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29 results on '"Wani, Mumtaz"'

2. Vitamin D receptor gene variations and their haplotypic association: Possible impact on gastric cancer risk

Author

Qadir, Jasiya, Majid, Sabhiya, Khan, Mosin, Wani, Mumtaz, and Naikoo, Niyaz

Subjects
Nucleotide sequencing -- Health aspects -- Genetic aspects, Genes -- Genetic aspects -- Health aspects, Alfacalcidol -- Health aspects, Genetic polymorphisms -- Health aspects -- Genetic aspects, Cancer -- Genetic aspects -- Research -- Prognosis -- Risk factors, Oncology, Experimental -- Health aspects -- Genetic aspects, DNA sequencing -- Health aspects -- Genetic aspects, Calcifediol -- Health aspects, Vitamin D -- Health aspects, Ethylenediaminetetraacetic acid -- Health aspects, Stomach cancer -- Prognosis -- Genetic aspects -- Risk factors, Health
Abstract

Byline: Jasiya. Qadir, Sabhiya. Majid, Mosin. Khan, Mumtaz. Wani, Niyaz. Naikoo Background: Vitamin D receptor (VDR) gene alterations have been associated with the occurrence and prognosis of various types of [...]

Published
2023

29. Implication of ARID1A Undercurrents and PDL1, TP53 Overexpression in Advanced Gastric Cancer.

Author

Qadir J, Majid S, Khan MS, Rashid F, Wani MD, and Bhat SA

Subjects
Aged, Cross-Sectional Studies, Disease Progression, Female, Gene Expression, Humans, India epidemiology, Male, Middle Aged, Mutation, RNA, Messenger genetics, Stomach Neoplasms epidemiology, Stomach Neoplasms pathology, B7-H1 Antigen genetics, DNA-Binding Proteins genetics, Stomach Neoplasms genetics, Transcription Factors genetics, Tumor Suppressor Protein p53 genetics
Abstract

AT-rich interactive domain-containing protein 1A (ARID1A), TP53 and programmed cell death-ligand 1 (PDL1) are involved in several protein interactions that regulate the expression of various cancer-related genes involved in the progression of the cell cycle, cell proliferation, DNA repair, and apoptosis. In addition, gene expression analysis identified some common downstream targets of ARID1A and TP53. It has been established that tumors formed by ARID1A -deficient cancer cells exhibited elevated PDL1 expression. However, the aberrations in these molecules have not been studied in this population especially in Gastric Cancer (GC). In this backdrop we aimed to investigate the role of the ARID1A mutation and expression of ARID1A , TP53 and PDL1 genes in the etiopathogenesis of Gastric Cancer (GC) in the ethnic Kashmiri population (North India). The study included 103 histologically confirmed GC cases. The mutations, if any, in exon-9 of ARID1A gene was analysed by Polymerase Chain Reaction (PCR) followed by Sanger sequencing. The mRNA expression of the ARID1A , TP53 and PDL1 genes was analysed by Quantitative real time-PCR (qRT-PCR). We identified a nonsense mutation (c.3219; C > T) in exon-9 among two GC patients (∼2.0%), which introduces a premature stop codon at protein position 1073. The mRNA expression of the ARID1A, TP53 and PDL1 gene was significantly reduced in 25.3% and elevated in 47.6 and 39.8% of GC cases respectively with a mean fold change of 0.63, 2.93 and 2.43. The data revealed that reduced mRNA expression of ARID1A and elevated mRNA expression of TP53 and PDL1 was significantly associated with the high-grade and advanced stage of cancer. Our study proposes that ARAD1A under-expression and overexpression of TP53 and PDL1 might be crucial for tumor progression with TP53 and PDL1 acting synergistically., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Qadir, Majid, Khan, Rashid, Wani and Bhat.)

Published
2021
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