Search

Your search keyword '"Warren, W.C."' showing total 26 results
Start Over Author "Warren, W.C."
26 results on '"Warren, W.C."'

1. Nanoscience and Nanotechnology Cross Borders

Author

Yury Gogotsi, Jeffrey Brinker, Takhee Lee, Manishkumar Chhowalla, C. N.R. Rao, Darrell J. Irvine, Wolfgang J. Parak, Ali Khademhosseini, Paula T. Hammond, Xing-Jie Liang, Emily A. Weiss, Warren W.C. Chan, Jill E. Millstone, Andre E. Nel, Molly M. Stevens, Christoph Gerber, Andrey L. Rogach, Graham J. Leggett, Yan Li, David S. Ginger, Maurizio Prato, Kostas Kostarelos, Cherie R. Kagan, Raymond E. Schaak, Andrew T. S. Wee, Sharon C. Glotzer, Luis M. Liz-Marzán, Nicholas A. Kotov, Laura L. Kiessling, Paul S. Weiss, Teri W. Odom, Reginald M. Penner, Michael F. Crommie, Xiaoyuan Chen, Omid C. Farokhzad, Christy Landes, Paul Mulvaney, Cees Dekker, Ali Javey, Michael J. Sailor, Shuit-Tong Lee, Mark C. Hersam, Lifeng Chi, Helmuth Möhwald, Aydogan Ozcan, Jason H. Hafner, Khademhosseini, Ali, Chan, Warren W. C., Chhowalla, Manish, Glotzer, Sharon C., Gogotsi, Yury, Hafner, Jason H., Hammond, Paula T., Hersam, Mark C., Javey, Ali, Kagan, Cherie R., Kotov, Nicholas A., Lee, Shuit Tong, Li, Yan, Möhwald, Helmuth, Mulvaney, Paul A., Nel, Andre E., Parak, Wolfgang J., Penner, Reginald M., Rogach, Andrey L., Schaak, Raymond E., Stevens, Molly M., Wee, Andrew T. S., Brinker, Jeffrey, Chen, Xiaoyuan, Chi, Lifeng, Crommie, Michael, Dekker, Cee, Farokhzad, Omid, Gerber, Christoph, Ginger, David S., Irvine, Darrell J., Kiessling, Laura L., Kostarelos, Kosta, Landes, Christy, Lee, Takhee, Leggett, Graham J., Liang, Xing Jie, Liz Marzán, Lui, Millstone, Jill, Odom, Teri W., Ozcan, Aydogan, Prato, Maurizio, Rao, C. N. R., Sailor, Michael J., Weiss, Emily, and Weiss, Paul S.

Subjects
Materials science, Andrey, Materials Science (all), Engineering (all), Physics and Astronomy (all), General Engineering, General Physics and Astronomy, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, General Materials Science, Nanoscience & Nanotechnology, 0210 nano-technology
Abstract

The recent ExecutiveOrder by President Trump attempting to ban temporarily the citizens of seven countries (Iran, Iraq, Libya, Somalia, Sudan, Syria, and Yemen) from entering the United States is having significant consequences within the country and around the world. The Order poses a threat to the health and vitality of science, barring students and scientists from these countries from traveling to the United States to study or to attend conferences. In preventing those members of the international scientific community from traveling beyond U.S. borders without guaranteed safe return, the Executive Order demeans them; in so doing, it demeans us all. Universities and research communities are especially impacted, as major universities have students and often faculty holding passports from one of these seven countries. This temporary ban would affect refugees fleeing war-torn areas, challenging the long-standing notion that the United States is a safe haven for those fleeing persecution and war in addition to being a magnet for talent from every corner of the world. The pages of this journal reflect the geographic, ethnic, and cultural diversity that underpins great science. The ban impacts domestic and global scientific efforts and communities. Science succeeds through the cooperation between collections of individuals and teams around the world discovering and learning from each other. To ensure rapid scientific progress, open communication and exchange between scientists are essential. As scientists, engineers, and clinicians, we have benefited from open interactions and collaborations with visitors and students from all parts of the world as well as through scientific publications and discussions at scientific meetings.

Published
2017

2. A Big Year Ahead for Nano in 2018

Author

Jason H. Hafner, Paula T. Hammond, Cherie R. Kagan, Yury Gogotsi, Sharon C. Glotzer, Omid C. Farokhzad, Paul S. Weiss, Raymond E. Schaak, Shuit-Tong Lee, Molly M. Stevens, Kazunori Kataoka, Ali Javey, Mark C. Hersam, Laura E. Fernandez, Wolfgang J. Parak, Peter Nordlander, Warren W.C. Chan, C. Grant Willson, Jill Millstone, Manish Chhowalla, Yan Li, Andrey L. Rogach, Ali Khademhosseini, Paul Mulvaney, Helmuth Möhwald, Andrew T. S. Wee, Nicholas A. Kotov, Reginald M. Penner, and Andre E. Nel

Subjects
Materials science, Nano, General Engineering, General Physics and Astronomy, General Materials Science, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 0210 nano-technology, 01 natural sciences, 0104 chemical sciences
Published
2017

3. Ruminant placental lactogens: structure and biology

Author

Byatt, J.C., Warren, W.C., Eppard, P.J., Staten, N.R., Krivi, G.G., and Collier, R.J.

