1,981 results on '"Wapner, Ronald J."'
Search Results
2. Serum Cotinine and Adverse Cardiovascular Outcomes: A Cross-sectional Secondary Analysis of the nuMoM2b Heart Health Study
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Theilen, Lauren H, McNeil, Rebecca B, Hunter, Shannon, Grobman, William A, Parker, Corette B, Catov, Janet M, Pemberton, Victoria L, Ehrenthal, Deborah B, Haas, David M, Hoffman, Matthew K, Chung, Judith H, Mukhtar, Farhana, Arzumanyan, Zorayr, Mercer, Brian, Parry, Samuel, Saade, George R, Simhan, Hyagriv N, Wapner, Ronald J, Silver, Robert M, and Network, for the NHLBI nuMoM2b Heart Health Study
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Clinical Research ,Tobacco ,Prevention ,Cardiovascular ,Tobacco Smoke and Health ,Reproductive health and childbirth ,Respiratory ,Good Health and Well Being ,Pregnancy ,Humans ,Female ,Adult ,Cotinine ,Cross-Sectional Studies ,Tobacco Smoke Pollution ,Metabolic Syndrome ,Dyslipidemias ,pregnancy ,cross-sectional studies ,tobacco smoke ,nicotine ,smokers ,pregnancy outcome ,cardiovascular diseases ,NHLBI nuMoM2b Heart Health Study Network ,Clinical Sciences ,Paediatrics and Reproductive Medicine ,Obstetrics & Reproductive Medicine ,Paediatrics ,Reproductive medicine ,Midwifery - Abstract
ObjectiveWe aimed to (1) compare serum cotinine with self-report for ascertaining smoking status among reproductive-aged women; (2) estimate the relative odds of adverse cardiovascular (CV) outcomes among women by smoking status; (3) assess whether the association between adverse pregnancy outcomes (APOs) and CV outcomes varies by smoking status.Study designWe conducted a cross-sectional study of the nuMoM2b Heart Health Study. Women attended a study visit 2 to 7 years after their first pregnancy. The exposure was smoking status, determined by self-report and by serum cotinine. Outcomes included incident chronic hypertension (HTN), metabolic syndrome (MetS), and dyslipidemia. Multivariable logistic regression estimated odds ratios (ORs) for each outcome by smoking status.ResultsOf 4,392 women with serum cotinine measured, 3,610 were categorized as nonsmokers, 62 as secondhand smoke exposure, and 720 as smokers. Of 3,144 women who denied tobacco smoke exposure, serum cotinine was consistent with secondhand smoke exposure in 48 (1.5%) and current smoking in 131 (4.2%) After adjustment for APOs, smoking defined by serum cotinine was associated with MetS (adjusted OR [aOR] = 1.52, 95% confidence interval [CI]: 1.21, 1.91) and dyslipidemia (aOR = 1.28, 95% CI: 1.01, 1.62). When stratified by nicotine exposure, nonsmokers with an APO in their index pregnancy had higher odds of stage 1 (aOR = 1.64, 95% CI: 1.32, 2.03) and stage 2 HTN (aOR = 2.92, 95% CI: 2.17, 3.93), MetS (aOR = 1.76, 95% CI: 1.42, 2.18), and dyslipidemia (aOR = 1.55, 95% CI: 1.25, 1.91) relative to women with no APO. Results were similar when smoking exposure was defined by self-report.ConclusionWhether determined by serum cotinine or self-report, smoking is associated with subsequent CV outcomes in reproductive-aged women. APOs are also independently associated with CV outcomes in women.Key points· Cotinine was detected in 5.7% of reported nonsmokers.. · Smoking and APOs were independently associated with CV health.. · Smoking was associated with MetS and dyslipidemia..
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- 2023
3. Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas
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Khan, Raiyan R., Guerrero, Rafael F., Wapner, Ronald J., Hahn, Matthew W., Raja, Anita, Salleb-Aouissi, Ansaf, Grobman, William A., Simhan, Hyagriv, Silver, Robert M., Chung, Judith H., Reddy, Uma M., Radivojac, Predrag, Pe’er, Itsik, and Haas, David M.
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- 2024
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4. Prenatal phenotyping: A community effort to enhance the Human Phenotype Ontology
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Dhombres, Ferdinand, Morgan, Patricia, Chaudhari, Bimal P, Filges, Isabel, Sparks, Teresa N, Lapunzina, Pablo, Roscioli, Tony, Agarwal, Umber, Aggarwal, Shagun, Beneteau, Claire, Cacheiro, Pilar, Carmody, Leigh C, Collardeau‐Frachon, Sophie, Dempsey, Esther A, Dufke, Andreas, Duyzend, Michael Henri, Ghosh, Mirna, Giordano, Jessica L, Glad, Ragnhild, Grinfelde, Ieva, Iliescu, Dominic G, Ladewig, Markus S, Munoz‐Torres, Monica C, Pollazzon, Marzia, Radio, Francesca Clementina, Rodo, Carlota, Silva, Raquel Gouveia, Smedley, Damian, Sundaramurthi, Jagadish Chandrabose, Toro, Sabrina, Valenzuela, Irene, Vasilevsky, Nicole A, Wapner, Ronald J, Zemet, Roni, Haendel, Melissa A, and Robinson, Peter N
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Genetics ,Human Genome ,Clinical Research ,Congenital Structural Anomalies ,Prevention ,Pediatric ,Perinatal Period - Conditions Originating in Perinatal Period ,Detection ,screening and diagnosis ,4.1 Discovery and preclinical testing of markers and technologies ,Neurological ,Reproductive health and childbirth ,Good Health and Well Being ,Infant ,Newborn ,Humans ,Female ,Pregnancy ,Placenta ,Computational Biology ,Phenotype ,Rare Diseases ,Exome Sequencing ,HPO ,human phenotype ontology ,GA4GH Phenopacket ,prenatal diagnosis ,fetal pathology ,prenatal phenotyping ,Clinical Sciences ,Genetics & Heredity - Abstract
Technological advances in both genome sequencing and prenatal imaging are increasing our ability to accurately recognize and diagnose Mendelian conditions prenatally. Phenotype-driven early genetic diagnosis of fetal genetic disease can help to strategize treatment options and clinical preventive measures during the perinatal period, to plan in utero therapies, and to inform parental decision-making. Fetal phenotypes of genetic diseases are often unique and at present are not well understood; more comprehensive knowledge about prenatal phenotypes and computational resources have an enormous potential to improve diagnostics and translational research. The Human Phenotype Ontology (HPO) has been widely used to support diagnostics and translational research in human genetics. To better support prenatal usage, the HPO consortium conducted a series of workshops with a group of domain experts in a variety of medical specialties, diagnostic techniques, as well as diseases and phenotypes related to prenatal medicine, including perinatal pathology, musculoskeletal anomalies, neurology, medical genetics, hydrops fetalis, craniofacial malformations, cardiology, neonatal-perinatal medicine, fetal medicine, placental pathology, prenatal imaging, and bioinformatics. We expanded the representation of prenatal phenotypes in HPO by adding 95 new phenotype terms under the Abnormality of prenatal development or birth (HP:0001197) grouping term, and revised definitions, synonyms, and disease annotations for most of the 152 terms that existed before the beginning of this effort. The expansion of prenatal phenotypes in HPO will support phenotype-driven prenatal exome and genome sequencing for precision genetic diagnostics of rare diseases to support prenatal care.
