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[Objective] To investigate the effects of long-term application of controlled-release urea on soil acidity, acid-base buffering capacity and fertility of northern calcareous tidal soils. [Methods] Based on a long-term field trial of positioning fertilization since 2008, two types of nitrogen fertilizers, blended controlled-release urea(CRF) and ordinary urea(BBF), and three levels of nitrogen application, namely, no nitrogen application (N 0 kg/hm2), constant nitrogen application (N 540 kg/hm2) and incremental nitrogen application (N 810 kg/hm2), were designed, and soil samples were collected from 0-80 cm during the ripening of the maize season of 2022 to determine the acid-base buffering capacity, soil calcium carbonate content and soil fertility of soil. Samples were collected from 0-80 cm soil at the maturity of the corn season in 2022 to determine the soil acid-base buffer capacity, soil calcium carbonate content and soil nutrients. [Results] (1) CRF slowed down the decline of soil buffer capacity and pH value caused by N application and alleviated the process of soil acidification. The buffer capacity of constant CRF and incremental CRF treatments increased by 5.22% and 11.17%, respectively, and the pH of constant CRF and incremental CRF treatments increased by 0.17 and 0.08 units, respectively, compared with that of constant BBF and incremental BBF. (2) CRF increased the soil cation exchange and exchangeable calcium and magnesium content and increased the active calcium carbonate content of the tillage soil, and the active calcium carbonate content of the constant CRF and incremental CRF treatments increased by 52.08% and 45.31% compared with that of the constant BBF and incremental BBF treatments. Meanwhile, CRF slowed down the loss of soil calcium carbonate content in deep soil layers. (3) CRF increased soil total nitrogen, organic matter, nitrate nitrogen and ammonium nitrogen content. [Conclusion] Long-term application of CRF alleviated soil acidification caused by nitrogen fertilizer application, increased soil active calcium carbonate content, and improved soil fertility.

Abstract Background Although bronchiectasis has been shown to be associated with cardiovascular disease, there is limited evidence of an association with subclinical atherosclerosis, especially carotid intima-media thickness (CIMT). Methods This prospective study compared CIMT among patients with and without bronchiectasis, and among bronchiectatic patients classified according to disease severity using the FACED score. The study was carried out at a major regional hospital and tertiary respiratory referral centre in Hong Kong. Results Total 155 Chinese patients with non-cystic fibrosis (CF) bronchiectasis and 512 controls were recruited. The mean CIMT was 0.58 ± 0.10 mm, 0.63 ± 0.11 mm and 0.66 ± 0.08 mm respectively among controls, patients with mild-to-moderate bronchiectasis and patients with severe bronchiectasis. There was no statistically significant difference in CIMT between patients with mild-to-moderate bronchiectasis and controls. Multivariate linear regression revealed that CIMT was significantly increased in patients with severe bronchiectasis relative to controls. The same phenomenon was observed among patients without a history of cardiovascular disease or cardiovascular risk factors. Conclusions CIMT was significantly increased in patients with severe bronchiectasis compared with controls without bronchiectasis, but not among patients with mild-to-moderate bronchiectasis, which suggested the subclinical atherosclerosis to be more prevalent among patients with severe bronchiectasis.

Objective To focus on the efficacy at variable frequency stimulation (VFS) after deep brain stimulation (DBS) for the treatment of axial symptoms in Parkinson's disease (PD). Methods Clinical data of 12 patients with PD who underwent bilateral DBS followed by VFS more than one year from January 2018 to June 2022 at Tianjin Huanhu Hospital, Tianjin University were retrospectively analyzed. Axial symptoms were assessed using Unified Parkinson's Disease Rating Scale (UPDRS)-gait posture, Timed Up and Go Test (TUGT) time and the occurrence of freezing of gait (FOG), The Freezing of Gait - Questionnaire (FOG - Q), and Berg Balance Scale (BBS). The above indicators were recorded one week before DBS surgery and in the drug "off" period (baseline), at the end of high frequency stimulation (the end of HFS), at one month follow-up of VFS (short-term VFS), and at one year or more follow-up of VFS (long-term VFS). Results Compared with baseline, BBS scores increased at the end of HFS (t = - 2.845, P = 0.008); UPDRS-gait posture (t = 12.703, P = 0.000; t = 11.737, P = 0.000), TUGT time (t = 8.923, P = 0.000; t = 8.025, P = 0.000) and the occurrence of FOG (t = 4.448, P = 0.000; t = 4.181, P = 0.000), and FOGQ scores (t = 9.186, P = 0.000; t = 8.186, P = 0.000) decreased, while the BBS scores increased (t = - 7.686, P = 0.000; t = - 6.106, P = 0.000) in both short-term VFS and long-term VFS. Compared with the end of HFS, UPDRS-gait posture (t = 11.583, P = 0.000; t = 10.618, P = 0.000), TUGT time (t = 6.922, P = 0.000; t = 6.022, P = 0.000) and the occurrence of FOG (t = 3.612, P = 0.001; t = 3.344, P = 0.002), and FOG-Q scores (t = 7.915, P = 0.000; t = 6.915, P = 0.000) decreased, while the BBS scores increased (t = - 4.842, P = 0.000; t = - 3.262, P = 0.003) in short-term VFS and long-term VFS. Conclusions For PD patients with HFS but poor axial symptoms efficacy after DBS, the use of VFS significantly improves multifaceted axial symptoms with reliable long-term efficacy.