Subjects
Ruminants -- Physiological aspects, Placental hormones -- Analysis, Fetus -- Growth, Zoology and wildlife conservation
Abstract

Ruminant placental lactogens (PL) are members of the somatotropin, prolactin gene family that are synthesized by trophectodermal binucleate cells. The structure and biology of PL has been studied in the cow, sheep, and goat. Ruminant PL have greater structural identity to prolactin than somatotropin, although they bind to both lactogenic and somatogenic receptors. The molecular weights of ovine and caprine PL are approximately 23,000, whereas bovine PL is larger (31,000 to 34,000) due to glycosylation. Placental lactogen is secreted into both the fetal and maternal circulations. The concentration of PL in the fetus decreases with advancing gestation, whereas PL concentration peaks in the maternal circulation during the last third of pregnancy then reaches a plateau. Furthermore, the maternal concentration of PL is 100- to 1000-fold higher in sheep and goats than in cows. The precise factors that modulate secretion of PL are unknown, although placental mass and nutrition seem to play a role. Ruminant PL have both lactogenic and somatogenic biological activities and may also have unique activities mediated through a specific receptor. There is circumstantial evidence to suggest that PL plays a role in stimulating mammogenesis. Placental lactogen secreted into the fetal compartment may also help regulate fetal growth. Direct experimental data indicate that PL can regulate maternal intermediary metabolism. Thus, it may act as a partitioning agent to regulate nutrient supply for fetal growth. The precise biological function of PL in ruminants, therefore, still needs to be defined. Key Words: Bovine, Sheep, Goats, Placental Lactogen, Choriomammotropin J. Anim. Sci. 1992. 70:2911-2923, Placental lactogens (PL) in ruminants, such as cows, sheep and goats, are structurally more similar to prolactin than to somatotrophins. PL is secreted in maternal as well as placental circulations and fetal concentration of PL decreases with advancing pregnancy. Though mass and nutrition of the placenta are related to Pl production, the exact mechanism for regulation of Pl secretion is not known. PL is believed to influence fetal growth and regulate maternal metabolism. It has both somatogeneic and lactogenic function.

Published
1992

4. Nanoscience and Nanotechnology Impacting Diverse Fields of Science, Engineering, and Medicine

Author

Warren W.C. Chan, Andrew T. S. Wee, C. Grant Willson, Paula T. Hammond, Nicholas A. Kotov, Reginald M. Penner, Yan Li, Wolfgang J. Parak, Andrey L. Rogach, Helmuth Möhwald, Andre E. Nel, Yury Gogotsi, Cherie R. Kagan, Sharon C. Glotzer, Paul Mulvaney, Raymond E. Schaak, Peter Nordlander, Paul S. Weiss, Laura E. Fernandez, Ali Khademhosseini, Ali Javey, Mark C. Hersam, Shuit-Tong Lee, Manish Chhowalla, Molly M. Stevens, and Jason H. Hafner

Subjects
Materials science, Andrey, General Engineering, General Physics and Astronomy, General Materials Science, Nanotechnology, 02 engineering and technology, Nanoscience & Nanotechnology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 0210 nano-technology, 01 natural sciences, 0104 chemical sciences
Abstract

Author(s): Chan, Warren WC; Chhowalla, Manish; Glotzer, Sharon; Gogotsi, Yury; Hafner, Jason H; Hammond, Paula T; Hersam, Mark C; Javey, Ali; Kagan, Cherie R; Khademhosseini, Ali; Kotov, Nicholas A; Lee, Shuit-Tong; Li, Yan; Mohwald, Helmuth; Mulvaney, Paul A; Nel, Andre E; Nordlander, Peter J; Parak, Wolfgang J; Penner, Reginald M; Rogach, Andrey L; Schaak, Raymond E; Stevens, Molly M; Wee, Andrew TS; Willson, C Grant; Fernandez, Laura E; Weiss, Paul S

Published
2016

5. Helmuth Möhwald (1946-2018)

Author

C. Grant Willson, Cherie R. Kagan, Andrew T. S. Wee, Sharon C. Glotzer, Yan Li, Nicholas A. Kotov, Reginald M. Penner, Young Hee Lee, Wolfgang J. Parak, Ali Khademhosseini, Warren W.C. Chan, Mark C. Hersam, Paul Mulvaney, Paula T. Hammond, Raymond E. Schaak, Andre E. Nel, Shuit-Tong Lee, Manish Chhowalla, Kazunori Kataoka, Ali Javey, Omid C. Farokhzad, Jill E. Millstone, Peter Nordlander, Andrey L. Rogach, Yury Gogotsi, Paul S. Weiss, and Molly M. Stevens

Subjects
Chemistry, Multidisciplinary approach, General Engineering, MEDLINE, General Physics and Astronomy, Library science, General Materials Science
Published
2018

6. Molecular Adaptations for Sensing and Securing Prey and Insight into Amniote Genome Diversity from the Garter Snake Genome

Author

Perry, B.W. (Blair W.), Card, D.C. (Daren C.), McGlothlin, J.W. (Joel W.), Pasquesi, G.I.M. (Giulia I M), Adams, R.H. (Richard H.), Schield, D.R. (Drew R.), Hales, N.R. (Nicole R.), Corbin, A.B. (Andrew B.), Demuth, J.P. (Jeffery P.), Hoffmann, F.G. (Federico G.), Vandewege, M.W. (Michael W.), Schott, R.K. (Ryan K.), Bhattacharyya, N. (Nihar), Chang, B.S.W. (Belinda S W), Casewell, N.R. (Nicholas R.), Whiteley, G. (Gareth), Reyes-Velasco, J. (Jacobo), Mackessy, S.P. (Stephen P.), Gamble, T. (Tony), Storey, K. (Kenneth B.), Biggar, K.K. (Kyle K.), Passow, C.N. (Courtney N.), Kuo, C.-H. (Chih-Horng), McGaugh, S.E. (Suzanne E.), Bronikowski, A.M. (Anne M.), de Koning, A.P.J. (A P Jason), Edwards, S.V. (Scott V.), Pfrender, M.E. (Michael E.), Minx, P. (Patrick), Brodie, E.D. (Edmund D.), Warren, W.C. (Wesley C.), Castoe, T.A. (Todd A.), Perry, B.W. (Blair W.), Card, D.C. (Daren C.), McGlothlin, J.W. (Joel W.), Pasquesi, G.I.M. (Giulia I M), Adams, R.H. (Richard H.), Schield, D.R. (Drew R.), Hales, N.R. (Nicole R.), Corbin, A.B. (Andrew B.), Demuth, J.P. (Jeffery P.), Hoffmann, F.G. (Federico G.), Vandewege, M.W. (Michael W.), Schott, R.K. (Ryan K.), Bhattacharyya, N. (Nihar), Chang, B.S.W. (Belinda S W), Casewell, N.R. (Nicholas R.), Whiteley, G. (Gareth), Reyes-Velasco, J. (Jacobo), Mackessy, S.P. (Stephen P.), Gamble, T. (Tony), Storey, K. (Kenneth B.), Biggar, K.K. (Kyle K.), Passow, C.N. (Courtney N.), Kuo, C.-H. (Chih-Horng), McGaugh, S.E. (Suzanne E.), Bronikowski, A.M. (Anne M.), de Koning, A.P.J. (A P Jason), Edwards, S.V. (Scott V.), Pfrender, M.E. (Michael E.), Minx, P. (Patrick), Brodie, E.D. (Edmund D.), Warren, W.C. (Wesley C.), and Castoe, T.A. (Todd A.)

