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2. Gestational period-specific renal functions: Evidence from a large, community-based, prospective cohort in rural Sri Lanka

Author

Agampodi, Suneth, primary, Agampodi, Thilini, additional, Amarasinghe, Gayani, additional, Warnasekara, Janith, additional, Hettiarachchi, Ayesh, additional, Jayasinghe, Imasha, additional, Koralagedara, Iresha, additional, Abeyrathna, Parami, additional, Srimantha, Shalka, additional, Silva, Nirmani de, additional, and Wickramasinghe, Nuwan Darshana, additional

Published
2024
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7. Incorporating early pregnancy mental health screening and management into routine maternal care: experience from the Rajarata Pregnancy Cohort (RaPCo), Sri Lanka

Author

Agampodi, Thilini, primary, Amarasinghe, Gayani, additional, Wickramasinghe, Anuprabha, additional, Wickramasinghe, Nuwan, additional, Warnasekara, Janith, additional, Jayasinghe, Imasha, additional, Hettiarachchi, Ayesh, additional, Nimesha, Dilshi, additional, Dilshani, Thivanka, additional, Senadheera, Subhashinie, additional, and Agampodi, Suneth, additional

Published
2023
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9. The Rajarata Pregnancy Cohort (RaPCo): study protocol

Author

Agampodi, Thilini Chanchala, Wickramasinghe, Nuwan Darshana, Prasanna, Rampathige Indika Ruwan, Irangani, Malawara Kankanamalage Lasandha, Banda, Jayasundara Mudiyanselage Samarakoon, Jayathilake, Pradana Mudiyanselage Bandula, Hettiarachchi, Ayesh, Amarasinghe, Gayani, Jayasinghe, Imasha, Koralagedara, Iresha, Gunarathne, Sajaan Praveena, Wickramage, Sujanthi, Warnasekara, Janith, Lokunarangoda, Niroshan, Mendis, Vasana, Dissanayaka, Ajith Kumara, Premadasa, Jagath, Hettigama, Nandana, Koralagedara, Dayaratne, Weerasinghe, Manjula, Malawanage, Krishanthi, Jayakodi, Hemali, Wickramasinghe, Anuprabha, and Agampodi, Suneth Buddhika

Published
2020
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10. Serum creatinine and estimated glomerular filtration rate (eGFR) in early pregnancy and changes during the pregnancy

Author

Agampodi, Suneth Buddhika, primary, Agampodi, Thilini Chanchala, additional, Amarasinghe, Gayani Shashikala, additional, Warnasekara, Janith Niwanthaka, additional, Hettiarachchi, Ayesh Umeshana, additional, Jayasinghe, Imasha Upulini, additional, Koralegedara, Iresha Sandamali, additional, Abeyrathna, Parami, additional, Srimantha, Shalka, additional, de Silva, Farika Nirmani, additional, Gunarathne, Sajaan Praveena, additional, and Wickramasinghe, Nuwan Darshana, additional

Published
2023
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16. Demographic, exposure, clinical, biochemical and diagnostic data of febrile patients recruited for the largest field study on leptospirosis in Sri Lanka

Author

Agampodi, Suneth, primary, Warnasekara, Janith, additional, Siribaddana, Sisira, additional, Kularatna, SAM, additional, Gamage, Chandika, additional, Jayasundara, Dinesha, additional, Senevirathna, Indika, additional, Srimantha, Shalka, additional, Kappagoda, Chamila, additional, Weerawansa, Prasanna, additional, Pilapitiya, Senaka, additional, Lokunarangoda, Niroshan, additional, Sarathchandra, Chamara, additional, Senanayake, Hemal, additional, Matthias, Michael, additional, and Vinetz, Joseph, additional

Published
2022
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18. Asthma in a prospective cohort of rural pregnant women from Sri Lanka: Need for better care during the pre-conceptional and antenatal period

Author

Rajapakse, Shashanka, primary, Wickramasinghe, Nuwan, additional, Warnasekara, Janith, additional, Abeyrathna, Parami, additional, Amarasinghe, Gayani, additional, Hettiarachchi, Ayesh Umeshana, additional, Jayasinghe, Imasha Upulini, additional, Koralegedara, Iresha, additional, Agampodi, Thilini Chanchala, additional, and Agampodi, Suneth B., additional

Published
2022
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32. Epidemiology of wheeze among preschool children: a population-based cross-sectional study from rural Sri Lanka

Author

Rajapakse Mudiyanselage, Shashanka Indeevara Rajapakse, Amarasiri, Wadu Arachchige Dharshika Lakmali, Yasaratne, Bannek Mudiyanselage Gedara Duminda, Warnasekara, Janith, and Agampodi, Suneth

