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233 results on '"Waranuch, Neti"'

8. Effectiveness and Safety of Hair Growth Formulation Containing Tectona grandis L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia.

Author

Tanuphol, Nutchaninad, Waranuch, Neti, Wisuitiprot, Vanuchawan, Wisuitiprot, Wudtichai, Insumrong, Kamonlak, Temkitthawon, Prapapan, Suphrom, Nungruthai, Jampachaisri, Katechan, Girard, Corine, and Ingkaninan, Kornkanok

Subjects
MEN, PATIENT safety, PLACEBOS, DATA analysis, RESEARCH funding, BALDNESS, BLIND experiment, STATISTICAL sampling, HAIR follicles, TREATMENT effectiveness, RANDOMIZED controlled trials, DESCRIPTIVE statistics, PLANT extracts, HAIR care products, ANALYSIS of variance, STATISTICS, LEAVES, DATA analysis software
Abstract

Background: Androgenic alopecia (AGA) is commonly known as male patterned baldness. A high level of dihydrotestosterone (DHT) plays a significant role in AGA development. Inhibition of the enzyme steroid 5-alpha reductase (S5AR), responsible for converting testosterone into DHT, has been shown to delay the progression of AGA. Teak (Tectona grandis L.f) leaf extract exhibited a potent S5AR inhibitory activity. To prove the effectiveness and safety of teak leaf extract as a hair growth promotor, a double-blind, randomized placebo-controlled trial was conducted. Methods: Eighty-one AGA subjects were randomly assigned to receive either a hair tonic containing 1% teak leaf extract (HT-teak), 5%minoxidil (positive control), or a placebo administered twice daily, for 24 weeks. Efficacy was assessed through target area hair count (TAHC), anagen-to-telogen ratio (A/T), hair shedding every 4 weeks, and patients' subjective assessments of hair regrowth were assessed at the end of the experiment. Data was analyzed using repeated measure ANOVA. Results: Both the HT-teak and minoxidil groups exhibited a significant increase in TAHC and A/T, along with a decrease in hair shedding compared to baseline values. Conversely, the placebo group showed no observable signs of hair regrowth. Furthermore, the HT-teak group reported the highest satisfaction scores, and there were no indications of skin irritation or systemic effects on sexual dysfunction and palpitation after 24 weeks of HT-teak application. Conclusion: Teak leaf extract, as incorporated in HT-teak, demonstrates potential as an alternative mild hair growth promoter for individuals with AGA, offering both efficacy and safety. Trial registration: This study was retrospectively registered on International Standard Randomised Controlled Trial Number (ISRCTN.com); ISRCTN24541842 (registered on January 8, 2024). [ABSTRACT FROM AUTHOR]

Published
2024
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12. Quality Assessment, Stability and In-Vitro Anti-Inflammatory Activities of a Topical Ointment Containing Cannabis Extract for Haemorrhoids and Skin Diseases

Author

Chaiwangrach, Nathareen, primary, Waranuch, Neti, additional, Temkitthawon, Prapapan, additional, Wongwad, Eakkaluk, additional, Nuengchamnong, Nitra, additional, Usuwanthim, Kanchana, additional, Saesong, Tongchai, additional, Rakkhetkorn, Yanika, additional, Pisutthanan, Sirintorn, additional, and Ingkaninan, Kornkanok, additional

Published
2024
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15. High-content screening of Thai medicinal plants reveals Boesenbergia rotunda extract and its component Panduratin A as anti-SARS-CoV-2 agents

Author

Kanjanasirirat, Phongthon, Suksatu, Ampa, Manopwisedjaroen, Suwimon, Munyoo, Bamroong, Tuchinda, Patoomratana, Jearawuttanakul, Kedchin, Seemakhan, Sawinee, Charoensutthivarakul, Sitthivut, Wongtrakoongate, Patompon, Rangkasenee, Noppawan, Pitiporn, Supaporn, Waranuch, Neti, Chabang, Napason, Khemawoot, Phisit, Sa-ngiamsuntorn, Khanit, Pewkliang, Yongyut, Thongsri, Piyanoot, Chutipongtanate, Somchai, Hongeng, Suradej, Borwornpinyo, Suparerk, and Thitithanyanont, Arunee

Published
2020
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20. Efficacy of Bacopa monnieri on memory and vascular functions: A randomised controlled trial