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- 2022
5. Sleep-disordered Breathing in Pregnancy and after Delivery: Associations with Cardiometabolic Health.
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Facco, Francesca L, Redline, Susan, Hunter, Shannon M, Zee, Phyllis C, Grobman, William A, Silver, Robert M, Louis, Judette M, Pien, Grace W, Mercer, Brian, Chung, Judith H, Bairey Merz, C Noel, Haas, David M, Nhan-Chang, Chia-Ling, Simhan, Hyagriv N, Schubert, Frank P, Parry, Samuel, Reddy, Uma, Saade, George R, Hoffman, Matthew K, Levine, Lisa D, Wapner, Ronald J, Catov, Janet M, and Parker, Corette B
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Clinical Research ,Prevention ,Sleep Research ,Lung ,Cardiovascular ,Reproductive health and childbirth ,Good Health and Well Being ,Cardiovascular Diseases ,Female ,Humans ,Odds Ratio ,Oxygen ,Polysomnography ,Pregnancy ,Risk Factors ,Sleep Apnea Syndromes ,sleep disordered breathing ,pregnancy ,postpartum ,cardiometabolic health ,hypertension ,sleep-disordered breathing ,Medical and Health Sciences ,Respiratory System - Abstract
Rationale: Knowledge gaps exist regarding health implications of sleep-disordered breathing (SDB) identified in pregnancy and/or after delivery. Objectives: To determine whether SDB in pregnancy and/or after delivery is associated with hypertension (HTN) and metabolic syndrome (MS). Methods: nuMoM2b-HHS (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be Heart Health Study) (N = 4,508) followed participants initially recruited during their first pregnancy. Participants returned for a visit 2-7 years after pregnancy. This study examined a subgroup who underwent SDB assessments during their first pregnancy (n = 1,964) and a repeat SDB assessment after delivery (n = 1,222). Two SDB definitions were considered: 1) apnea-hypopnea index (AHI) ⩾ 5 and 2) oxygen desaturation index (ODI) ⩾ 5. Associations between SDB and incident HTN and MS were evaluated with adjusted risk ratios (aRRs). Measurements and Main Results: The aRR for MS given an AHI ⩾ 5 during pregnancy was 1.44 (95% confidence interval [CI], 1.08-1.93), but no association with HTN was found. ODI ⩾ 5 in pregnancy was associated with both an increased risk for HTN (aRR, 2.02; 95% CI, 1.30-3.14) and MS (aRR, 1.53; 95% CI, 1.19-1.97). Participants with an AHI ⩾ 5 in pregnancy that persisted after delivery were at higher risk for both HTN (aRR, 3.77; 95% CI, 1.84-7.73) and MS (aRR, 2.46; 95% CI, 1.59-3.76). Similar associations were observed for persistent ODI ⩾ 5 after delivery. Conclusions: An AHI ⩾ 5 in pregnancy was associated with an increased risk of MS. An ODI ⩾ 5 in pregnancy was significantly associated with both HTN and MS. Participants with persistent elevations in AHI and ODI during pregnancy and at 2-7 years after delivery were at the highest risk for HTN and MS. Clinical trial registered with www.clinicaltrials.gov (NCT02231398).
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- 2022
6. Breastfeeding Associations with Childhood Obesity and Body Composition: Findings from a Racially Diverse Maternal–Child Cohort
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Hildebrand, Janet S, Ferguson, Pamela L, Sciscione, Anthony C, Grobman, William A, Newman, Roger B, Tita, Alan T, Wapner, Ronald J, Nageotte, Michael P, Palomares, Kristy, Skupski, Daniel W, Cooper, Daniel M, Zhang, Cuilin, Neelon, Brian, Vena, John E, and Hunt, Kelly J
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Pediatric ,Prevention ,Obesity ,Nutrition ,2.3 Psychological ,social and economic factors ,Aetiology ,Oral and gastrointestinal ,Cancer ,Metabolic and endocrine ,Good Health and Well Being ,Body Composition ,Body Mass Index ,Breast Feeding ,Child ,Child ,Preschool ,Cross-Sectional Studies ,Female ,Humans ,Male ,Overweight ,Pediatric Obesity ,Risk Factors ,adiposity ,body fat ,breastfeeding ,childhood obesity ,exclusive breastfeeding ,Nursing ,Nutrition and Dietetics ,Paediatrics and Reproductive Medicine ,Endocrinology & Metabolism - Abstract
Background: Studies suggest breastfeeding lowers obesity risk in childhood, but generalizability of existing evidence is limited. We examined associations of breastfeeding with childhood overweight, obesity, and percentage body fat, in a racially diverse maternal-child cohort. Methods: This cross-sectional study included 823 children, ages 4-8 years, enrolled in the Environmental Exposures and Child Health Outcomes (ECHO) cohort, a subset of the National Institute of Child Health and Human Development Fetal Growth Studies cohort. Logistic regression was used to estimate odds ratios and 95% confidence intervals (CIs) for overweight [BMI (kg/m2) 85th to
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- 2022
7. Factors associated with duration of breastfeeding in women giving birth for the first time
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Haas, David M, Yang, Ziyi, Parker, Corette B, Chung, Judith, Parry, Samuel, Grobman, William A, Mercer, Brian M, Simhan, Hyagriv N, Silver, Robert M, Wapner, Ronald J, Saade, George R, Greenland, Philip, Merz, Noel Bairey, Reddy, Uma M, and Pemberton, Victoria L
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Reproductive Medicine ,Midwifery ,Biomedical and Clinical Sciences ,Health Sciences ,Clinical Research ,Prevention ,Contraception/Reproduction ,Reproductive health and childbirth ,Breast Feeding ,Cohort Studies ,Female ,Hispanic or Latino ,Humans ,Odds Ratio ,Parturition ,Pregnancy ,Breastfeeding ,Longevity ,Nulliparous patients ,nuMoM2b study and the nuMoM2b Heart Health Study ,Nursing ,Paediatrics and Reproductive Medicine ,Public Health and Health Services ,Obstetrics & Reproductive Medicine ,Reproductive medicine - Abstract
ObjectiveTo examine maternal, psychosocial, and pregnancy factors associated with breastfeeding for at least 6 months in those giving birth for the first time.MethodsWe performed a planned secondary analysis of an observational cohort study of 5249 women giving birth for the first time. Women were contacted at least 6 months after delivery and provided information regarding breastfeeding initiation, duration, and exclusivity. Maternal demographics, psychosocial measures, and delivery methods were compared by breastfeeding groups.Results4712 (89.8%) of the women breastfed at some point, with 2739 (58.2%) breastfeeding for at least 6 months. Of those who breastfed, 1161 (24.7% of the entire cohort), breastfed exclusively for at least 6 months. In the multivariable model among those who ever breastfed, not smoking in the month prior to delivery (adjusted odds ratio [aOR] 2.04, 95%CI 1.19-3.45), having a Master's degree of higher (aOR 1.89, 95%CI 1.51-2.36), having a planned pregnancy (aOR 1.48, 95%CI 1.27-1.73), older age (aOR 1.02, 95% CI, 1.01-1.04), lower BMI (aOR 0.96 95% CI 0.95-0.97), and having less anxiety measured during pregnancy (aOR 0.990, 95%CI 0.983-0.998) were associated with breastfeeding for at least 6 months. Compared to non-Hispanic White women, Hispanic women, while being more likely to breastfeed initially (aOR 1.40, 95%CI 1.02-1.92), were less likely to breastfeed for 6 months (aOR 0.72, 95%CI 0.59-0.88). While non-Hispanic Black women were less likely than non-Hispanic White women to initiate breastfeeding (aOR 0.68, 95%CI 0.51-0.90), the odds of non-Hispanic Black women of continuing to breastfeed for at least 6 months was similar to non-Hispanic White women (aOR 0.92, 95%CI 0.71-1.19).ConclusionsIn this cohort of women giving birth for the first time, duration of breastfeeding was associated with several characteristics which highlight groups at greater risk of not breastfeeding as long as currently recommended.Trial registrationNCT01322529 (nuMoM2b) and NCT02231398 (nuMoM2b-Heart Health).
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- 2022
8. Genomics of stillbirth
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Giordano, Jessica L. and Wapner, Ronald J.
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- 2024
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9. Amniocentesis in pregnancies at or beyond 24 weeks: an international multicenter study
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Zemet, Roni, Maktabi, Mohamad Ali, Tinfow, Alexandra, Giordano, Jessica L., Heisler, Thomas M., Yan, Qi, Plaschkes, Roni, Stokes, Jenny, Walsh, Jennifer M., Corcoran, Siobhán, Schindewolf, Erica, Miller, Kendra, Talati, Asha N., Miller, Kristen A., Blakemore, Karin, Swanson, Kate, Ramm, Jana, Bedei, Ivonne, Sparks, Teresa N., Jelin, Angie C., Vora, Neeta L., Gebb, Juliana S., Crosby, David A., Berkenstadt, Michal, Weisz, Boaz, Wapner, Ronald J., and Van Den Veyver, Ignatia B.
