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546 results on '"Warren, Edward"'

1. Median U-turn intersection

Author

Hughes, Warren Edward

Subjects
Roads -- Interchanges and intersections -- Design and construction.
Published
2009

2. Quadrant roadway intersection

Author

Hughes, Warren Edward

Subjects
Roads -- Interchanges and intersections -- Design and construction.
Published
2009

3. Double crossover diamond interchange

Author

Hughes, Warren Edward

Subjects
Roads -- Interchanges and intersections -- Design and construction., Traffic engineering.
Published
2009

4. Displaced left-turn interchange

Author

Hughes, Warren Edward

Subjects
Left-turn lanes., Roads -- Interchanges and intersections -- Design and construction.
Published
2009

10. Evaluation of microdialysis as a tool for studying percutaneous drug absorption and cutaneous metabolism

Author

Keene, Warren Edward

Subjects
615, Skin
Abstract

Cutaneous microdialysis is a method used to sample the extra-cellular fluid in dermal tissue. It uses a semi-permeable fibre, which is implanted in the dermis parallel to the skins surface. The fibre is perfused with a sterile physiological solution, which is collected at set periods. Low molecular weight compounds are able to diffuse freely into or out of the fibre in the direction of the concentration gradient. Once fibres have been implanted and are perfused, drug solutions can be applied to the skin surface directly above. Methyl salicylate (MeS) was the initial model drug. Occlusion of the drug site had no effect on the tissue Cmax but gave an increased AUC. Blood flow restriction using noradrenaline resulted in an increased Cmax and an increased AUC. Analysis for salicylic acid (the major metabolite) found higher concentrations than could be explained by the concentration present in the applied formulation, indicating that MeS was metabolised as it penetrated the skin. Comparisons of two vehicle formulations, one containing ethanol the other propylene glycol, showed that ethanol enhanced the transdermal absorption of methyl salicylate relative to the propylene glycol formulation. The transdermal absorption of salicylic acid and methyl salicylate was compared, salicylic acid gave the highest dermal concentrations despite being less lipophilic than methyl salicylate. MeS was introduced directly into the dermis via a microdialysis fibre in order to compare the metabolic activity of the epidermis to the dermis. Technical difficulties were encountered but the data indicated that MeS is metabolised in the dermis though to a lesser degree than in the epidermis. Ketoprofen was used to study the dialysis of highly protein bound drug, it has a literature protein binding value of 95%. Two fibres were used, a 2kDa fibre, which only dialysed free drug, and a 3MDa fibre, which dialysed both free and protein bound drug. The 3MDa fibres dialysed a higher concentration of ketoprofen however the increase was due to the increased efficiency of 3MDa fibres to dialyse free drug.

Published
2002

12. The Impact of an Electronic Health Record Intervention on Spirometry Completion in Patients with Chronic Obstructive Pulmonary Disease

Author

Wang, Christine, Siff, Jonathan, Greco, Peter J., Warren, Edward, Thornton, J. Daryl, and Tarabichi, Yasir

Subjects
Pulmonary and Respiratory Medicine, Pulmonary Disease, Chronic Obstructive, Spirometry, Electronic Health Records, Humans, Bronchodilator Agents, Retrospective Studies
Abstract

Spirometry is necessary to diagnose chronic obstructive pulmonary disease (COPD), yet a large proportion of patients are diagnosed and treated without having received testing. This study explored whether the effects of interventions using the electronic health record (EHR) to target patients diagnosed with COPD without confirmatory spirometry impacted the incidence rates of spirometry referrals and completions. This retrospective before and after study assessed the impact of provider-facing clinical decision support that identified patients who had a diagnosis of COPD but had not received spirometry. Spirometry referrals, completions, and results were ascertained 1.5 years prior to and 1.5 years after the interventions were initiated. Inhaler prescriptions by class were also tallied. There were 10,949 unique patients with a diagnosis of COPD who were eligible for inclusion. 4,895 patients (44.7%) were excluded because they had completed spirometry prior to the cohort start dates. The pre-intervention cohort consisted of 2,622 patients, while the post-intervention cohort had 3,392. Spirometry referral rates pre-intervention were 20.2% compared to 31.6% post-intervention (p < 0.001). Spirometry completion rates rose from 13.2% pre-intervention to 19.3% afterwards (p < 0.001). 61.7% (585 of 948) had no evidence of airflow obstruction. After excluding patients with a diagnosis of asthma, 25.8% (126 of 488) patients who had no evidence of airflow obstruction had prescriptions for long-acting bronchodilators or inhaled steroids. A concerted EHR intervention modestly increased spirometry referral and completion rates in patients with a diagnosis of COPD without prior spirometry and decreased misclassification of disease.

Published
2022
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13. Use of Big Data to Aid Patient Recruitment for Clinical Trials Involving Biosimilars and Rare Diseases

Author

Huml, Raymond A., Dawson, Jill, Lipworth, Karen, Rojas, Luis, Warren, Edward J., Manaktala, Charu, and Huml, Jonathan R.

