, and Peter L. Kench
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iterative reconstruction ,Image quality ,Computed Tomography Angiography ,Iterative reconstruction ,Signal-To-Noise Ratio ,Coronary Angiography ,Radiation Dosage ,Noise (electronics) ,Imaging phantom ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Medical Imaging ,Optical transfer function ,Image noise ,image quality ,Humans ,Radiology, Nuclear Medicine and imaging ,Instrumentation ,Mathematics ,Radiation ,Radon transform ,business.industry ,Phantoms, Imaging ,Coronary ct angiography ,3D printing ,phantom ,030220 oncology & carcinogenesis ,Printing, Three-Dimensional ,Radiographic Image Interpretation, Computer-Assisted ,Nuclear medicine ,business ,radiation dose ,Tomography, X-Ray Computed ,Algorithms ,CT - Abstract
Purpose The purpose of this study was to investigate the effect of increasing iterative reconstruction (IR) algorithm strength at different tube voltages in coronary computed tomography angiography (CCTA) protocols using a three‐dimensional (3D)‐printed and Catphan® 500 phantoms. Methods A 3D‐printed cardiac insert and Catphan 500 phantoms were scanned using CCTA protocols at 120 and 100 kVp tube voltages. All CT acquisitions were reconstructed using filtered back projection (FBP) and Adaptive Statistical Iterative Reconstruction (ASIR) algorithm at 40% and 60% strengths. Image quality characteristics such as image noise, signal–noise ratio (SNR), contrast–noise ratio (CNR), high spatial resolution, and low contrast resolution were analyzed. Results There was no significant difference (P > 0.05) between 120 and 100 kVp measures for image noise for FBP vs ASIR 60% (16.6 ± 3.8 vs 16.7 ± 4.8), SNR of ASIR 40% vs ASIR 60% (27.3 ± 5.4 vs 26.4 ± 4.8), and CNR of FBP vs ASIR 40% (31.3 ± 3.9 vs 30.1 ± 4.3), respectively. Based on the Modulation Transfer Function (MTF) analysis, there was a minimal change of image quality for each tube voltage but increases when higher strengths of ASIR were used. The best measure of low contrast detectability was observed at ASIR 60% at 120 kVp. Conclusions Changing the IR strength has yielded different image quality noise characteristics. In this study, the use of 100 kVp and ASIR 60% yielded comparable image quality noise characteristics to the standard CCTA protocols using 120 kVp of ASIR 40%. A combination of 3D‐printed and Catphan® 500 phantoms could be used to perform CT dose optimization protocols.
- Published
- 2020
40. Development of an organ-specific insert phantom generated using a 3D printer for investigations of cardiac computed tomography protocols
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Kamarul Amin Abdullah, Mark F. McEntee, Peter L. Kench, and Warren Reed
- Subjects
Scanner ,Cardiac computed tomography ,Computer science ,Computed tomography ,Imaging phantom ,030218 nuclear medicine & medical imaging ,3d printer ,03 medical and health sciences ,0302 clinical medicine ,Hounsfield scale ,Organ specific ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,rapid prototyping ,Insert (composites) ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,Phantoms, Imaging ,computed tomography ,Original Articles ,3D printing ,Cardiac Imaging Techniques ,030220 oncology & carcinogenesis ,Printing, Three-Dimensional ,Original Article ,computer aided design (CAD) ,cardiac insert phantom ,Tomography, X-Ray Computed ,Biomedical engineering - Abstract
Introduction An ideal organ‐specific insert phantom should be able to simulate the anatomical features with appropriate appearances in the resultant computed tomography (CT) images. This study investigated a 3D printing technology to develop a novel and cost‐effective cardiac insert phantom derived from volumetric CT image datasets of anthropomorphic chest phantom. Methods Cardiac insert volumes were segmented from CT image datasets, derived from an anthropomorphic chest phantom of Lungman N‐01 (Kyoto Kagaku, Japan). These segmented datasets were converted to a virtual 3D‐isosurface of heart‐shaped shell, while two other removable inserts were included using computer‐aided design (CAD) software program. This newly designed cardiac insert phantom was later printed by using a fused deposition modelling (FDM) process via a Creatbot DM Plus 3D printer. Then, several selected filling materials, such as contrast media, oil, water and jelly, were loaded into designated spaces in the 3D‐printed phantom. The 3D‐printed cardiac insert phantom was positioned within the anthropomorphic chest phantom and 30 repeated CT acquisitions performed using a multi‐detector scanner at 120‐kVp tube potential. Attenuation (Hounsfield Unit, HU) values were measured and compared to the image datasets of real‐patient and Catphan® 500 phantom. Results The output of the 3D‐printed cardiac insert phantom was a solid acrylic plastic material, which was strong, light in weight and cost‐effective. HU values of the filling materials were comparable to the image datasets of real‐patient and Catphan® 500 phantom. Conclusions A novel and cost‐effective cardiac insert phantom for anthropomorphic chest phantom was developed using volumetric CT image datasets with a 3D printer. Hence, this suggested the printing methodology could be applied to generate other phantoms for CT imaging studies.
