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Atherosclerosis (AS) is a chronic inflammatory disease that leads to the formation of atherosclerotic plaques in arterial walls, which can eventually result in cardiovascular diseases. It has been confirmed that the imbalance in the polarization of M1-type pro-inflammatory and M2-type anti-inflammatory macrophages in AS plaques is closely related to plaque instability and the development of cardiovascular diseases like AS-related heart and cerebrovascular diseases. Triptolide (TP) is a promising drug for the treatment of AS due to its anti-inflammatory and anti-proliferative effects. However, its poor solubility and lack of specificity limit its clinical application. We developed a targeted delivery system for TP to M1-type macrophages using mesoporous polydopamine (MPDA) nanospheres modified with the LyP-1 peptide. We then observed the performance of this targeted delivery system and explored its regulatory effects on macrophage polarization in AS. The results showed that the LYP-1-modified MPDA-TP delivery system had an average encapsulation rate of 66.5%, a drug loading capacity of 4.5%, and an average diameter of 250 nm. It exhibited excellent targeting ability and drug release rate towards target cells. LYP-MPDA-TP was capable of inhibiting the proportion of M1 macrophages induced by oxidized low-density lipoprotein stimulation in mouse macrophages, promoting apoptosis in M1-type macrophages significantly, and demonstrating a significant inhibitory effect on AS in experimental animals. The LYP-1 peptide-modified MPDA delivery system provides a new approach for TP treatment of AS and an important theoretical basis and methodological reference for the design of targeted delivery systems for anti-AS nanoparticles.

To provide new context-creation tools in architectural education to give students a full sense of immersion and presence. This paper discusses the integration of artificial intelligence and virtual reality technology in architectural education, and then the integration of artificial intelligence and virtual reality technology proposed architecture education virtual learning environment human-computer interaction system. Through the experimental study, in the application effect satisfaction analysis, the student satisfaction in the virtual reality learning environment in stimulating students’ learning interest is 80%, and 72% of the students agree to learn architectural expertise in the virtual reality learning environment.

Natural graphite is a new-technology mineral resource led by new mineral preparation and application technologies and an important raw material that supports the development of China’s strategic emerging industries. This paper analyzes the demand for high-quality development of graphite resources and the graphite material industry, summarizes the development status, unveiled development potentials and major challenges, and puts forward goals for next stage development. Furthermore, this paper proposes the following measures: (1) establishing a technology innovation system that focuses on the deep processing of graphite; (2) optimizing the allocation of resources and boosting the development of green graphite plants and mines; (3) strengthening the capacities of platforms to consolidate the technological innovation foundation for industrial and supply chains; and (4) focusing on breakthroughs in the xclusive application of graphene’s uniqu physical properties and avoiding excessive marketing. Additionally, it is necessary to set up a sophisticate database that covers the entire industrial and supply chains of graphite, establish a long-term policy mechanism that supports the high-quality development of China’s graphite industry, accelerate resource integration to construct an international graphite valley, and improve innovation platforms to enhance talent trainning.

This study was a retrospective analysis of the efficacy of thrombectomy plus local catheter-directed thrombolysis (CDT) for the treatment of lower extremity deep venous thrombosis (LDVT).

Based on the annual panel data of Beijing-Tianjin-Hebei area from 1985 to 2018, this paper established a Panel Vector Autoregressive Model, variance decomposition, and impulse response function analyzing the linkage effect between the transportation and regional economy. The conclusions are as follows: Beijing-Tianjin-Hebei transportation integration and regional economic integration development are mutually reinforcing, but the results of variance decomposition show that they have different pulling forces, and the latter is more effectively than the former. The impulse response analysis show that the development of railways has made greater contributions to regional economic development than highways. In summary, there is a close relationship between the transportation integration and regional economic integration in the Beijing- Tianjin-Hebei region. They promote and coordinate with each other, but how to strengthen the relationship between them to make the area develop faster, more further research is needed.

For the control of the robot arm of a medical delivery robot, firstly, the forward kinematic equations of this 7-degree-of-freedom redundant robot arm are constructed according to a modified D-H method. Secondly, the analytical solution of the inverse kinematics of the redundant robotic arm is solved using the parameterised arm angle. Thirdly, kinematic simulation experiments were carried out by gazebo and RVIZ in ROS to verify the correctness of the forward and inverse kinematic solution process. Finally, the Monte Carlo method was used to generate the point cloud map of the workspace of the redundant robotic arm within the allowed range of joints, and the boundary points of the workspace were extracted, and the extracted boundary points were fitted with least squares curves to find the workspace of the robotic arm, which laid the foundation for future research directions such as motion control and path planning of medical delivery robots.