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7. Creating Coordination in the Cerebellum Catania, 2–4 October 2003

Author

Andjus, P. R., Zhu, L., Strata, P., Arata, A., Ito, M., Bearzatto, B., Servais, L., Baba-Aïssa, F., de Kerchove d’Exaerde, A., Schurmans, S., Cheron, G., Schiffmann, S. N., Bower, J. M., Devor, A., Burguière, E., Rutteman, M., De Zeeuw, C. I., Berthoz, A., Wiener, S., Rondi-Reig, L., Campana, A., Dusart, I., Wherlé, R., Weitzman, J., Yaniv, M., Sotelo, C., Mariani, J., Cavallari, P., Esposti, R., Cerri, G., Cerminara, N. L., Apps, R., Marple-Horvat, D. E., Wagstaff, J., Dan, B., Chorev, E., Manor, Y., Sohl, G., Willecke, K., Yarom, Y., Philipona, D., Dognin, E., Coenen, O. J., Sola, E., Prestori, F., Rossi, P., Taglietti, V., D’Angelo, E., De Filippi, G., Baldwinson, T., Sher, E., Ekerot, C., Jorntell, H., Fernández, G., Martínez, S., Gall, D., Roussel, C., Forti, L., Schiffmann, S., Gruol, D. L., Netzeband, J. G., Quina, L. A., Blakely Gonzalez, P. K., Hoebeek, F. E., Van Alphen, A. M., Schonewille, M., Frens, M. A., Goossens, H. H. L. M., Stahl, J., Ango, F., di Cristo, G., Hagashiyama, H., Bennett, V., Huang, Z. J., Jörntell, H., Ekerot, C.- F., Launey, T., Endo, S., Sakai, R., Harano, J., Lohof, A. M., Sherrard, R. M., Lu, H., Huang, C., Hartmann, M. J., Marshall, S. P., Lang, E. J., Michikawa, T., Mikoshiba, K., Nitschke, M. F., Erdmann, C., Melchert, U., Arp, T., Sprenger, A., Petersen, D., Kömpf, D., Binkofski, F., Heide, W., Pedroarena, C., Schwarz, C., Parsons, L. M., Schmahmann, J. D., Grill, S. E., Walker, M. S., Petacchi, A., Rokni, D., Saito, S., Kato, K., Sajdel-Sulkowska, E. M., Nguon, K., Selimi, F., Wang, Q., Cristea, I., Chait, B., Heintz, N., Serapide, M. F., Cicirata, F., De Saedeleer, C., Schwaller, B., Swinny, J. D., Ijkema-Paassen, J., Metzger, F., Kalicharan, D., Gramsbergen, A., van der Want, J. J. L., Slemmer, J. E., Weber, J. T., Winkelman, B. H. J., Chédotal, A., De Schutter, E., Maex, R., Koekkoek, S. K. E., Bouslama, L., Ghoumari, A., Ebner, T., Häusser, M., Hawkes, R., Herrup, K., Lisberger, S. G., Mugnaini, E., Nunzi, M. -G., Russo, M., Ptak, K., Orr, H. T., Zoghbi, H. Y., Rossi, F., Ruigrok, T. J. H., Sabel-Goedknegt, E., Simpson, J. I., Morando, L., Cesa, R., Dumoulin, A., Dieudonné, S., Dugué, G., Triller, A., Louvi, A., Alexandre, P., Wurst, W., and Wassef, M.

Published
2004
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17. Immunological Methods

Author

van der Veken, J. A., van Slogteren, D. H. M., van der Want, J. P. H., Biemann, K., editor, Boardman, N. K., editor, Breyer, B., editor, Burg, S. P., editor, Butler, W. L., editor, David, D. J., editor, Davis, P. S., editor, Dimond, A. E., editor, Hildebrandt, A. C., editor, Hommes, F. A., editor, Kratky, O., editor, Linskens, H. F., editor, Moor, H., editor, Norris, K. H., editor, O’Donnell, I. J., editor, Possingham, J. V., editor, Prat, H., editor, van Slogteren, D. H. M., editor, Stahl, E., editor, van der Veken, J. A., editor, van der Want, J. P. H., editor, and Woods, E. F., editor

Published
1962
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18. Pflanzenviren

Author

Ragetli, H. W. J., van der Want, J. P. H., Beiss, U., editor, Dörfel, H., editor, Fujisawa, K., editor, Hänsel, R., editor, Hager, A., editor, Hohl, H. R., editor, Linskens, H. F., editor, Machleidt, H., editor, Makino, K., editor, Marten, G., editor, van Os, G. A. J., editor, Prijs, B., editor, Ragetli, H. W. J., editor, Romeike, A., editor, Sanwal, B. D., editor, Schweppe, H., editor, Seiler, H., editor, Sen, S. P., editor, Stange, L., editor, von Kamienski, E. Stein, editor, Wachtmeister, C. A., editor, van der Want, J. P. H., editor, and Yamatodani, S., editor

Published
1959
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19. Nachweis der Steroide durch Farbreaktionen

