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192 results on '"Warfel, Noel A."'

2. Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension

Author

Tang, Haiyang, Gupta, Akash, Morrisroe, Seth A., Bao, Changlei, Schwantes-An, Tae-Hwi, Gupta, Geetanjali, Liang, Shuxin, Sun, Yanan, Chu, Aiai, Luo, Ang, Ramamoorthi Elangovan, Venkateswaran, Sangam, Shreya, Shi, Yinan, Naidu, Samisubbu R., Jheng, Jia-Rong, Ciftci-Yilmaz, Sultan, Warfel, Noel A., Hecker, Louise, Mitra, Sumegha, Coleman, Anna W., Lutz, Katie A., Pauciulo, Michael W., Lai, Yen-Chun, Javaheri, Ali, Dharmakumar, Rohan, Wu, Wen-Hui, Flaherty, Daniel P., Karnes, Jason H., Breuils-Bonnet, Sandra, Boucherat, Olivier, Bonnet, Sebastien, Yuan, Jason X.-J., Jacobson, Jeffrey R., Duarte, Julio D., Nichols, William C., Garcia, Joe G.N., and Desai, Ankit A.

Published
2024
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6. Hypoxia

Author

Jensen, Corbin C., primary and Warfel, Noel A., additional

Published
2022
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9. Bifunctional Glycosylase NEIL2 Plays an Important Role in Maintaining Cellular Genomic Integrity

Author

Wondrak, Georg T., Warfel, Noel A., Wilson, Justin, Doublie, Sylvie, Hua, Anh Buu, Wondrak, Georg T., Warfel, Noel A., Wilson, Justin, Doublie, Sylvie, and Hua, Anh Buu

Abstract

Over 70,000 DNA lesions occur in the cell every day, and the inability to properly repair them can lead to mutations and destabilize the genome, resulting in carcinogenesis. The base excision repair (BER) pathway is critical for maintaining genomic integrity by repairing small base lesions, abasic sites, and single-stranded breaks. The Nei-like 2 (NEIL2) enzyme is a critical bifunctional DNA glycosylase in BER that preferentially excises abasic sites from single-stranded, double-stranded, and bubble-structured DNA. NEIL2 is both structurally and functionally dynamic. It undergoes a large conformational change when bound to a DNA substrate and is involved in various molecular pathways including the canonical BER, BER associated with transcription, epigenetic regulation, and immune regulation, converging on its role as an AP lyase. Several germline and somatic variants of NEIL2 with altered expression and enzymatic activity have been reported in the literature linking them to cancers. The G230W somatic variant has defective glycosylase and lyase activities. Functional studies performed on G230W-expressing MCF10A reveal induction of anchorage-independent growth, AP site accumulation, genomic instability, and altered cell cycle progression. High-throughput drug screen performed on G230W-expressing MCF7 reveals several intriguing candidates that could affect therapeutic response. Preliminary validation assays suggest a mild sensitivity of G230W-expressing cells to olaparib and cabozantinib. Furthermore, additional MCF10A cell lines with the expression of germline variants R103Q and R203Q were also generated, providing avenues for future exciting studies into NEIL2 cellular functions.

Published
2024

11. The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer

Author

Singh, Neha, Ramnarine, Varune R., Song, Jin H., Pandey, Ritu, Padi, Sathish K. R., Nouri, Mannan, Olive, Virginie, Kobelev, Maxim, Okumura, Koichi, McCarthy, David, Hanna, Michelle M., Mukherjee, Piali, Sun, Belinda, Lee, Benjamin R., Parker, J. Brandon, Chakravarti, Debabrata, Warfel, Noel A., Zhou, Muhan, Bearss, Jeremiah J., Gibb, Ewan A., Alshalalfa, Mohammed, Karnes, R. Jefferey, Small, Eric J., Aggarwal, Rahul, Feng, Felix, Wang, Yuzhuo, Buttyan, Ralph, Zoubeidi, Amina, Rubin, Mark, Gleave, Martin, Slack, Frank J., Davicioni, Elai, Beltran, Himisha, Collins, Colin, and Kraft, Andrew S.

