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Background: To explore the effect of calcium dobesilate combined with hypoglycemic drugs in the treatment of cataract complicated with non-proliferative diabetic retinopathy (NPDR) and its effects on fundus microcirculation, intercellular adhesion molecule 1 (ICAM-1), mono - cyte chemoattractant protein 1 (MCP-1), and macrophage migration inhibitory factor (MIF). Methods: From March 2019 to January 2021, a total of 114 patients with cataract and NPDR were included, and the patients were assigned into the control and the observation groups by random number table method, with 57 cases/group. The control was given hypoglycemic drugs, and the observation was given calcium dobesilate combined therapy. The therapeutic efficacy, blood glucose and blood lipid levels, fluorescein fundus angiography results, fundus microcirculation indexes, retinal neovascularizationrelated factors, and ICAM-1, MCP-1, and MIF levels before and after treatment were compared between the two groups. Results: The total effective rate of treatment in the observation was higher vs. the control (P < 0.05); Fasting blood glucose (FBG), 2 h postprandial blood glucose (2hPG), glycosylated hemoglobin (HbA1c), triglyceride (TG), total cholesterol (TC) and low density lipoprotein (LDL) in the observation after treatment were reduced vs. the control (P < 0.05); The number of micro-hemangiomas in the observation after treatment was less vs. the control, and the area of hemorrhage, the area of exudation and the thickness of the yellow plate were smaller vs. the control (P < 0.05); The resistance index (RI) value of the observation after treatment was lower than the control, and the end-diastolic blood flow velocity (EDV) and the peak systolic blood flow velocity (PSV) of the observation were higher vs. the control (P < 0.05). ICAM-1, MCP-1, MIF, vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF1) in the observation after treatment were reduced vs. the control, but pigment epithelium-derived factor (PEDF) were higher vs. the control (P < 0.05); one case of gastrointestinal reaction took place in the observation, but no adverse reaction occurred in the control, and no clear difference exhibited in the incidence of adverse reactions between the two groups (P > 0.05). Conclusions: Calcium dobesilate combined with hypoglycemic drugs has good clinical efficacy in the treatment of cataract complicated with NPDR, which can effectively reduce the level of blood glucose and blood lipids, reduce inflammation, and mitigate the microcirculation of branch retinal vein occlusion lesions.

An embedded NOR Flash controller is descripted for quickly IAP(in application programming),no need of interrupt vector remap by software, but direct address remap by hardware reboot from middle location with dual Flash banks. The Flash controller can support read operation in the process of IAP, and get right read results. The Flash controller has a 1 ?滋s configuration register which can be used to calculate expected timing values for programming or erase automatically, reducing the software workload to configure more timing values one by one with different working frequency. It is verified after simulation and FPGA prototype verification,and taped out on UMC55 nm process in MCU. The samples of MCU with IAP working well prove further the Flash controller.

Aiming at the limitation of SOC′s pin number, and in security IC applications, on chip capless LDO and on chip decouple capacitor were preferred for suppling digital cores power. But On Chip Capless LDO′s finite bandwidth limited it responses sharp current pulses existed in digital core, huge on chip decouple capacitors of several nano farads are necessary for these situations. These on chip capacitors occupy significant chip area, so these capacitors must be mapped out in the whole chip floorplan and so did LDO designs. In conventional design flow, the on chip capacitor′s size was confirmed after P&R with power simulations at the late design procedure, which results in iterations of LDO design and whole chip floorplan distribution. A new accurate method was given based on deeply understanding digital circuit how to work in order to estimate the values of on chip capacitors at the early procedure of the flow, so the floorplan of the chip and LDO design could be started earlier, the iteration of these procedure was limited to one time. This method was succeeded applied in one SOC design, the post simulation and test results show that the estimated on chip capacitors are very accurate.

Aiming at the problems of complex supply voltage and high sensitivity of power in ADC for the industrial Internet of Things, this paper presents a flexible, low power and low noise reference voltage generator for the SAR ADC to obtain good PSRR and a stable supply-independent full-scale range. The 2.5 V or 1.5 V is available based on the different range of supply voltage(2.65 V～3.6 V or 2.2 V～3.6 V). This circuit support off-chip capacitor to provide transient current for the ADC to avoid the power-hungry integrated buffer in series sampling mode. An energy-efficient mode which uses integrated buffer rather than off-chip capacitor can be configured to obtain short setting time to save energy during each one-shot sample. Testing result shows the circuit can save power/energy with no loss in ADC performance.

As journal editors play an important role in defining and shaping academic discourse, knowing their opinions could likely prove beneficial for both current and future academic journal stakeholders. Within this vein, this study used the Delphi method to help build a profile on the trends and priorities within educational technology, from the unique perspective of the journals' editors-in-chief. This expert panel--initially built from 117 national and international research journals--concluded with 25 editors-in-chief who finished all three rounds of the survey. Results indicated five emerging themes for trends and priorities: computer-focused, teaching and learning, online and digital education, societal, and research and theory. By exploring these current trends and priorities within educational technology, this study may provide meaningful insights to better understand the field as a whole and may also help scholars in their goal of publishing relevant, high-quality academic scholarship.