Author

Beiss, U., Dörfel, H., Fujisawa, K., Hänsel, R., Hager, A., Hohl, H. R., Linskens, H. F., Machleidt, H., Makino, K., Marten, G., van Os, G. A. J., Prijs, B., Ragetli, H. W. J., Romeike, A., Sanwal, B. D., Schweppe, H., Seiler, H., Sen, S. P., Stange, L., von Kamienski, E. Stein, Wachtmeister, C. A., van der Want, J. P. H., Yamatodani, S., Beiss, U., editor, Dörfel, H., editor, Fujisawa, K., editor, Hänsel, R., editor, Hager, A., editor, Hohl, H. R., editor, Linskens, H. F., editor, Machleidt, H., editor, Makino, K., editor, Marten, G., editor, van Os, G. A. J., editor, Prijs, B., editor, Ragetli, H. W. J., editor, Romeike, A., editor, Sanwal, B. D., editor, Schweppe, H., editor, Seiler, H., editor, Sen, S. P., editor, Stange, L., editor, von Kamienski, E. Stein, editor, Wachtmeister, C. A., editor, van der Want, J. P. H., editor, and Yamatodani, S., editor

Published
1959
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21. Lipid droplets hypertrophy: a crucial determining factor in insulin regulation by adipocytes.

Author

Sanjabi, B., Dashty, M., Ozcan, B., Akbarkhanzadeh, V., Rahimi, M., Vinciguerra, M., Rooij, F. van, Al-Lahham, S., Sheedfar, F., Kooten, T.G. van, Spek, C.A., Rowshani, A.T., Want, J. van der, Klaassen, R., Sijbrands, E., Peppelenbosch, M.P., Rezaee, F., Sanjabi, B., Dashty, M., Ozcan, B., Akbarkhanzadeh, V., Rahimi, M., Vinciguerra, M., Rooij, F. van, Al-Lahham, S., Sheedfar, F., Kooten, T.G. van, Spek, C.A., Rowshani, A.T., Want, J. van der, Klaassen, R., Sijbrands, E., Peppelenbosch, M.P., and Rezaee, F.

Abstract

Contains fulltext : 153283.pdf (publisher's version ) (Open Access), Lipid droplets (LDs) hypertrophy in adipocytes is the main cause of energy metabolic system dysfunction, obesity and its afflictions such as T2D. However, the role of adipocytes in linking energy metabolic disorders with insulin regulation is unknown in humans. Human adipocytes constitutively synthesize and secrete insulin, which is biologically functional. Insulin concentrations and release are fat mass- and LDs-dependent respectively. Fat reduction mediated by bariatric surgery repairs obesity-associated T2D. The expression of genes, like PCSK1 (proinsulin conversion enzyme), GCG (Glucagon), GPLD1, CD38 and NNAT, involved in insulin regulation/release were differentially expressed in pancreas and adipose tissue (AT). INS (insulin) and GCG expression reduced in human AT-T2D as compared to AT-control, but remained unchanged in pancreas in either state. Insulin levels (mRNA/protein) were higher in AT derived from prediabetes BB rats with destructed pancreatic beta-cells and controls than pancreas derived from the same rats respectively. Insulin expression in 10 human primary cell types including adipocytes and macrophages is an evidence for extrapancreatic insulin-producing cells. The data suggest a crosstalk between AT and pancreas to fine-tune energy metabolic system or may minimize the metabolic damage during diabetes. This study opens new avenues towards T2D therapy with a great impact on public health.

Published
2015

29. Book reviews

Author

Linskens, H. F., Esser, K., Gilissen, L. J. W., Barendse, G. W. M., Hagemann, R., van der Drift, C., van der Kroon, P. H. W., Hennig, W., Martens, M. J. M., Schnepf, E., van der Want, J. P. H., and Stumm, C. K.

Published
1986
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50. Nonpenetrating vascular clips for small-caliber anastomosis

Author

Zeebregts, CJ, Van den Dungen, JJ, Kalicharan, D, Cromheecke, M, Van der Want, J, Man, Biomaterials and Microbes (MBM), and Vascular Ageing Programme (VAP)

Subjects
REPAIR, surgical procedures, operative, education, cardiovascular system, LASER, cardiovascular diseases, ARTERIAL, MICROVASCULAR ANASTOMOSIS
Abstract

In the search for better anastomosing techniques, an improved vascular stapler device (VCS clip applier system(R)) has been introduced. The system uses nonpenetrating clips to approximate everted vessel walls. The objective of this study was to determine the effects of nonpenetrating vascular clips on endothelial wound healing. Aortic end-to-end anastomoses were performed in male Wistar rats. A comparison was made between clipped (n = 12) and conventional hand-sewn (n = 6) anastomoses. Patency rates were verified at different time intervals (after 1, 4, and 8 weeks), after which the anastomotic sites were removed. Morphological evaluation was carried out using scanning electron microscopy, All rats survived the procedure. Closure with clips took less time than closure with conventional sutures, with decreasing aortic clamping times for the clipped procedures during the course of the experiments. Patency rates were 100% in both the "clipped" and "sutured" groups. Microscopic examination showed favorable endothelial healing at the clipped anastomotic sites, with less inflammatory reaction at 1 week, and a more complete endothelial regeneration at 4 and 8 weeks follow-up, as compared with the sutured anastomoses. The clip applier holds the promise of a useful device in anastomosing small-caliber vessels, since clip closure takes less time than suturing, while patency rates are identical, and morphological results are favorable. Training is mandatory to obtain technical skills and to achieve optimal results. (C) 2000 Wiley-Liss, Inc.

Published
2000

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