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1. Daratumumab binds to mobilized CD34+ cells of myeloma patients in vitro without cytotoxicity or impaired progenitor cell growth

Author

Ma, Xun, Wong, Sandy W, Zhou, Ping, Chaulagain, Chakra P, Doshi, Parul, Klein, Andreas K, Sprague, Kellie, Kugelmass, Adin, Toskic, Denis, Warner, Melissa, Miller, Kenneth B, Lee, Lisa, Varga, Cindy, and Comenzo, Raymond L

Subjects
Rare Diseases, Regenerative Medicine, Transplantation, Stem Cell Research - Nonembryonic - Human, Clinical Research, Cancer, Hematology, Stem Cell Research, Myeloma, Daratumumab, CD34+, Progenitor cells
Abstract

BackgroundThe monoclonal antibody daratumumab, approved for treating myeloma, targets CD38, a protein on myeloma and also on CD34+ hematopoietic progenitor cells. Because mobilized CD34+ cells are critical for stem cell transplant, we investigated the in vitro activity of daratumumab on mobilized CD34+ cells from myeloma patients with no prior exposure to daratumumab.MethodsWe determined the number of CD38 molecules per CD34+ cell, and whether daratumumab bound to CD34+ cells, whether C1q bound to daratumumab-coated CD34+ cells and whether daratumumab-related complement-dependent cytotoxicity (CDC) occurred. We also examined CD34+ cell progenitor cell colony capacity in assays with pre-plating incubation of CD34+ cells with daratumumab alone or with daratumumab and the CD59 inhibitory antibody BRIC229, and also assessed CD34+ cell responses to increasing doses of daratumumab in caspase 3/7 activity assays.ResultsAlthough 75% of mobilized CD34+ cells co-express CD38, CD38 was minimally present on CD34+ cells compared to Daudi and KG-1 controls, C1q did not bind to daratumumab-coated CD34+ cells, and CDC did not occur. CD34+ cells incubated in complement-rich human serum with daratumumab alone or with daratumumab and BRIC229, and then plated in progenitor cell assays, produced similar numbers of colonies as controls. In progenitor cell assays with cryopreserved or fresh unselected or CD34-selected cells, daratumumab did not affect progenitor cell capacity, and in caspase 3/7 activity assays CD34+ cells were not affected by increasing doses of daratumumab.ConclusionIn vitro, daratumumab is not toxic to mobilized CD34+ progenitor cells from myeloma patients.

Published
2018

2. Key findings from the 2023 'ACT NOW on Global HIV Migration, Mobility and Health Equity' community forum.

Author

Wells, N., Ong, J. J., Stackpool-Moore, L., Warner, Melissa, Carter, D. J., McGoldrick, R., Wlodek, A., Riley, B., Holland, J., Heath-Paynter, D., Stratigos, A., Murphy, E., Haerry, D., Parczewski, M., Poonkasetwattana, M., Medland, N., Wade, S., and Allan, B.

Abstract

Background. People living with HIV continue to face laws, policies, and practices that impact their potential for travel and migration. These laws include: mandatory HIV testing and involuntary disclosure of HIV; lack of access to affordable HIV-related health care, treatment and counselling during the migration process; deportation of foreign nationals living with HIV; and restrictions on the length of stays. Methods. HIV migration laws were the topic of a half-day community forum held as part of the 12th International AIDS Society Conference on HIV Science held in Brisbane, Australia, in July 2023. Over 150 delegates attended and, after a series of presentations, delegates were invited to participate in structured, facilitated conversations about issues related to policy, health and law concerning migration of people living with HIV. In this paper, we report on key themes from those discussions and identify areas for ongoing investigation. Results. Advocates recommended the removal of unfair and unjust migration laws and policies that contribute to HIV stigma and discrimination; updated migration policies that reflect the current context and cost of biomedical approaches to HIV management and prevention; expanded and equitable access to HIV-related care regardless of migration or residency status; and the development of advocacy networks to promote changes to migration policies. Conclusions. Laws limiting the migration of people living with HIV actively discourage individuals from seeking HIV testing, treatment and care. Ultimately, restrictive migration laws and policies undermine global efforts to end AIDS as a public health concern and to virtually eliminate HIV transmission by 2030. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Online HIV Self-Testing (HIVST) Dissemination by an Australian Community Peer HIV Organisation: A Scalable Way to Increase Access to Testing, Particularly for Suboptimal Testers

Author

Bell, Sara Fiona Elisabeth, primary, Lemoire, Jime, additional, Debattista, Joseph, additional, Redmond, Andrew M., additional, Driver, Glen, additional, Durkin, Izriel, additional, Coffey, Luke, additional, Warner, Melissa, additional, Howard, Chris, additional, Williams, Owain David, additional, Gilks, Charles F., additional, and Dean, Judith Ann, additional

Published
2021
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21. Toxicities, response and survival: Autologous stem cell transplantation for multiple myeloma over 25 years at a single center