Abstract While studies have suggested increased risks of severe COVID-19 infection in chronic obstructive pulmonary disease (COPD), the persistent and delayed consequences of COVID-19 infection on patients with COPD upon recovery remain unknown. A prospective clinical study was conducted in Hong Kong to investigate the persistent and delayed outcomes of patients with COPD who had COVID-19 infection of different severity (mild-moderate COVID-19 and severe COVID-19), compared with those who did not. Chinese patients with COPD ≥ 40 years old were recruited from March to September 2021. They were prospectively followed up for 24.9 ± 5.0 months until 31st August 2023. The primary outcome was the deterioration in COPD control defined as the change in mMRC dyspnea scale. The secondary outcomes included the change in exacerbation frequency and non-COVID-19 respiratory mortality (including death from COPD exacerbation or bacterial pneumonia). 328 patients were included in the analysis. Patients with mild-moderate and severe COVID-19 infection had statistically significant increased risks of worsening of mMRC dyspnoea scale by increase in 1 score from baseline to follow-up with adjusted odds ratios of 4.44 (95% CI = 1.95–10.15, p

Background Bronchiectasis is a disease with predominantly neutrophilic inflammation. As a readily available biomarker, there is little evidence to support the use of blood neutrophil-to-lymphocyte ratio (NLR) to predict bronchiectasis exacerbation severe enough to warrant hospitalization.Methods A registry-based retrospective cohort study was conducted at a in Hong Kong. Chinese patients with non-cystic fibrosis (CF) bronchiectasis were retrospectively reviewed and subsequently followed up to investigate the association of NLR and the need for hospitalization for bronchiectasis exacerbation. Data on the NLR for patients in a clinically stable state in 2018 were collected and patients followed up from 1 January 2019 to 31 December 2022. The primary outcome was the need for hospitalization due to bronchiectasis exacerbation over the next 4 years.Results We reviewed 473 Chinese patients with non-CF bronchiectasis, of whom 94 required hospitalization for bronchiectasis exacerbation during the 4-year follow-up period. Multi-variable logistic regression adjusted for E-FACED score (Exacerbation, Forced expiratory volume in 1 s (FEV1), Age, Chronic colonization, Extension, and Dyspnea score), gender, age, smoking status, and presence of co-existing chronic obstructive pulmonary disease (COPD) was conducted to compare patients with highest and lowest quartile NLR. Results revealed that those with NLR at the highest quartile were at increased risk of hospitalization for bronchiectasis exacerbation with an adjusted odds ratio (aOR) of 2.02 (95% confidence interval = 1.00–4.12, p = 0.05).Conclusion Blood NLR may serve as a marker to predict the need for hospitalization due to bronchiectasis exacerbation.