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- 2024
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10. Multiethnic growth standards for fetal body composition and organ volumes derived from 3D ultrasonography
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Grantz, Katherine L., Lee, Wesley, Mack, Lauren M., Sanz Cortes, Magdalena, Goncalves, Luis F., Espinoza, Jimmy, Newman, Roger B., Grobman, William A., Wapner, Ronald J., Fuchs, Karin, D'Alton, Mary E., Skupski, Daniel W., Owen, John, Sciscione, Anthony, Wing, Deborah A., Nageotte, Michael P., Ranzini, Angela C., Chien, Edward K., Craigo, Sabrina, Sherman, Seth, Gore-Langton, Robert E., He, Dian, Tekola-Ayele, Fasil, Zhang, Cuilin, Grewal, Jagteshwar, and Chen, Zhen
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- 2024
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11. The Role of cfDNA Biomarkers and Patient Data in the Early Prediction of Preeclampsia: Artificial Intelligence Model
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Khalil, Asma, Bellesia, Giovanni, Norton, Mary E., Jacobsson, Bo, Haeri, Sina, Egbert, Melissa, Malone, Fergal D., Wapner, Ronald J., Roman, Ashley, Faro, Revital, Madankumar, Rajeevi, Strong, Noel, Silver, Robert M., Vohra, Nidhi, Hyett, Jon, Macpherson, Cora, Prigmore, Brittany, Ahmed, Ebad, Demko, Zach, Ortiz, J. Bryce, Souter, Vivienne, and Dar, Pe’er
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- 2024
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12. Association of second trimester uterine artery Doppler parameters with maternal hypertension 2–7 years after delivery
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Miller, Eliza C, Carper, Benjamin, Bello, Natalie A, Merz, C Noel Bairey, Greenland, Philip, Levine, Lisa D, Haas, David M, Grobman, William A, McNeil, Rebecca B, Chung, Judith H, Jolley, Jennifer, Saade, George R, Silver, Robert M, Simhan, Hyagriv N, Wapner, Ronald J, Parker, Corette B, and Networks, NIH NICHD nuMoM2b and NHLBI nuMoM2b Heart Health Study
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Clinical Research ,Hypertension ,Prevention ,Cardiovascular ,Reproductive health and childbirth ,Good Health and Well Being ,Pregnancy ,Preeclampsia ,Vascular ultrasound ,Doppler ,Biomarkers ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
BackgroundReduced uterine artery compliance is associated with adverse pregnancy outcomes (APOs) and may indicate underlying maternal cardiovascular pathology. We investigated associations between second trimester uterine artery Doppler (UAD) parameters and incident maternal hypertension 2-7 years after delivery.MethodsA cohort of 10,038 nulliparous US participants was recruited early in pregnancy. A subgroup of 3739, without baseline hypertension and with complete follow-up visits 2-7 years after delivery, were included in this analysis. We investigated UAD indicators of compliance including: 1) early diastolic notch; 2) resistance index (RI); and 3) pulsatility index (PI). We defined hypertension as systolic blood pressure ≥130 mmHg, diastolic ≥80 mmHg, or antihypertensive medication use. We calculated odds ratios (OR) and 95 % confidence intervals (95%CI) for associations between UAD parameters and hypertension, adjusting for age, obesity, race/ethnicity, insurance, smoking, and APOs.ResultsA total of 187 (5 %) participants developed hypertension after the index pregnancy. Presence of early diastolic notch on UAD was not associated with incident hypertension. Increased RI and PI correlated with higher odds of hypertension (RI: adjusted OR 1.15 [95 % CI 1.03-1.30]; PI: adjusted OR 1.03 [95%CI 1.01-1.05] for each 0.1 unit increase). Maximum RI above 0.84 or maximum PI above 2.3 more than doubled the odds of incident hypertension (RI: adjusted OR 2.49, 95%CI 1.45-4.26; PI: adjusted OR 2.36, 95%CI 1.45-3.86).ConclusionHigher resistance and pulsatility indices measured on second trimester UAD were associated with increased odds of incident hypertension 2-7 years later, and may be biomarkers of higher maternal cardiovascular risk.
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- 2021
13. Mouse and human studies support DSTYK loss of function as a low-penetrance and variable expressivity risk factor for congenital urinary tract anomalies
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Martino, Jeremiah, Liu, Qingxue, Vukojevic, Katarina, Ke, Juntao, Lim, Tze Y., Khan, Atlas, Gupta, Yask, Perez, Alejandra, Yan, Zonghai, Milo Rasouly, Hila, Vena, Natalie, Lippa, Natalie, Giordano, Jessica L., Saraga, Marijan, Saraga-Babic, Mirna, Westland, Rik, Bodria, Monica, Piaggio, Giorgio, Bendapudi, Pavan K., Iglesias, Alejandro D., Wapner, Ronald J., Tasic, Velibor, Wang, Fan, Ionita-Laza, Iuliana, Ghiggeri, Gian Marco, Kiryluk, Krzysztof, Sampogna, Rosemary V., Mendelsohn, Cathy L., D’Agati, Vivette D., Gharavi, Ali G., and Sanna-Cherchi, Simone
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- 2023
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14. Early Pregnancy Atherogenic Profile in a First Pregnancy and Hypertension Risk 2 to 7 Years After Delivery
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Catov, Janet M, McNeil, Rebecca B, Marsh, Derek J, Mercer, Brian M, Merz, C Noel Bairey, Parker, Corette B, Pemberton, Victoria L, Saade, George R, Chen, Yii‐Der, Chung, Judith H, Ehrenthal, Deborah B, Grobman, William A, Haas, David M, Parry, Samuel, Polito, LuAnn, Reddy, Uma M, Silver, Robert M, Simhan, Hyagriv N, Wapner, Ronald J, Kominiarek, Michelle, Kreutz, Rolf, Levine, Lisa D, Greenland, Philip, and Study, for the NHLBI nuMoM2b Heart Health
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Cardiovascular ,Diabetes ,Hypertension ,Clinical Research ,Prevention ,Reproductive health and childbirth ,Good Health and Well Being ,Adult ,Atherosclerosis ,Biomarkers ,Blood Pressure ,Diabetes ,Gestational ,Female ,Follow-Up Studies ,Humans ,Incidence ,Infant ,Newborn ,Male ,Pregnancy ,Pregnancy Complications ,Cardiovascular ,Pregnancy Outcome ,Retrospective Studies ,Risk Factors ,Time Factors ,United States ,high blood pressure ,hypertension ,lipids ,preeclampsia ,pregnancy ,pregnancy and postpartum ,NHLBI nuMoM2b Heart Health Study ,preeclampsia/pregnancy ,Cardiorespiratory Medicine and Haematology ,Cardiovascular medicine and haematology - Abstract
Background Cardiovascular risk in young adulthood is an important determinant of lifetime cardiovascular disease risk. Women with adverse pregnancy outcomes (APOs) have increased cardiovascular risk, but the relationship of other factors is unknown. Methods and Results Among 4471 primiparous women, we related first-trimester atherogenic markers to risk of APO (hypertensive disorders of pregnancy, preterm birth, small for gestational age), gestational diabetes mellitus (GDM) and hypertension (130/80 mm Hg or antihypertensive use) 2 to 7 years after delivery. Women with an APO/GDM (n=1102) had more atherogenic characteristics (obesity [34.2 versus 19.5%], higher blood pressure [systolic blood pressure 112.2 versus 108.4, diastolic blood pressure 69.2 versus 66.6 mm Hg], glucose [5.0 versus 4.8 mmol/L], insulin [77.6 versus 60.1 pmol/L], triglycerides [1.4 versus 1.3 mmol/L], and high-sensitivity C-reactive protein [5.6 versus 4.0 nmol/L], and lower high-density lipoprotein cholesterol [1.8 versus 1.9 mmol/L]; P
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- 2021
15. Systematic evaluation of genome sequencing for the diagnostic assessment of autism spectrum disorder and fetal structural anomalies
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Lowther, Chelsea, Valkanas, Elise, Giordano, Jessica L., Wang, Harold Z., Currall, Benjamin B., O’Keefe, Kathryn, Pierce-Hoffman, Emma, Kurtas, Nehir E., Whelan, Christopher W., Hao, Stephanie P., Weisburd, Ben, Jalili, Vahid, Fu, Jack, Wong, Isaac, Collins, Ryan L., Zhao, Xuefang, Austin-Tse, Christina A., Evangelista, Emily, Lemire, Gabrielle, Aggarwal, Vimla S., Lucente, Diane, Gauthier, Laura D., Tolonen, Charlotte, Sahakian, Nareh, Stevens, Christine, An, Joon-Yong, Dong, Shan, Norton, Mary E., MacKenzie, Tippi C., Devlin, Bernie, Gilmore, Kelly, Powell, Bradford C., Brandt, Alicia, Vetrini, Francesco, DiVito, Michelle, Sanders, Stephan J., MacArthur, Daniel G., Hodge, Jennelle C., O'Donnell-Luria, Anne, Rehm, Heidi L., Vora, Neeta L., Levy, Brynn, Brand, Harrison, Wapner, Ronald J., and Talkowski, Michael E.
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- 2023
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16. Diagnostic yield with exome sequencing in prenatal severe bilateral ventriculomegaly: a systematic review and meta-analysis
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Mustafa, Hiba J., Sambatur, Enaja V., Barbera, Julie P., Pagani, Giorgio, Yaron, Yuval, Baptiste, Caitlin D., Wapner, Ronald J., and Khalil, Asma
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- 2023
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17. Performance of prenatal cfDNA screening for sex chromosomes
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Martin, Kimberly, Dar, Pe’er, MacPherson, Cora, Egbert, Melissa, Demko, Zachary, Parmar, Sheetal, Hashimoto, Katelyn, Haeri, Sina, Malone, Fergal, Wapner, Ronald J., Roman, Ashley S., Khalil, Asma, Faro, Revital, Madankumar, Rajeevi, Strong, Noel, Silver, Robert M., Vohra, Nidhi, Hyett, Jon, Rabinowitz, Matt, Kao, Charlly, Hakonarson, Hakon, Jacobsson, Bo, and Norton, Mary E.
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- 2023
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18. Outcomes of induction vs prelabor cesarean delivery at
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Bushman, Elisa T., Grobman, William A., Bailit, Jennifer L., Reddy, Uma M., Wapner, Ronald J., Varner, Michael W., Thorp, John M., Jr, Caritis, Steve N., Prasad, Mona, Saade, George R., Sorokin, Yoram, Rouse, Dwight J., Blackwell, Sean C., and Tolosa, Jorge E.