Published
2021
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13. PIM1 drives lipid droplet accumulation to promote proliferation and survival in prostate cancer

Author

Chauhan, Shailender S., primary, Casillas, Andrea L., additional, Vizzerra, Andres D., additional, Liou, Hope, additional, Clements, Amber N., additional, Flores, Caitlyn E., additional, Prevost, Christopher T., additional, Kashatus, David F., additional, Snider, Ashley J., additional, Snider, Justin M., additional, and Warfel, Noel A., additional

Published
2023
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14. PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer

Author

Torres-Ayuso, Pedro, primary, Katerji, Meghri, additional, Mehlich, Dawid, additional, Lookingbill, Sophia A., additional, Sabbasani, Venkata R., additional, Liou, Hope, additional, Casillas, Andrea L., additional, Chauhan, Shailender S., additional, Serwa, Remigiusz, additional, Rubin, Maxine R., additional, Marusiak, Anna A., additional, Swenson, Rolf E., additional, Warfel, Noel A., additional, and Brognard, John, additional

Published
2023
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18. PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion

Author

Jensen, Corbin C., primary, Clements, Amber N., additional, Liou, Hope, additional, Ball, Lauren E., additional, Bethard, Jennifer R., additional, Langlais, Paul R., additional, Toth, Rachel K., additional, Chauhan, Shailender S., additional, Casillas, Andrea L., additional, Daulat, Sohail R., additional, Kraft, Andrew S., additional, Cress, Anne E., additional, Miranti, Cindy K., additional, Mouneimne, Ghassan, additional, Rogers, Greg C., additional, and Warfel, Noel A., additional

Published
2023
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23. Data from Gene Editing of α6 Integrin Inhibits Muscle Invasive Networks and Increases Cell–Cell Biophysical Properties in Prostate Cancer

Author

Rubenstein, Cynthia S., primary, Gard, Jaime M.C., primary, Wang, Mengdie, primary, McGrath, Julie E., primary, Ingabire, Nadia, primary, Hinton, James P., primary, Marr, Kendra D., primary, Simpson, Skyler J., primary, Nagle, Raymond B., primary, Miranti, Cindy K., primary, Warfel, Noel A., primary, Garcia, Joe G.N., primary, Arif-Tiwari, Hina, primary, and Cress, Anne E., primary

Published
2023
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24. Supplementary Figure 3 from Gene Editing of α6 Integrin Inhibits Muscle Invasive Networks and Increases Cell–Cell Biophysical Properties in Prostate Cancer

Author

Rubenstein, Cynthia S., primary, Gard, Jaime M.C., primary, Wang, Mengdie, primary, McGrath, Julie E., primary, Ingabire, Nadia, primary, Hinton, James P., primary, Marr, Kendra D., primary, Simpson, Skyler J., primary, Nagle, Raymond B., primary, Miranti, Cindy K., primary, Warfel, Noel A., primary, Garcia, Joe G.N., primary, Arif-Tiwari, Hina, primary, and Cress, Anne E., primary

Published
2023
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25. Supplementary Figure 4 from Gene Editing of α6 Integrin Inhibits Muscle Invasive Networks and Increases Cell–Cell Biophysical Properties in Prostate Cancer

Author

Rubenstein, Cynthia S., primary, Gard, Jaime M.C., primary, Wang, Mengdie, primary, McGrath, Julie E., primary, Ingabire, Nadia, primary, Hinton, James P., primary, Marr, Kendra D., primary, Simpson, Skyler J., primary, Nagle, Raymond B., primary, Miranti, Cindy K., primary, Warfel, Noel A., primary, Garcia, Joe G.N., primary, Arif-Tiwari, Hina, primary, and Cress, Anne E., primary

Published
2023
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26. Supplementary Figure 5 from Gene Editing of α6 Integrin Inhibits Muscle Invasive Networks and Increases Cell–Cell Biophysical Properties in Prostate Cancer

Author

Rubenstein, Cynthia S., primary, Gard, Jaime M.C., primary, Wang, Mengdie, primary, McGrath, Julie E., primary, Ingabire, Nadia, primary, Hinton, James P., primary, Marr, Kendra D., primary, Simpson, Skyler J., primary, Nagle, Raymond B., primary, Miranti, Cindy K., primary, Warfel, Noel A., primary, Garcia, Joe G.N., primary, Arif-Tiwari, Hina, primary, and Cress, Anne E., primary