Abstract

Colubridae represents the most phenotypically diverse and speciose family of snakes, yet no well-assembled and annotated genome exists for this lineage. Here, we report and analyze the genome of the garter snake, Thamnophis sirtalis, a colubrid snake that is an important model species for research in evolutionary biology, physiology, genomics, behavior, and the evolution of toxin resistance. Using the garter snake genome, we show how snakes have evolved numerous adaptations for sensing and securing prey, and identify features of snake genome structure that provide insight into the evolution of amniote genomes. Analyses of the garter snake and other squamate reptile genomes highlight shifts in repeat element abundance and expansion within snakes, uncover evidence of genes under positive selection, and provide revised neutral substitution rate estimates for squamates. Our identification of Z and W sex chromosome-specific scaffolds provides evidence for multiple origins of sex chromosome systems in snakes and demonstrates the value of this genome

Published
2018
Full Text
View/download PDF

7. Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Author

Adema, C.M. (Coen M.), Hillier, L.W. (LaDeana W.), Jones, C.S. (Catherine S.), Loker, E.S. (Eric S.), Knight, M. (Matty), Minx, P. (Patrick), Oliveira, G. (Guilherme), Raghavan, N. (Nithya), Shedlock, A. (Andrew), Do Amaral, L.R. (Laurence Rodrigues), Arican-Goktas, H.D. (Halime D.), Assis, J.G. (Juliana G.), Baba, E.H. (Elio Hideo), Baron, O.L. (Olga L.), Bayne, C.J. (Christopher J.), Bickham-Wright, U. (Utibe), Biggar, K.K. (Kyle K.), Blouin, M. (Michael), Bonning, B.C. (Bryony C.), Botka, C. (Chris), Bridger, J.M. (Joanna M.), Buckley, K.M. (Katherine M.), Buddenborg, S.K. (Sarah K.), Lima Caldeira, R. (Roberta), Carleton, J. (Julia), Carvalho, O.S. (Omar S.), Castillo, M.G. (Maria G.), Chalmers, I.W. (Iain W.), Christensens, M. (Mikkel), Clifton, S. (Sandra), Cosseau, C. (Celine), Coustau, C. (Christine), Cripps, R.M. (Richard M.), Cuesta-Astroz, Y. (Yesid), Cummins, S.F. (Scott F.), DI Stephano, L. (Leon), DInguirard, N. (Nathalie), Duval, D. (David), Emrich, S. (Scott), Feschotte, C. (Cédric), Feyereisen, R. (Rene), Fitzgerald, P. (Peter), Fronick, C. (Catrina), Fulton, L. (Lucinda), Galinier, R. (Richard), Gava, S.G. (Sandra G.), Geusz, M. (Michael), Geyer, K.K. (Kathrin K.), Giraldo-Calderón, G.I. (Gloria I.), De Souza Gomes, M. (Matheus), Gordy, M.A. (Michelle A.), Gourbal, B. (Benjamin), Grunau, C. (Christoph), Hanington, P.C. (Patrick C.), Hoffmann, K.F. (Karl F.), Hughes, D. (Daniel), Humphries, J. (Judith), Jackson, D.J. (Daniel J.), Jannotti-Passos, L.K. (Liana K.), De Jesus Jeremias, W. (Wander), Jobling, S. (Susan), Kamel, B. (Bishoy), Kapusta, A. (Aurélie), Kaur, S. (Satwant), Koene, J.M. (Joris M.), Kohn, A.B. (Andrea B.), Lawson, D. (Dan), Lawton, S.P. (Scott P), Liang, D. (Di), Limpanont, Y. (Yanin), Liu, S. (Sijun), Lockyer, A.E. (Anne E.), Lovato, T.L. (TyAnna L.), Ludolf, F. (Fernanda), Magrini, V. (Vince), McManus, D.P. (Donald P.), Medina, M. (Monica), Misra, M. (Milind), Mitta, G. (Guillaume), Mkoji, G.M. (Gerald M.), Montague, M.J. (Michael J.), Montelongo, C. (Cesar), Moroz, L.L. (Leonid L.), Munoz-Torres, M.C. (Monica C.), Niazi, U. (Umar), Noble, L.R. (Leslie R.), Oliveira, F.S. (Francislon S.), Pais, F.S. (Fabiano S.), Papenfuss, A.T. (Anthony T.), Peace, R. (Rob), Pena, J.J. (Janeth J.), Pila, E.A. (Emmanuel A.), Quelais, T. (Titouan), Raney, B.J. (Brian J.), Rast, J.P. (Jonathan P.), Rollinson, D. (David), Rosse, I.C. (Izinara C.), Rotgans, B. (Bronwyn), Routledge, E.J. (Edwin J.), Ryan, K.M. (Kathryn M.), Scholte, L.L.S. (Larissa L. S.), Storey, K. (Kenneth B.), Swain, M. (Martin), Tennessen, J.A. (Jacob A.), Tomlinson, C. (Chad), Trujillo, D.L. (Damian L.), Volpi, E.V. (Emanuela V.), Walker, A.J. (Anthony J.), Wang, T. (Tianfang), Wannaporn, I. (Ittiprasert), Warren, W.C. (Wesley C.), Wu, X.-J. (Xiao-Jun), Yoshino, T.P. (Timothy P.), Yusuf, M. (Mohammed), Zhang, S.