Author

Kamkaew, Natakorn, primary, Ingkaninan, Kornkanok, additional, Waranuch, Neti, additional, Kaewmahanin, Watchara, additional, Wasuntarawat, Chanchira, additional, Khongsombat, Onrawee, additional, Thiarawat, Peeraphong, additional, Roongpiboonsopit, Duangnapa, additional, Wattanathorn, Jintanaporn, additional, Scholfield, C. Norman, additional, Ngamdokmai, Ngamrayu, additional, Wisutthathum, Sutthinee, additional, Chatturong, Usana, additional, Inchan, Anjaree, additional, and Chootip, Krongkarn, additional

Published
2022
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33. Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract

Author

Waranuch,Neti, Phimnuan,Preeyawass, Yakaew,Swanya, Nakyai,Wongnapa, Grandmottet,Francois, Onlom,Churanya, Srivilai,Jukkarin, and Viyoch,Jarupa

Subjects
mangosteen rinds, Clinical, Cosmetic and Investigational Dermatology, aloe vera gel, inflamed lesions, herbal extracts, green tea leaf, acne, Original Research
Abstract

Neti Waranuch,1,2 Preeyawass Phimnuan,2 Swanya Yakaew,2 Wongnapa Nakyai,3 Francois Grandmottet,4 Churanya Onlom,5 Jukkarin Srivilai,6 Jarupa Viyoch1,21Cosmetics and Natural Products Research Center, Faculty of Pharmaceutical Sciences Naresuan University, Phitsanulok 65000, Thailand; 2Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand; 3Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand; 4Department of Biochemistry, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand; 5Aga Siam, Phitsanulok, 65000, Thailand; 6Department of Cosmetic Science, School of Pharmaceutical Sciences, University of Phayao, Phayao 56000, ThailandObjective: We compared the efficacy of an antiacne hydrogel formulated with a combination of Aloe barbadensis leaf extract, Garcinia mangostana peel extract, and Camellia sinensis leaf extract (AGC) at a ratio of 50:25:1 with a marketed 1% clindamycin gel (CG) formulation on antiacne and antiblotch activities.Methods: A single-center, parallel-arm, randomized controlled trial was performed from November 2017 to April 2018. Sixty subjects with mild–moderate acne severity according to the the American Academy of Dermatology were enrolled for the study. Outcome end points were total acne lesions (TALs) and acne-severity index (ASI) by counting the inflamed lesions and comedones and skin colors using erythema and melanin values.Results: For TALss, a decrease (P

Published
2019

39. Characterization of Metabolites in Plasma, Urine and Feces of Healthy Participants after Taking Brahmi Essence for Twelve Weeks Using LC-ESI-QTOF-MS Metabolomic Approach

Author

Minale, Genet, primary, Saesong, Tongchai, additional, Temkitthawon, Prapapan, additional, Waranuch, Neti, additional, Nuengchamnong, Nitra, additional, Chootip, Krongkarn, additional, Kamkaew, Natakorn, additional, Kongbangkerd, Teeraporn, additional, Engsuwan, Jinutda, additional, and Ingkaninan, Kornkanok, additional

Published
2021
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40. Effect of green tea extract loaded chitosan microparticles on facial skin: A split‐face, double‐blind, randomized placebo‐controlled study.

Author

Wisuitiprot, Wudtichai, Ingkaninan, Kornkanok, Jones, Sirada, and Waranuch, Neti

Subjects
TEA extracts, GREEN tea, CHITOSAN, WRINKLES (Skin), VOLUNTEER recruitment, FACIAL transplantation
Abstract

Introduction: The bioactivities of green tea extract were indicated to promote skin health in vitro. Few clinical studies reported on skin nourishment of topical applying green tea extract due to the limited skin absorption. Methods: This current study evaluated the clinical effectiveness and safety of green tea extract encapsulated chitosan microparticles (GTP) in emulsion base on a split‐face, double‐blind, randomized placebo‐controlled study. Twenty‐nine female volunteers were recruited into the study. They were randomly assigned to apply GTP and placebo creams on each half face for 8 weeks. The facial skin properties on both sides were monitored and evaluated every 2 weeks. Results: The results revealed that skin elasticity (R2) of half face treated with GTP cream (0.748 ± 0.05) was superior to another that received placebo cream (0.722 ± 0.05) at 4th week. In addition, melanin index implying skin dullness of the half face that received GTP cream significantly improved within the 6th week after application (placebo =295.60 ± 58.81, GTP =282.70 ± 59.62). Most importantly, the photographs clearly indicated that the decreasing in facial wrinkles of volunteers applied with GTP cream was more than those applying placebo cream. Signs of skin irritation were not evident in both treatment and placebo cream groups. Conclusion: Based on study outcomes, the green tea extract encapsulated chitosan microparticles appear to be the promising active candidate for promoting skin elasticity and improving skin dullness and wrinkles. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Enhancement of Lipolysis in 3T3-L1 Adipocytes by Nitroarene Capsaicinoid Analogs

