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1,351 results on '"Ware, R."'

5. P-039: ALTERNATIVE DOSING AND PREVENTION OF TRANSFUSIONS (ADAPT): A PROSPECTIVE TRIAL EVALUATING TRANSFUSION UTILIZATION AND THE FEASIBILITY OF PHARMACOKINETIC HYDROXYUREA DOSING IN CHILDREN WITH SICKLE CELL ANEMIA IN UGANDA

Author

POWER-HAYS, MD, A., NAMAZZI R., MBCHB, MMED, KATO C., MD, CONROY A., PHD, HUME H., MD, FRCPC, JOHN C., MD, MS, STUBER, MA S., LANE A., PHD, LATHAM T., MA, OPOKA R., MBCHB, PHD, and WARE R., MD, PHD

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
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17. Hydroxyurea treatment is associated with lower malaria incidence in children with sickle cell anemia in sub-Saharan Africa: the REACH trial

Author

Olupot-Olupot, P, Tomlinson, G, Williams, T, Tshilolo, L, Santos, B, Smart, L, McElhinney, K, Howard, T, Aygun, B, Stuber, S, Lane, A, Latham, T, and Ware, R

Abstract

Realizing Effectiveness Across Continents with Hydroxyurea (REACH, NCT01966731) provides hydroxyurea at maximum tolerated dose (MTD) for children with sickle cell anemia (SCA) in sub-Saharan Africa. Beyond reducing sickle-related clinical events, documented treatment benefits include ~50% malaria incidence. To identify associations and propose mechanisms by which hydroxyurea could be associated with lower malaria rates, infections were recorded across all clinical sites (Angola, Democratic Republic of Congo, Kenya, and Uganda). Hazard ratios (HR) with 95% Confidence Intervals (CI) for baseline demographic, and time-varying laboratory and clinical parameters were estimated in a modified Cox gap-time model for repeated events. A total of 717 clinical malaria episodes occurred in 336 of 606 study participants over 3,387 patient-years of hydroxyurea treatment; over half were confirmed by blood smear and/or rapid diagnostic testing with 97.8% Plasmodium falciparum. In univariate analysis limited to 4 confirmed infections per child, malaria risk was significantly associated with absolute neutrophil count (ANC), splenomegaly, hemoglobin, and achieving MTD; age, malaria season, MTD dose, fetal hemoglobin, a-thalassemia, and G6PD deficiency had no effect. In multivariable regression of confirmed infections, ANC was significant (HR=1.37 per doubled value, CI=1.10-1.70, p=0.0052) and ANC values

Published
2022

21. Health Advocacy: A Vital Step in Attaining Human Rights for Adults with Intellectual Disability

Author

Brolan, C. E., Boyle, F. M., Dean, J. H., Gomez, M. Taylor, Ware, R. S., and Lennox, N. G.

Abstract

Background: People with intellectual disability (ID) experience health inequity compared with the general population, a key contributing factor being disparities in social determinants of health. The enactment of the United Nations Convention on the Rights of Persons with Disabilities (CRPD) provides a platform for the progression and promotion of health and other interconnected rights to address barriers to the highest attainable standard of health for this populace. Rights can be brought to life through advocacy efforts. This paper explores the meaning, perceptions and experiences of advocacy by family members and paid support workers of adults with ID and locates the findings within a health and human rights discourse. Methods: As part of a larger randomised controlled trial, 113 parents and 84 support workers of adults with ID completed a telephone interview that included open-ended questions about their understanding and experiences of advocacy. Thematic analysis was used to identify relevant themes. Results: Five key themes were identified. The first underscored how advocacy to "speak up" for the person with ID is integral to both parent and support worker roles. The second and third themes considered the contexts for advocacy efforts. Access to quality health care was a core concern, along with advocacy across other areas and sectors to address the person's wider psychosocial needs. The remaining themes highlighted the many dimensions to advocacy, including differences between parent and support worker views, with parental advocacy being an expression of "caring" and support workers motivated by a "duty of care" to protect the individual's "rights". Conclusion: Parent and support worker advocacy provides one means to address the social determinants of health and fulfilment of health rights of and for people with ID. Policy and practice in the context of governmental obligation under the CRPD should support advocacy and make health rights the reality not rhetoric for this group of men and women.

Published
2012
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42. Notes and News

Author

Rugg, Harold Goddard and Ware, R. A.

Published
1913

43. New Books

Author

Ware, R. X., Borst, C. V., and Whiteley, C. H.

Published
1972

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