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2. Frequency of cannabis and illicit opioid use among people who use drugs and report chronic pain: A longitudinal analysis.

Author

Lake, Stephanie, Walsh, Zach, Kerr, Thomas, Cooper, Ziva D, Buxton, Jane, Wood, Evan, Ware, Mark A, and Milloy, MJ

Subjects
Humans, Cannabis, Pain, Opioid-Related Disorders, Analgesics, Analgesics, Opioid, Longitudinal Studies, Prospective Studies, Marijuana Smoking, Adult, Middle Aged, Canada, Female, Male, Pain Management, Chronic Pain, Medical Marijuana, Opioid, Pain Research, Clinical Research, Drug Abuse, Neurosciences, Substance Abuse, 2.1 Biological and endogenous factors, Medical and Health Sciences, General & Internal Medicine
Abstract

BACKGROUND:Ecological research suggests that increased access to cannabis may facilitate reductions in opioid use and harms, and medical cannabis patients describe the substitution of opioids with cannabis for pain management. However, there is a lack of research using individual-level data to explore this question. We aimed to investigate the longitudinal association between frequency of cannabis use and illicit opioid use among people who use drugs (PWUD) experiencing chronic pain. METHODS AND FINDINGS:This study included data from people in 2 prospective cohorts of PWUD in Vancouver, Canada, who reported major or persistent pain from June 1, 2014, to December 1, 2017 (n = 1,152). We used descriptive statistics to examine reasons for cannabis use and a multivariable generalized linear mixed-effects model to estimate the relationship between daily (once or more per day) cannabis use and daily illicit opioid use. There were 424 (36.8%) women in the study, and the median age at baseline was 49.3 years (IQR 42.3-54.9). In total, 455 (40%) reported daily illicit opioid use, and 410 (36%) reported daily cannabis use during at least one 6-month follow-up period. The most commonly reported therapeutic reasons for cannabis use were pain (36%), sleep (35%), stress (31%), and nausea (30%). After adjusting for demographic characteristics, substance use, and health-related factors, daily cannabis use was associated with significantly lower odds of daily illicit opioid use (adjusted odds ratio 0.50, 95% CI 0.34-0.74, p < 0.001). Limitations of the study included self-reported measures of substance use and chronic pain, and a lack of data for cannabis preparations, dosages, and modes of administration. CONCLUSIONS:We observed an independent negative association between frequent cannabis use and frequent illicit opioid use among PWUD with chronic pain. These findings provide longitudinal observational evidence that cannabis may serve as an adjunct to or substitute for illicit opioid use among PWUD with chronic pain.

Published
2019

7. Anti-drug Antibody Validation Testing and Reporting Harmonization

Author

Myler, Heather, Pedras-Vasconcelos, João, Phillips, Kelli, Hottenstein, Charles Scott, Chamberlain, Paul, Devanaryan, Viswanath, Gleason, Carol, Goodman, Joanne, Manning, Marta Starcevic, Purushothama, Shobha, Richards, Susan, Shen, Honglue, Zoghbi, Jad, Amaravadi, Lakshmi, Barger, Troy, Bowen, Steven, Bowsher, Ronald R., Clements-Egan, Adrienne, Geng, Dong, Goletz, Theresa J., Gunn, George R., Hallett, William, Hodsdon, Michael E., Janelsins, Brian M., Jawa, Vibha, Kamondi, Szilard, Kirshner, Susan, Kramer, Daniel, Liang, Meina, Lindley, Kathryn, Liu, Susana, Liu, ZhenZhen, McNally, Jim, Mikulskis, Alvydas, Nelson, Robert, Ahbari, Mohsen Rajabi, Qu, Qiang, Ruppel, Jane, Snoeck, Veerle, Song, An, Yan, Haoheng, and Ware, Mark

Published
2022
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8. Cannabis

Author

Ware, Mark A., additional, Pitt, Rebecca, additional, and Ingelmo, Pablo, additional

Published
2021
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12. Inhaled Cannabis for Chronic Neuropathic Pain: A Meta-analysis of Individual Patient Data

Author

Andreae, Michael H, Carter, George M, Shaparin, Naum, Suslov, Kathryn, Ellis, Ronald J, Ware, Mark A, Abrams, Donald I, Prasad, Hannah, Wilsey, Barth, Indyk, Debbie, Johnson, Matthew, and Sacks, Henry S

