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【Objective】 A pre-planting border irrigation in spring coupled with a drip irrigation in summer during crops growth season is an irrigation technique to reduce soil salinity and safeguard crops growth in the salt-affected soils in the Hetao Irrigation District in Inner Mongolia. This paper investigates the impact of different combinations of irrigation amounts in the dual irrigations on changes in soil water and salt, as well as the growth of sunflower. 【Method】 The field experiment compared two spring (S) irrigation amounts: 95 mm and 135 mm, and three summer (W) irrigation amounts: 68, 100 mm and 135 mm. In each treatment, we measured the spatiotemporal changes in soil water and salt, as well as crop growth characteristics. 【Result】 ① The soil water content in the S135W135 treatment was the highest among all treatments during the experimental period, with the average soil water content and saturation being 17.10% and 75.53%, respectively. The coefficient of variation of soil water content in the S95W135 treatment was 22.40%, the lowest among all treatments. ② Depending on the summer irrigation amount, the desalination rate of the 0-80 cm soil layer under S135 and S95 varied from 32.64% to 50.50% and 21.8% to 38.87%, respectively. Although the spring irrigation amounts did not significantly affect immediate post-irrigation salt content, the S135W100 and S95W135 combinations showed deeper leaching depths and higher desalination rates (40.77% and 33.37%, respectively) than other treatments. ③ Aboveground dry matter production was significantly higher in the S95W135 and S135W100 combinations than in other combinations, surpassing the S135W135 combination by 10.55% and 9.94%, respectively. The S135W100 combination achieved the highest water use efficiency at 21.59%, an increase of 13.03% compared to S135W135. 【Conclusion】 Reducing spring irrigation by 30% to 95 mm combined with a summer drip irrigation of 135 mm is the most efficient irrigation scheme for sunflower cultivation in the salt-affected soils in the Hetao Irrigation District.

Abstract Background None of the early M-Health applications are designed for case management care services. This study aims to describe the process of developing a M-health component for the case management model in breast cancer transitional care and to highlight methods for solving the common obstacles faced during the application of M-health nursing service. Methods We followed a four-step process: (a) Forming a cross-functional interdisciplinary development team containing two sub-teams, one for content development and the other for software development. (b) Applying self-management theory as the theoretical framework to develop the M-health application, using contextual analysis to gain a comprehensive understanding of the case management needs of oncology nursing specialists and the supportive care needs of out-of-hospital breast cancer patients. We validated the preliminary concepts of the framework and functionality of the M-health application through multiple interdisciplinary team discussions. (c) Adopting a multi-stage optimization strategy consisting of three progressive stages: screening, refining, and confirmation to develop and continually improve the WeChat mini-programs. (d) Following the user-centered principle throughout the development process and involving oncology nursing specialists and breast cancer patients at every stage. Results Through a continuous, iterative development process and rigorous testing, we have developed patient-end and nurse-end program for breast cancer case management. The patient-end program contains four functional modules: “Information”, “Interaction”, “Management”, and “My”, while the nurse-end program includes three functional modules: “Consultation”, “Management”, and “My”. The patient-end program scored 78.75 on the System Usability Scale and showed a 100% task passing rate, indicating that the programs were easy to use. Conclusions Based on the contextual analysis, multi-stage optimization strategy, and interdisciplinary team work, a WeChat mini-program has been developed tailored to the requirements of the nurses and patients. This approach leverages the expertise of professionals from multiple disciplines to create effective and evidence-based solutions that can improve patient outcomes and quality of care.