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- 2018
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41. Predictors of radiation dose for uterine artery embolisation are angiography system-dependent
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Don J Nocum, John Robinson, Mark Halaki, Magnus Båth, John D Thompson, Nadine Thompson, Michelle Moscova, Eisen Liang, Nejc Mekiš, and Warren Reed
- Subjects
Fluoroscopy ,Angiography ,Public Health, Environmental and Occupational Health ,Humans ,Female ,General Medicine ,Uterine Artery Embolization ,Radiation Dosage ,Radiography, Interventional ,Waste Management and Disposal - Abstract
This study sought to achieve radiation dose reductions for patients receiving uterine artery embolisation (UAE) by evaluating radiation dose measurements for the preceding generation (Allura) and upgraded (Azurion) angiography system. Previous UAE regression models in the literature could not be applied to this centre’s practice due to being based on different angiography systems and radiation dose predictor variables. The aims of this study were to establish whether radiation dose is reduced with the upgraded angiography system and to develop a regression model to determine predictors of radiation dose specific to the upgraded angiography system. A comparison between Group I (Allura, n = 95) and Group II (Azurion, n = 95) demonstrated a significant reduction in kerma-area product (KAP) and Ka, r (reference air kerma) by 63% (143.2 Gy cm2 vs 52.9 Gy cm2; P < 0.001, d = 0.8) and 67% (0.6 Gy vs 0.2 Gy; P < 0.001, d = 0.8), respectively. The multivariable linear regression (MLR) model identified the UAE radiation dose predictors for KAP on the upgraded angiography system as total fluoroscopy dose, Ka, r, and total uterus volume. The predictive accuracy of the MLR model was assessed using a Bland-Altman plot. The mean difference was 0.39 Gy cm2 and the limits of agreement were +28.49 and −27.71 Gy cm2, and thus illustrated no proportional bias. The resultant MLR model was considered system-dependent and validated the upgraded angiography system and its advance capabilities to significantly reduce radiation dose. Interventional radiologist and interventional radiographer familiarisation of the system’s features and the implementation of the newly established MLR model would further facilitate dose optimisation for all centres performing UAE procedures using the upgraded angiography system.
- Published
- 2022
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42. 3D printing in medical imaging and healthcare services
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Warren Reed and Kamarul Amin Abdullah
- Subjects
Diagnostic Imaging ,3D bioprinting ,medicine.medical_specialty ,Engineering ,Radiological and Ultrasound Technology ,business.industry ,MEDLINE ,3D printing ,030218 nuclear medicine & medical imaging ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,030220 oncology & carcinogenesis ,Printing, Three-Dimensional ,Health care ,Commentary ,Medical imaging ,medicine ,Radiology, Nuclear Medicine and imaging ,Medical physics ,business - Abstract
Three‐dimensional (3D) printing technology has demonstrated a huge potential for the future of medicine. Since its introduction, it has been used in various areas, for example building anatomical models, personalising medical devices and implants, aiding in precision medical interventions and the latest development, 3D bioprinting. This commentary is provided to outline the current use of 3D printing in medical imaging and its future directions for advancing the healthcare services.
- Published
- 2018
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43. Comparing senior residents performance to radiologists in lung cancer detection
- Author
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Charbel Saade, Patrick C. Brennan, Stephen L. Hillis, Badera Al Mohammad, and Warren Reed
- Subjects
medicine.medical_specialty ,Receiver operating characteristic ,business.industry ,Chest ct ,Early detection ,Cancer ,medicine.disease ,Screening programs ,Medicine ,Radiology ,business ,Lung cancer ,Cancer death ,Lung cancer screening - Abstract
Background: Lung cancer, the leading cause of cancer death worldwide, can be survived if early detection through screening programs occurs. However if a large scale lung cancer screening program needs to be implemented, it may require a substantial increase in qualified readers’ numbers. To investigate whether senior radiology residents may potentially increase the pool of available readers in screening for lung cancer, by comparing their performance with that of board-certified radiologists. Methodology: Twenty board-certified radiologists and ten senior residents read sixty chest CT scans. Thirty cases had surgically or biopsy-proven lung cancer and the remaining thirty were cancer-free cases. The cancer cases were validated by four expert radiologists who located the malignant lung nodules. Reader performance was evaluated by calculating sensitivity, location sensitivity, specificity, area under the receiver-operating-characteristic curve (AUC) and sensitivity at fixed specificity = 0.8. Results: Readers had the following (radiologists, residents) pairs of values: sensitivity = (0.782, 0.687); location sensitivity = (0.702, 0.597); specificity = (0.8, 0.83); AUC = (0.844, 0.85) and sensitivity for fixed 0.8 specificity = (0.74, 0.73). Conclusion: Initial findings suggest that senior residents compare favorably with board-certified radiologists based on the similarity of the AUCs and the summary ROC curves in terms of the ability to discriminate between diseased and non-diseased patients. However, they have demonstrated significantly lower detection sensitivity than board-certified radiologists and may require additional training, considering the importance of having high sensitivity when screening for cancer.