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Chronic Pain, Neurodegenerative, Peripheral Neuropathy, Pain Research, Clinical Trials and Supportive Activities, Clinical Research, Substance Misuse, Drug Abuse (NIDA only), Neurological, Administration, Inhalation, Adult, Aged, Bayes Theorem, Cannabis, Female, Humans, Male, Medical Marijuana, Middle Aged, Pain, Peripheral Nervous System, Peripheral Nervous System Diseases, Randomized Controlled Trials as Topic, Young Adult, chronic pain, neuropathy, painful, polyneuropathy, meta-analysis, meta-analysis of individual patient data, Bayesian analysis, human immunodeficiency virus, Medical and Health Sciences, Psychology and Cognitive Sciences, Anesthesiology, Clinical sciences, Epidemiology
Abstract

UnlabelledChronic neuropathic pain, the most frequent condition affecting the peripheral nervous system, remains underdiagnosed and difficult to treat. Inhaled cannabis may alleviate chronic neuropathic pain. Our objective was to synthesize the evidence on the use of inhaled cannabis for chronic neuropathic pain. We performed a systematic review and a meta-analysis of individual patient data. We registered our protocol with PROSPERO CRD42011001182. We searched in Cochrane Central, PubMed, EMBASE, and AMED. We considered all randomized controlled trials investigating chronic painful neuropathy and comparing inhaled cannabis with placebo. We pooled treatment effects following a hierarchical random-effects Bayesian responder model for the population-averaged subject-specific effect. Our evidence synthesis of individual patient data from 178 participants with 405 observed responses in 5 randomized controlled trials following patients for days to weeks provides evidence that inhaled cannabis results in short-term reductions in chronic neuropathic pain for 1 in every 5 to 6 patients treated (number needed to treat = 5.6 with a Bayesian 95% credible interval ranging between 3.4 and 14). Our inferences were insensitive to model assumptions, priors, and parameter choices. We caution that the small number of studies and participants, the short follow-up, shortcomings in allocation concealment, and considerable attrition limit the conclusions that can be drawn from the review. The Bayes factor is 332, corresponding to a posterior probability of effect of 99.7%.PerspectiveThis novel Bayesian meta-analysis of individual patient data from 5 randomized trials suggests that inhaled cannabis may provide short-term relief for 1 in 5 to 6 patients with neuropathic pain. Pragmatic trials are needed to evaluate the long-term benefits and risks of this treatment.

Published
2015

16. 2022 White Paper on Recent Issues in Bioanalysis: Enzyme Assay Validation, BAV for Primary End Points, Vaccine Functional Assays, Cytometry in Tissue, LBA in Rare Matrices, Complex NAb Assays, Spectral Cytometry, Endogenous Analytes, Extracellular Vesicles Part 2 – Recommendations on Biomarkers/CDx, Flow Cytometry, Ligand-Binding Assays Development & Validation; Emerging Technologies; Critical Reagents Deep Characterization

Author

Sumner, Giane, primary, Keller, Steve, additional, Huleatt, James, additional, Staack, Roland F, additional, Wagner, Leslie, additional, Azadeh, Mitra, additional, Bandukwala, Abbas, additional, Cao, Liching, additional, Du, Xiulian, additional, Salinas, Gabriela Franco, additional, Garofolo, Fabio, additional, Harris, Shannon, additional, Hopper, Shirley, additional, Irwin, Chad, additional, Ji, Qin, additional, Joseph, Julie, additional, King, Lindsay, additional, Kinhikar, Arvind, additional, Lu, Yang, additional, Luo, Rosa, additional, Mabrouk, Omar, additional, Malvaux, Ludovic, additional, Marshall, Jean-Claude, additional, McGuire, Kristina, additional, Mikol, Vincent, additional, Neely, Robert, additional, Qiu, Xiazi, additional, Saito, Yoshiro, additional, Salaun, Bruno, additional, Scully, Ingrid, additional, Smeraglia, John, additional, Solstad, Therese, additional, Stoop, Jeroen, additional, Tang, Huaping, additional, Teixeira, Priscila, additional, Wang, Yixin, additional, Wright, Mike, additional, Mendez, Luis, additional, Beaver, Chris, additional, Eacret, Jacqueline, additional, Au-Yeung, Amelia, additional, Decman, Vilma, additional, Dessy, Francis, additional, Eck, Steven, additional, Goihberg, Polina, additional, Alcaide, Enrique Gomez, additional, Gonneau, Christele, additional, Grugan, Katharine, additional, Hedrick, Michael Nathan, additional, Kar, Sumit, additional, Sehra, Sarita, additional, Stevens, Erin, additional, Stevens, Chad, additional, Sun, Yongliang, additional, McCush, Fred, additional, Williams, LaKenya, additional, Fischer, Sally, additional, Wu, Bonnie, additional, Jordan, Gregor, additional, Burns, Chris, additional, Cludts, Isabelle, additional, Coble, Kelly, additional, Grimaldi, Christine, additional, Henderson, Neil, additional, Joyce, Alison, additional, Lotz, Gregor, additional, Lu, Yanmei, additional, Luo, Linlin, additional, Neff, Florian, additional, Sperinde, Gizette, additional, Stubenrauch, Kay-Gunnar, additional, Wang, Yuting, additional, Ware, Mark, additional, and Xu, Weifeng, additional

Published
2023
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18. Teaching beyond the Classroom: Mentoring Student Publications and Presentations.

