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Humans are now recognized as the main drivers of environmental change, leaving the future ofour planet dependent on human action or inaction. Although the outlook of our planet is often depicted in a 'doom and gloom' manner due to recent troubling environmental trends, we suggest that a 'good Anthropocene' (in which human quality of life may be maintained or improved without cost to the environment) is attainable if we engage in adaptive, multi-disciplinary actions capable of addressing the socio-ecological issues of today and tomorrow. Early-career conservation scientists and practitioners have an unmatched understanding of novel technologies and social connectivity and, as those left with the ever-growing responsibility to be the problem solvers of the attributed increasing environmental consequences of living in the Anthropocene, their perspectives on steps towards a good Anthropocene are valuable. Here we present a list of 20 actions derived by early-career conservation scientists and practitioners for conservationists to help achieve a good Anthropocene that utilize the social connectivity and technology of today. Central to these actions are the notions that multi-, inter-, and trans-disciplinary collaboratives that embrace diverse world views need to be integrated into decision-making processes; training and outreach platforms need to communicate both environmental challenges and solutions broadly; and conservation successes need to be acknowledged and disseminated in a forward-looking, adaptive capacity. Together the 20 actions identified here reinforce the underlying paradigm shift that must accompany living in the Anthropocene, given that biodiversity and healthy ecosystems are requisite for sustained human life. By sharing this list of actions, we look to promote positive socio-environmental changes towards the collective goal of achieving a good Anthropocene. Key words: Anthropocene, positive futures, early-career researchers. On reconnait maintenant que les etres humains sont les principaux responsables des changements environnementaux, laissant l'avenir de notre planete dependant de l'action ou de l'inaction humaine. Meme si les perspectives de notre planete sont souvent depeintes de maniere pessimiste a cause des recentes tendances environnementales inquietantes, les auteurs suggerent qu'un <> (dans lequel la qualite de vie des humains peut etre maintenue ou amelioree sans cout environnemental) est atteignable si nous nous engageons dans des actions adaptatives multidisciplinaires capables de s'attaquer aux problemes socioecologiques d'aujourd'hui et de demain. Les scientifiques et les praticiens de la conservation en debut de carriere ont une comprehension sans precedent des nouvelles technologies et de la connectivite sociale et, en tant que personnes a qui l'on confie la responsabilite de plus en plus lourde d'agir comme solutionneurs de problemes en ce qui a trait aux consequences environnementales croissantes que l'on attribue a vivre dans l'Anthropocene, leurs perspectives sur les etapes conduisant a un bon Anthropocene sont precieuses. Les auteurs presentent ici une liste de 20 actions proposees par des scientifiques et des praticiens de la conservation en debut de carriere a l'intention des agents de protection de l'environnement pour les aider a atteindre un bon Anthropocene par l'utilisation de la connectivite sociale et de la technologie d'aujourd'hui. Au coeur de ces actions se trouvent des notions : de collaborations multi-, inter- et transdisciplinaires qui epousent diverses conceptions du monde qui doivent etre integrees aux processusde prisede decision;de plateformes de formation et dediffusion necessaires pour communiquer largement les defis et les solutions en matiere d'environnement; et de succes en matiere de conservation qui doivent etre reconnus et dissemines dans la perspective d'une capacite d'adaptation tournee vers l'avenir. L'ensemble des 20 actions identifiees ici renforcent le changement de paradigme sous-jacent qui doit accompagner la vie dans l'Anthropocene, puisque la biodiversite et des ecosystemes en sante sont necessaires au developpement humain durable. En partageant cette liste d'actions, les auteurs desirent promouvoir des changements socio-environnementaux positifs vers l'objectif collectif d'atteindre un bon Anthropocene. [Traduit par la Redaction] Mots-cles : Anthropocene, avenir prometteur, chercheurs en debut de carriere., Introduction Human actions have led planet Earth into the Anthropocene epoch (Crutzen and Stoermer 2000). Humans are now recognized as a predominant agent of ecosystem change on the planet, exemplified [...]

The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such as L-glycine and L-glutamate or sweet molecules such as sucrose and fructose when dimerized with TAS1R member 1 (TAS1R1) or TAS1R member 2 (TAS1R2), respectively. It was recently reported that deletion of TAS1R3 expression in Tas1R3 mutant mice leads to increased cortical bone mass but the underlying cellular mechanism leading to this phenotype remains unclear. Here, we independently corroborate the increased thickness of cortical bone in femurs of 20-week-old male Tas1R3 mutant mice and confirm that Tas1R3 is expressed in the bone environment. Tas1R3 is expressed in undifferentiated bone marrow stromal cells (BMSCs) in vitro and its expression is maintained during BMP2-induced osteogenic differentiation. However, levels of the bone formation marker procollagen type I N-terminal propeptide (PINP) are unchanged in the serum of 20-week-old Tas1R3 mutant mice as compared to controls. In contrast, levels of the bone resorption marker collagen type I C-telopeptide are reduced greater than 60% in Tas1R3 mutant mice. Consistent with this, Tas1R3 and its putative signaling partner Tas1R2 are expressed in primary osteoclasts and their expression levels positively correlate with differentiation status. Collectively, these findings suggest that high bone mass in Tas1R3 mutant mice is due to uncoupled bone remodeling with reduced osteoclast function and provide rationale for future experiments examining the cell-type-dependent role for TAS1R family members in nutrient sensing in postnatal bone remodeling. [ABSTRACT FROM AUTHOR]