-M. (Si-Ming), Zhao, M. (Min), Wilson, R.K. (Richard K.), Adema, C.M. (Coen M.), Hillier, L.W. (LaDeana W.), Jones, C.S. (Catherine S.), Loker, E.S. (Eric S.), Knight, M. (Matty), Minx, P. (Patrick), Oliveira, G. (Guilherme), Raghavan, N. (Nithya), Shedlock, A. (Andrew), Do Amaral, L.R. (Laurence Rodrigues), Arican-Goktas, H.D. (Halime D.), Assis, J.G. (Juliana G.), Baba, E.H. (Elio Hideo), Baron, O.L. (Olga L.), Bayne, C.J. (Christopher J.), Bickham-Wright, U. (Utibe), Biggar, K.K. (Kyle K.), Blouin, M. (Michael), Bonning, B.C. (Bryony C.), Botka, C. (Chris), Bridger, J.M. (Joanna M.), Buckley, K.M. (Katherine M.), Buddenborg, S.K. (Sarah K.), Lima Caldeira, R. (Roberta), Carleton, J. (Julia), Carvalho, O.S. (Omar S.), Castillo, M.G. (Maria G.), Chalmers, I.W. (Iain W.), Christensens, M. (Mikkel), Clifton, S. (Sandra), Cosseau, C. (Celine), Coustau, C. (Christine), Cripps, R.M. (Richard M.), Cuesta-Astroz, Y. (Yesid), Cummins, S.F. (Scott F.), DI Stephano, L. (Leon), DInguirard, N. (Nathalie), Duval, D. (David), Emrich, S. (Scott), Feschotte, C. (Cédric), Feyereisen, R. (Rene), Fitzgerald, P. (Peter), Fronick, C. (Catrina), Fulton, L. (Lucinda), Galinier, R. (Richard), Gava, S.G. (Sandra G.), Geusz, M. (Michael), Geyer, K.K. (Kathrin K.), Giraldo-Calderón, G.I. (Gloria I.), De Souza Gomes, M. (Matheus), Gordy, M.A. (Michelle A.), Gourbal, B. (Benjamin), Grunau, C. (Christoph), Hanington, P.C. (Patrick C.), Hoffmann, K.F. (Karl F.), Hughes, D. (Daniel), Humphries, J. (Judith), Jackson, D.J. (Daniel J.), Jannotti-Passos, L.K. (Liana K.), De Jesus Jeremias, W. (Wander), Jobling, S. (Susan), Kamel, B. (Bishoy), Kapusta, A. (Aurélie), Kaur, S. (Satwant), Koene, J.M. (Joris M.), Kohn, A.B. (Andrea B.), Lawson, D. (Dan), Lawton, S.P. (Scott P), Liang, D. (Di), Limpanont, Y. (Yanin), Liu, S. (Sijun), Lockyer, A.E. (Anne E.), Lovato, T.L. (TyAnna L.), Ludolf, F. (Fernanda), Magrini, V. (Vince), McManus, D.P. (Donald P.), Medina, M. (Monica), Misra, M. (Milind), Mitta, G. (Guillaume), Mkoji, G.M. (Gerald M.), Montague, M.J. (Michael J.), Montelongo, C. (Cesar), Moroz, L.L. (Leonid L.), Munoz-Torres, M.C. (Monica C.), Niazi, U. (Umar), Noble, L.R. (Leslie R.), Oliveira, F.S. (Francislon S.), Pais, F.S. (Fabiano S.), Papenfuss, A.T. (Anthony T.), Peace, R. (Rob), Pena, J.J. (Janeth J.), Pila, E.A. (Emmanuel A.), Quelais, T. (Titouan), Raney, B.J. (Brian J.), Rast, J.P. (Jonathan P.), Rollinson, D. (David), Rosse, I.C. (Izinara C.), Rotgans, B. (Bronwyn), Routledge, E.J. (Edwin J.), Ryan, K.M. (Kathryn M.), Scholte, L.L.S. (Larissa L. S.), Storey, K. (Kenneth B.), Swain, M. (Martin), Tennessen, J.A. (Jacob A.), Tomlinson, C. (Chad), Trujillo, D.L. (Damian L.), Volpi, E.V. (Emanuela V.), Walker, A.J. (Anthony J.), Wang, T. (Tianfang), Wannaporn, I. (Ittiprasert), Warren, W.C. (Wesley C.), Wu, X.-J. (Xiao-Jun), Yoshino, T.P. (Timothy P.), Yusuf, M. (Mohammed), Zhang, S.-M. (Si-Ming), Zhao, M. (Min), and Wilson, R.K. (Richard K.)

Abstract

Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.

Published
2017
Full Text
View/download PDF

8. Evolutionary signals of selection on cognition from the great tit genome and methylome

Author

Laine, V.N., Gossmann, T.I., Schachtschneider, K.M., Garroway, C.J., Madsen, O., Verhoeven, K.J.F., de Jager, V., Megens, H-J., Warren, W.C., Minx, P., Crooijmans, R.P.M.A., Corcoran, P., Sheldon, B.C., Slate, J., Zeng, K., van Oers, K., Visser, M.E., Groenen, M.A.M., and Consortium, G.T.H.

Abstract

For over 50 years, the great tit (Parus major) has been a model species for research in evolutionary, ecological and behavioural research; in particular, learning and cognition have been intensively studied. Here, to provide further insight into the molecular mechanisms behind these important traits, we de novo assemble a great tit reference genome and whole-genome re-sequence another 29 individuals from across Europe. We show an overrepresentation of genes related to neuronal functions, learning and cognition in regions under positive selection, as well as increased CpG methylation in these regions. In addition, great tit neuronal non-CpG methylation patterns are very similar to those observed in mammals, suggesting a universal role in neuronal epigenetic regulation which can affect learning-, memory- and experience-induced plasticity. The high-quality great tit genome assembly will play an instrumental role in furthering the integration of ecological, evolutionary, behavioural and genomic approaches in this model species.

