Search

The present study aims to prepare resin-based permeable bricks with micron-sized pores using fine aggregate with a particle diameter of 0.08mm-0.6mm and bisphenol-A epoxy resin, a polymer binder. The rainfall area of China was divided into 5 levels by using ArcGIS and Geoda geographic analysis software; The performance indexes of key components of resin-based permeable brick were selected by correlation with relevant standards, and the performance of materials is adjusted and designed according to the corresponding performance indexes, so as to meet the design requirements of “Sponge City”. The main method of material design is to adjust the key parameters of raw materials, such as aggregates, binder materials and admixtures, by using Image Pro Plus software and SEM and other test methods, so as to optimize the selection of “graded” aggregates and admixtures for different performance requirements scenarios to achieve the material selection goal. The highest permeable rate of resin-based permeable brick is 6.22× 10–2cm/s s, and the maximum compressive strength is more than 60MPa.

The permeable pavement plays an important role in mitigating urban flooding. In order to explore the relationship between materials and properties to better guide the practical production of resin-based permeable bricks, 10 kinds of representative aggregate samples with obvious different characteristics were selected for preparation. In this study, Image Pro Plus was used to binarize the acquired image pictures of the aggregate so as to obtain particle group characteristic parameters. The properties and porosity of the brick were measured in order to describe the influence of the material. The results are as follows. The relative standard deviation of aggregate and the amount of cementing material are negatively related to the compressive strength of permeable bricks, but positively related to water permeability and filtration performance. The roundness and roughness of the aggregate are the opposite. Furthermore, the porosity of the permeable brick is the essential reason for this phenomenon, that is, as the porosity increase, the compressive strength decrease, but the water permeability and the filtration performance become better. In the end, an optimization method for the compatibility of resin-based pavement permeable bricks was proposed through reflecting all factors in a two-bit flat grayscale image which can be applied in performance prediction and guidance of material selection.

Chronic liver disease is driven by a prolonged wound healing response leading to fibrogenesis, potentially progressing to cirrhosis. Hepatic stellate cells (HSCs) are the primary cells driving hepatic fibrosis because they are major producers of extracellular matrix. The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-ΚB) pathway is a key regulator of inflammatory signaling, and survival of activated HSCs has been found to be NF-KB dependent. Our team previously synthesized HJC0416—a signal transducer and activator of transcription three inhibitor with potent anti-inflammatory effects. In HSCs, HJC0416 reduced cell viability, extracellular matrix production, and—notably—NF-KB activation. However, HJC0416's antifibrogenetic mechanism remains unknown. This study examined the effects of HJC0416 on NF-KB and its associate factor HSP-90 in HSCs. The activated human HSC line LX-2 was treated with either HJC0416 or 17-AAG, then exposed to TNFα as indicated. Nuclear and cytosolic proteins were isolated for Western blot or immunofluorescence assay. HJC0416 significantly attenuated TNFα-induced IκBα phosphorylation, NF-KBp65 nuclear translocation, and DNA binding activity. Endogenous and TNFα-induced p65 phosphorylation of S536 was suppressed by HJC0416. Notably, HJC0416 dose-dependently attenuated the expression of FAK, IKKα, and signal transducer and activator of transcription three which are Heat Shock Protein 90 (HSP90) interacting proteins. The expression of other HSP90 interacting proteins—RIP1, AKT, FAK, and cyclin-dependent kinase nine—were decreased. HSP90-specific inhibitor 17-AAG significantly attenuated TNFα-induced IκBα phosphorylation and degradation, p65 nuclear translocation, DNA binding, and production of collagen type I and fibronectin. The HSP90 chaperone protein may be a key intermediary linking HJC0416's ability to inhibit NF-κB activity. HJC0416 may be a promising drug candidate for liver fibrosis. [ABSTRACT FROM AUTHOR]