Author

Wong, Sandy W., primary, Warner, Melissa, additional, Moreno-Koehler, Alejandro, additional, Kritharis, Athena, additional, Coyle, Michael E., additional, Black, Deborah, additional, Relias, Valerie, additional, Fogaren, Terry, additional, Lyons, Nancy Cody, additional, Toka, Francois, additional, Larivee, Denise, additional, Evens, Andrew M., additional, Kao, Grace, additional, Sprague, Kellie, additional, Klein, Andreas K., additional, Miller, Kenneth B., additional, and Comenzo, Raymond L., additional

Published
2017
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22. Stakeholder analysis of community distribution of misoprostol in Lao PDR: A qualitative study

Author

Durham, Jo, Warner, Melissa, Phengsavanh, Alongkone, Sychareun, Vanphanom, Vongxay, Viengnakhone, Rickart, Keith, Durham, Jo, Warner, Melissa, Phengsavanh, Alongkone, Sychareun, Vanphanom, Vongxay, Viengnakhone, and Rickart, Keith

Abstract

Background Globally, significant progress has been made in reducing maternal mortality, yet in many low-resource contexts it remains unacceptably high. Many of these deaths are due to postpartum haemorrhage and are preventable with access to essential obstetric care. Where there are barriers to access, maternal deaths could be prevented if community-level misoprostol was available. The purpose of this study was to explore perceptions of stakeholders regarding misoprostol use in the Lao People’s Democratic Republic, a setting with high maternal mortality. Methods Semi-structured interviews were conducted with 35 stakeholders in the capital, Vientiane and in one northern province identified as a site for a possible intervention. The sample included international and national stakeholders involved in policy-making and providing maternal and reproductive health services. Findings Most stakeholders supported a pilot program for community distribution of misoprostol but levels of awareness of the drug’s use in preventing postpartum haemorrhage and level of influence over policy direction varied considerably. Some international organizations, all identified as powerful in influencing policy, were ambivalent about the use of community distribution of misoprostol. Concerns related to the capacity of village health workers or lay people to safely administer misoprostol, whether its distribution would undermine efforts to improve access to safe delivery services and active management of the third stage of labour, the ease with which prescription drugs can be bought over the counter, and technical, logistical, and financial constraints. Conclusion Access to appropriate oxytocic drugs is a matter of health equity. In settings without access to essential obstetrical care, misoprostol represents a viable solution for the prevention of postpartum haemorrhage. Understanding stakeholders’ perspectives and their legitimate concerns on misoprostol can inform

Published
2016

26. Improvements in Patient Outcomes with Autologous Stem Cell Transplantation for Multiple Myeloma over 25 Years at a Single Center

Author

Wong, Sandy W., primary, Warner, Melissa, additional, Moreno-Koehler, Alejandro, additional, Kritharis, Athena, additional, Coyle, Michael E, additional, Black, Deborah, additional, Relias, Valerie, additional, Fogaren, Terry, additional, Lyons, Nancy Cody, additional, Toka, Francois, additional, Larivee, Denise, additional, Smith, Hedy, additional, Evens, Andrew M., additional, Kao, Grace, additional, Sprague, Kellie, additional, Klein, Andreas K., additional, Miller, Kenneth B., additional, and Comenzo, Raymond L., additional

Published
2015
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28. The Finding of Del 17p in Marrow Plasma Cells from Patients with Light-Chain Amyloidosis (AL) May Confer a Worse Prognosis

Author

Wong, Sandy W., primary, Palladini, Giovanni, additional, Hegenbart, Ute, additional, Landau, Heather, additional, Warner, Melissa, additional, Jaccard, Arnaud, additional, Avet-Loiseau, Herve, additional, Hansen, Timon, additional, Bladé, Joan, additional, Cibeira, María Teresa, additional, Kastritis, Efstathios, additional, Schönland, Stefan, additional, and Comenzo, Raymond L., additional

Published
2015
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31. The role of organizational and manager support on the experience of work-to-family conflict

Author

Warner, Melissa A. and Hausdorf, P.

Subjects
work-family conflict, manager support, organizational support, reduction, work-life balance
Abstract

The following study investigated the role of organizational and manager support for work-life balance in the reduction of work-family conflict and its subsequent outcomes. Specifically, the role of organizational and managerial support for work-life balance was explored as interrelated antecedents, moderators, and independent antecedents in relation to work-to-family conflict and, ultimately, job and life satisfaction. Observed variable path analyses were used with two health care samples (N = 93 and 103) to test the hypothesis that work-related support operates as an antecedent to work overload and job control with subsequent effects on work-to-family conflict. Overall, results supported this hypothesis and revealed that work-related support for work-life balance reduces work-to-family conflict through a reduction in work overload and an increase in job control. However, inconsistencies across the samples regarding the parameter estimates within the antecedent models suggested that manager support for work-life balance might be operating differently across the two samples.

Published
2003

37. Job Analysis Methods.

Author

Warner, Melissa A.

Subjects
JOB analysis, PERSONNEL management, JOB evaluation, HUMAN resource directors
Abstract

The article focuses on the factors to consider by human resources personnel on selecting job analysis methods. It is noted that most job analysis techniques lack adequate base in theory, reliability and validity needed for organizational applications. It is suggested that companies evaluate the costs and benefits of various job analysis techniques used. An overview of the process involved in the Functional Job Analysis used by the U.S. Veterans Health Administration is provided.

Published
2007

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