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531 results on '"Warner, Steven A."'

2. Optimizing Surveillance Satellites for the Synthetic Theater Operations Research Model

Author

Warner, Steven M. and Royset, Johannes O.

Subjects
Electrical Engineering and Systems Science - Systems and Control, Mathematics - Optimization and Control
Abstract

The Synthetic Theater Operations Research Model (STORM) simulates theater-level conflict and requires inputs about utilization of surveillance satellites to search large geographical areas. We develop a mixed-integer linear optimization model that prescribes plans for how satellites and their sensors should be directed to best search an area of operations. It also specifies the resolution levels employed by the sensors to ensure a suitable fidelity of the resulting images. We solve large-scale instances of the model involving up to 22 million variables and 11 million constraints in scenarios derived from STORM. On average, the model yields 55% improvement in search coverage relative to an existing heuristic algorithm in STORM.

Published
2022

5. TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth

Author

Chan, Tsz-Yin, Egbert, Christina M, Maxson, Julia E, Siddiqui, Adam, Larsen, Logan J, Kohler, Kristina, Balasooriya, Eranga Roshan, Pennington, Katie L, Tsang, Tsz-Ming, Frey, Madison, Soderblom, Erik J, Geng, Huimin, Müschen, Markus, Forostyan, Tetyana V, Free, Savannah, Mercenne, Gaelle, Banks, Courtney J, Valdoz, Jonard, Whatcott, Clifford J, Foulks, Jason M, Bearss, David J, O’Hare, Thomas, Huang, David CS, Christensen, Kenneth A, Moody, James, Warner, Steven L, Tyner, Jeffrey W, and Andersen, Joshua L

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Cancer, 2.1 Biological and endogenous factors, Aetiology, 14-3-3 Proteins, A549 Cells, Animals, Antineoplastic Agents, Cell Line, Tumor, Fetal Proteins, Fusion Proteins, bcr-abl, Gene Expression Regulation, Neoplastic, HEK293 Cells, Humans, Lymphocytes, Mice, Phospholipase C gamma, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Protein Binding, Protein Kinase Inhibitors, Protein-Tyrosine Kinases, Pyrimidines, STAT3 Transcription Factor, STAT5 Transcription Factor, Signal Transduction, Survival Analysis, Tumor Burden, Ubiquitin, Xenograft Model Antitumor Assays
Abstract

TNK1 is a non-receptor tyrosine kinase with poorly understood biological function and regulation. Here, we identify TNK1 dependencies in primary human cancers. We also discover a MARK-mediated phosphorylation on TNK1 at S502 that promotes an interaction between TNK1 and 14-3-3, which sequesters TNK1 and inhibits its kinase activity. Conversely, the release of TNK1 from 14-3-3 allows TNK1 to cluster in ubiquitin-rich puncta and become active. Active TNK1 induces growth factor-independent proliferation of lymphoid cells in cell culture and mouse models. One unusual feature of TNK1 is a ubiquitin-association domain (UBA) on its C-terminus. Here, we characterize the TNK1 UBA, which has high affinity for poly-ubiquitin. Point mutations that disrupt ubiquitin binding inhibit TNK1 activity. These data suggest a mechanism in which TNK1 toggles between 14-3-3-bound (inactive) and ubiquitin-bound (active) states. Finally, we identify a TNK1 inhibitor, TP-5801, which shows nanomolar potency against TNK1-transformed cells and suppresses tumor growth in vivo.

Published
2021

8. A dynamic graph-cuts method with integrated multiple feature maps for segmenting kidneys in ultrasound images

Author

Zheng, Qiang, Warner, Steven, Tasian, Gregory, and Fan, Yong

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Purpose: To improve kidney segmentation in clinical ultrasound (US) images, we develop a new graph cuts based method to segment kidney US images by integrating original image intensity information and texture feature maps extracted using Gabor filters. Methods: To handle large appearance variation within kidney images and improve computational efficiency, we build a graph of image pixels close to kidney boundary instead of building a graph of the whole image. To make the kidney segmentation robust to weak boundaries, we adopt localized regional information to measure similarity between image pixels for computing edge weights to build the graph of image pixels. The localized graph is dynamically updated and the GC based segmentation iteratively progresses until convergence. The proposed method has been evaluated and compared with state of the art image segmentation methods based on clinical kidney US images of 85 subjects. We randomly selected US images of 20 subjects as training data for tuning the parameters, and validated the methods based on US images of the remaining 65 subjects. The segmentation results have been quantitatively analyzed using 3 metrics, including Dice Index, Jaccard Index, and Mean Distance. Results: Experiment results demonstrated that the proposed method obtained segmentation results for bilateral kidneys of 65 subjects with average Dice index of 0.9581, Jaccard index of 0.9204, and Mean Distance of 1.7166, better than other methods under comparison (p<10-19, paired Wilcoxon rank sum tests). Conclusions: The proposed method achieved promising performance for segmenting kidneys in US images, better than segmentation methods that built on any single channel of image information. This method will facilitate extraction of kidney characteristics that may predict important clinical outcomes such progression chronic kidney disease.