Published
2016

9. Grand Plans for Nano

Author

Yury Gogotsi, Shuit-Tong Lee, Paul S. Weiss, Heather L. Tierney, Warren W.C. Chan, Paula T. Hammond, Raymond E. Schaak, Jason H. Hafner, Mark C. Hersam, Molly M. Stevens, Ali Khademhosseini, Helmuth Möhwald, Cherie R. Kagan, Sharon C. Glotzer, Andrew T. S. Wee, Nicholas A. Kotov, Wolfgang J. Parak, Andrey L. Rogach, C. Grant Willson, Ali Javey, Paul Mulvaney, Reginald M. Penner, Andre E. Nel, and Peter Nordlander

Subjects
Materials science, Andrey, General Engineering, General Physics and Astronomy, Art history, General Materials Science, Nanoscience & Nanotechnology
Abstract

Author(s): Chan, Warren WC; Glotzer, Sharon; Gogotsi, Yury; Hafner, Jason H; Hammond, Paula T; Hersam, Mark C; Javey, Ali; Kagan, Cherie R; Khademhosseini, Ali; Kotov, Nicholas A; Lee, Shuit-Tong; Mohwald, Helmuth; Mulvaney, Paul A; Nel, Andre E; Nordlander, Peter J; Parak, Wolfgang J; Penner, Reginald M; Rogach, Andrey L; Schaak, Raymond E; Stevens, Molly M; Wee, Andrew TS; Willson, C Grant; Tierney, Heather L; Weiss, Paul S

Published
2015

10. Guiding principles for a successful multidisciplinary research collaboration

Author

Jumi A. Shin, Warren W.C Chan, Sarmitha Sathiamoorthy, Ichiro Inamoto, Linda Z. Penn, Peter S. Tang, Romina Ponzielli, and Lindsay C. Lustig

Subjects
0303 health sciences, medicine.medical_specialty, productivity, multidisciplinary collaboration, Guiding Principles, business.industry, Multidisciplinary Collaboration, Grant funding, 03 medical and health sciences, 0302 clinical medicine, Mentorship, Multidisciplinary approach, Family medicine, Commentary, Medicine, Engineering ethics, guidelines, 030212 general & internal medicine, mentorship, business, Productivity, grant funding, 030304 developmental biology, Biotechnology
Published
2015

11. Evolutionary signals of selection on cognition from the great tit genome and methylome

Author

Laine, Veronika, Gossmann, T.I., Schachtschneider, K.M., Garroway, C.J., Madsen, O., Verhoeven, K.J.F., de Jager, V.C.L., Megens, H-J., Warren, W.C., Minx, P., Crooijmans, R.P.M.A., Corcoran, P., The Great Tit Hapmap Consortium, Sheldon, B.C., Slate, J., Zeng, K., van Oers, K., Visser, M.E., Groenen, M.A.M., Laine, Veronika, Gossmann, T.I., Schachtschneider, K.M., Garroway, C.J., Madsen, O., Verhoeven, K.J.F., de Jager, V.C.L., Megens, H-J., Warren, W.C., Minx, P., Crooijmans, R.P.M.A., Corcoran, P., The Great Tit Hapmap Consortium, Sheldon, B.C., Slate, J., Zeng, K., van Oers, K., Visser, M.E., and Groenen, M.A.M.

Abstract

For over 50 years, the great tit (Parus major) has been a model species for research in evolutionary, ecological and behavioural research; in particular, learning and cognition have been intensively studied. Here, to provide further insight into the molecular mechanisms behind these important traits, we de novo assemble a great tit reference genome and whole-genome re-sequence another 29 individuals from across Europe. We show an overrepresentation of genes related to neuronal functions, learning and cognition in regions under positive selection, as well as increased CpG methylation in these regions. In addition, great tit neuronal non-CpG methylation patterns are very similar to those observed in mammals, suggesting a universal role in neuronal epigenetic regulation which can affect learning-, memory- and experience-induced plasticity. The high-quality great tit genome assembly will play an instrumental role in furthering the integration of ecological, evolutionary, behavioural and genomic approaches in this model species.

Published
2016

13. Abstract A24: Characterizing a novel 'Minimalist Hybrid Protein' inhibitor designed to target Myc activity in cancer

Author

Christina Bros, Warren W.C Chan, Linda Z. Penn, K. Ashley Hickman, Romina Ponzielli, Jumi Shin, Lindsay C. Lustig, and Dharmendra Dingar

Subjects
Cancer Research, Two-hybrid screening, Cell, Promoter, Biology, medicine.anatomical_structure, Oncology, Mechanism of action, Transcription (biology), medicine, Cancer research, medicine.symptom, Molecular Biology, Chromatin immunoprecipitation, Transcription factor, Nucleolin
Abstract