Subjects
Male, medicine.medical_specialty, Passive smoking, Cross-sectional study, Protective factor, Disease cluster, medicine.disease_cause, 03 medical and health sciences, Dogs, 0302 clinical medicine, Risk Factors, Surveys and Questionnaires, Wheeze, Environmental health, Epidemiology, Prevalence, medicine, Animals, Humans, 030212 general & internal medicine, Respiratory Medicine, Respiratory Sounds, Sri Lanka, Asthma, business.industry, Public health, public health, General Medicine, asthma, medicine.disease, Rhinitis, Allergic, Cross-Sectional Studies, 030228 respiratory system, wheeze, Child, Preschool, paediatric thoracic medicine, Medicine, epidemiology, Female, medicine.symptom, business, community child health
Abstract

ObjectivesTo assess the prevalence of wheeze and factors associated with its severity among 3–6 years old children.MethodologyDesignA population-based, cross-sectional study using the WHO 30 cluster methodology with probability proportionate to size sampling.Setting36 preschools registered at the divisional secretariat offices of Anuradhapura district, Sri Lanka.ParticipantsWe recruited 1060 preschool children from 36 preschools aged 3–6 years.Main outcome measurementsWe used the International Study of Asthma and Allergy in Childhood questionnaire to assess the prevalence, symptomatology and associated factors of wheeze.ResultsThe study sample consisted of 548 (51.70%) male and 512 (48.30%) female children with a mean age of 4.41 (±0.66) years. At least one wheezing episode ever was reported in 323 (30.47%; 95% CI 27.71% to 33.34%) children and 247 (23.30%; 95% CI 20.79% to 25.97%) children had a wheezing attack in the preceding year. Severe episodes of wheezing were reported in 76 (7.17%; 95% CI 5.69% to 8.89%) participants. However, only 27 (35.53%; 95% CI 24.88% to 47.34%) children with severe wheezing had been diagnosed as asthmatics by a clinician. The identified independent risk factors for severe wheeze were allergic rhinitis (OR 6.90; 95% CI 3.84 to 12.40), domestic dog(s) (OR 2.34; 95% CI 1.01 to 5.40), frequent consumption of skipjack tuna (OR 1.94; 95% CI 1.11 to 3.39) and passive smoking (OR 1.70; 95% CI 0.93 to 3.11) while living in a house with a cement floor is a protective factor (OR 0.41; 95% CI 0.21 to 0.80).ConclusionWheezing commonly affects one-fourth of preschool children in rural Sri Lanka. Severe wheezing is often not diagnosed as asthma despite frequent symptoms, probably due to hesitancy in labelling preschool children as asthmatics. Allergic rhinitis, domestic dogs, frequent consumption of Skipjack tuna fish and exposure to passive smoking were independent risk factors for severe wheeze.

Published
2021

33. Effect of pregnancy on asthma control: a cohort study in rural Sri Lanka

Author

Rajapakse Mudiyanselage, Shashanka Indeevara Rajapakse, primary, Wickramasinghe, Nuwan Darshana, additional, Agampodi, Thilini Chanchala, additional, Amarasinghe, Gayani, additional, Hettiarachchi, Ayesh, additional, Jayasinghe, Imasha Upulini, additional, Koralegedara, Iresha, additional, Warnasekara, Janith, additional, and Agampodi, Suneth Buddhika, additional

Published
2021
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35. Is the Presence of Leptospira in the Environment Merely Random? an Epidemiological Explanation Based on Serial Analysis of Water Samples

Author

Warnasekara, Janith, Srimantha, Shalka, Senevirathna, Indika, Kappagoda, Chamila, Farika, Nirmani, Nawinna, Achala, and Agampodi, Suneth

Subjects
allergology
Abstract

Human leptospirosis cannot be investigated without studying zoonotic and environmental as-pects of the disease. The objectives of this study are to explore the abundance of Leptospira in dif-ferent climate zones of Sri Lanka and to describe the presence of Leptospira in same water source at different time points. First, water and soil samples were collected from whole-island, secondly, water sampling continued only in dry-zone, finally serial sampling of water from ten open wells was performed at five different time points. Quantitative PCR for water and metagenomic se-quencing for soil were used to detect Leptospira. In first component, 2 out of 12 water sites were positive and both are situated in wet-zone. Very small quantities of Genus Leptospira was detect-ed by metagenomic analysis of soil. Only 5 out of 26 samples were positive in the second compo-nent. Six, five, four, five, six wells were positive respectively in serial measurements of third component. All wells were positive at least one measurement while only one well was positive in all measurements. Closer to tank and higher distance from main road were significant risk fac-tors associated with well positivity. Presence of Leptospira seems not consistent indicating ran-dom abundance of Leptospira in natural environment.