Published
2023
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27. Supplementary Figures S1-S5 from Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo

Author

Gills, Joell J., primary, LoPiccolo, Jaclyn, primary, Tsurutani, Junji, primary, Shoemaker, Robert H., primary, Best, Carolyn J.M., primary, Abu-Asab, Mones S., primary, Borojerdi, Jennifer, primary, Warfel, Noel A., primary, Gardner, Erin R., primary, Danish, Matthew, primary, Hollander, M. Christine, primary, Kawabata, Shigeru, primary, Tsokos, Maria, primary, Figg, William D., primary, Steeg, Patricia S., primary, and Dennis, Phillip A., primary

Published
2023
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28. Supplementary Movie 1 from Gene Editing of α6 Integrin Inhibits Muscle Invasive Networks and Increases Cell–Cell Biophysical Properties in Prostate Cancer

Author

Rubenstein, Cynthia S., primary, Gard, Jaime M.C., primary, Wang, Mengdie, primary, McGrath, Julie E., primary, Ingabire, Nadia, primary, Hinton, James P., primary, Marr, Kendra D., primary, Simpson, Skyler J., primary, Nagle, Raymond B., primary, Miranti, Cindy K., primary, Warfel, Noel A., primary, Garcia, Joe G.N., primary, Arif-Tiwari, Hina, primary, and Cress, Anne E., primary

Published
2023
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30. Supplementary Figure 2 from Gene Editing of α6 Integrin Inhibits Muscle Invasive Networks and Increases Cell–Cell Biophysical Properties in Prostate Cancer

Author

Rubenstein, Cynthia S., primary, Gard, Jaime M.C., primary, Wang, Mengdie, primary, McGrath, Julie E., primary, Ingabire, Nadia, primary, Hinton, James P., primary, Marr, Kendra D., primary, Simpson, Skyler J., primary, Nagle, Raymond B., primary, Miranti, Cindy K., primary, Warfel, Noel A., primary, Garcia, Joe G.N., primary, Arif-Tiwari, Hina, primary, and Cress, Anne E., primary

Published
2023
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31. Supplementary Figure 1 from Gene Editing of α6 Integrin Inhibits Muscle Invasive Networks and Increases Cell–Cell Biophysical Properties in Prostate Cancer

Author

Rubenstein, Cynthia S., primary, Gard, Jaime M.C., primary, Wang, Mengdie, primary, McGrath, Julie E., primary, Ingabire, Nadia, primary, Hinton, James P., primary, Marr, Kendra D., primary, Simpson, Skyler J., primary, Nagle, Raymond B., primary, Miranti, Cindy K., primary, Warfel, Noel A., primary, Garcia, Joe G.N., primary, Arif-Tiwari, Hina, primary, and Cress, Anne E., primary

Published
2023
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32. Supplementary Table 1 from Gene Editing of α6 Integrin Inhibits Muscle Invasive Networks and Increases Cell–Cell Biophysical Properties in Prostate Cancer

Author

Rubenstein, Cynthia S., primary, Gard, Jaime M.C., primary, Wang, Mengdie, primary, McGrath, Julie E., primary, Ingabire, Nadia, primary, Hinton, James P., primary, Marr, Kendra D., primary, Simpson, Skyler J., primary, Nagle, Raymond B., primary, Miranti, Cindy K., primary, Warfel, Noel A., primary, Garcia, Joe G.N., primary, Arif-Tiwari, Hina, primary, and Cress, Anne E., primary

Published
2023
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33. Supplementary Movie 2 from Gene Editing of α6 Integrin Inhibits Muscle Invasive Networks and Increases Cell–Cell Biophysical Properties in Prostate Cancer

Author

Rubenstein, Cynthia S., primary, Gard, Jaime M.C., primary, Wang, Mengdie, primary, McGrath, Julie E., primary, Ingabire, Nadia, primary, Hinton, James P., primary, Marr, Kendra D., primary, Simpson, Skyler J., primary, Nagle, Raymond B., primary, Miranti, Cindy K., primary, Warfel, Noel A., primary, Garcia, Joe G.N., primary, Arif-Tiwari, Hina, primary, and Cress, Anne E., primary