- Published
- 2019
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44. The Potential Role of Cytokines in the Treatment of Viral Infections
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Warren, Reed P. and Sidwell, Robert W.
- Published
- 1994
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45. Reading Disability, Attention-Deficit Hyperactivity Disorder, and the Immune System
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Warren, Reed P., Odell, J. Dennis, Warren, W. Louise, Burger, Roger A., Maciulis, Alma, Daniels, Wayne W., Torres, Anthony R., Cordon, Lon R., Smith, Shelley D., Fulker, David W., Kimberling, William J., Pennington, Bruce F., and DeFries, John C.
- Published
- 1995
46. Possible association of the exetended MHC haplotype B44-SC30-DR4 with autism
- Author
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Warren, Reed P., Singh, Vijendra K., Cole, Phyllis, Odell, J. Dennis, Pingree, Carmen B., Warren, W. Louise, DeWitt, Charles W., and McCullough, Maxine
- Published
- 1992
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47. Is decreased blood plasma concentration of the complement C4B protein associated with attention-deficit hyperactivity disorder
- Author
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Warren, Reed P., Odell, J. Dennis, Warren, W. Louise, Burger, Roger A., Maciulis, Alma, and Torres, Anthony R.
- Subjects
Blood proteins -- Physiological aspects ,Blood plasma -- Physiological aspects ,Attention-deficit hyperactivity disorder -- Physiological aspects ,Family and marriage ,Psychology and mental health - Published
- 1995
48. Binding of [3H]serotonin to lymphocytes in patients with neuropsychiatric disorders
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Singh, Vijendra K., Warren, Reed P., and Singh, Edith A.
- Published
- 1990
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49. Does Expectation of Abnormality Affect the Search Pattern of Radiologists When Looking for Pulmonary Nodules?
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Patrick C. Brennan, Claudia Mello-Thoms, Stephen Littlefair, and Warren Reed
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medicine.medical_specialty ,Lung Neoplasms ,Radiography ,Fixation, Ocular ,Affect (psychology) ,Article ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Radiologists ,Prevalence ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Lung ,Observer Variation ,Visual search ,Solitary pulmonary nodule ,High prevalence ,Radiological and Ultrasound Technology ,business.industry ,Solitary Pulmonary Nodule ,medicine.disease ,Computer Science Applications ,Fixation (visual) ,Eye tracking ,Radiography, Thoracic ,Radiology ,Abnormality ,business ,030217 neurology & neurosurgery - Abstract
This experiment investigated whether there might be an effect on the visual search strategy of radiologists during image interpretation of the same adult chest radiographs when given different clinical information. Each of 17 experienced radiologists was asked to interpret a set of 57 (10 abnormal) posteroanterior chest images to identify the presence of pulmonary lesions using differing clinical information (leading to unknown, low and high expectations of prevalence). Eye position metrics (search time, dwell time and time to first fixation) were compared for normal and abnormal images, as well as between conditions. For all images, there was a significantly longer search time at high prevalence expectation compared to low prevalence expectation (W = 75.19, P =
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- 2016
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50. Outcomes Knowledge May Bias Radiological Decision-making
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Stephen Littlefair, Phuong Dung, Roland Talanow, Warren Reed, Marius Pietryzk, Patrick C. Brennan, and Claudia Mello-Thoms
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Adult ,medicine.medical_specialty ,Lung Neoplasms ,Radiography ,Clinical Decision-Making ,Sensitivity and Specificity ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Expert witness ,Clinical history ,Malpractice ,Radiologists ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Expert Testimony ,business.industry ,Significant difference ,030220 oncology & carcinogenesis ,Radiological weapon ,Radiology ,Lung tumours ,Abnormality ,business ,Prejudice - Abstract
Rationale and Objectives This research investigates whether an expectation of abnormality and prior knowledge might potentially influence the decision-making of radiologists, and discusses the implications for radiological expert witness testimony. Materials and Methods This study was a web-based perception experiment. A total of 12 board-certified radiologists were asked to interpret 40 adult chest images (20 abnormal) twice and decide if pulmonary lesions were present. Before the first viewing, a general clinical history was given for all images: cough for 3 + weeks . This was called the “defendants read.” Two weeks later, the radiologists were asked to view the same dataset (unaware that the dataset was unchanged). For this reading, the radiologists were given the following information for all images: “ These images were reported normal but all of these patients have a lung tumour diagnosed on a subsequent radiograph 6 months later. ” They were also given the lobar location of the newly diagnosed tumor. This was called the “expert witness read.” Results There was a significant difference in location-based sensitivity (W = −45, P = 0.02) between the two conditions with nodule detection increasing under the second condition. Specificity increased outside the lobe of interest (W = 727, P = P = 0.03) significantly in the “expert witness” read. Case-based sensitivity and case-based specificity were unaffected. Conclusions This study showed evidence that increased clinical information affects the performance of radiologists. This effect may bias expert witnesses in radiological malpractice litigation.
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- 2016
- Full Text
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