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Your search keyword '"Wanke, Kerstin"' showing total 21 results
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21 results on '"Wanke, Kerstin"'

1. Primary immune responses are negatively impacted by persistent herpesvirus infections in older people: results from an observational study on healthy subjects and a vaccination trial on subjects aged more than 70 years old

Author

Nicoli, Francesco, Clave, Emmanuel, Wanke, Kerstin, von Braun, Amrei, Bondet, Vincent, Alanio, Cécile, Douay, Corinne, Baque, Margaux, Lependu, Claire, Marconi, Peggy, Stiasny, Karin, Heinz, Franz X., Muetsch, Margot, Duffy, Darragh, Boddaert, Jacques, Sauce, Delphine, Toubert, Antoine, Karrer, Urs, and Appay, Victor

Published
2022
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4. Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases

Author

Akdis, Mübeccel, Aab, Alar, Altunbulakli, Can, Azkur, Kursat, Costa, Rita A., Crameri, Reto, Duan, Su, Eiwegger, Thomas, Eljaszewicz, Andrzej, Ferstl, Ruth, Frei, Remo, Garbani, Mattia, Globinska, Anna, Hess, Lena, Huitema, Carly, Kubo, Terufumi, Komlosi, Zsolt, Konieczna, Patricia, Kovacs, Nora, Kucuksezer, Umut C., Meyer, Norbert, Morita, Hideaki, Olzhausen, Judith, O'Mahony, Liam, Pezer, Marija, Prati, Moira, Rebane, Ana, Rhyner, Claudio, Rinaldi, Arturo, Sokolowska, Milena, Stanic, Barbara, Sugita, Kazunari, Treis, Angela, van de Veen, Willem, Wanke, Kerstin, Wawrzyniak, Marcin, Wawrzyniak, Paulina, Wirz, Oliver F., Zakzuk, Josefina Sierra, and Akdis, Cezmi A.

Published
2016
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7. Inhibition of angiogenesis by IL-32: Possible role in asthma

Author

Meyer, Norbert, Christoph, Janine, Makrinioti, Heidi, Indermitte, Philippe, Rhyner, Claudio, Soyka, Michael, Eiwegger, Thomas, Chalubinski, Maciej, Wanke, Kerstin, Fujita, Hiroyuki, Wawrzyniak, Paulina, Bürgler, Simone, Zhang, Sherrie, Akdis, Mübeccel, Menz, Günter, and Akdis, Cezmi

Published
2012
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9. TGFβ

Author

Akdis, Cezmi A., primary and Wanke, Kerstin, additional

Published
2016
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13. TGFβ

Author

Akdis, Cezmi A., Wanke, Kerstin, and Ogulur, Ismail

Published
2017
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16. Regulation of bronchial epithelial barrier integrity by type 2 cytokines and histone deacetylases in asthma

Author

Wawrzyniak, Paulina, Wawrzyniak, Marcin, Wanke, Kerstin, Sokolowska, Milena, Bendelja, Kreso, Rückert, Beate, Globinska, Anna, Jakiela, Bogdan, Kast, Jeannette I, Idzko, Marco, Akdis, Mübeccel, Sanak, Marek, and Akdis, Cezmi A

Subjects
asthma, histone deacetylases, bronchial epithelial barrier
Abstract

Tight junctions (TJs) form a barrier on the apical side of neighboring epithelial cells in the bronchial mucosa. Changes in their integrity might play a role in asthma pathogenesis by enabling the paracellular influx of allergens, toxins, and microbes to the submucosal tissue. The regulation of bronchial epithelial TJs by TH2 cells and their cytokines and their involvement in epigenetic regulation of barrier function were investigated. The expression, regulation, and function of TJs were determined in air-liquid interface (ALI) cultures of control and asthmatic primary human bronchial epithelial cells (HBECs) by means of analysis of transepithelial electrical resistance, paracellular flux, mRNA expression, Western blotting, and immunofluorescence staining. HBECs from asthmatic patients showed a significantly low TJ integrity in ALI cultures compared with HBECs from healthy subjects. TH2 cell numbers and levels of their cytokines, IL-4 and IL-13, decreased barrier integrity in ALI cultures of HBECs from control subjects but not in HBECs from asthmatic patients. They induced a physical separation of the TJs of adjacent cells in immunofluorescence staining of the TJ molecules occludin and zonula occludens-1. We observed that expression of histone deacetylases (HDACs) 1 and 9, and Silent information regulator genes (sirtuins [SIRTs]) 6 and 7 were significantly high in HBECs from asthmatic patients. IL-4 and IL-13 significantly increased the expression of HDACs and SIRTs. The role of HDAC activation on epithelial barrier leakiness was confirmed by HDAC inhibition, which improved barrier integrity through increased synthesis of TJ molecules in epithelium from asthmatic patients to the level seen in HBECs from control subjects. Our data demonstrate that barrier leakiness in asthmatic patients is induced by TH2 cells, IL-4, and IL-13 and HDAC activity. The inhibition of endogenous HDAC activity reconstitutes defective barrier by increasing TJ expression.