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- 2023
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19. Later sleep timing is associated with an increased risk of preterm birth in nulliparous women
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Facco, Francesca L, Parker, Corette B, Hunter, Shannon, Reid, Kathryn J, Zee, Phyllis P, Silver, Robert M, Pien, Grace, Chung, Judith H, Louis, Judette M, Haas, David M, Nhan-Chang, Chia-Ling, Simhan, Hyagriv N, Parry, Samuel, Wapner, Ronald J, Saade, George R, Mercer, Brian M, Bickus, Melissa, Reddy, Uma M, Grobman, William A, and Networks, NICHD NuMoM2b and NHLBI NuMoM2b Heart Health Study
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Paediatrics ,Reproductive Medicine ,Biomedical and Clinical Sciences ,Behavioral and Social Science ,Preterm ,Low Birth Weight and Health of the Newborn ,Sleep Research ,Basic Behavioral and Social Science ,Clinical Research ,Pediatric ,Perinatal Period - Conditions Originating in Perinatal Period ,Infant Mortality ,Reproductive health and childbirth ,Good Health and Well Being ,Female ,Gestational Age ,Humans ,Infant ,Newborn ,Pregnancy ,Pregnancy Outcome ,Premature Birth ,Prospective Studies ,Sleep ,pregnancy ,preterm birth ,sleep duration ,sleep midpoint ,sleep timing ,NICHD NuMoM2b and NHLBI NuMoM2b Heart Health Study Networks ,Reproductive medicine - Abstract
BackgroundAlthough uterine contractions have a diurnal periodicity and increase in frequency during hours of darkness, data on the relationship between sleep duration and sleep timing patterns and preterm birth are limited.ObjectiveWe sought to examine the relationship of self-reported sleep duration and timing in pregnancy with preterm birth.Study designIn the prospective Nulliparous Pregnancy Outcome Study: Monitoring Mothers-to-be cohort, women completed a survey of sleep patterns at 6-13 weeks gestation (visit 1) and again at 22-29 weeks gestation (visit 3). Additionally, at 16-21 weeks gestation (visit 2), a subgroup completed a weeklong actigraphy recording of their sleep. Weekly averages of self-reported sleep duration and sleep midpoint were calculated. A priori, sleep duration of 5 am) was associated with preterm birth . Women with a late sleep midpoint (>5 am) in early pregnancy had a preterm birth rate of 9.5%, compared with 6.9% for women with sleep midpoint ≤5 am (P=.005). Similarly, women with a late sleep midpoint had a higher rate of spontaneous preterm birth (6.2% vs 4.4%; P=.019). Comparable results were observed for women with a late sleep midpoint at visit 3 (all preterm birth 8.9% vs 6.6%; P=.009; spontaneous preterm birth 5.9% vs 4.3%; P=.023). All adjusted analyses on self-reported sleep midpoint (models 1 and 2) maintained statistical significance (P
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- 2019
20. Prospective Evaluation of Maternal Sleep Position Through 30 Weeks of Gestation and Adverse Pregnancy Outcomes.
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Silver, Robert M, Hunter, Shannon, Reddy, Uma M, Facco, Francesca, Gibbins, Karen J, Grobman, William A, Mercer, Brian M, Haas, David M, Simhan, Hyagriv N, Parry, Samuel, Wapner, Ronald J, Louis, Judette, Chung, Judith M, Pien, Grace, Schubert, Frank P, Saade, George R, Zee, Phyllis, Redline, Susan, and Parker, Corette B
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Pediatric ,Sleep Research ,Conditions Affecting the Embryonic and Fetal Periods ,Neurosciences ,Clinical Research ,Perinatal Period - Conditions Originating in Perinatal Period ,Reproductive health and childbirth ,Good Health and Well Being ,Adult ,Female ,Gestational Age ,Humans ,Hypertension ,Pregnancy-Induced ,Infant ,Newborn ,Infant ,Small for Gestational Age ,Logistic Models ,Posture ,Pregnancy ,Pregnancy Complications ,Pregnancy Outcome ,Pregnancy Trimesters ,Prospective Studies ,Risk Factors ,Sleep ,Sleep Wake Disorders ,Stillbirth ,Young Adult ,Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (NuMoM2b) Study ,Paediatrics and Reproductive Medicine ,Obstetrics & Reproductive Medicine ,Reproductive medicine - Abstract
ObjectiveTo examine the relationship between prospectively assessed maternal sleep position and subsequent adverse pregnancy outcomes.MethodsThis was a secondary analysis of a prospective observational multicenter cohort study of nulliparous women with singleton gestations who were enrolled between October 2010 and May 2014. Participants had three study visits that were not part of clinical care. They prospectively completed in-depth sleep questionnaires between 6 0/7 and 13 6/7 weeks of gestation and 22 0/7 and 29 6/7 weeks of gestation, the first and third study visits. A subset of women also underwent level 3 home sleep tests using the Embletta Gold device. The primary outcome was a composite of adverse pregnancy outcomes such as stillbirth, a small-for-gestational-age newborn, and gestational hypertensive disorders.ResultsA total of 8,706 (of 10,038) women had data from at least one sleep questionnaire and for pregnancy outcomes, and they comprised the population for this analysis. The primary outcome occurred in 1,903 pregnancies (22%). There was no association between reported non-left lateral or supine sleep during the last week of the first visit (adjusted odds ratio [aOR] 1.00 [95% CI 0.89-1.14]) or third visit (aOR 0.99 [95% CI 0.89-1.11] and the composite or any individual outcome, except for an apparent protective effect for stillbirth at the third visit (aOR 0.27 (95% CI 0.09-0.75). Women with objectively measured supine sleep position for at least 50% of the time were no more likely than those in the supine position 50% or less of the time to have the composite adverse outcome.ConclusionsGoing to sleep in the supine or right lateral position, as self-reported before the development of pregnancy outcome and objectively assessed through 30 weeks of gestation, was not associated with an increased risk of stillbirth, a small-for-gestational-age newborn, or gestational hypertensive disorders.
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- 2019
21. Association of Adverse Pregnancy Outcomes With Hypertension 2 to 7 Years Postpartum
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Haas, David M, Parker, Corette B, Marsh, Derek J, Grobman, William A, Ehrenthal, Deborah B, Greenland, Philip, Merz, C Noel Bairey, Pemberton, Victoria L, Silver, Robert M, Barnes, Shannon, McNeil, Rebecca B, Cleary, Kirsten, Reddy, Uma M, Chung, Judith H, Parry, Samuel, Theilen, Lauren H, Blumenthal, Elizabeth A, Levine, Lisa D, Mercer, Brian M, Simhan, Hyagriv, Polito, LuAnn, Wapner, Ronald J, Catov, Janet, Chen, Ida, Saade, George R, and Study, for the NHLBI nuMoM2b Heart Health
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Cardiovascular ,Hypertension ,Perinatal Period - Conditions Originating in Perinatal Period ,Preterm ,Low Birth Weight and Health of the Newborn ,Pediatric ,Clinical Research ,Infant Mortality ,Contraception/Reproduction ,Prevention ,Reproductive health and childbirth ,Good Health and Well Being ,Adult ,Birth Weight ,Blood Pressure ,Female ,Gestational Age ,Humans ,Incidence ,Infant ,Newborn ,Infant ,Premature ,Infant ,Small for Gestational Age ,Pregnancy ,Pregnancy Complications ,Pregnancy Outcome ,Prognosis ,Prospective Studies ,Risk Assessment ,Risk Factors ,Time Factors ,United States ,Young Adult ,adverse pregnancy outcomes ,hypertension ,risk ,preeclampsia ,preterm birth ,NHLBI nuMoM2b Heart Health Study ,Cardiorespiratory Medicine and Haematology - Abstract
Background Identifying pregnancy-associated risk factors before the development of major cardiovascular disease events could provide opportunities for prevention. The objective of this study was to determine the association between outcomes in first pregnancies and subsequent cardiovascular health. Methods and Results The Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-be Heart Health Study is a prospective observational cohort that followed 4484 women 2 to 7 years (mean 3.2 years) after their first pregnancy. Adverse pregnancy outcomes (defined as hypertensive disorders of pregnancy, small-for-gestational-age birth, preterm birth, and stillbirth) were identified prospectively in 1017 of the women (22.7%) during this pregnancy. The primary outcome was incident hypertension (HTN). Women without adverse pregnancy outcomes served as controls. Risk ratios (RR) and 95% CIs were adjusted for age, smoking, body mass index, insurance type, and race/ethnicity at enrollment during pregnancy. The overall incidence of HTN was 5.4% (95% CI 4.7% to 6.1%). Women with adverse pregnancy outcomes had higher adjusted risk of HTN at follow-up compared with controls (RR 2.4, 95% CI 1.8-3.1). The association held for individual adverse pregnancy outcomes: any hypertensive disorders of pregnancy (RR 2.7, 95% CI 2.0-3.6), preeclampsia (RR 2.8, 95% CI 2.0-4.0), and preterm birth (RR 2.7, 95% CI 1.9-3.8). Women who had an indicated preterm birth and hypertensive disorders of pregnancy had the highest risk of HTN (RR 4.3, 95% CI 2.7-6.7). Conclusions Several pregnancy complications in the first pregnancy are associated with development of HTN 2 to 7 years later. Preventive care for women should include a detailed pregnancy history to aid in counseling about HTN risk. Clinical Trial Registration URL: http://www.clinicaltrials.gov Unique identifier: NCT02231398.
