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638 results on '"Wang Guang-Ming"'

1. Exploration of the main sites for the transformation of normal prion protein (PrPC) into pathogenic prion protein (PrPsc)

Author

Liu Xi-Lin, Feng Xiao-Li, Wang Guang-Ming, Gong Bin-Bin, Ahmad Waqas, Liu Nan-Nan, Zhang Yuan-Yuan, Yang Li, Ren Hong-Lin, and Cui Shu-Sen

Subjects
mice, brain, prion proteins, myelin sheath, particle aggregation, Veterinary medicine, SF600-1100
Abstract

Introduction: The functions and mechanisms of prion proteins (PrPC) are currently unknown, but most experts believe that deformed or pathogenic prion proteins (PrPSc) originate from PrPC, and that there may be plural main sites for the conversion of normal PrPC into PrPSc. In order to better understand the mechanism of PrPC transformation to PrPSc, the most important step is to determine the replacement or substitution site.

Published
2017
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48. Time-dependent creep and shrinkage analysis of curved steel–concrete composite box beams.

Author

Zhu, Li, Zhao, Guan-Yuan, Su, Ray Kai-Leung, Liu, Wei, and Wang, Guang-Ming

Subjects
BOX beams, COMPOSITE construction, STEEL-concrete composites, SHEAR (Mechanics), FINITE element method
Abstract

Curved steel–concrete composite box beams are widely used in urban overpasses and ramp bridges as they are light in weight, have large spanning ability and high torsional rigidity. One-dimensional models are generally used to analyze bridge performance due to their calculation and numerical efficiencies. An incremental step-by-step method based on the Kelvin rheological model together with a discrete algorithm in finite element space is adopted in this study to analyze the mechanical behavior of curved composite box beams. A model with a beam finite element with 26 degrees of freedom (DOFs) is proposed for curved composite box beams that considers the constrained torsion, distortion, shear lag, biaxial slip at the interface and time-dependent effects. Furthermore, the experimental results of the long-term loading tests of three curved composite box beams are selected to validate the proposed beam element model. Finally, the proposed model is applied to analyze the long-term behavior of a curved composite box beam that is used in real engineering applications. [ABSTRACT FROM AUTHOR]

Published
2023
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