The standardized workflow of computer-aided static guided implant surgery includes preoperative examination, data acquisition, guide design, guide fabrication and surgery. Errors may occur at each step, leading to irreversible cumulative effects and thus impacting the accuracy of implant placement. However, clinicians tend to focus on factors causing errors in surgical operations, ignoring the possibility of irreversible errors in nonstandard guided surgery. Based on the clinical practice of domestic experts and research progress at home and abroad, this paper summarizes the sources of errors in guided implant surgery from the perspectives of preoperative inspection, data collection, guide designing and manufacturing and describes strategies to resolve errors so as to gain expert consensus. Consensus recommendation: 1. Preoperative considerations: the appropriate implant guide type should be selected according to the patient's oral condition before surgery, and a retaining screw-assisted support guide should be selected if necessary. 2. Data acquisition should be standardized as much as possible, including beam CT and extraoral scanning. CBCT performed with the patient’s head fixed and with a small field of view is recommended. For patients with metal prostheses inside the mouth, a registration marker guide should be used, and the ambient temperature and light of the external oral scanner should be reasonably controlled. 3. Optimization of computer-aided design: it is recommended to select a handle-guided planting system and a closed metal sleeve and to register images by overlapping markers. Properly designing the retaining screws, extending the support structure of the guide plate and increasing the length of the guide section are methods to feasibly reduce the incidence of surgical errors. 4. Improving computer-aided production: it is also crucial to set the best printing parameters according to different printing technologies and to choose the most appropriate postprocessing procedures.

ObjectiveTo investigate the current status of allergen labeling in prepackaged food products in China.MethodsA total of 986 prepackaged foods in 18 categories were from 26 provinces （autonomous regions， centrally administered municipalities） randomly selected from the nationwide market. The labeling type and accuracy were analyzed by collecting allergen labeling information and detecting allergens using ELISA.ResultsThe overall allergen labeling rate was 44.7% （441/986）. Except for eight types of allergens， sesame had the highest prevalence （20.6%； 91/441）. Primary allergens were present in 61.9% （273/441） of samples. Most allergens were labeled below the ingredient list （76.4%， 337/441） and almost all allergens were not highlighted （93.4%， 412/441）. Approximately 80.3% （290/361） of surveyed samples accurately used “milk” allergen labeling， with 13.0% （47/361） of surveyed samples containing hidden allergens. Moreover， 6.6% （24/361） of surveyed samples showed allergen over-labeling.ConclusionThe overall labeling of allergens in prepackaged food in China met the standard requirements. However， certain risks of hidden allergens and low accuracy of precautionary labeling were observed in certain products.

Objective To investigate the clinical efficacy and related adverse reactions of the combination of camrelizumab with anlotinib as the third-line therapy on advanced non-small cell lung cancer. Methods We retrospectively analyzed the clinical data of 84 patients with advanced non-small cell lung cancer after second-line treatment. According to different treatment methods, 44 patients who received camrelizumab combined with anlotinib were included in the observation group, and 40 patients who received anlotinib alone were included in the control group. The PFS, ORR, DCR and incidence of adverse reactions were analyzed and compared between the two groups. Results The median PFS of the observation group was longer than that of the control group (7.0 vs. 5.6 months, P=0.001). No statistically significant difference was observed in ORR, DCR, the incidence of adverse reactions or the incidence of adverse reactions above grade 3 between two groups (all P > 0.05). Conclusion The clinical efficacy of camrelizumab combined with anlotinib as third-line therapy on advanced non-small cell lung cancer is better than anlotinib alone, and the safety is good.

This study aims to elucidate the relationship between user demand and library virtual reference services, as well as to explore the development of such services across fifteen colleges and universities in China. Leveraging user research data, we established goals for virtual reference services. We introduced the VCRA-CP (Virtual Consultation Resource Allocation-Customer Profile) model for resource scheduling to better align with user needs. User clustering techniques were utilized to categorize users, and a hybrid push information service combining clustering service and collaborative filtering was adopted. This approach was further enhanced by integrating a “user-service evaluation model” to score and deliver services. The operational dynamics of the virtual reference consultation service were meticulously analyzed, particularly focusing on the real-time consulting function module. We proposed evaluating the effectiveness of virtual reference services based on three dimensions: consulting system performance, service impact, and information control. The evaluation metrics included average acceptance value, average perceived value, and average expected value from users. A critical finding concerning the “timeliness and accuracy of responses in virtual reference consultations” revealed a discrepancy, with the average perceived value minus the average acceptance value equaling −0.15, indicating a significant area for improvement in response timeliness and accuracy. User satisfaction was quantified at 65.86%, with a dissatisfaction rate of 6.93%. Although the overall satisfaction with the virtual reference consulting service was high, there remains a need to enhance the standardization of these services to better meet user expectations.