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- 2019
22. Comparing population-based fetal growth standards in a US cohort
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Gleason, Jessica L., Reddy, Uma M., Chen, Zhen, Grobman, William A., Wapner, Ronald J., Steller, Jon G., Simhan, Hyagriv, Scifres, Christina M., Blue, Nathan, Parry, Samuel, and Grantz, Katherine L.
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- 2024
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23. Effects of repeat prenatal corticosteroids given to women at risk of preterm birth: An individual participant data meta-analysis
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Crowther, Caroline A, Middleton, Philippa F, Voysey, Merryn, Askie, Lisa, Zhang, Sasha, Martlow, Tanya K, Aghajafari, Fariba, Asztalos, Elizabeth V, Brocklehurst, Peter, Dutta, Sourabh, Garite, Thomas J, Guinn, Debra A, Hallman, Mikko, Hardy, Pollyanna, Lee, Men-Jean, Maurel, Kimberley, Mazumder, Premasish, McEvoy, Cindy, Murphy, Kellie E, Peltoniemi, Outi M, Thom, Elizabeth A, Wapner, Ronald J, Doyle, Lex W, and Group, the PRECISE
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Paediatrics ,Reproductive Medicine ,Biomedical and Clinical Sciences ,Lung ,Clinical Research ,Clinical Trials and Supportive Activities ,Infant Mortality ,Conditions Affecting the Embryonic and Fetal Periods ,Perinatal Period - Conditions Originating in Perinatal Period ,Preterm ,Low Birth Weight and Health of the Newborn ,Pediatric ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Reproductive health and childbirth ,Adrenal Cortex Hormones ,Adult ,Clinical Trials as Topic ,Drug Administration Schedule ,Female ,Humans ,Infant ,Newborn ,Obstetric Labor ,Premature ,Parturition ,Pregnancy ,Pregnancy Outcome ,Premature Birth ,Prenatal Exposure Delayed Effects ,Recurrence ,Risk Assessment ,Risk Factors ,Young Adult ,PRECISE Group ,Medical and Health Sciences ,General & Internal Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundInfants born preterm compared with infants born at term are at an increased risk of dying and of serious morbidities in early life, and those who survive have higher rates of neurological impairments. It remains unclear whether exposure to repeat courses of prenatal corticosteroids can reduce these risks. This individual participant data (IPD) meta-analysis (MA) assessed whether repeat prenatal corticosteroid treatment given to women at ongoing risk of preterm birth in order to benefit their infants is modified by participant or treatment factors.Methods and findingsTrials were eligible for inclusion if they randomised women considered at risk of preterm birth who had already received an initial, single course of prenatal corticosteroid seven or more days previously and in which corticosteroids were compared with either placebo or no placebo. The primary outcomes for the infants were serious outcome, use of respiratory support, and birth weight z-scores; for the children, they were death or any neurosensory disability; and for the women, maternal sepsis. Studies were identified using the Cochrane Pregnancy and Childbirth search strategy. Date of last search was 20 January 2015. IPD were sought from investigators with eligible trials. Risk of bias was assessed using criteria from the Cochrane Collaboration. IPD were analysed using a one-stage approach. Eleven trials, conducted between 2002 and 2010, were identified as eligible, with five trials being from the United States, two from Canada, and one each from Australia and New Zealand, Finland, India, and the United Kingdom. All 11 trials were included, with 4,857 women and 5,915 infants contributing data. The mean gestational age at trial entry for the trials was between 27.4 weeks and 30.2 weeks. There was no significant difference in the proportion of infants with a serious outcome (relative risk [RR] 0.92, 95% confidence interval [CI] 0.82 to 1.04, 5,893 infants, 11 trials, p = 0.33 for heterogeneity). There was a reduction in the use of respiratory support in infants exposed to repeat prenatal corticosteroids compared with infants not exposed (RR 0.91, 95% CI 0.85 to 0.97, 5,791 infants, 10 trials, p = 0.64 for heterogeneity). The number needed to treat (NNT) to benefit was 21 (95% CI 14 to 41) women/fetus to prevent one infant from needing respiratory support. Birth weight z-scores were lower in the repeat corticosteroid group (mean difference -0.12, 95%CI -0.18 to -0.06, 5,902 infants, 11 trials, p = 0.80 for heterogeneity). No statistically significant differences were seen for any of the primary outcomes for the child (death or any neurosensory disability) or for the woman (maternal sepsis). The treatment effect varied little by reason the woman was considered to be at risk of preterm birth, the number of fetuses in utero, the gestational age when first trial treatment course was given, or the time prior to birth that the last dose was given. Infants exposed to between 2-5 courses of repeat corticosteroids showed a reduction in both serious outcome and the use of respiratory support compared with infants exposed to only a single repeat course. However, increasing numbers of repeat courses of corticosteroids were associated with larger reductions in birth z-scores for weight, length, and head circumference. Not all trials could provide data for all of the prespecified subgroups, so this limited the power to detect differences because event rates are low for some important maternal, infant, and childhood outcomes.ConclusionsIn this study, we found that repeat prenatal corticosteroids given to women at ongoing risk of preterm birth after an initial course reduced the likelihood of their infant needing respiratory support after birth and led to neonatal benefits. Body size measures at birth were lower in infants exposed to repeat prenatal corticosteroids. Our findings suggest that to provide clinical benefit with the least effect on growth, the number of repeat treatment courses should be limited to a maximum of three and the total dose to between 24 mg and 48 mg.
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- 2019
24. Association of Adverse Pregnancy Outcomes With Self-Reported Measures of Sleep Duration and Timing in Women Who Are Nulliparous.
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Facco, Francesca L, Parker, Corette B, Hunter, Shannon, Reid, Kathryn J, Zee, Phyllis C, Silver, Robert M, Haas, David M, Chung, Judith H, Pien, Grace W, Nhan-Chang, Chia-Ling, Simhan, Hyagriv N, Parry, Samuel, Wapner, Ronald J, Saade, George R, Mercer, Brian M, Torres, Caroline, Knight, Jordan, Reddy, Uma M, and Grobman, William A
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Sleep Research ,Clinical Research ,Reproductive health and childbirth ,Good Health and Well Being ,Adult ,Cohort Studies ,Correlation of Data ,Female ,Gestational Age ,Humans ,Parity ,Pregnancy ,Pregnancy Complications ,Pregnancy Outcome ,Prospective Studies ,Sleep Deprivation ,Sleep Wake Disorders ,Time Factors ,gestational diabetes ,hypertension ,pregnancy ,sleep duration ,sleep midpoint ,NICHD NuMoM2b and NHLBI NuMoM2b Heart Health Study Networks ,Clinical Sciences ,Other Medical and Health Sciences ,Psychology ,Neurology & Neurosurgery - Abstract
Study objectivesTo examine the relationship of self-reported sleep during pregnancy with adverse pregnancy outcomes. A secondary objective was to describe the concordance between self-reported and objectively assessed sleep during pregnancy.MethodsIn this prospective cohort, women completed a survey of sleep patterns at 6 to 13 weeks' gestation (visit 1) and again at 22 to 29 weeks' gestation (visit 3). Additionally, at 16 to 21 weeks (visit 2), a subgroup completed a week-long sleep diary coincident with an actigraphy recording. Weekly averages of self-reported sleep duration and sleep midpoint were calculated. A priori, sleep duration < 7 hours was defined as "short," and sleep midpoint after 5:00 AM was defined as "late." The relationship of these sleep abnormalities with hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM) was determined.ResultsOf the 10,038 women enrolled, sleep survey data were available for 7,524 women at visit 1 and 7,668 women at visit 3. A total of 752 women also provided ≥ 5 days of sleep diary data coincident with actigraphy at visit 2. We did not observe any consistent relationship between self-reported short sleep and HDP or GDM. There was an association between self-reported late sleep midpoint and GDM (visit 1 adjusted odds ratio 1.67, 95% confidence interval 1.17, 2.38; visit 2 adjusted odds ratio 1.73, 95% confidence interval 1.23, 2.43). At visit 2, 77.1% of participants had concordance between their diary and actigraphy for short sleep duration, whereas 94.3% were concordant for sleep midpoint.ConclusionsSelf-reported sleep midpoint, which is more accurate than self-reported sleep duration, is associated with the risk of GDM.Clinical trial registrationRegistry: ClinicalTrials.gov, Title: Pregnancy as a Window to Future Cardiovascular Health: Adverse Pregnancy Outcomes as Predictors of Increased Risk Factors for Cardiovascular Disease, Identifier: NCT02231398, URL: https://clinicaltrials.gov/ct2/show/NCT02231398.