Author

Badura, Amy S., Ware, Mark E., and Davis, Stephen F.

Abstract

Classroom assignments have limitations in their ability to encourage student learning, communication skills, and appreciation for the professional aspects of psychology as a science. This document emphasizes the value of teaching beyond the classroom by mentoring undergraduate student scholarship. It identifies many opportunities for students to publish and present in both student and professional forums, and presents pedagogical, personal, and professional benefits of such joint endeavors for students and faculty. The benefits for students presenting research include: (1) promoting creativity and critical thinking skills; (2) encouraging collaborative learning; (3) refining communication skills; and (4) developing feelings of competence and familiarity with the entire research process. Interviews with former American Psychological Association presidents and anecdotal reports by instructors who have mentored students reinforce the advantages of the mentor approach. Table 1 lists information about psychology journals that publish undergraduate students' scholarly work. (Contains 18 references.) (JDM)

Published
2000

19. Developing Students, Developing Faculty: Incompatible or Compatible Goals?

Author

Ware, Mark E., Davis, Stephen F., and Smith, Randolph A.

Abstract

Grounding students in research methodology is at the core of the undergraduate curriculum. Students usually conduct individual projects in the experimental psychology or research methods courses, and most undergraduate courses in the psychology curriculum contain a strong research component. The opportunities and benefits for undergraduate student and faculty development after students have completed their research projects are addressed. Specifically, convention presentations and journal publication opportunities are examined. Suggestions for poster and paper presentations on campus and at regional, national, or statewide meetings are presented. The benefits for students and for faculty working with and sponsoring undergraduate students in presenting their work are reviewed. Developing students' scholarly skills is compatible with developing faculty's teaching and research skills. A win-win situation exists for both faculty and students when faculty facilitate the implementation of students' presenting and publishing opportunities. Originally a poster presentation, this brief paper contains contact information for journals that publish undergraduate research. (EMK)

Published
1998

20. Student Publications Enhance Teaching: Experimental Psychology and Research Methods Courses.

Author

Ware, Mark E. and Davis, Stephen F.

Abstract

Recent years have witnessed an increased emphasis on the professional development of undergraduate psychology students. One major thrust of this professional development has been on research that results in a convention presentation or journal publication. Research leading to journal publication is becoming a requirement for admission to many graduate programs. It is therefore important to assist undergraduate students in the accumulation of skills required to conduct research and to write articles for publication. To help students in these efforts, several exercises involving the use of a journal that only publishes undergraduate students' research were conducted. The journal is intended to teach students about statistical, design, and American Psychological Association (APA)-format issues for empirical studies and literature reviews. Participants for this study were students in statistics, research methods, and personality classes at private and public universities in Nebraska, Kansas, and Arkansas. Students were asked to perform eight exercises. Their narrative reactions to the exercises indicated that they found the journal articles written by undergraduates helpful in gaining insight into the uses of statistical techniques and research methods, as well as clarification about APA-style writing. (MKA)

Published
1997

21. Autobiographical and Biographical Resources for History of Psychology.

Author

Ware, Mark E.

Abstract

This document presents a variety of resources for students to use in preparing class presentations and historical research projects on the history of psychology. The resources pertain to historical figures in the field of psychology. Many of the references included in this bibliography are annotated and the names of the psychologists contained within most of books are listed as well. The first section of the bibliography lists four indexes to autobiographies and biographies of noted psychologists. The next section focuses on autobiographical references and includes references and/or annotations for both monograph- and book-length autobiographies. This section is followed by a section on biographical references. Included are sources for biographical sketches (1-2 paragraphs in length) of psychologists, as well as references and/or annotations for both monograph- and book-length biographies. A list of 4 necrology references which contain the death dates for 638 psychologists is also included. The document concludes with a list of bibliographic references on individual psychologists. (NB)

Published
1993

22. Advising in the Classroom: Teaching a Career Development Course.

Author

Ware, Mark E.