Published
2017

9. Dietary Zinc and Incident Calcium Kidney Stones in Adolescence

Author

Tasian, Gregory E, Ross, Michelle E, Song, Lihai, Grundmeier, Robert W, Massey, James, Denburg, Michelle R, Copelovitch, Lawrence, Warner, Steven, Chi, Thomas, Killilea, David W, Stoller, Marshall L, and Furth, Susan L

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Prevention, Pediatric, Nutrition, Clinical Research, Urologic Diseases, Kidney Disease, Renal and urogenital, Adolescent, Calcium, Case-Control Studies, Child, Diet, Female, Humans, Kidney Calculi, Male, Risk Factors, Urinalysis, Zinc, zinc, nutritional status, kidney calculi, pediatrics, Clinical Sciences, Urology & Nephrology, Clinical sciences
Abstract

PurposeWe determined the association between dietary zinc intake and incident calcium kidney stones in adolescents. We also examined the relationship between dietary zinc intake and urinary zinc excretion between cases and controls.Materials and methodsWe conducted a nested case-control study within a large pediatric health care system. Three 24-hour dietary recalls and spot urine chemistry analyses were obtained for 30 participants 12 to 18 years old with a first idiopathic calcium based kidney stone and 30 healthy controls matched for age, sex, race and month of enrollment. Conditional logistic regression models were used to estimate the association between daily zinc intake and incident calcium kidney stones, adjusting for dietary phytate, protein, calcium, sodium and oxalate. Multivariable linear regression was used to estimate the association between dietary and urine zinc, adjusting for urine creatinine and dietary phytate and calcium.ResultsCases had lower daily zinc intake (8.1 mg) than controls (10 mg, p = 0.029). Daily zinc intake of boys and girls with calcium stones was 2 mg and 1.2 mg less, respectively, than the daily intake recommended by the Institute of Medicine. Odds of incident stones were reduced by 13% for every 1 mg increase in daily zinc intake (OR 0.87, 95% CI 0.75-0.99). There was an estimated 4.5 μg/dl increase in urine zinc for every 1 mg increase in dietary zinc (p = 0.009), with weak evidence of a smaller increase in urine zinc in cases than in controls (interaction p = 0.08).ConclusionsDecreased dietary zinc intake was independently associated with incident calcium nephrolithiasis in this population of adolescents.

Published
2017

11. TP-0184 inhibits FLT3/ACVR1 to overcome FLT3 inhibitor resistance and hinder AML growth synergistically with venetoclax

Author

Tyagi, Anudishi, primary, Jaggupilli, Appalaraju, additional, Ly, Stanley, additional, Yuan, Bin, additional, El-Dana, Fouad, additional, Hegde, Venkatesh L., additional, Anand, Vivek, additional, Kumar, Bijender, additional, Puppala, Mamta, additional, Yin, Zheng, additional, Wong, Stephen T. C., additional, Mollard, Alexis, additional, Vankayalapati, Hariprasad, additional, Foulks, Jason M., additional, Warner, Steven L., additional, Daver, Naval, additional, Borthakur, Gautam, additional, and Battula, V. Lokesh, additional

Published
2023
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12. Data from AXL Inhibition Improves the Antitumor Activity of Chimeric Antigen Receptor T Cells

Author

Sakemura, R. Leo, primary, Hefazi, Mehrdad, primary, Cox, Michelle J., primary, Siegler, Elizabeth L., primary, Sinha, Sutapa, primary, Hansen, Michael J., primary, Stewart, Carli M., primary, Feigin, Jennifer M., primary, Manriquez Roman, Claudia, primary, Schick, Kendall J., primary, Can, Ismail, primary, Tapper, Erin E., primary, Horvei, Paulina, primary, Adada, Mohamad M., primary, Bezerra, Evandro D., primary, Kankeu Fonkoua, Lionel Aurelien, primary, Ruff, Michael W., primary, Forsman, Cynthia L., primary, Nevala, Wendy K., primary, Boysen, Justin C., primary, Tschumper, Renee C., primary, Grand, Cory L., primary, Kuchimanchi, Kameswara R., primary, Mouritsen, Lars, primary, Foulks, Jason M., primary, Warner, Steven L., primary, Call, Timothy G., primary, Parikh, Sameer A., primary, Ding, Wei, primary, Kay, Neil E., primary, and Kenderian, Saad S., primary