Published
2016

17. 気管支上皮のバリア維持におけるCpG-DNAの役割

Author

Kubo, Terufumi, Wawrzyniak, Paulina, Morita, Hideaki, Sugita, Kazunari, Wanke, Kerstin, Kast, Jeannette I, Altunubulakli, Can, Rückert, Beate, Akdis, Mübeccel, Akdis, Cezmi A, and University of Zurich

Subjects
10183 Swiss Institute of Allergy and Asthma Research, 610 Medicine & health
Published
2016

18. Japanese Journal of Clinical Immunology

Author

Kubo, Terufumi, primary, Wawrzyniak, Paulina, additional, Morita, Hideaki, additional, Sugita, Kazunari, additional, Wanke, Kerstin, additional, Kast, Jeannette I., additional, Altunubulakli, Can, additional, Rückert, Beate, additional, Akdis, Mübeccel, additional, and Akdis, Cezmi A., additional

Published
2016
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19. Reduced naïve CD 8 + T ‐cell priming efficacy in elderly adults

Author

Briceño, Olivia, primary, Lissina, Anna, additional, Wanke, Kerstin, additional, Afonso, Georgia, additional, Braun, Amrei, additional, Ragon, Kristanto, additional, Miquel, Tiphaine, additional, Gostick, Emma, additional, Papagno, Laura, additional, Stiasny, Karin, additional, Price, David A., additional, Mallone, Roberto, additional, Sauce, Delphine, additional, Karrer, Urs, additional, and Appay, Victor, additional

Published
2015
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20. Soluble mediators derived from bronchial epithelium are able to drive Th2 differentiation in the context of rhinovirus infection

Author

Makrinioti, Heidi, primary, Walton, Ross, additional, Papadopoulos, Nikolaos, additional, Edwards, Michael, additional, Telcian, Aurica, additional, Cousins, David, additional, Wanke, Kerstin, additional, Stanciu, Luminita, additional, Akdis, Mubeccel, additional, Megremis, Spyridon, additional, Akdis, Cezmi, additional, and Johnston, Sebastian, additional

Published
2013
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21. Reduced naïve CD8+ T-cell priming efficacy in elderly adults.

Author

Briceño, Olivia, Lissina, Anna, Wanke, Kerstin, Afonso, Georgia, Braun, Amrei, Ragon, Kristanto, Miquel, Tiphaine, Gostick, Emma, Papagno, Laura, Stiasny, Karin, Price, David A., Mallone, Roberto, Sauce, Delphine, Karrer, Urs, and Appay, Victor

Subjects
CD8 antigen, T cells, DRUG efficacy, IMMUNE response, LABORATORY mice
Abstract

Aging is associated with impaired vaccine efficacy and increased susceptibility to infectious and malignant diseases. CD8+ T-cells are key players in the immune response against pathogens and tumors. In aged mice, the dwindling naïve CD8+ T-cell compartment is thought to compromise the induction of de novo immune responses, but no experimental evidence is yet available in humans. Here, we used an original in vitro assay based on an accelerated dendritic cell coculture system in unfractioned peripheral blood mononuclear cells to examine CD8+ T-cell priming efficacy in human volunteers. Using this approach, we report that old individuals consistently mount quantitatively and qualitatively impaired de novo CD8+ T-cell responses specific for a model antigen. Reduced CD8+ T-cell priming capacity in vitro was further associated with poor primary immune responsiveness in vivo. This immune deficit likely arises as a consequence of intrinsic cellular defects and a reduction in the size of the naïve CD8+ T-cell pool. Collectively, these findings provide new insights into the cellular immune insufficiencies that accompany human aging. [ABSTRACT FROM AUTHOR]

Published
2016
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