Abstract

Patient recruitment and retention are arguably the greatest challenges to the timely execution of clinical trials. This is particularly true in the case of trials involving biosimilars and those focused on rare diseases. For biosimilars, recruitment success typically hinges on difficulty of access to reimbursement for the originator product and may be hindered by competition from studies with other biosimilars and those with new chemical entities. For rare diseases, recruitment success depends not only on finding enough patients but also on retaining them for the duration of the trial. Historical success with patient recruitment—in addition to site qualifications—needs to be considered in parallel with current market competition and results in an ever-changing patient recruitment environment. Multiple companies supporting the biopharmaceutical industry, such as Contract Research Organizations, have begun to leverage sophisticated data modeling tools and techniques to find additional patients for biosimilar and rare disease trials and/or to find patients more quickly. In addition, these companies seek to better understand the population of interest and refine their statistical assumptions when conducting clinical trials or real-world analyses. The largest and most well-established companies that support the biopharmaceutical industry now have unparalleled access to big data from clinical trials, electronic health records, medical claims, laboratory tests, and prescriptions. This paper will discuss how big data can be harnessed to aid patient recruitment with a focus on clinical trials for biosimilars and orphan rare diseases.

Published
2024
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14. When Context Is Hard to Come By: External Comparators and How to Use Them

Author

Mack, Christina, Christian, Jennifer, Brinkley, Emma, Warren, Edward J., Hall, Marni, and Dreyer, Nancy

Abstract

External comparators, also referred to as historical or synthetic controls, present transformational opportunities for broad context and insights alongside clinical research results. The recent confluence of access to quality real-world data (RWD), advanced epidemiologic methods, and legislative directives to regulators for expanded use of RWD is increasing interest in real-world external comparators, opening the door to achieve broader generalizability and learn more, faster. In this less standardized area of research, tailored scientific methodology must be applied for external comparators to accomplish clinical development objectives. Here, we describe methodological considerations for design and illustrate how RWD comparators have been used for regulatory and reimbursement decisions.

Published
2024
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15. Letters

Author

Kuder, Armin U., Graver, David, Murphy, Richard, Rothschild, Toby, Landsberg, Brian K., Heidenreich, Douglas R., Warren, Edward, Silverman, Barry G., Hyman, Michael B., Delaney, Gerard M., Schütte, Michael, and Wright, Nick

Published
2012

16. Summer Institute for High School Students: A Research Project in Pre-Vocational Education. Semi-Final Report.

Author

Pitt Technical Inst., Greenville, NC., Warren, Edward N., and Finch, Willard C.

Abstract

A total of 160 high school students in the Pitt County and the Greenville city school systems participated in two summer institutes which were conducted to alter the attitudes and interests of students regarding vocational education. Participants for the institutes were chosen from the top two academic quartiles, after which an experimental and control group were established. The experimental group participated in a specially designed four-week institute involving many kinds of exposure to vocational education. The control group did not receive any treatment. Followup studies were conducted on both groups to determine the type of postsecondary education institution that participants chose to attend. Student attitudes and interests did change, more so for males than for females. Fourteen percent of the total experimental group enrolled in a technical institute, community college, or trade school compared to five percent of the control group. (Author/VA)

Published
1974

30. From Field and Study

Author

Wright, George M., Warren, Edward R., Pickwell, Gayle, McLaughlin, Donald Thomas, Compton, Lawrence V., Huey, Laurence M., Bailey, Alfred M., Widmann, Gloria, Wetmore, Alexander, Miller, Loye, and McCabe, T. T.

Published
1932
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34. From Field and Study

Author

Warren, Edward R., Taylor, Walter P., Skinner, M. P., Allen, W. E., Miller, Mary Mann, Kofoid, Charles A., Grinnell, J., Mailliard, Joseph, La Jeunesse, H. V., Woods, Robert S., and Jewett, Stanley G.

Published
1923
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42. General Notes

Author

Kennard, Fred H., Saunders, P. B., Snyder, L. L., Holt, Ernest G., Jewett, Stanley G., Moore, A. W., Warren, Edward R., Cook, Harold J., Grinnell, George Bird, and Harper, Francis

Published
1929
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44. General Notes

Author

Coleman, Robert H., Ulmer,, Frederick A., Doutt, J. Kenneth, Cook, Arthur H., Henry, W. Herman, Harriot, Samuel C., Warren, Edward R., Miller,, Gerrit S., Durand, Forrest V., Goodwin, G. G., and Bailey, Alfred M.

Published
1940
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45. General Notes

Author

Thomas, Oldfield, Shaw, William T., Seton, Ernest Thompson, Hobson, Edward Charles, Wood, N. A., Bishop, Sherman C., Synder, L. L., Johnson, Charles Eugene, Skinner, M. P., Warren, Edward R., Anthony, A. W., and Mailliard, Joseph

Published
1921
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46. General Notes

Author

Kirk, George L., Pray, Leon L., Loring, J. Alden, Warren, Edward R., Anthony, A. W., Skinner, M. P., and Howell, A. Brazier

Published
1921
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47. General Notes

Author

Chamberlain, E. B., Wetmore, Alexander, Gander, Frank F., Moseley, E. L., Hamilton,, W. J., Ross, Roland Case, Bailey, Alfred M., Kittredge,, Joseph, Harlow, William M., Rush, W. M., Warren, Edward R., Green, Morris M., and Hall, E. Raymond

Published
1928
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49. General Notes

Author

Green, Morris M., Sherman, Althea R., Warren, Edward R., Fryxell, F. M., and Skinner, M. P.

Published
1926
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50. General Notes

Author

Dice, L. R., Nichols, John Treadwell, Ballou, W. H., Whitehead, L. C., Silver, James, Strecker, John K., Warren, Edward R., Hay, Oliver P., and Allen, Glover M.

Published
1927
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