Published
2023
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13. Supplementary Table S2 from AXL Inhibition Improves the Antitumor Activity of Chimeric Antigen Receptor T Cells

Author

Sakemura, R. Leo, primary, Hefazi, Mehrdad, primary, Cox, Michelle J., primary, Siegler, Elizabeth L., primary, Sinha, Sutapa, primary, Hansen, Michael J., primary, Stewart, Carli M., primary, Feigin, Jennifer M., primary, Manriquez Roman, Claudia, primary, Schick, Kendall J., primary, Can, Ismail, primary, Tapper, Erin E., primary, Horvei, Paulina, primary, Adada, Mohamad M., primary, Bezerra, Evandro D., primary, Kankeu Fonkoua, Lionel Aurelien, primary, Ruff, Michael W., primary, Forsman, Cynthia L., primary, Nevala, Wendy K., primary, Boysen, Justin C., primary, Tschumper, Renee C., primary, Grand, Cory L., primary, Kuchimanchi, Kameswara R., primary, Mouritsen, Lars, primary, Foulks, Jason M., primary, Warner, Steven L., primary, Call, Timothy G., primary, Parikh, Sameer A., primary, Ding, Wei, primary, Kay, Neil E., primary, and Kenderian, Saad S., primary

Published
2023
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14. Supplementary Figure Legends from AXL Inhibition Improves the Antitumor Activity of Chimeric Antigen Receptor T Cells

Author

Sakemura, R. Leo, primary, Hefazi, Mehrdad, primary, Cox, Michelle J., primary, Siegler, Elizabeth L., primary, Sinha, Sutapa, primary, Hansen, Michael J., primary, Stewart, Carli M., primary, Feigin, Jennifer M., primary, Manriquez Roman, Claudia, primary, Schick, Kendall J., primary, Can, Ismail, primary, Tapper, Erin E., primary, Horvei, Paulina, primary, Adada, Mohamad M., primary, Bezerra, Evandro D., primary, Kankeu Fonkoua, Lionel Aurelien, primary, Ruff, Michael W., primary, Forsman, Cynthia L., primary, Nevala, Wendy K., primary, Boysen, Justin C., primary, Tschumper, Renee C., primary, Grand, Cory L., primary, Kuchimanchi, Kameswara R., primary, Mouritsen, Lars, primary, Foulks, Jason M., primary, Warner, Steven L., primary, Call, Timothy G., primary, Parikh, Sameer A., primary, Ding, Wei, primary, Kay, Neil E., primary, and Kenderian, Saad S., primary

Published
2023
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15. Supplementary Figures from AXL Inhibition Improves the Antitumor Activity of Chimeric Antigen Receptor T Cells

Author

Sakemura, R. Leo, primary, Hefazi, Mehrdad, primary, Cox, Michelle J., primary, Siegler, Elizabeth L., primary, Sinha, Sutapa, primary, Hansen, Michael J., primary, Stewart, Carli M., primary, Feigin, Jennifer M., primary, Manriquez Roman, Claudia, primary, Schick, Kendall J., primary, Can, Ismail, primary, Tapper, Erin E., primary, Horvei, Paulina, primary, Adada, Mohamad M., primary, Bezerra, Evandro D., primary, Kankeu Fonkoua, Lionel Aurelien, primary, Ruff, Michael W., primary, Forsman, Cynthia L., primary, Nevala, Wendy K., primary, Boysen, Justin C., primary, Tschumper, Renee C., primary, Grand, Cory L., primary, Kuchimanchi, Kameswara R., primary, Mouritsen, Lars, primary, Foulks, Jason M., primary, Warner, Steven L., primary, Call, Timothy G., primary, Parikh, Sameer A., primary, Ding, Wei, primary, Kay, Neil E., primary, and Kenderian, Saad S., primary

Published
2023
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19. AXL Inhibition Improves the Antitumor Activity of Chimeric Antigen Receptor T Cells