Abstract

This paper discusses the teaching of a career development course in college. The stated goals of the course are to increase students' knowledge about themselves, about postgraduate educational and occupational opportunities, and about job entry skills. The mechanics of the course are described, including its length, format, written assignments, videotape programs and booklets, career inventories, out-of-class skill development tasks and grading. The course content is described, noting use of paper and pencil exercises; small group in-class discussion; use of career inventories; graduate education, including graduate study in psychology; world of work; decision-making; job search skills and resume writing; and interviewing. Previous evaluations by students of the course are described. Students' comments are interspersed in the descriptions of course mechanics and course content. A list of selected readings for career development in psychology and a reference list of career information are included. (ABL)

Published
1992

23. Affect and Dialogue in Collaborative Cross- Disciplinary Research: Developing Interactive Public Art on Cardiff Bay Barrage

Author

Entwistle Alice, Burrows Inga, Carroll Fiona, Thomas Nathan, Ware Mark, and Loudon Gareth

Subjects
interactive public art, site-specificity, affect, human-centred design, social disability, social inclusion, Social sciences (General), H1-99
Abstract

Where Cartesian philosophy distinguishes the perceiving and perceptual mind from the body, phenomenology constitutes the experiential/experiencing body as the subject, giving rise to the affective potential of art. An immersive world of digital connections, smart cities and the Internet of Everything dramatises the centrality of relationship, the intertwining of Self and Other, in the lived environments of human experience. This article addresses the contextual, disciplinary and practical challenges encountered in developing an ambitious interactive public art project embedding SMART technology on the coastal fringes of Cardiff, the capital city of Wales (UK). It examines the processes and problems involved in delivering a stimulating aesthetic experience in and on a complex site, for a complex audience profile. It traces, in particular, the dependence of a multi-disciplinary project team on the theoretical and practical effects of affect in their ongoing effort to produce engaging, provocative, socially inclusive interactive public art, in and through human-centred design techniques.

Published
2017
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26. The Quebec Low Back Pain Study: a protocol for an innovative 2-tier provincial cohort

Author

Pagé, Gabrielle M., Lacasse, Anaïs, Beaudet, Nicolas, Choinière, Manon, Deslauriers, Simon, Diatchenko, Luda, Dupuis, Laurent, Grégoire, Stéphanie, Hovey, Richard, Leclair, Erwan, Leonard, Guillaume, Meloto, Carolina B., Montagna, Francesca, Parent, Alexandre, Rainville, Pierre, Roy, Jean-Sébastien, Roy, Mathieu, Ware, Mark A., Wideman, Timothy H., and Stone, Laura S.

Published
2020
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30. HIV vaccine-induced sero-reactivity: A challenge for trial participants, researchers, and physicians

Author

Voronin, Yegor, Zinszner, Helene, Karg, Carissa, Brooks, Katie, Coombs, Robert, Hural, John, Holt, Renee, Fast, Pat, Allen, Mary, Busch, Michael, Fruth, Ulrich, Golding, Hana, Khurana, Surender, Mulenga, Joseph, Peel, Sheila, Schito, Marco, Barnabas, Nomampondo, Bentsen, Christopher, Graham, Barney, Gray, Glenda, Levin, Andrew, McCluskey, Margaret, O’Connell, Robert, Snow, Bill, and Ware, Mark

Published
2015
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42. Representation and Management of Evolving Features in OS MasterMap ITN Data

Author

Lohfink, Alex, Carnduff, Tom, Thomas, Nathan, Ware, Mark, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Cooper, Richard, editor, and Kennedy, Jessie, editor

Published
2007
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43. Automated Schematization for Web Service Applications

Author

Swan, Jerry, Anand, Suchith, Ware, Mark, Jackson, Mike, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Ware, J. Mark, editor, and Taylor, George E., editor

Published
2007
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45. Prediction of GPS Multipath Effect Using LiDAR Digital Surface Models and Building Footprints

Author

Li, Jing, Taylor, George, Kidner, David, Ware, Mark, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Carswell, James D., editor, and Tezuka, Taro, editor

Published
2006
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47. Predictors of Pain Reduction Among Fibromyalgia Patients Using Medical Cannabis: A Long‐TermProspective Cohort Study

Author

Sotoodeh, Romina, Waldman, Lilach Eyal, Vigano, Antonio, Moride, Yola, Canac‐Marquis, Michelle, Spilak, Tristan, Gamaoun, Rihab, Kalaba, Maja, Hachem, Yasmina, Beaulieu, Pierre, Desroches, Julie, Ware, Mark A., Perez, Jordi, Shir, Yoram, Fitzcharles, Mary‐Ann, and Martel, Marc O.