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- 2018
25. Patterns of leisure-time physical activity across pregnancy and adverse pregnancy outcomes
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Catov, Janet M, Parker, Corette B, Gibbs, Bethany Barone, Bann, Carla M, Carper, Benjamin, Silver, Robert M, Simhan, Hyagriv N, Parry, Samuel, Chung, Judith H, Haas, David M, Wapner, Ronald J, Saade, George R, Mercer, Brian M, Bairey-Merz, C Noel, Greenland, Philip, Ehrenthal, Deborah B, Barnes, Shannon E, Shanks, Anthony L, Reddy, Uma M, Grobman, William A, and for the NICHD NuMoM2b and NHLBI NuMoM2b Heart Health Study Network
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Clinical Research ,Contraception/Reproduction ,Nutrition ,Prevention ,Pediatric ,Perinatal Period - Conditions Originating in Perinatal Period ,Reproductive health and childbirth ,Metabolic and endocrine ,Good Health and Well Being ,Adult ,Black or African American ,Diabetes ,Gestational ,Exercise ,Female ,Gestational Age ,Hispanic or Latino ,Humans ,Hypertension ,Pregnancy-Induced ,Infant ,Newborn ,Infant ,Small for Gestational Age ,Leisure Activities ,Obesity ,Odds Ratio ,Pregnancy ,Pregnancy Outcome ,Premature Birth ,Smoking ,Young Adult ,Physical activity ,Gestational diabetes ,Preterm birth ,NICHD NuMoM2b and NHLBI NuMoM2b Heart Health Study Network ,Medical and Health Sciences ,Education ,Nutrition and dietetics ,Epidemiology ,Sports science and exercise - Abstract
BackgroundAlthough leisure-time physical activity (PA) contributes to overall health, including pregnancy health, patterns across pregnancy have not been related to birth outcomes. We hypothesized that women with sustained low leisure-time PA would have excess risk of adverse pregnancy outcomes, and that changing patterns across pregnancy (high to low and low to high) may also be related to risk of adverse pregnancy outcomes.MethodsNulliparous women (n = 10,038) were enrolled at 8 centers early in pregnancy (mean gestational age in weeks [SD] = 12.05 [1.51]. Frequency, duration, and intensity (metabolic equivalents) of up to three leisure activities reported in the first, second and third trimesters were analyzed. Growth mixture modeling was used to identify leisure-time PA patterns across pregnancy. Adverse pregnancy outcomes (preterm birth, [PTB, overall and spontaneous], hypertensive disorders of pregnancy [HDP], gestational diabetes [GDM] and small-for-gestational-age births [SGA]) were assessed via chart abstraction.ResultsFive patterns of leisure-time PA across pregnancy were identified: High (35%), low (18%), late decreasing (24%), early decreasing (10%), and early increasing (13%). Women with sustained low leisure-time PA were younger and more likely to be black or Hispanic, obese, or to have smoked prior to pregnancy. Women with low vs. high leisure-time PA patterns had higher rates of PTB (10.4 vs. 7.5), HDP (13.9 vs. 11.4), and GDM (5.7 vs. 3.1, all p
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- 2018
26. Associations of Maternal Prenatal Stress and Depressive Symptoms With Childhood Neurobehavioral Outcomes in the ECHO Cohort of the NICHD Fetal Growth Studies: Fetal Growth Velocity as a Potential Mediator
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Babineau, Vanessa, Fonge, Yaneve N., Miller, Emily S., Grobman, William A., Ferguson, Pamela L., Hunt, Kelly J., Vena, John E., Newman, Roger B., Guille, Constance, Tita, Alan T.N., Chandler-Laney, Paula C., Lee, Seonjoo, Feng, Tianshu, Scorza, Pamela, Takács, Lea, Wapner, Ronald J., Palomares, Kristy T., Skupski, Daniel W., Nageotte, Michael P., Sciscione, Anthony C., Gilman, Stephen, and Monk, Catherine
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- 2022
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27. Predictive performance of newborn small for gestational age by a United States intrauterine vs birthweight-derived standard for short-term neonatal morbidity and mortality
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Blue, Nathan R., Mele, Lisa, Grobman, William A., Bailit, Jennifer L., Wapner, Ronald J., Thorp, John M., Jr, Caritis, Steve N., Prasad, Mona, Tita, Alan T.N., Saade, George R., Rouse, Dwight J., and Blackwell, Sean C.
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- 2022
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28. An evaluation of seasonal maternal–neonatal morbidity related to trainee cycles
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Oben, Ayamo, McGee, Paula, Grobman, William A., Bailit, Jennifer L., Wapner, Ronald J., Varner, Michael W., Thorp, John M., Jr, Caritis, Steve N., Prasad, Mona, Saade, George R., Rouse, Dwight J., and Blackwell, Sean C.
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- 2022
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29. Elevated prenatal maternal sex hormones, but not placental aromatase, are associated with child neurodevelopment
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Firestein, Morgan R., Romeo, Russell D., Winstead, Hailey, Goldman, Danielle A., Grobman, William A., Haas, David, Mercer, Brian, Parker, Corette, Parry, Samuel, Reddy, Uma, Silver, Robert, Simhan, Hyagriv, Wapner, Ronald J., and Champagne, Frances A.
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- 2022
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30. Comparison of Cesarean Deliveries in a Multicenter U.S. Cohort Using the 10-Group Classification System.
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Pasko, Daniel N., McGee, Paula, Grobman, William A., Bailit, Jennifer L., Reddy, Uma M., Wapner, Ronald J., Varner, Michael W., Thorp Jr., John M., Caritis, Steve N., Prasad, Mona, Saade, George R., Sorokin, Yoram, Rouse, Dwight J., and Tolosa, Jorge E.
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CESAREAN section ,SECONDARY analysis ,DATA analysis ,RESEARCH funding ,LOGISTIC regression analysis ,HOSPITALS ,DESCRIPTIVE statistics ,INDUCED labor (Obstetrics) ,STATISTICS ,RESEARCH ,COMPARATIVE studies ,FETAL presentation - Abstract
Objective We sought to (1) use the Robson 10-Group Classification System (TGCS), which classifies deliveries into 10 mutually exclusive groups, to characterize the groups that are primary contributors to cesarean delivery frequencies, (2) describe inter-hospital variations in cesarean delivery frequencies, and (3) evaluate the contribution of patient characteristics by TGCS group to hospital variation in cesarean delivery frequencies. Study Design This was a secondary analysis of an observational cohort of 115,502 deliveries from 25 hospitals between 2008 and 2011. The TGCS was applied to the cohort and each hospital. We identified and compared the TGCS groups with the greatest relative contributions to cohort and hospital cesarean delivery frequencies. We assessed variation in hospital cesarean deliveries attributable to patient characteristics within TGCS groups using hierarchical logistic regression. Results A total of 115,211 patients were classifiable in the TGCS (99.7%). The cohort cesarean delivery frequency was 31.4% (hospital range: 19.1–39.3%). Term singletons in vertex presentation with a prior cesarean delivery (group 5) were the greatest relative contributor to cohort (34.8%) and hospital cesarean delivery frequencies (median: 33.6%; range: 23.8–45.5%). Nulliparous term singletons in vertex (NTSV) presentation (groups 1 [spontaneous labor] and 2 [induced or absent labor]: 28.9%), term singletons in vertex presentation with a prior cesarean delivery (group 5: 34.8%), and preterm singletons in vertex presentation (group 10: 9.8%) contributed to 73.2% of the relative cesarean delivery frequency for the cohort and were correlated with hospital cesarean delivery frequencies (Spearman's rho = 0.96). Differences in patient characteristics accounted for 34.1% of hospital-level cesarean delivery variation in group 2. Conclusion The TGCS highlights the contribution of NTSV presentation to cesarean delivery frequencies and the impact of patient characteristics on hospital-level variation in cesarean deliveries among nulliparous patients with induced or absent labor. Key Points We report on the cesarean delivery frequencies in a multicenter U.S. cohort. NTSV gestations (groups 1 and 2) are a primary driver of cesarean deliveries. Patient characteristics contributed most to hospital variation in cesarean deliveries in group 2. [ABSTRACT FROM AUTHOR]
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- 2024
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31. Prescription and Other Medication Use in Pregnancy
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Haas, David M, Marsh, Derek J, Dang, Danny T, Parker, Corette B, Wing, Deborah A, Simhan, Hyagriv N, Grobman, William A, Mercer, Brian M, Silver, Robert M, Hoffman, Matthew K, Parry, Samuel, Iams, Jay D, Caritis, Steve N, Wapner, Ronald J, Esplin, M Sean, Elovitz, Michal A, Peaceman, Alan M, Chung, Judith, Saade, George R, and Reddy, Uma M
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Clinical Research ,Chronic Pain ,Clinical Trials and Supportive Activities ,Pain Research ,Reproductive health and childbirth ,Adult ,Ethnicity ,Female ,Humans ,Longitudinal Studies ,Nonprescription Drugs ,Parity ,Polypharmacy ,Pregnancy ,Pregnancy Complications ,Pregnancy Outcome ,Pregnancy Trimester ,First ,Prescription Drugs ,Prospective Studies ,United States ,Paediatrics and Reproductive Medicine ,Obstetrics & Reproductive Medicine ,Reproductive medicine - Abstract
ObjectiveTo characterize prescription and other medication use in a geographically and ethnically diverse cohort of women in their first pregnancy.MethodsIn a prospective, longitudinal cohort study of nulliparous women followed through pregnancy from the first trimester, medication use was chronicled longitudinally throughout pregnancy. Structured questions and aids were used to capture all medications taken as well as reasons they were taken. Total counts of all medications taken including number in each category and class were captured. Additionally, reasons the medications were taken were recorded. Trends in medications taken across pregnancy and in the first trimester were determined.ResultsOf the 9,546 study participants, 9,272 (97.1%) women took at least one medication during pregnancy with 9,139 (95.7%) taking a medication in the first trimester. Polypharmacy, defined as taking at least five medications, occurred in 2,915 (30.5%) women. Excluding vitamins, supplements, and vaccines, 73.4% of women took a medication during pregnancy with 55.1% taking one in the first trimester. The categories of drugs taken in pregnancy and in the first trimester include the following: gastrointestinal or antiemetic agents (34.3%, 19.5%), antibiotics (25.5%, 12.6%), and analgesics (23.7%, 15.6%, which includes 3.6%; 1.4% taking an opioid pain medication).ConclusionIn this geographically and ethnically diverse cohort of nulliparous pregnant women, medication use was nearly universal and polypharmacy was common.Clinical trial registrationClinicalTrials.gov, NCT01322529.