Author

Sakemura, R. Leo, primary, Hefazi, Mehrdad, additional, Cox, Michelle J., additional, Siegler, Elizabeth L., additional, Sinha, Sutapa, additional, Hansen, Michael J., additional, Stewart, Carli M., additional, Feigin, Jennifer M., additional, Manriquez Roman, Claudia, additional, Schick, Kendall J., additional, Can, Ismail, additional, Tapper, Erin E., additional, Horvei, Paulina, additional, Adada, Mohamad M., additional, Bezerra, Evandro D., additional, Kankeu Fonkoua, Lionel Aurelien, additional, Ruff, Michael W., additional, Forsman, Cynthia L., additional, Nevala, Wendy K., additional, Boysen, Justin C., additional, Tschumper, Renee C., additional, Grand, Cory L., additional, Kuchimanchi, Kameswara R., additional, Mouritsen, Lars, additional, Foulks, Jason M., additional, Warner, Steven L., additional, Call, Timothy G., additional, Parikh, Sameer A., additional, Ding, Wei, additional, Kay, Neil E., additional, and Kenderian, Saad S., additional

Published
2023
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20. Abstract 3635: TBK1 inhibition potentiates the efficacy of AXL-targeted therapy by modulating tumor microenvironment in aggressive breast cancers

Author

Phi, Lan, primary, Semba, Takashi, additional, Trinh, Ngu V., additional, Zou, Fang, additional, Foulks, Jason M., additional, Warner, Steven L., additional, Krishnamurthy, Savitri, additional, Long, James P., additional, Reuben, James M., additional, Tripathy, Debu, additional, Ueno, Naoto T., additional, and Wang, Xiaoping, additional

Published
2023
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21. Abstract 3489: TNK1 is a ubiquitin sensing kinase that can be targeted in vivo to block tumor growth

Author

Lopez-Palacios, Tania, primary, Chan, Tsz-Yin, additional, Egbert, Christina M., additional, Ashworth, Spencer, additional, Vaughan, Alec, additional, Forostyan, Tanya V., additional, Siddiqui, Adam, additional, Foulks, Jason M., additional, Moody, James, additional, Maxson, Julia E., additional, Tyner, Jeffrey W., additional, Warner, Steven L., additional, and Andersen, Joshua Lyon, additional

Published
2023
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26. Abstract 5171: TP-6379, an investigational TGFBR1 inhibitor, shown to remodel the tumor microenvironment and enhance anti-tumorigenic immunological responses in syngeneic mouse models of cancer

Author

Kircher, David A., primary, Forostyan, Tetyana V., additional, Heinz, Richard E., additional, Allred, Curtis A., additional, Sommakia, Sal, additional, Matsumura, Yuta, additional, Siddiqui, Adam, additional, Foulks, Jason M., additional, and Warner, Steven L., additional

Published
2023
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29. Supplementary Table 1 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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30. Supplementary Methods from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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31. Supplementary Figure 3 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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32. Supplementary Figure 7 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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33. Supplementary Figure 5 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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34. Supplementary Table 2 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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35. Supplementary Figure 4 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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36. Supplementary Figure 1 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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37. Supplementary Figure 2 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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39. Supplementary Figure 6 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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40. Supplementary Table 3 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Author

Byers, Lauren Averett, primary, Diao, Lixia, primary, Wang, Jing, primary, Saintigny, Pierre, primary, Girard, Luc, primary, Peyton, Michael, primary, Shen, Li, primary, Fan, Youhong, primary, Giri, Uma, primary, Tumula, Praveen K., primary, Nilsson, Monique B., primary, Gudikote, Jayanthi, primary, Tran, Hai, primary, Cardnell, Robert J.G., primary, Bearss, David J., primary, Warner, Steven L., primary, Foulks, Jason M., primary, Kanner, Steven B., primary, Gandhi, Varsha, primary, Krett, Nancy, primary, Rosen, Steven T., primary, Kim, Edward S., primary, Herbst, Roy S., primary, Blumenschein, George R., primary, Lee, J. Jack, primary, Lippman, Scott M., primary, Ang, K. Kian, primary, Mills, Gordon B., primary, Hong, Waun K., primary, Weinstein, John N., primary, Wistuba, Ignacio I., primary, Coombes, Kevin R., primary, Minna, John D., primary, and Heymach, John V., primary

Published
2023
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41. Supplementary Table 2 from TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase

Author

Wang, Xiaoping, primary, Saso, Hitomi, primary, Iwamoto, Takayuki, primary, Xia, Weiya, primary, Gong, Yun, primary, Pusztai, Lajos, primary, Woodward, Wendy A., primary, Reuben, James M., primary, Warner, Steven L., primary, Bearss, David J., primary, Hortobagyi, Gabriel N., primary, Hung, Mien-Chie, primary, and Ueno, Naoto T., primary