Published
2021

37. Correction: 12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka

Author

Jayasundara, Dinesha, primary, Senavirathna, Indika, additional, Warnasekara, Janith, additional, Gamage, Chandika, additional, Siribaddana, Sisira, additional, Kularatne, Senanayake Abeysinghe Mudiyanselage, additional, Matthias, Michael, additional, Mariet, Jean-François, additional, Picardeau, Mathieu, additional, Agampodi, Suneth, additional, and Vinetz, Joseph M., additional

Published
2021
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40. Gestational Period-Specific Renal Functions: Evidence From a Large, Community-Based, Prospective Cohort in Rural Sri Lanka

Author

Agampodi, Suneth Buddhika, primary, Agampodi, Thilini Chanchala, additional, Amarasinghe, Gayani Shashikala, additional, Warnasekara, Janith Niwanthaka, additional, Hettiarachchi, Ayesh Umeshana, additional, Jayasinghe, Imasha Upulini, additional, Koralegedara, Iresha Sandamali, additional, Abeyrathna, Parami, additional, Sriman, Shalka Madushan, additional, de Silva, Farika Nirmani, additional, Gunaratne, Sajaan Praveen, additional, and Wickramasinghe, Nuwan Dharshana, additional

Published
2021
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44. Temporal Variation and Factors Associated with Allergic Rhinitis in a Cohort of Rural Preschool Children from Sri Lanka.

Author

Rajapakse, Shashanka, Amarasiri, Lakmali, Yasaratne, Duminda, Warnasekara, Janith, and Agampodi, Suneth

Subjects
PRESCHOOL children, ALLERGIC rhinitis, RURAL children, RURAL geography, DEW point, JUVENILE diseases, CROSS-sectional method, RHINITIS, ACTIVITIES of daily living, QUALITY of life, DISEASE prevalence
Abstract

Background: Allergic rhinitis is a common chronic childhood disease with a low diagnosis rate, causing poor quality of life, absenteeism, decreased school performance and significant healthcare cost. However, data on the prevalence of allergic rhinitis is sparse in preschoolers of rural geography, especially in developing countries.Aim: To describe the epidemiology of allergic rhinitis in preschoolers from a rural geography of a developing country.Methods: A population-based cross-sectional study was conducted in Anuradhapura district, Sri Lanka using the WHO-30 cluster methodology with probability proportionate to size sampling. The International Study of Asthma and Allergy in Childhood questionnaire was used to assess symptomatology.Results: The response rate was 91.8%, with 548 (51.7%) male and 512 (48.3%) female participants. The mean age was 4.4 (± 0.7) years. Allergic rhinitis was reported in 123 (11.6%; 95% CI 9.7-13.5), and eye symptoms were reported in 41 (3.9%; 95% CI 2.8-5.2) children. Activities of daily living were disturbed due to nasal symptoms in 113 (10.7%; 95% CI 8.8-12.5). Allergic rhinitis was independently associated with severe asthma (OR 6.26; 95% CI 3.54-11.06), sleeping on the floor (OR 4.79; 95% CI 1.33-17.25) and having cats in the households (OR 1.86; 95% CI 1.18-2.91). Nasal symptoms were more common in January and August to October months. The standardized local highest monthly temperature, lowest monthly temperature, highest monthly humidity and dew point strongly predicted allergic rhinitis symptom exacerbation (F=4.8, p=0.036, adjusted R square=57.8%, VIF≤2.259, DW=2.1).Conclusions: Allergic rhinitis affects 1 in 10 preschool children of rural Sri Lanka. The factors associated and environmental factor model developed to predict symptom exacerbation could be used to prevent allergic rhinitis exacerbations. [ABSTRACT FROM AUTHOR]

Published
2022
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46. 12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka

Author

Jayasundara, Dinesha, primary, Senavirathna, Indika, additional, Warnasekara, Janith, additional, Gamage, Chandika, additional, Siribaddana, Sisira, additional, Kularatne, Senanayake Abeysinghe Mudiyanselage, additional, Matthias, Michael, additional, Mariet, Jean-François, additional, Picardeau, Mathieu, additional, Agampodi, Suneth, additional, and M. Vinetz, Joseph, additional

Published
2021
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47. The Hidden Burden of Adolescent Pregnancies in Rural Sri Lanka; Findings of The Rajarata Pregnancy Cohort

Author

Agampodi, Thilini Chanchala, primary, Wickramasinghe, Nuwan Darshana, additional, Jayakodi, Hemali Gayathri, additional, Amarasinghe, Gayani Shashikala, additional, Warnasekara, Janith Niwanthaka, additional, Hettiarachchi, Ayesh Umeshana, additional, Jayasinghe, Imasha Upulini, additional, Koralegedara, Iresha Sandamali, additional, Somasiri, Dulani Kanchana, additional, and Agampodi, Suneth Buddhika, additional

Published
2021
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