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- 2018
32. Genotype–phenotype correlations in individuals with pathogenic RERE variants
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Jordan, Valerie K, Fregeau, Brieana, Ge, Xiaoyan, Giordano, Jessica, Wapner, Ronald J, Balci, Tugce B, Carter, Melissa T, Bernat, John A, Moccia, Amanda N, Srivastava, Anshika, Martin, Donna M, Bielas, Stephanie L, Pappas, John, Svoboda, Melissa D, Rio, Marlène, Boddaert, Nathalie, Cantagrel, Vincent, Lewis, Andrea M, Scaglia, Fernando, Network, Undiagnosed Diseases, Kohler, Jennefer N, Bernstein, Jonathan A, Dries, Annika M, Rosenfeld, Jill A, DeFilippo, Colette, Thorson, Willa, Yang, Yaping, Sherr, Elliott H, Bi, Weimin, and Scott, Daryl A
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Congenital Structural Anomalies ,Genetics ,Genetic Testing ,Rare Diseases ,Pediatric ,Aetiology ,2.1 Biological and endogenous factors ,Adolescent ,Carrier Proteins ,Child ,Preschool ,Fatal Outcome ,Female ,Genetic Association Studies ,Humans ,Infant ,Male ,Mutation ,Young Adult ,1p36 deletion syndrome ,CHARGE syndrome ,CHD7 ,genotype-phenotype correlations ,NEDBEH ,RERE ,Undiagnosed Diseases Network ,Clinical Sciences ,Genetics & Heredity - Abstract
Heterozygous variants in the arginine-glutamic acid dipeptide repeats gene (RERE) have been shown to cause neurodevelopmental disorder with or without anomalies of the brain, eye, or heart (NEDBEH). Here, we report nine individuals with NEDBEH who carry partial deletions or deleterious sequence variants in RERE. These variants were found to be de novo in all cases in which parental samples were available. An analysis of data from individuals with NEDBEH suggests that point mutations affecting the Atrophin-1 domain of RERE are associated with an increased risk of structural eye defects, congenital heart defects, renal anomalies, and sensorineural hearing loss when compared with loss-of-function variants that are likely to lead to haploinsufficiency. A high percentage of RERE pathogenic variants affect a histidine-rich region in the Atrophin-1 domain. We have also identified a recurrent two-amino-acid duplication in this region that is associated with the development of a CHARGE syndrome-like phenotype. We conclude that mutations affecting RERE result in a spectrum of clinical phenotypes. Genotype-phenotype correlations exist and can be used to guide medical decision making. Consideration should also be given to screening for RERE variants in individuals who fulfill diagnostic criteria for CHARGE syndrome but do not carry pathogenic variants in CHD7.
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- 2018
33. Racial Disparities in Adverse Pregnancy Outcomes and Psychosocial Stress
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Grobman, William A, Parker, Corette B, Willinger, Marian, Wing, Deborah A, Silver, Robert M, Wapner, Ronald J, Simhan, Hyagriv N, Parry, Samuel, Mercer, Brian M, Haas, David M, Peaceman, Alan M, Hunter, Shannon, Wadhwa, Pathik, Elovitz, Michal A, Foroud, Tatiana, Saade, George, and Reddy, Uma M
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Infant Mortality ,Contraception/Reproduction ,Behavioral and Social Science ,Clinical Research ,Perinatal Period - Conditions Originating in Perinatal Period ,Pediatric ,Preterm ,Low Birth Weight and Health of the Newborn ,Mental Health ,Basic Behavioral and Social Science ,Aetiology ,2.3 Psychological ,social and economic factors ,Reproductive health and childbirth ,Good Health and Well Being ,Adult ,Ethnicity ,Female ,Health Status Disparities ,Humans ,Hypertension ,Pregnancy-Induced ,Infant ,Newborn ,Infant ,Small for Gestational Age ,Pregnancy ,Pregnancy Outcome ,Premature Birth ,Prospective Studies ,Self Report ,Stress ,Psychological ,White People ,Eunice Kennedy Shriver National Institute of Child Health and Human Development Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b) Network* ,Paediatrics and Reproductive Medicine ,Obstetrics & Reproductive Medicine ,Reproductive medicine - Abstract
ObjectiveTo assess the relationships between self-reported psychosocial stress and preterm birth, hypertensive disease of pregnancy, and small-for-gestational-age (SGA) birth and to assess the extent to which these relationships account for racial and ethnic disparities in these adverse outcomes.MethodsSelf-reported measures of psychosocial stress (perceived stress, depression, racism, anxiety, resilience, and social support) were collected during pregnancy among a racially and ethnically diverse cohort of women enrolled in a prospective observational study of nulliparous women with singleton pregnancies, from eight clinical sites across the United States, between October 2010 and May 2014. The associations of preterm birth, hypertensive disease of pregnancy, and SGA birth with the self-reported measures of psychosocial stress as well as with race and ethnicity were evaluated.ResultsThe study included 9,470 women (60.4% non-Hispanic white, 13.8% non-Hispanic black, 16.7% Hispanic, 4.0% Asian, and 5.0% other). Non-Hispanic black women were significantly more likely to experience any preterm birth, hypertensive disease of pregnancy, and SGA birth than were non-Hispanic white women (12.2% vs 8.0%, 16.7% vs 13.4%, and 17.2% vs 8.6%, respectively; P
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- 2018
34. LIST OF Contributors
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Best, Robert G., primary, Bhandari, Vineet, additional, Dungan, Jeffrey S., additional, Erbe, Richard W., additional, Goldberg, James D., additional, Govindavari, John Paul, additional, Gregg, Anthony R., additional, Gross, Susan J., additional, Gruen, Jeffrey R., additional, Krausz, Csilla, additional, Lazarin, Gabriel, additional, Prosnitz, Aaron R., additional, Rajkovic, Aleksandar, additional, Rosta, Viktoria, additional, Sahai, Inderneel, additional, Schreck, Rhona, additional, Shulman, Lee P., additional, Simpson, Joe Leigh, additional, Strom, Charles M., additional, Swerdloff, Ronald S., additional, Taber, Katherine Johansen, additional, Wagner, Andrew F., additional, Wang, Christina, additional, Wapner, Ronald J., additional, Williams, John, additional, and Yatsenko, Svetlana A., additional
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- 2022
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35. Expanded Carrier Screening
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Wapner, Ronald J., primary, Taber, Katherine Johansen, additional, Lazarin, Gabriel, additional, and Goldberg, James D., additional
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- 2022
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36. Obstetrical, Perinatal, and Genetic Outcomes Associated With Nonreportable Prenatal Cell-Free DNA Screening Results
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Norton, Mary E., primary, MacPherson, Cora, additional, Demko, Zachary, additional, Egbert, Melissa, additional, Malone, Fergal, additional, Wapner, Ronald J., additional, Roman, Ashley S., additional, Khalil, Asma, additional, Faro, Revital, additional, Madankumar, Rajeevi, additional, Strong, Noel, additional, Haeri, Sina, additional, Silver, Robert, additional, Vohra, Nidhi, additional, Hyett, Jon, additional, Martin, Kimberly, additional, Rabinowitz, Matthew, additional, Jacobsson, Bo, additional, and Dar, Pe'er, additional
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- 2024
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37. Noninvasive single‐cell‐based prenatal genetic testing: A proof of concept clinical study
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Bellair, Michelle, primary, Amaral, Elisabete, additional, Ouren, Mason, additional, Roark, Cameron, additional, Kim, Jaeweon, additional, O'Connor, April, additional, Soriano, Adrianna, additional, Schindler, Margaret L., additional, Wapner, Ronald J., additional, Stone, Joanne L., additional, Tavella, Nicola, additional, Merriam, Audrey, additional, Perley, Lauren, additional, Breman, Amy M., additional, and Beaudet, Arthur L., additional
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- 2024
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38. Improving prenatal diagnosis through standards and aggregation
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Duyzend, Michael H., primary, Cacheiro, Pilar, additional, Jacobsen, Julius O. B., additional, Giordano, Jessica, additional, Brand, Harrison, additional, Wapner, Ronald J., additional, Talkowski, Michael E., additional, Robinson, Peter N., additional, and Smedley, Damian, additional
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- 2024
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39. 471 Association of neighborhood socioeconomic disadvantage and stillbirth