Abstract

Many patients with fibromyalgia (FM) report using cannabis as a strategy to improve pain. Given that pain often co‐occurs with symptoms of anxiety and depression (i.e., negative affect) and sleep problems among patients with FM, improvements in these symptoms might indirectly contribute to reductions in pain intensity following cannabis use. The main objective of the study was to examine whether changes in pain intensity following initiation of medical cannabis among patients with FM could be attributed to concurrent changes (i.e., reductions) in negative affect and sleep problems. This was a 12‐month prospective cohort study among patients with FM (n = 323) initiating medical cannabis under the care of physicians. Patients were assessed at baseline, and follow‐up assessment visits occurred every 3 months after initiation of medical cannabis. Patients’ levels of pain intensity, negative affect, and sleep problems were assessed across all visits. Multilevel mediation analyses indicated that reductions in patients’ levels of pain intensity were partly explained by concurrent reductions in sleep problems and negative affect (both P< 0.001). This remained significant even when accounting for patients’ baseline characteristics or changes in medical cannabis directives over time (all P> 0.05). Our findings provide preliminary insight into the potential mechanisms of action underlying pain reductions among patients with FM who are using medical cannabis. Given the high attrition rate (i.e., 75%) observed in the present study at 12 months, our findings cannot be generalized to all patients with FM who are using medical cannabis.

Published
2023
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48. Surface Modelling for GPS Satellite Visibility

Author

Taylor, George, Li, Jing, Kidner, David, Ware, Mark, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Li, Ki-Joune, editor, and Vangenot, Christelle, editor

Published
2005
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49. 2021 White Paper on Recent Issues in Bioanalysis: ISR for Biomarkers, Liquid Biopsies, Spectral Cytometry, Inhalation/Oral & Multispecific Biotherapeutics, Accuracy/LLOQ for Flow Cytometry (Part 2 – Recommendations on Biomarkers/CDx Assays Development & Validation, Cytometry Validation & Innovation, Biotherapeutics PK LBA Regulated Bioanalysis, Critical Reagents & Positive Controls Generation)

Author

Hersey, Sarah, primary, Keller, Steve, additional, Mathews, Joel, additional, King, Lindsay, additional, Bandukwala, Abbas, additional, Berisha, Flora, additional, Birchler, Mary, additional, Bower, Joe, additional, Clausen, Valerie, additional, Duarte, Jose, additional, Garofolo, Fabio, additional, Hopper, Shirley, additional, Kar, Sumit, additional, Mabrouk, Omar, additional, Marshall, Jean-Claude, additional, McGuire, Kristina, additional, Naughton, Michael, additional, Saito, Yoshiro, additional, Schuhmann, Imelda, additional, Sperinde, Gizette, additional, Teixeira, Priscila, additional, Vitaliti, Alessandra, additional, Wang, Yow-Ming, additional, Wnek, Richard, additional, Zhang, Yan, additional, Spitz, Sue, additional, Decman, Vilma, additional, Eck, Steven, additional, Estevam, Jose, additional, Goihberg, Polina, additional, Alcaide, Enrique Gómez, additional, Gonneau, Christèle, additional, Hedrick, Michael Nathan, additional, Hopkins, Gregory, additional, Junker, Fabian, additional, Nuti, Sandra, additional, Sommer, Ulrike, additional, Standifer, Nathan, additional, Stevens, Chad, additional, Stevens, Erin, additional, Hendricks, Carrie, additional, Wadhwa, Meenu, additional, Torri, Albert, additional, Ma, Mark, additional, Harris, Shannon, additional, Kumar, Seema, additional, Partridge, Michael A, additional, Caiazzo, Teresa, additional, Chilewski, Shannon, additional, Cludts, Isabelle, additional, Coble, Kelly, additional, Gorovits, Boris, additional, Grimaldi, Christine, additional, Jordan, Gregor, additional, Kamerud, John, additional, Leary, Beth, additional, Liang, Meina, additional, Lim, Hanjo, additional, Mayer, Andrew, additional, O'Connor, Ellen, additional, Palackal, Nisha, additional, Poetzl, Johann, additional, Prior, Sandra, additional, Abhari, Mohsen Rajabi, additional, Savoie, Natasha, additional, Soo, Catherine, additional, Ware, Mark, additional, Wu, Bonnie, additional, Xu, Yang, additional, Yang, Tong-Yuan, additional, and Zoghbi, Jad, additional

Published
2022
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