Published
2023
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42. Data from TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase

Author

Wang, Xiaoping, primary, Saso, Hitomi, primary, Iwamoto, Takayuki, primary, Xia, Weiya, primary, Gong, Yun, primary, Pusztai, Lajos, primary, Woodward, Wendy A., primary, Reuben, James M., primary, Warner, Steven L., primary, Bearss, David J., primary, Hortobagyi, Gabriel N., primary, Hung, Mien-Chie, primary, and Ueno, Naoto T., primary

Published
2023
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43. Supplementary Figures from TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase

Author

Wang, Xiaoping, primary, Saso, Hitomi, primary, Iwamoto, Takayuki, primary, Xia, Weiya, primary, Gong, Yun, primary, Pusztai, Lajos, primary, Woodward, Wendy A., primary, Reuben, James M., primary, Warner, Steven L., primary, Bearss, David J., primary, Hortobagyi, Gabriel N., primary, Hung, Mien-Chie, primary, and Ueno, Naoto T., primary

Published
2023
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44. Supplementary Table 1 from TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase

Author

Wang, Xiaoping, primary, Saso, Hitomi, primary, Iwamoto, Takayuki, primary, Xia, Weiya, primary, Gong, Yun, primary, Pusztai, Lajos, primary, Woodward, Wendy A., primary, Reuben, James M., primary, Warner, Steven L., primary, Bearss, David J., primary, Hortobagyi, Gabriel N., primary, Hung, Mien-Chie, primary, and Ueno, Naoto T., primary

Published
2023
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45. Supplementary Materials and Methods from TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase

Author

Wang, Xiaoping, primary, Saso, Hitomi, primary, Iwamoto, Takayuki, primary, Xia, Weiya, primary, Gong, Yun, primary, Pusztai, Lajos, primary, Woodward, Wendy A., primary, Reuben, James M., primary, Warner, Steven L., primary, Bearss, David J., primary, Hortobagyi, Gabriel N., primary, Hung, Mien-Chie, primary, and Ueno, Naoto T., primary

Published
2023
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46. Supplementary Figure Legends from TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase

Author

Wang, Xiaoping, primary, Saso, Hitomi, primary, Iwamoto, Takayuki, primary, Xia, Weiya, primary, Gong, Yun, primary, Pusztai, Lajos, primary, Woodward, Wendy A., primary, Reuben, James M., primary, Warner, Steven L., primary, Bearss, David J., primary, Hortobagyi, Gabriel N., primary, Hung, Mien-Chie, primary, and Ueno, Naoto T., primary

Published
2023
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48. TP-0184 inhibits FLT3/ACVR1to overcome FLT3 inhibitor resistance and hinder AML growth synergistically with venetoclax

Author

Tyagi, Anudishi, Jaggupilli, Appalaraju, Ly, Stanley, Yuan, Bin, El-Dana, Fouad, Hegde, Venkatesh L., Anand, Vivek, Kumar, Bijender, Puppala, Mamta, Yin, Zheng, Wong, Stephen T. C., Mollard, Alexis, Vankayalapati, Hariprasad, Foulks, Jason M., Warner, Steven L., Daver, Naval, Borthakur, Gautam, and Battula, V. Lokesh

Abstract

We identified activin A receptor type I (ACVR1), a member of the TGF-β superfamily, as a factor favoring acute myeloid leukemia (AML) growth and a new potential therapeutic target. ACVR1is overexpressed in FLT3-mutated AML and inhibition of ACVR1expression sensitized AML cells to FLT3 inhibitors. We developed a novel ACVR1inhibitor, TP-0184, which selectively caused growth arrest in FLT3-mutated AML cell lines. Molecular docking and in vitro kinase assays revealed that TP-0184 binds to both ACVR1and FLT3 with high affinity and inhibits FLT3/ACVR1downstream signaling. Treatment with TP-0184 or in combination with BCL2 inhibitor, venetoclax dramatically inhibited leukemia growth in FLT3-mutated AML cell lines and patient-derived xenograft models in a dose-dependent manner. These findings suggest that ACVR1is a novel biomarker and plays a role in AML resistance to FLT3 inhibitors and that FLT3/ACVR1dual inhibitor TP-0184 is a novel potential therapeutic tool for AML with FLT3mutations.

Published
2024
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