The paper mulberry is one of the multifunctional tree species in agroforestry systems and is also commonly utilized in traditional medicine in China and other Asian countries. However, little is known about its molecular genetics, which hinders research on and exploitation of this valuable resource. To discern the correlation between gene expression and the essential properties of the paper mulberry, we performed a transcriptomics analysis, assembling a total of 37,725 unigenes from 54,638,676 reads generated by RNA-seq. Among these, 22,692 unigenes showed greater than 60% similarity with genes from other species. The lengths of 13,566 annotated unigenes were longer than 1,000 bp. Functional clustering analysis with COG (Cluster of Orthologous Groups) revealed that 17,184 unigenes are primarily involved in transcription, translation, signal transduction, carbohydrate metabolism, secondary metabolism, and energy metabolism. GO (Gene Ontology) annotation suggests enrichment of genes encoding antioxidant activity, transporter activity, biosynthesis, metabolism and stress response, with a total of 30,659 unigenes falling in these categories. KEGG (Kyoto Encyclopedia of Genes and Genomes) metabolic pathway analysis showed that 7,199 unigenes are associated with 119 metabolic pathways. In addition to the basic metabolism, these genes are enriched for plant pathogen interaction, flavonoid metabolism and other secondary metabolic processes. Furthermore, differences in the transcriptomes of leaf, stem and root tissues were analyzed and 7,233 specifically expressed unigenes were identified. This global expression analysis provided novel insights about the molecular mechanisms of the biosynthesis of flavonoid, lignin and cellulose, as well as on the response to biotic and abiotic stresses including the remediation of contaminated soil by the paper mulberry.

Computational thinking is believed to be beneficial for Science, Technology, Engineering, and Mathematics (STEM) learning as it is closely related to many other skills required by STEM disciplines. There has been an increasing interest in integrating computational thinking into STEM and many studies have been conducted to examine the effects of this intervention. This meta-analysis examined the effects of computational thinking integration in STEM on students' STEM learning performance in the K-12 education context. Following systematic procedures, we identified 20 publications with 21 studies meeting the inclusion and exclusion criteria from a range of academic databases. We extracted effect sizes on student learning outcomes in one-group pretest-posttest designs. We also examined a range of moderating variables in the models, including student levels, STEM disciplines, intervention durations, alignment with content standards (e.g., CSTA/NGSS), types of intervention (e.g., simulation), and the use of unplugged/plugged activities. Overall, we found a statistically significant large effect size (g = 0. 85 [95% CI of 0.57-1.14]; p < 0.001), indicating a large overall effect of computational thinking integration on STEM learning outcomes. The effect sizes were significantly moderated by intervention durations. We provide a discussion of the findings and present implications for future research and practice.

The mechanism of Fe+NO was calculated by the Density Functional Theory (DFT) with the B3LYP methods combined with the 6-311+G (d, p) basis set. The geometry of reactants, transition states, intermediates and products of two reaction systems were completely optimized, and all the transition states were verified by the vibration analysis and intrinsic reaction coordinate (IRC) calculations. The “Two State Reactivity (TSR)” was used to analyze the reaction mechanisms; Results showed that the reaction system preferentially involves low-spin state entrance channel and the high-spin state exit channel. In the reaction channel, the crossing point appears, which would effectively reduce the activation energy and increase the release of reaction heat, play a significant and beneficial role in the kinetic and thermodynamic aspects of this catalytic reaction.

The recent evolution of technology and the Internet has transformed how individuals find and share information. Research shows that citizens of all ages and backgrounds struggle with critical online information evaluation (COIE), which could result in serious societal consequences. Although it is crucial to develop student proficiency within this key information literacy construct beginning in middle school, there is currently no interdisciplinary framework for designing COIE instruction or assessments. To address this gap, we have developed a comprehensive COIE model for curriculum developers, assessment creators, and practitioners to implement at the secondary and post-secondary level. In this paper, we provide cross-disciplinary theoretical context and empirical grounding for our model, offer guidance for its practical application in the 6-16 curriculum, and discuss metacognitive and sociocultural considerations for developing and measuring learners' COIE proficiency.

Purpose: The purpose of this study is to explore the role skepticism plays among adolescents' online information literacy skills. Design/methodology/approach: The authors provide the conceptual grounding to operationalize and measure the notion of skepticism in an online information literacy context. Inspired by an existing measure known as the Skepticism Scale (Hurtt, 2010), the authors made substantial revisions to the scale to target middle school and high school students' skepticism in six distinct, but related factors: questioning mind; search for knowledge; suspension of judgment; self-esteem; interpersonal understanding; and autonomy. The authors provide preliminary evidence of validity and reliability of the revised Skepticism Scale using Exploratory Factor Analysis and performed multiple linear regression using the Skepticism Scale measures to predict an adolescents' online information literacy skills. Findings: The Skepticism Scale was found to produce internally consistent constructs for all six measures. Three of the six measures were related to online information literacy skills, including the search for knowledge, interpersonal understanding and questioning mind. Originality/value: This paper attempts to examine the potentially positive role of skepticism in information literacy skills among adolescents.