ObjectiveTo understand the concentration levels of benzene， toluene and xylene in the workplaces of enterprises involved in benzene and benzene series in Jinshan District， and to provide the basis for the government to formulate key occupational disease prevention and control strategies.MethodsFrom 2016 to 2021， enterprises involved in benzene and benzene series were sampled individually， and the monitoring results of benzene and benzene series were statistically analyzed through workplace air sampling and laboratory detection.ResultsFrom 2016 to 2021， a total of 80 enterprises were monitored， and the total passing rate of individual monitoring was 87.50%， which decreased first and then increased. The difference was not statistically significant. A total of 387 individuals were sampled with a total passing rate of 95.61% and a detection rate of 73.38% （284 individuals）. The detection rates of benzene， toluene and xylene were 6.46%， 29.97% and 36.95%， respectively. The exceedance rates were 1.03%， 0.26% and 3.10%， respectively. Among the companies exceeding the standard， the metal products industry had the highest rate of exceedance （19.05%）. For individuals， those working in the printing and recording media reproduction industry had the highest rate of exceedance （10.26%）.ConclusionThe passing rate and detection rate of benzene and benzene series are relatively high in Jinshan District. The metal products industry and the printing and recording media reproduction industry have a higher exceedance rate of benzene and benzene series.

Objective To investigate the etiology, clinical manifestations, treatment and prevention of jaw necrosis caused by arsenic trioxide to provide a reference for clinical diagnosis and treatment. Methods To analyze the clinical data and related literature of patients with jaw necrosis caused by acute promyelocytic leukemia treated with arsenic trioxide. Results We report a case of jaw necrosis caused by the use of arsenic trioxide (10 mg once a day for one month) during the treatment of acute promyelocytic leukemia. About 20 days after treatment, the patient developed right maxillary pain accompanied by gingival redness and swelling and mucosal ulcer, 14-17 teeth had buccal and palatal alveolar bone exposed, gingival mucosa was missing, gingival tissue was damaged to the bottom of vestibular groove, and palatal soft tissue was damaged to 5-8 mm of palatal suture. Due to the unstable condition of acute promyelocytic leukemia, the patient was given conservative treatment such as oral vitamin and Kangfuxin liquid gargle to keep his mouth clean. Drug induced jaw necrosis reported in the literature can be caused by bisphosphonates. Arsenic trioxide can also cause local jaw necrosis. Clinically, it is often manifested as long-term wound nonunion, pus, alveolar bone or jaw bone exposure, dead bone formation, accompanied by pain, loose teeth, facial swelling and other symptoms. Anti inflammation, debridement and surgical removal of dead bone are commonly used treatment methods. Conclusion In clinical practice, we should be alert to drug-induced jaw necrosis and strengthen prevention.

Fractional differential equations are one of the important contents of advanced mathematics courses. The article uses fractional differential equations to describe the effects of children’s innovative education courses. Through the qualitative analysis of the basic model, several conditions to ensure the effect of children’s innovative education courses are obtained. At the same time, combined with practical experience, the teaching curriculum case design analyzes the specific application of the fractional differential equation in the effect of children’s innovative education curriculum. Research has found that the fractional differential equation algorithm improves the efficiency of innovation.

This article studies point concentration phenomena of nonlinear Schrödinger equations with magnetic potentials and constant electric potentials. The existing results show that a common magnetic field has no effect on the locations of point concentrations, as long as the electric potential is not a constant. This article finds out the role of the magnetic fields in the locations of point concentrations when the electric potential is a constant.

【Objective】 Irrigation in Hetao Irrigation District relies on water diverted from the Yellow River, and it has a direct consequence for physicochemical properties of both soil and groundwater. The purpose of this paper is to study the impact of spring irrigation on depth and physicochemical properties of the groundwater. 【Method】 The experiment was conducted on a saline-alkali soil. We measured the changes in groundwater table, typical cation and anion ions, EC, pH, and other factors in the groundwater before and after the spring irrigation. The impacts of the irrigation on changes in groundwater depth and its physicochemical properties were analyzed using statistical methods. 【Result】 The irrigation increased the concentrations of TDS, Ca2+, K+ + Na+, SO42- and Cl-, especially K+ + Na+ + and Cl- which not only had the largest coefficient of variation but also varied most erratically over space. Along with rock weathering and evaporation crystallization, cation exchange was another factor that modulated the change in chemical composition of the groundwater. After the irrigation, chemical composition of the groundwater shifted from Na-Mg-Cl-SO4-HCO3 type and Na-Cl-SO4-HCO3 to Na-Cl-SO4 type. Depending on irrigation amount and region, it took 10~20 day for the groundwater to respond to the irrigation, with the groundwater table rising by 1.197~2.142 m at a daily rate 0.079 8~0.169 m/d. 【Conclusion】 Spring irrigation increased the average TDS content of grounded by 15.6%, indicating a salt leaching, but it also raised the groundwater table giving rise to soil salinity. Therefore, to alleviate soil salinization, spring irrigation amount should be reduced, and drainage system should be improved in the region.