When deregulated, the c-Myc oncoprotein plays a key role in the development and progression of over 50% of all human cancers. As such, innovative and effective therapeutics are urgently needed to improve the treatment and survival of cancer patients, and we believe that directly modulating the activity of Myc would fill this important gap. Recent studies using a dominant negative protein, Omomyc, have provided evidence regarding the therapeutic value of inhibiting Myc activity in cancer. Specifically, perturbing Myc activity in vivo eradicates tumors without irreversible damage to normal cells, as demonstrated in mouse models of cancer. Using a similar yet novel strategy, we have generated a minimalist hybrid protein inhibitor known as MaxE47 (ME47), which is composed of the subdomains of different b-HLH-LZ and b-HLH transcription factor families. ME47 is designed to act as a competitive inhibitor of DNA E-box binding by the Myc/Max heterodimer. We hypothesize that ME47 can be used as a tool to better understand how best to interfere with oncogenic Myc and will lead to the development of Myc-targeted therapeutics. Using our prototype inhibitor, ME47, with Omomyc as a proof-of-concept control, we have established the cell systems and assays necessary to (1) evaluate the anti-cancer efficacy of our Minimalist Hybrid Proteins in human cancer cells, and (2) to determine their mechanism of action and specificity. Here we have demonstrated that ME47 significantly reduces anchorage-independent growth in soft agar and cell viability in tumor-derived breast cancer cell line MDA-MB-231, but not the non-transformed MCF10A breast cells. ME47 also significantly decreases tumor formation in xenograft mice. To begin to characterize the specificity and mechanism of action of ME47, luciferase reporter and chromatin immunoprecipitation assays were used to evaluate whether ME47 is Myc and/or E-box specific. Using luciferase reporter constructs fused to the promoters of established Myc target genes such as Nucleolin, we have also demonstrated that MaxE47 decreases the ability of Myc to activate target gene transcription. While this work is focused on the development of a Myc/Max E-box interaction inhibitor, Dr. Linda Penn's research group is also implementing BioID mass spectrometry to identify novel Myc interacting partners (see Penn lab abstract Dingar et al.). This work could potentially reveal new targets for a similar mode of disruptive inhibition, where a Minimalist Hybrid Protein designed to inhibit the association of the novel interacting partner and Myc would disrupt Myc activity. A direct inhibitor of Myc activity in cancer would re-define the field of Myc therapeutics and could develop into a valuable tool for personalized cancer medicine in those patients with deregulated Myc. The success we have had with our ME47 inhibitor suggests that we are progressing along the path to such an inhibitor, and we look forward to continuing our work with this inhibitor and other Minimalist Hybrid Proteins. Citation Format: K. Ashley Hickman, Lindsay C. Lustig, Dharmendra Dingar, Romina Ponzielli, Christina Bros, Warren W.C Chan, Jumi Shin, Linda J.Z Penn. Characterizing a novel “Minimalist Hybrid Protein” inhibitor designed to target Myc activity in cancer. [abstract]. In: Proceedings of the AACR Special Conference on Myc: From Biology to Therapy; Jan 7-10, 2015; La Jolla, CA. Philadelphia (PA): AACR; Mol Cancer Res 2015;13(10 Suppl):Abstract nr A24.

Published
2015

14. The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage

Author

Bradley Shaffer, H. (H), Minx, P. (Patrick), Warren, D.E. (Daniel E.), Shedlock, A.M. (Andrew M.), Thomson, R.C. (Robert C.), Valenzuela, N. (Nicole), Abramyan, J. (John), Amemiya, C.T. (Chris T.), Badenhorst, D. (Daleen), Biggar, K.K. (Kyle K.), Borchert, G.M. (Glen M.), Botka, C.W. (Christopher W.), Bowden, R.M. (Rachel M.), Braun, E.L. (Edward L.), Bronikowski, A.M. (Anne M.), Bruneau, B.G. (Benoit G.), Buck, L.T. (Leslie T.), Capel, B. (Blanche), Castoe, T.A. (Todd A.), Czerwinski, M. (Mike), Delehaunty, K.D. (Kim D.), Edwards, S.V. (Scott V.), Fronick, C.C. (Catrina C.), Fujita, M.K. (Matthew K.), Fulton, L. (Lucinda), Graves, T.A. (Tina A.), Green, R.E. (Richard E.), Haerty, W. (Wilfried), Hariharan, R. (Ramkumar), Hernandez, O. (Omar), Hillier, L.W. (LaDeana W.), Holloway, A.K. (Alisha K.), Janes, D. (Daniel), Janzen, F.J. (Fredric J.), Kandoth, C. (Cyriac), Kong, L. (Lesheng), de Koning, A.P.J. (A.P. Jason), Li, Y. (Yang), Literman, R. (Robert), McGaugh, S.E. (Suzanne E.), Mork, L. (Lindsey), O'Laughlin, M. (Michelle), Paitz, R.T. (Ryan T.), Pollock, D.D. (David D.), Ponting, C.P. (Chris P.), Radhakrishnan, S. (Srihari), Raney, B.J. (Brian J.), Richman, J.M. (Joy M.), St John, J. (John), Schwartz, T. (Tonia), Sethuraman, A. (Arun), Spinks, P.Q. (Phillip Q.), Storey, K. (Kenneth B.), Thane, N. (Nay), Vinar, T. (Tomas), Zimmerman, L.M. (Laura M.), Warren, W.C. (Wesley C.), Mardis, E.R. (Elaine R.), Wilson, R.K. (Richard K.), Bradley Shaffer, H. (H), Minx, P. (Patrick), Warren, D.E. (Daniel E.), Shedlock, A.M. (Andrew M.), Thomson, R.C. (Robert C.), Valenzuela, N. (Nicole), Abramyan, J. (John), Amemiya, C.T. (Chris T.), Badenhorst, D. (Daleen), Biggar, K.K. (Kyle K.), Borchert, G.M. (Glen M.), Botka, C.W. (Christopher W.), Bowden, R.M. (Rachel M.), Braun, E.L. (Edward L.), Bronikowski, A.M. (Anne M.), Bruneau, B.G. (Benoit G.), Buck, L.T. (Leslie T.), Capel, B. (Blanche), Castoe, T.A. (Todd A.), Czerwinski, M. (Mike), Delehaunty, K.D. (Kim D.), Edwards, S.V. (Scott V.), Fronick, C.C. (Catrina C.), Fujita, M.K. (Matthew K.), Fulton, L. (Lucinda), Graves, T.A. (Tina A.), Green, R.E. (Richard E.), Haerty, W. (Wilfried), Hariharan, R. (Ramkumar), Hernandez, O. (Omar), Hillier, L.W. (LaDeana W.), Holloway, A.K. (Alisha K.), Janes, D. (Daniel), Janzen, F.J. (Fredric J.), Kandoth, C. (Cyriac), Kong, L. (Lesheng), de Koning, A.P.J. (A.P. Jason), Li, Y. (Yang), Literman, R. (Robert), McGaugh, S.E. (Suzanne E.), Mork, L. (Lindsey), O'Laughlin, M. (Michelle), Paitz, R.T. (Ryan T.), Pollock, D.D. (David D.), Ponting, C.P. (Chris P.), Radhakrishnan, S. (Srihari), Raney, B.J. (Brian J.), Richman, J.M. (Joy M.), St John, J. (John), Schwartz, T. (Tonia), Sethuraman, A. (Arun), Spinks, P.Q. (Phillip Q.), Storey, K. (Kenneth B.), Thane, N. (Nay), Vinar, T. (Tomas), Zimmerman, L.M. (Laura M.), Warren, W.C. (Wesley C.), Mardis, E.R. (Elaine R.), and Wilson, R.K. (Richard K.)