Author

Laolob, Thanet, primary, Bunyapraphatsara, Nuntavan, additional, Waranuch, Neti, additional, Pongcharoen, Sutatip, additional, Punyain, Wikorn, additional, Chancharunee, Sirirat, additional, Sakchaisri, Krisada, additional, Pratuangdejkul, Jaturong, additional, Chongruchiroj, Sumet, additional, Kielar, Filip, additional, and Wichai, Uthai, additional

Published
2021
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48. High-Content Screening of Thai Medicinal Plants Reveals Boesenbergia rotunda Extract and its Component Panduratin A as Anti-SARS-CoV-2 Agents

Author

Kanjanasirirat, Phongthon, primary, Suksatu, Ampa, additional, Manopwisedjaroen, Suwimon, additional, Munyoo, Bamroong, additional, Tuchinda, Patoomratana, additional, Jearawuttanakul, Kedchin, additional, Seemakhan, Sawinee, additional, Charoensutthivarakul, Sitthivut, additional, Wongtrakoongate, Patompon, additional, Rangkasenee, Noppawan, additional, Pitiporn, Supaporn, additional, Waranuch, Neti, additional, Chabang, Napason, additional, Khemawoot, Phisit, additional, Chutipongtanate, Somchai, additional, Hongeng, Suradej, additional, Borwornpinyo, Suparerk, additional, and Thitithanyanont, Arunee, additional

Published
2020
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50. Effectiveness and Safety of Hair Growth Formulation Containing Tectona grandisL.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia

Author

Tanuphol, Nutchaninad, Waranuch, Neti, Wisuitiprot, Vanuchawan, Wisuitiprot, Wudtichai, Insumrong, Kamonlak, Temkitthawon, Prapapan, Suphrom, Nungruthai, Jampachaisri, Katechan, Girard, Corine, and Ingkaninan, Kornkanok

Abstract

Background Androgenic alopecia (AGA) is commonly known as male patterned baldness. A high level of dihydrotestosterone (DHT) plays a significant role in AGA development. Inhibition of the enzyme steroid 5-alpha reductase (S5AR), responsible for converting testosterone into DHT, has been shown to delay the progression of AGA. Teak (Tectona grandisL.f) leaf extract exhibited a potent S5AR inhibitory activity. To prove the effectiveness and safety of teak leaf extract as a hair growth promotor, a double-blind, randomized placebo-controlled trial was conducted.Methods Eighty-one AGA subjects were randomly assigned to receive either a hair tonic containing 1% teak leaf extract (HT-teak), 5%minoxidil (positive control), or a placebo administered twice daily, for 24 weeks. Efficacy was assessed through target area hair count (TAHC), anagen-to-telogen ratio (A/T), hair shedding every 4 weeks, and patients’ subjective assessments of hair regrowth were assessed at the end of the experiment. Data was analyzed using repeated measure ANOVA.Results Both the HT-teak and minoxidil groups exhibited a significant increase in TAHC and A/T, along with a decrease in hair shedding compared to baseline values. Conversely, the placebo group showed no observable signs of hair regrowth. Furthermore, the HT-teak group reported the highest satisfaction scores, and there were no indications of skin irritation or systemic effects on sexual dysfunction and palpitation after 24 weeks of HT-teak application.Conclusion Teak leaf extract, as incorporated in HT-teak, demonstrates potential as an alternative mild hair growth promoter for individuals with AGA, offering both efficacy and safety.Trial registration This study was retrospectively registered on International Standard Randomised Controlled Trial Number (ISRCTN.com); ISRCTN24541842 (registered on January 8, 2024).

Published
2024
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