Background Although bronchiectasis is reported to be associated with cardiovascular disease, evidence for an association with cardiovascular events (CVEs) is lacking.Methods A territory-wide retrospective cohort study was conducted in Hong Kong involving all patients who had bronchiectasis diagnosed in public hospitals and clinics between 1 January 1993 and 31 December 2017 were included. Patients were allocated to be exacerbator or non-exacerbator group based on hospitalzied bronchiecsis history and CVEs over the next 5 years determined. Propensity score matching was used to balance baseline characteristics.Results 10 714 bronchiectasis patients (mean age 69.6±14.4 years, 38.9% men), including 1230 in exacerbator group and 9484 in non-exacerbator group, were analysed. At 5 years, 113 (9.2%) subjects in the exacerbator group and 87 (7.1%) in the non-exacerbator group developed composite CVEs. After adjustment for age, sex, smoking and risk factors for cardiovascular disease, bronchiectasis exacerbation was associated with increased risks for acute myocardial infarction (AMI), congestive heart failure (CHF) and CVE compared with those in the non-exacerbator group with adjusted HR of 1.602 (95% CI 1.006–2.552, p value=0.047), 1.371 (95% CI 1.016–1.851, p value=0.039) and 1.238 (95% CI 1.001–1.532, p=0.049) in the whole cohort. Findings were similar for the propensity score-matched cohort for AMI and CVE.Conclusion Patients who were hospitalised for exacerbation of bronchiectasis were at significantly increased risk of AMI, CHF and CVE over a 5-year follow-up period.

The alkaline process of spent nuclear fuel(SNF) reprocessing refers to reprocessing methods that use the alkaline solution of carbonates or hydroxides as the media to conduct the dissolution of SNF and subsequent separations of uranium, plutonium and other elements. Most of the fission products and minor actinides are either insoluble or changed to insoluble carbonates or hydroxides during the alkaline dissolution of SNF, indicating that the resulted dissolver solution contains less amount of fission and minor actinide elements. Thus, the solution is less radioactive and less corrosive in contrast to the acidic dissolver solution of commercial PUREX(plutonium uranium redox extraction) process. Due to advantages of the alkaline process and its important potential application in SNF reprocessing, researchers from Japan, Russia, the United States, South Korea, etc. have carried out some research work around this reprocessing method. This paper will review technical routes of the alkaline process proposed by these researchers and research progress related to the main processes such as oxidation dissolution of SNF, separation technologies and recovery of used reagents. The challenges and prospects in this field are also discussed.

Abstract Background Elevation of systemic inflammatory markers were found to correlate with increased disease extent, reduced lung function and higher risk of future severe exacerbations in patients with bronchiectasis. Although a significant correlation of circulating hs-CRP levels with HRCT scores and resting oxygen saturation in patients with stable-state non-cystic fibrosis (CF) bronchiectasis was suggested, there is little data on the relationship between hs-CRP and the prognosis of bronchiectasis and a lack of data on the role of hs-CRP in predicting bronchiectasis exacerbation. Methods A prospective study was conducted on Chinese patients with non- CF bronchiectasis from 1st October to 31st December 2021. Baseline serum hs-CRP were obtained at stable-state. The follow-up period lasted for one year. Co-primary endpoints were the development of any bronchiectasis exacerbation and hospitalized bronchiectasis exacerbation. Results Totally 123 patients were included. Higher hs-CRP was associated with increased risk to develop any bronchiectasis exacerbation, adjusted odds ratio (aOR) of 2.254 (95% CI = 1.040–4.885, p = 0.039), and borderline significantly increased hospitalized bronchiectasis exacerbation with aOR of 1.985 (95% CI = 0.922–4.277, p = 0.080). Conclusion Baseline serum hs-CRP level at stable-state can predict risk of bronchiectasis exacerbation, which is reflecting chronic low-grade inflammation in bronchiectasis.

Abstract Introduction Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common and preventable event in patients with chronic obstructive pulmonary disease (COPD). Data regarding the impact of AECOPD on short- and long-term renal outcomes are lacking. Methods We included all COPD patients who were followed at Queen Mary Hospital (QMH) in year 2015 and reviewed their clinical/renal outcomes in subsequent five years. Relationships between AECOPD and adverse renal outcomes were evaluated. Results 371 COPD patients were included. 169 patients had hospitalized AECOPD in past one year (HAE group) while 202 patients did not (non-HAE group). 285 patients (76.8%) had renal progression/death and 102 (27.5%) patients developed acute kidney injury (AKI). HAE group showed a more rapid eGFR decline than non-HAE group (-4.64 mL/min/1.73m2/year vs. -2.40 mL/min/1.73m2/year, p = 0.025). HAE group had significantly higher risk for renal progression/death at 5 years [adjusted OR (aOR) 2.380 (95% CI = 1.144–4.954), p = 0.020]. The frequency of hospitalized AECOPD in past 3 years, any AECOPD in past 3 years, hospitalized AECOPD in past 3 years were also predictive of renal progression/death at 5 years [aOR were 1.176 (95% CI = 1.038– 1.331), 2.998 (95% CI = 1.438–6.250) and 2.887 (95% CI = 1.409–5.917) respectively; p = 0.011, 0.003 and 0.004]. HAE group also showed significantly higher risk of AKI [adjusted HR (aHR) 2.430; 95% CI = 1.306–4.519, p = 0.005]. Conclusions AECOPD, in particular HAE, was associated with increased risk of renal progression/death and AKI. Prevention of AECOPD, especially HAE, may potentially improve short- and long-term renal outcomes in COPD patients.