Published
2023
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35. Supplementary Materials and Methods from Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53

Author

Zhang, Shengliang, primary, Zhou, Lanlan, primary, Hong, Bo, primary, van den Heuvel, A. Pieter J., primary, Prabhu, Varun V., primary, Warfel, Noel A., primary, Kline, Christina Leah B., primary, Dicker, David T., primary, Kopelovich, Levy, primary, and El-Deiry, Wafik S., primary

Published
2023
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36. Supplementary Figures S1-2, Tables 1-2 from Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53

Author

Zhang, Shengliang, primary, Zhou, Lanlan, primary, Hong, Bo, primary, van den Heuvel, A. Pieter J., primary, Prabhu, Varun V., primary, Warfel, Noel A., primary, Kline, Christina Leah B., primary, Dicker, David T., primary, Kopelovich, Levy, primary, and El-Deiry, Wafik S., primary

Published
2023
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38. Digital image analysis using video microscopy of human-derived prostate cancer vs normal prostate organoids to assess migratory behavior on extracellular matrix proteins

Author

Marr, Kendra D., Ignatenko, Natalia A., Warfel, Noel A., Batai, Ken, Cress, Anne E., Pollock, Grant R., Wong, Ava C., and Lee, Benjamin R.

Subjects
Cancer Research, Oncology
Abstract

The advent of perpetuating living organoids derived from patient tissue is a promising avenue for cancer research but is limited by difficulties with precise characterization. In this brief communication, we demonstrate via time-lapse imaging distinct phenotypes of prostate organoids derived from patient material– without confirmation of cellular identity. We show that organoids derived from histologically normal tissue more readily spread on a physiologic extracellular matrix (ECM) than on pathologic ECM (p

Published
2023
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46. Molecular Mechanisms by Which HSP90 Inhibition in the Spinal Cord Enhances Opioid Receptor Signaling

Author

Lee, Nam, Ibrahim, Mohab, Largent-Milnes, Tally, Warfel, Noel, Gabriel, Katherin, Lee, Nam, Ibrahim, Mohab, Largent-Milnes, Tally, Warfel, Noel, and Gabriel, Katherin

Abstract

Our current focus to improve opioid therapy has been studying signal transduction cascades of the mu opioid receptor. Our lab has identified heat shock protein 90 (HSP90) as a key regulator of opioid signaling by demonstrating that when HSP90 is inhibited in spinal cord using 17-AAG, ERK MAPK signaling, and subsequent opioid anti-nociception is enhanced. Quantitative proteomic analysis on the spinal cords of CD-1 mice treated with 17-AAG revealed that both 5' AMP-activated protein kinase subunit beta-1 (AMPK) and Epidermal Growth Factor Receptor (EGFR) were downregulated by 26%, while the Dual Specificity Phosphatase 15 (DUSP15) was upregulated by 35%. This result suggested that a reduction in AMPK and EGFR activity and an increase in DUSP15 activity could lead to enhanced opioid signaling and pain relief. We tested this hypothesis using the AMPK activators AICAR and PT1 (i.t) and EGFR activator EGF (i.t) and found they decreased 17-AAG-enhanced morphine (subcutaneous, SC) antinociception in the tail flick test and paw-incision pain model in both male and female mice. Conversely, the AMPK inhibitor dorsomorphin (i.t) and the EGFR inhibitor Afatinib (i.t) enhanced morphine antinociception greater than 17-AAG alone. This suggests that both AMPK and EGFR work as negative regulators to suppress opioid signaling. Immunohistochemical studies showed opioid treatment increased pAMPK signal in the dorsal horn of the spinal cord; for EGFR there was an upregulation of total receptor expression with a concentrated phosphorylation in the dorsal horn, which are then decreased as a response to 17-AAG. Colocalization studies demonstrated AMPK colocalized with the neuropeptide CGRP and the neuronal marker NeuN, and EGFR colocalized with CGRP. We further used CRISPR gene editing to knockdown AMPK in CGRP neurons, which was sufficient to enhance opioid antinociception without HSP90 inhibition. When we knocked down EGFR in CGRP expressing neurons however, there was no enhancement, even

Published
2022

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