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Purpose: Physalis angulata Linn. (Ciplukan) is a plant widely used in traditional medicine in subtropical and tropical regions. Most studies focus on its antioxidant and anti-inflammatory activity. Many studies also reported its therapeutic potential for treating cancer, malaria, hepatitis, rheumatism, liver problems, and tumors, but few studies have reported its anti-fibrosis activity. Here, we aimed to investigate the potential of P. angulata as an antioxidant and anti-inflammatory that may be correlated with its anti-fibrosis action. Methods: In our study, we treated 3T3-L1 and TGF-β-induced 3T3-L1 cells with an ethanol extract of P. angulata. We then monitored the cell's response, evaluated the antioxidant activity using an MTT assay, and observed the cells' migration using the cell scratch assay. We used RT-PCR to determine the expression of HIF-1α and IL-6 on TGF-β-induced 3T3-L1 cells. Results: The ethanol extract of P. angulata showed antioxidant activity and promoted cell proliferation on 3T3-L1 cells. Interestingly, the extract inhibited the migration of TGF-β-induced 3T3-L1 cells. Further analysis revealed that the extract could inhibit HIF-1α expression and suppress IL-6 expression on TGF-β-induced 3T3-L1 cells. Conclusion: The ethanol extract of P. angulata showed antioxidant and anti-inflammation activities in 3T3-L1 cells. Both activities are associated with the antifibrotic activity of P. angulata's ethanol extract. [ABSTRACT FROM AUTHOR]

Antioxidants are essential for reducing oxidative stress, protecting cells from damage, and supporting overall well-being. Functionalized mesoporous silica materials have garnered interest due to their flexible uses in diverse domains, such as drug delivery systems. This review aims to thoroughly examine and evaluate the progress made in utilizing functionalized mesoporous silica materials as a possible approach to enhancing antioxidant activity. The authors performed a thorough search of reliable databases, including Scopus, PubMed, Google Scholar, and Clarivate Web of Science, using precise keywords linked to functionalized mesoporous silica nanoparticles and antioxidants. The identified journals serve as the major framework for the main discussion in this study. Functionalized mesoporous silica nanoparticles have been reported to greatly enhance antioxidant activity by allowing for an increased loading capacity, controlled release behavior, the targeting of specific drugs, improved biocompatibility and safety, and enhanced penetration. The results emphasize the significant capacity of functionalized mesoporous silica (FSM) to bring about profound changes in a wide range of applications. FSM materials can be designed as versatile nanocarriers, integrating intrinsic antioxidant capabilities and augmenting the efficacy of current drugs, offering substantial progress in antioxidant therapies and drug delivery systems, as well as enhanced substance properties in the pharmaceutical field. Functionalized mesoporous silica materials are a highly effective method for enhancing antioxidant activity. They provide new opportunities for the advancement of cutting-edge treatments and materials in the field of antioxidant research. The significant potential of FSM materials to change drug delivery methods and improve substance properties highlights their crucial role in future breakthroughs in the pharmaceutical field and antioxidant applications. [ABSTRACT FROM AUTHOR]

Copyright of Indonesian Journal of Gastroenterology, Hepatology & Digestive Endoscopy is the property of Indonesian Society of Gastroenterology/Assoc for the Study of the Liver/Soc. for Digestive Endoscopy and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

An increasing proportion of the global population have or are at risk of developing non-alcoholic fatty liver disease (NAFLD). Fibrosis is the most important predictor of prognosis in NAFLD patients. Ciplukan (Physalis angulata Linn.) has been reported to have antifibrotic potency in CCl4-induced liver fibrotic rats, so this study was designed to evaluate the antifibrotic effect of ciplukan extract on liver function, inflammation, and cholesterol levels. The liver fibrosis model was established using 20% margarine injected subcutaneously 8 times twice a week for 4 weeks in 35 male and 35 female Wistar rats. The rats were then treated orally with ciplukan extract (CPL) in 70% alcohol, starting the 6th week of treatment with 2 different doses, namely 13.5 mg (CPL-1) and 27 mg (CPL-2) every day for 4 weeks. The histopathological changes in the liver were analyzed by Haematoxylin Eosin (HE) staining. Serum IL-6 and TGF-ß1 levels were determined by ELISA. ALT and cholesterol levels were measured using a diagnostic kit. Single and multiple doses of ciplukan extract with or without standard therapy (Vitamin E) reduced the fibrotic scores to 1.30±0.95 (p=0.001), TGF-ß1 levels to 24.20±2.02 ng/mL (p = 0.000), IL-6 levels to 1.68±0.52 pg/mL (p=0.156), ALT levels to 104.57±2.02 U/mL (p=0.001), and cholesterol levels to 81, 07±2.02 mg/dL (p=0.000). In conclusion, the ciplukan herb ethanol extract possesses potent liver antifibrotic activity, thus it is a potential new liver antifibrotic drug. [ABSTRACT FROM AUTHOR]

Polymorphism occurs in pharmaceutical compounds affect to the physicochemical quality and goal of therapy. Thus, quality evaluation of different crystal forms should be assessed especially the solubility and dissolution behaviors among polymorphic forms, which correlate to bioavailability and therapy efficacy. To achieved the different of a polymorph various solvent were used such as acetonitrile, methanol, ethyl acetate, acetone, water, n-hexane, and nheptane. All of the crystal modification resulted were characterized by a polarization light microscopy (PLM), Fourier-Transform Infrared (FTIR) differential scanning calorimetry (DSC) and powdered X-ray diffraction (PXRD). Besides that, nature of solubility in water (24 and 48 hours test times) and particulate dissolution profile (an hour test) were carried out. There were various polymorphs success resulted and have significant differences in morphology, definite spectral fingerprints, crystal structure and thermal behavior. From the solubility of the samples found the top three highest soluble forms i.e. Form 6, 2 and 3, respectively. But there are showed became in order reverse performance after 60 minutes dissolution (Form 3, 2 and 6, respectively). The polymorphic forms of EFV were successful to obtained by the solvents treatment. Therefore, the physicochemical properties of polymorphic forms from active pharmaceutical ingredients (APIs) should be carefully considered in dosage forms pre-formulation approaches. [ABSTRACT FROM AUTHOR]