The activation of hepatic stellate cells (HSCs) is regarded as the primary driving factor of liver fibrosis. miR-192, a miRNA associated with hepatocellular carcinoma and enriched in HSCs, has an undisclosed role in HSC activation and liver fibrosis. In this study, a CCl4-induced rat liver fibrosis model and transforming growth factor-beta 1 (TGF-β1)-treated HSC lines (LX-2 and HSC-T6) were used to detect miR-192 and Rictor levels in vivo and in vitro. Bioinformatic analysis and a dual luciferase assay were used to predict and confirm the interaction of Rictor with miR-192. Gain- and/or loss-of-function methods evaluated molecular changes and HSC activation phenotypes, detected by quantitative real-time PCR, western blotting, and immunofluorescence. We observed a gradual downregulation of miR-192 and upregulation of Rictor during CCl4-induced liver fibrosis/cirrhosis in rats. Enriched miR-192 was downregulated, while Rictor was upregulated in TGF-β1-activated HSCs. miR-192 inhibited the activation of HSCs by directly targeting Rictor. High miR-192/low Rictor expression attenuated the fibrotic-related gene expression by AKT/mTORC2 signaling. In conclusion, miR-192 could inhibit the activation of HSCs by directly targeting Rictor in the AKT/mTORC2 signaling pathway. This study provides insights into potential therapeutic targets for liver fibrosis and cirrhosis.

Clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated protein (Cas)-mediated genome editing has greatly accelerated progress in plant genetic research and agricultural breeding by enabling targeted genomic modifications. Moreover, the prime editing system, derived from the CRISPR/Cas system, has opened the door for even more precise genome editing. Prime editing has the capability to facilitate all 12 types of base-to-base conversions, as well as desired insertions or deletions of fragments, without inducing double-strand breaks and requiring donor DNA templet. In a short time, prime editing has been rapidly verified as functional in various plants, and can be used in plant genome functional analysis as well as precision breeding of crops. In this review, we summarize the emergence and development of prime editing, highlight recent advances in improving its efficiency in plants, introduce the current applications of prime editing in plants, and look forward to future prospects for utilizing prime editing in genetic improvement and precision molecular breeding.

Objective: The study aimed to research the physicochemical properties, structure, antioxidant activity and hypoglycemic activity of different fractions of polysaccharide of goldenmelon. Methods: Four kinds of goldenmelon polysaccharides (CP-40, CP-60, CP-70, CP-80) were obtained by graded purification of water extraction and alcoholic precipitation. Their molecular weight, monosaccharide composition, group composition, antioxidant and hypoglycemic activities were investigated by high performance liquid chromatography and fourier transform infrared spectroscopy. Results: With the increase of ethanol volume fraction, the total sugar content increased and the glucuronic acid content decreased. The molecular weights of these four polysaccharides were different, which indicated by the same composition of monosaccharides but different composition ratios, and they all had the characteristic absorption peaks of polysaccharides. The antioxidant capacity and hypoglycemic activity of the polysaccharides in vitro had obvious quantity-effect relationships, CP-70 had the strongest antioxidant effect on DPPH radicals, hydroxyl radicals and superoxide anions scavenging than other groups, while CP-80 had the best hypoglycemic activity since it had the strongest inhibitory effects on α-glucosidase and α-amylase. Conclusion: The polysaccharide of goldenmelon had good antioxidant properties and hypoglycemic activity.