Phlebitis is one of common complications of the intravenous infusion of fluids. This paper summarized the nursing experience of an acute cerebral infarction patient with phlebitis. In addition to the routine methods such as external application of potato slices and 50% magnesium sulfate wet dressing, the Comfeel hydrocolloid dressing was used to treat the phlebitis. Swelling and pain degree were measured. After 8 days after intervention with Comfeel hydrocolloid dressing, clinical symptoms of phlebitis disappeared and pain was relieved. The application of Comfeel hydrocolloid dressing is effective to relieve the irritation symptoms caused by phlebitis, it has advantages of easy-to-use, safe and being relatively painless. (静脉炎是经外周留置针穿刺常见的并发症。本研究总结1例急性脑梗死合并静脉炎患者的护理经验。在常规方法(土豆片、50%硫酸镁外敷)基础上, 给予康惠尔水胶体敷料治疗, 通过红肿面积、疼痛评分等评估护理效果。给予康惠尔水胶体敷料干预后8 d, 患者临床症状消失, 皮肤完好, 无疼痛。使用康惠尔水胶体敷料治疗静脉炎, 能改善血管的刺激症状, 具有操作简单、使用安全、无疼痛的优点。)

【Background】 The wide distribution of saline and alkali soils in Ordos of Inner Mongolia is a main abiotic factor hindering crop growth. Their remediation is a prerequisite for developing sustainable agriculture in this region. Subsurface drain is a technology widely used to alleviate salt accumulation and enhance salt leaching. 【Objective】 The objective of this paper is to experimentally study the effects of subsurface drain on salt dynamics in soils heavily affected by salinity and alkalinity. 【Method】 The experiment was conducted from May to October 2015 at Dalat Banner, with the drains spaced 18 m apart and buried in a depth varying from 1.2 m to 1.5 m; the depth of the drainage ditches was 1.8~2.0 m. In each treatment, we measured soil salt distribution up to 1.0 m deep, the change in groundwater table and salinity, as well as the quality of the irrigation water and drainage water, salt ion data and their relationship. 【Result】 ①Spatial variation of salt in the top 0~100 cm soil was moderate with a coefficient of variation of 25%~75%; the majority of salt was accumulated in regions proximal to the soil surface. ②The drains dropped the groundwater table by 50~60 cm and reduced soil salinity by approximately 10%, compared with data measured before experiment. ③At the end of the experiment, the main salt ions in the soil were K++Na+, SO42- and Cl-, while in the groundwater they were K++Na+, Cl- and HCO3-. ④Irrigating using the Yellow river water increased HCO3- in soil by 56% and the decreased of other salt ions, with SO42-, K++Na+ and Cl- reduced by 36%, 34% and 31% respectively. Leaching of the irrigation water increased ion contents in both drainage water and groundwater, especially the drainage water whose salinity was 3.43 times that of groundwater. 【Conclusion】 Subsurface drains can control the groundwater depth and reduce soil salt content; it facilitates leaching of SO42-, K++Na+ and Cl- from the soil. However, care should be taken to avoid an increase in HCO3- and its consequence for soil alkalization when irrigating with the Yellow river water.