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Hajmurad, Seema, primary, Grobman, William A., additional, Silver, Robert M., additional, Wu, Jiqiang, additional, McNeil, Rebecca B., additional, Haas, David M., additional, Yee, Lynn M., additional, Mercer, Brian M., additional, Simhan, Hyagriv, additional, Reddy, Uma M., additional, Parry, Samuel, additional, Saade, George R., additional, Wapner, Ronald J., additional, Lynch, Courtney Denning-Johnson, additional, and Venkatesh, Kartik, additional
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- 2024
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40. 169 Curating the fetal genome: experience of the ClinGen prenatal gene curation expert panel (GCEP)
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Galloway, Stephanie, primary, Giordano, Jessica L., additional, Thomas-Wilson, Amanda, additional, Okur, Volkan, additional, Shawber, Carrie J., additional, Gilmore, Kelly L., additional, Ratliff, Julie, additional, Lazar, Roni Zemet, additional, Ganapathi, Mythily, additional, Chandler, Natalie, additional, Vora, Neeta L., additional, Dharmadhikari, Avinash V., additional, Van Ziffle, Jessica, additional, Sparks, Teresa N., additional, Chitayat, David, additional, Chitty, Lyn, additional, Riggs, Erin, additional, Byrne, Alicia B., additional, Wapner, Ronald J., additional, Chung, Wendy, additional, and Van den Veyver, Ignatia B., additional
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- 2024
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41. 1144 Predicting preeclampsia and gestational hypertension using the vasculature of the eye
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Shenav, Liat, primary, Laine, Andrew, additional, Thakoor, Kaveri, additional, Tian, Ye, additional, Wu, Geoffrey, additional, Castillo, Zoilo, additional, Gutierrez, Yessenia, additional, Hark, Lisa, additional, Wapner, Ronald J., additional, and Bearelly, Srilaxmi, additional
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- 2024
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42. 781 Multiethnic Growth Standards for Fetal Body Composition and Organ Volumes Derived from 3D Ultrasonography
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Grantz, Katherine, primary, Lee, Wesley, additional, Mack, Lauren, additional, Cortes, Magdalena Sanz, additional, Goncalves, Luis, additional, Espinoza, Jimmy, additional, Newman, Roger, additional, Grobman, William A., additional, Wapner, Ronald J., additional, Fuchs, Karin, additional, D'Alton, Mary, additional, Skupski, Daniel, additional, Owen, John, additional, Sciscione, Anthony C., additional, Wing, Deborah, additional, Nageotte, Michael P., additional, Ranzini, Angela, additional, Chien, Edward, additional, Craigo, Sabrina, additional, Sherman, Seth, additional, He, Dian, additional, Hinkle, Stefanie, additional, Zhang, Cuilin, additional, Grewal, Jagteshwar, additional, and Chen, Zhen, additional
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- 2024
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43. 1066 Serial measurements of ultrasonic dimensions of gravid maternal anatomy and aspirated cervical stiffness
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Louwagie, Erin, primary, Russell, Serena, additional, Hairston, Jacqueline C., additional, Nhan Chang, Chia Ling, additional, Fuchs, Karin, additional, Gyamfi-Bannerman, Cynthia, additional, Booker, Whitney A., additional, Andrikopoulou, Maria, additional, Friedman, Alexander M., additional, Zork, Noelia, additional, Wapner, Ronald J., additional, Vink, Joy, additional, Mourad, Mirella, additional, and Myers, kristin, additional
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- 2024
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44. 86 Genome sequencing as a first-tier prenatal diagnostic test: Is it time to change?
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Jobanputra, Vaidehi, primary, Giordano, Jessica L., additional, Pervola, Josie, additional, Okur, Volkan, additional, Thomas-Wilson, Amanda, additional, Guha, Saurav, additional, Rehman, Atteeq U., additional, Wilson, Ashley, additional, Tinfow, Alexandra, additional, Galloway, Stephanie, additional, Abhyankar, Avinash, additional, Felice, Vanessa, additional, Esteves, Cecilia, additional, Hegedus, Endre, additional, Phadke, Shruti, additional, Srinivasa, Sowmya Thirumalai, additional, Khan, Shahid Y., additional, Nava, Caroline, additional, Yan, Qi, additional, Levy, Brynn, additional, and Wapner, Ronald J., additional
- Published
- 2024
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45. 1 Multicenter, prospective cohort of genome sequencing in 750 fetal structural anomalies
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Wapner, Ronald J., primary, Giordano, Jessica L., additional, de Voest, Jessica, additional, Gilmore, Kelly L., additional, Westerfield, Lauren, additional, Tinfow, Alexandra, additional, Galloway, Stephanie, additional, Tolusso, Leandra, additional, Wong, Beatrix, additional, Jackson, Farrah, additional, Bonesteele, Grant, additional, Wittman, Theresa, additional, Stevens, Blair, additional, Stover, Samantha, additional, Johnson, Anthony, additional, Leslie, Nancy Doan, additional, Swarr, Daniel, additional, Caughey, Aaron B., additional, Chung, Wendy, additional, Clifton, Rebecca, additional, Van den Veyver, Ignatia B., additional, and Vora, Neeta L., additional
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- 2024
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46. 989 Maternal and ultrasound characteristics associated with persistence of cell-free DNA from a vanishing twin pregnancy
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Dugoff, Lorraine, primary, Kohari, Katherine, additional, Adams, Tracy, additional, Scholl, Jessica, additional, Roman, Ashley S., additional, Berkin, Jill, additional, Hurt, Joseph, additional, Chueh, Jane, additional, Wolf, Samuel, additional, Gorman, Kelly, additional, Palomares, Kristy, additional, Wick, Myra, additional, Al-Khan, Abdulla, additional, Alpay Savasan, Zeynep, additional, Wapner, Ronald J., additional, Livingston, Jeff M., additional, Prigmore, Brittany, additional, Ahmed, Ebad, additional, Butskova, Anastasia, additional, Egbert, Melissa, additional, Vourthis, Sophia, additional, Rochon, Meredith, additional, and Souter, Vivienne, additional
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- 2024
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47. 578 Dilapan-S versus Standard Methods for Cervical Ripening in Term Pregnancies: An Individual Patient Data Meta-Analysis
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Saad, Antonio F., primary, Pedroza, Claudia, additional, Gavara, Rachana, additional, Janesh, Gupta, additional, Wapner, Ronald J., additional, and Saade, George R., additional
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- 2024
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48. 388 Eye towards Artificial Intelligence: Retinal Vascular Tortuosity vs. Vasoconstriction to Differentiate Preeclamptic and Normotensive Subjects
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Bearelly, Srilaxmi, primary, Moscoso, Andrea Perez, additional, Ciccone, Lyam, additional, Coleman, Hannah R., additional, Ananth, Cande V., additional, and Wapner, Ronald J., additional
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- 2024
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49. Association of second trimester uterine artery Doppler parameters with maternal hypertension 2–7 years after delivery
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Miller, Eliza C., Carper, Benjamin, Bello, Natalie A., Bairey Merz, C. Noel, Greenland, Philip, Levine, Lisa D., Haas, David M., Grobman, William A., McNeil, Rebecca B., Chung, Judith H., Jolley, Jennifer, Saade, George R., Silver, Robert M., Simhan, Hyagriv N., Wapner, Ronald J., and Parker, Corette B.
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- 2021
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50. Abstract 11843: Association of Individual- And Neighborhood-Level Factors With Racial and Ethnic Differences in Cardiovascular Health During Early Pregnancy
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Cameron, Natalie A, Huang, Xiaoning, Petito, Lucia C, Ning, Hongyan, Shah, Nilay S, Yee, Lynn M, Perak, Amanda M, Kim, Jin K, Haas, David, Mercer, Brian M, Parry, Samuel, Saade, George R, Silver, Robert M, Simhan, Hyagriv N, Wapner, Ronald J, Greenland, Philip, Lloyd-Jones, Donald M, Kershaw, Kiarri N, Grobman, William A, and Khan, Sadiya S
- Published
- 2022
- Full Text
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