Abstract

Background: We describe the genome of the western painted turtle, Chrysemys picta bellii, one of the most widespread, abundant, and well-studied turtles. We place the genome into a comparative evolutionary context, and focus on genomic features associated with tooth loss, immune function, longevity, sex differentiation and determination, and the species' physiological capacities to withstand extreme anoxia and tissue freezing.Results: Our phylogenetic analyses confirm that turtles are the sister group to living archosaurs, and demonstrate an extraordinarily slow rate of sequence evolution in the painted turtle. The ability of the painted turtle to withstand complete anoxia and partial freezing appears to be associated with common vertebrate gene networks, and we identify candidate genes for future functional analyses. Tooth loss shares a common pattern of pseudogenization and degradation of tooth-specific genes with birds, although the rate of accumulation of mutations is much slower in the painted turtle. Genes associated with sex differentiation generally reflect phylogeny rather than convergence in sex determination functionality. Among gene families that demonstrate exceptional expansions or show signatures of strong natural selection, immune function and musculoskeletal patterning genes are consistently over-represented.Conclusions: Our comparative genomic analyses indicate that common vertebrate regulatory networks, some of which have analogs in human diseases, are often involved in the western painted turtle's extraordinary physiological capacities. As these regulatory pathways are analyzed at the functional level, the painted turtle may offer important insights into the management of a number of human health disorders.

Published
2013
Full Text
View/download PDF

15. Adenosine increases nasal mucociliary clearance rate in mice through A 2A and A2B adenosine receptors

Author

Hua, Xiaoyang, Naselsky, Warren W.C., Bennett, William, Ledent, Catherine, Senior, Brent B.A., Tilley, Stephen S.L., Hua, Xiaoyang, Naselsky, Warren W.C., Bennett, William, Ledent, Catherine, Senior, Brent B.A., and Tilley, Stephen S.L.

Abstract

Objectives/Hypothesis: Mucociliary clearance (MCC) is an important mechanism of host defense in the upper and lower respiratory tract. Impaired MCC plays a critical role in the development and perpetuation of chronic rhinosinusitis (CRS). The aim of this investigation was to determine the influence of adenosine on nasal MCC, and to determine the receptors mediating this physiology in vivo. Study Design: Prospective study using an animal model. Methods: Nasal MCC was measured by whole-nose scintigraphic acquisition in vivo. The effects of both endogenous and exogenous adenosine were investigated in wild-type and adenosine receptor knockout (A 2A-/-, A 2B-/-, A 2A-/-A 2B-/-, and A 1-/- A 3-/-) mice. Results: Exogenous adenosine aerosol robustly enhanced nasal MCC. The augmentation of MCC by adenosine was abolished in mice lacking both A2A and A2B receptors, but remained robust in mice lacking either A2A or A2B. Likewise, basal nasal MCC was reduced in mice lacking both the A2A and A2B receptors, but was statistically identical among wild-type mice and mice lacking either A2A or A2B. Conclusions: These findings indicate that activation of both Gs-coupled adenosine receptors can accelerate nasal MCC. Targeting these receptors may represent a novel therapeutic approach for enhancing MCC in CRS. Laryngoscope, 2012 Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc., SCOPUS: ar.j, FLWIN, info:eu-repo/semantics/published

Published
2013

16. Parus major Genome sequencing and assembly

Author

Laine, V.N., Gossmann, T.I., Schachtschneider, Kyle, Garroway, C.J., Madsen, Ole, Verhoeven, K.J.F., De Jager, Victor, Megens, Hendrik-Jan, Warren, W.C., Minx, Patrick, Crooijmans, Richard, Corcoran, Pádraic, Adriaensen, Frank, Belda, Eduardo, Bushuev, Andrey, Cichon, Mariusz, Charmantier, Anne, Dingemanse, Niels, Doligez, Blandine, Eeva, Tapio, Erikstad, Kjell Einar, Fedorov, Slava, Hau, Michaela, Hille, Sabine, Hinde, Camilla, Kempenaers, Bart, Kerimov, Anvar, Krist, Milos, Mand, Raivo, Matthysen, Erik, Nager, Reudi, Norte, Claudia, Orell, Markku, Richner, Heinz, Slagsvold, Tore, Tilgar, Vallo, Tinbergen, Joost, Torok, Janos, Tschirren, Barbara, Yuta, Tera, Sheldon, B.C., Slate, Jon, Zeng, Kai, van Oers, K., Visser, Marcel, Groenen, Martien, Laine, V.N., Gossmann, T.I., Schachtschneider, Kyle, Garroway, C.J., Madsen, Ole, Verhoeven, K.J.F., De Jager, Victor, Megens, Hendrik-Jan, Warren, W.C., Minx, Patrick, Crooijmans, Richard, Corcoran, Pádraic, Adriaensen, Frank, Belda, Eduardo, Bushuev, Andrey, Cichon, Mariusz, Charmantier, Anne, Dingemanse, Niels, Doligez, Blandine, Eeva, Tapio, Erikstad, Kjell Einar, Fedorov, Slava, Hau, Michaela, Hille, Sabine, Hinde, Camilla, Kempenaers, Bart, Kerimov, Anvar, Krist, Milos, Mand, Raivo, Matthysen, Erik, Nager, Reudi, Norte, Claudia, Orell, Markku, Richner, Heinz, Slagsvold, Tore, Tilgar, Vallo, Tinbergen, Joost, Torok, Janos, Tschirren, Barbara, Yuta, Tera, Sheldon, B.C., Slate, Jon, Zeng, Kai, van Oers, K., Visser, Marcel, and Groenen, Martien