Clathrin-mediated endocytosis is an essential cellular pathway that enables signaling and recycling of transmembrane proteins and lipids. During endocytosis, dozens of cytosolic proteins come together at the plasma membrane, assembling into a highly interconnected network that drives endocytic vesicle biogenesis. Recently, multiple groups have reported that early endocytic proteins form flexible condensates, which provide a platform for efficient assembly of endocytic vesicles. Given the importance of this network in the dynamics of endocytosis, how might cells regulate its stability? Many receptors and endocytic proteins are ubiquitylated, while early endocytic proteins such as Eps15 contain ubiquitin-interacting motifs. Therefore, we examined the influence of ubiquitin on the stability of the early endocytic protein network. In vitro, we found that recruitment of small amounts of polyubiquitin dramatically increased the stability of Eps15 condensates, suggesting that ubiquitylation could nucleate endocytic assemblies. In live-cell imaging experiments, a version of Eps15 that lacked the ubiquitin-interacting motif failed to rescue defects in endocytic initiation created by Eps15 knockout. Furthermore, fusion of Eps15 to a deubiquitylase enzyme destabilized nascent endocytic sites within minutes. In both in vitro and live-cell settings, dynamic exchange of Eps15 proteins, a measure of protein network stability, was decreased by Eps15-ubiquitin interactions and increased by loss of ubiquitin. These results collectively suggest that ubiquitylation drives assembly of the flexible protein network responsible for catalyzing endocytic events. More broadly, this work illustrates a biophysical mechanism by which ubiquitylated transmembrane proteins at the plasma membrane could regulate the efficiency of endocytic internalization.

With the continuous development of metal manufacturing technology, high-strength and high-hardness ductile iron materials have excellent comprehensive performance. Many performance indexes are comparable to those of alloy steels, and they have excellent casting properties. Many large-scale parts produced by cast steel are slowly being replaced by this material. Ductile iron is obtained by a spheroidizing treatment and inoculation to obtain spheroidal graphite. The mechanical properties of cast iron have been effectively improved, especially plasticity and toughness, and the strength obtained is higher than that of carbon steel. Ductile iron has the properties of iron and the properties of steel. It is a new type of engineering material with high plasticity, strength, corrosion resistance, and wear-resistance. Because of its excellent performance, it has been successfully used to cast parts with high-stress conditions, high strength, toughness and wear resistance. Due to the small splitting effect of ductile iron on the metal matrix, the stress concentration is effectively eliminated. Therefore, the matrix structure of ductile cast iron is changed by heat treatment, thereby improving its mechanical properties and the damping performance of the material itself. Through a heat treatment process experiment of ductile iron, the related process and technical measures of damping performance in the heat treatment production process are obtained.

The aim of this study was to investigate the clinical effects of insulin resistance (IR) in the development of mild cognitive impairment (MCI) in elderly adults with Type 2 diabetes mellitus (T2DM).

S-shaped test piece is used to assess the performance of five-axis numerical control machine tools. Compared to traditional test method and test pieces, it performs better and was agreed to be included in the draft international standard at the 79th ISO/TC39SC2 meeting. However, the lack of theoretical research is the barrier to apply for standard and to be widely used. Therefore, this paper aims to study one of the theoretical research that how to choose the suitable tool diameter. We proposed a new research method based on software AdvantEdge, Vector Method for error calculation, Microelement Model of cutting force and deformation model of cantilever beam. The simulation results show that the 20 ≤ diameter

Objective To investigate the mechanism of lutein on the proliferation and apoptosis of human prostate cancer PC3 cells, and to provide a new theoretical basis for the treatment and prevention of prostate cancer. Methods CCK8 assay was used to detect the proliferation of PC3 cells treated with different concentrations of lutein; flow cytometry was used to detect the changes of cell cycle distribution and apoptosis after 48 h; cell scratch (wound healing) and Transwell experiment was applied to observe cell migration and invasion; the mRNA and protein expression levels of Bcl-2 and Bax were detected by RT-PCR and Western blot. Results Lutein significantly inhibited the proliferation of PC3 cells in a time- and dose-dependent manner. Lutein could block the growth of PC3 cells in G0/G1 phase and inhibit cell migration and invasion; it could induce cell apoptosis, downregulate the expression of Bcl-2 and upregulate the expression of Bax. RT-PCR results showed that lutein could downregulate Bcl-2 mRNA expression and upregulate Bax mRNA expression in a dose-dependent manner. Conclusion Lutein could inhibit the proliferation and promote the apoptosis of human prostate cancer PC3 cells. The mechanism may be related to blocking cell cycle, inhibiting cell migration and invasion, as well as regulating apoptosis-related gene and protein expression.