Abstract

Seasonal timing is a key life-history trait with major fitness consequences. The small songbird Parus major (great tit) for decades has been a model to study fitness traits like e.g. avian timing of reproduction. The research is closely linked to the impact of global climate change on timing and its consequences. Linking quantitative genetic variation in life-history traits with polymorphisms in specific genes is essential for better understanding the causes and consequences of the diversity in these traits. Genetic variation in life-history traits in wild songbirds has been demonstrated in many, often long-term, studies throughout the world. Linking this variation to genomic information requires the development of the necessary genomics tools specifically aimed at these non-model species. The assembly and annotation of the genome of the great tit will greatly enhance the further use of the great tit as a model species in this research field.

Published
2013

17. The development and characterization of a 60K SNP chip for chicken

Author

Groenen, M.A.M., Megens, H.J.W.C., Zare, Y., Warren, W.C., Hillier, L.W., Crooijmans, R.P.M.A., Vereijken, A., Okimoto, R., Muir, W.M., Cheng, H.H., Groenen, M.A.M., Megens, H.J.W.C., Zare, Y., Warren, W.C., Hillier, L.W., Crooijmans, R.P.M.A., Vereijken, A., Okimoto, R., Muir, W.M., and Cheng, H.H.

Abstract

Background In livestock species like the chicken, high throughput single nucleotide polymorphism (SNP) genotyping assays are increasingly being used for whole genome association studies and as a tool in breeding (referred to as genomic selection). To be of value in a wide variety of breeds and populations, the success rate of the SNP genotyping assay, the distribution of the SNP across the genome and the minor allele frequencies (MAF) of the SNPs used are extremely important. Results We describe the design of a moderate density (60k) Illumina SNP BeadChip in chicken consisting of SNPs known to be segregating at high to medium minor allele frequencies (MAF) in the two major types of commercial chicken (broilers and layers). This was achieved by the identification of 352,303 SNPs with moderate to high MAF in 2 broilers and 2 layer lines using Illumina sequencing on reduced representation libraries. To further increase the utility of the chip, we also identified SNPs on sequences currently not covered by the chicken genome assembly (Gallus_gallus-2.1). This was achieved by 454 sequencing of the chicken genome at a depth of 12x and the identification of SNPs on 454-derived contigs not covered by the current chicken genome assembly. In total we added 790 SNPs that mapped to 454-derived contigs as well as 421 SNPs with a position on Chr_random of the current assembly. The SNP chip contains 57,636 SNPs of which 54,293 could be genotyped and were shown to be segregating in chicken populations. Our SNP identification procedure appeared to be highly reliable and the overall validation rate of the SNPs on the chip was 94%. We were able to map 328 SNPs derived from the 454 sequence contigs on the chicken genome. The majority of these SNPs map to chromosomes that are already represented in genome build Gallus_gallus-2.1.0. Twenty-eight SNPs were used to construct two new linkage groups most likely representing two micro-chromosomes not covered by the current genome assembly. Con

Published
2011

18. Mapping microsatellite markers identified in porcine EST sequences. (Breeding And Genetics)

Author

Rohrer, G.A., Fahrenkrug, S.C., Tao, N., and Warren, W.C.

Subjects
Swine -- Genetic aspects, Genomes -- Analysis, Chromosome mapping -- Analysis, Introns -- Analysis, Zoology and wildlife conservation
Abstract

A recent focus of swine genomics research has been to sequence a significant number of the genes which are expressed in the pig. The most popular approach to accomplish this goal is to collect single-pass sequence data from cDNA clones. The sequence data obtained, often between 400 and 600 bases in length, are called expressed sequence tags (EST). A sequence search of these data in GenBank and the MARC swine EST data identified over 100 sequence files which contained a microsatellite repeat. Most repeat motifs detected were dinucleotide (CA/GT) repeats; however, a number of tri-, tetra-, penta- and hexa-nucleotide repeats were also detected. The selection criteria for testing a microsatellite marker was that it span more than 18 bases of uninterrupted sequence. There was a considerable level of redundancy in the sequences identified and some files did not contain enough data adjacent to the microsatellite repeat to yield useful primers for amplification. Fifty-eight pair of primers were ordered representing 44 di-, 7 tri-, 1 tetra-, 1 penta-, and 4 hexa-nucleotide repeats, as well as 1 compound (contained a di-, tri- and tetra-nucleotide repeat) repeat motif. Thirty-four markers were polymorphic in the MARC reference population, 13 markers were uninformative and 11 primer pairs failed to satisfactorily amplify genomic DNA. A comparison of di-nucleotide repeat versus markers with repeat motifs of 3-6 bases determined that 73% of the di-nucleotide markers were useful relative to only 8% for the other repeat motifs. The difference was due to a much higher percentage of monomorphic markers in the 3-6 base repeat motif markers than in the di-nucleotide markers (69% vs 9%). Either the higher order repeat motifs are less polymorphic in the porcine genome or our selection criteria was too low. The percentage of monomorphic di-nucleotide markers was slightly higher, and the rate of unsatisfactory amplification was double that observed when di-nucleotide markers were derived from genomic sequence. This increased amplification failure rate could be due to the presence of introns between primer sites or base calling errors in the EST sequence files. Nonetheless, the mapped markers not only add useful microsatellites to the porcine genetic map but they also provide valuable links between the porcine and human genome. Key Words: Porcine, EST, Microsatellite

Published
2001

Catalog

Books, media, physical & digital resources
See catalog results