【Objective】 Saline water has been used as a supplementary irrigation resource in most countries to sustain agricultural production. The purpose of this paper is to study the influence of ionic composition in saline water on soil properties and growth of corn under mulched drip irrigation. 【Method】 The field experiment was conducted from April to September 2021 in the Hetao Irrigation District (HID) in Inner Mongolia. The saline water was created by adding different chloride salts: NaCl (T1), KCl (T2), CaCl2 (T3) and MgCl2 (T4) to fresh water. Irrigation with fresh underground water served as the control (CK). During each treatment, change in soil structure, transport of water and salt in soil, and crop growth were measured. 【Result】 ① Compared to CK, T1 significantly increased the number of small pores in the top 0~20 cm soil layer. This had a detrimental impact on soil structure but increased its water storage, particularly during the jointing stage. Compared to CK, T3 and T4 reduced the small porosity by 147.73% and 132.01%, respectively, but increased permeability of the soil. ② Compared to CK, all treatments increased the concentrations of Na+, K+, Ca2+ and Mg2+ in the 0~60 cm soil layer. Except T1, other treatments increased the concentrations of K+, Ca2+, and Mg2+, compared to CK. T1 resulted in salt accumulation in the soil surface, while other treatments did not show noticeable impact on ion composition. It was found that T3 and T4 moved the salt out the zone controlled by the mulch in the lateral direction, particularly T4. The electrical conductivity (EC) of the saturated extract from the root zone soil was influenced by the EC of irrigation water and varied in the range of 3~4 dS/m. ③ Na+ and K+ contents were the lowest and highest in the aboveground part, respectively. Na+, K+, and Cl- contents were higher in leaves than in stems, while Ca2+ and Mg2+ contents were higher in stem than in leaves. Increasing irrigation amount enhanced crop yield only in some treatments. Among all treatments, T4 gave the highest corn seed yield, 17.33% more than CK. 【Conclusion】 Irrigation with saline water containing high Na+ increased the small porosity of the topsoil, affecting soil water infiltration. In contrast, increasing K+, Ca2+, and Mg2+ contents reduced small porosity, promoting salt leaching due to the increased soil permeability. Keeping concentration of K+, Ca2+ and Mg2+ at appropriate levels under saline water irrigation is beneficial to increasing dry matter accumulation and the final yield, as it offsets the negative effects of excessive Na+. These findings provide guidance for safe utilization of saline water for irrigation in HID.

A novel homogenous braid-reinforced (HBR) poly (p-phenylene terephthamide) (PPTA) hollow fiber membrane was prepared in this study. The effects of PPTA concentration on the morphologies and properties of the membranes were further investigated. The results showed that when the PPTA concentration was 2.0 wt%, the cross-sectional morphology of satisfactory interfacial bonding was achieved and the permeation was still maintained at about 200 (L·m−2·h−1) after ultrasonic vibration. In addition, the tensile force exceeded 600 N, which indicated that the homogeneous effect effectively improved the poor mechanical properties and interfacial bonding. In addition, the HBR PPTA hollow fiber membranes were applied to simulate the membrane bioreactor system to explore the control factors of membrane fouling. The results demonstrated that the average removal of total phosphorus and NH4 +–N was above 49% and 96%, respectively; meanwhile, the operating time was up to 120 days. Furthermore, it was easier to nearly remove the pollutants by chemical cleaning.

The researches on the diffusion of key nuclide Se in Beishan granite, which is the pre-selected surrounding rock of China’s high-level radioactive waste geological repository, were summarized, including research methods, relevant data obtained and work to be carried out. Moreover, the influence of temperature on the diffusion of 75Se(Ⅳ) in Beishan granite and the possible influence mechanism were analyzed emphatically, in order to provide useful references for domestic peers.

Abstract Introduction The role of inhaled corticosteroid (ICS) among patients with bronchiectasis remains controversial. There is limited evidence of using baseline eosinophil count (absolute and percentage) as a marker to predict the role of ICS among patients with bronchiectasis. Methods A retrospective case–control study was conducted in a major regional hospital and tertiary respiratory referral centre in Hong Kong, including 140 Chinese patients with noncystic fibrosis (CF) bronchiectasis, to investigate the exacerbation risks of bronchiectasis among ICS users and nonusers with different baseline eosinophil counts. Results ICS user had significantly lower risk to develop bronchiectasis exacerbation with adjusted odds ratio (OR) of 0.461 (95% confidence interval [CI] 0.225–0.945, p‐value 0.035). Univariate logistic regression was performed for different cut‐offs of blood eosinophil count (by percentage) from 2% to 4% (with a 0.5% grid each time). Baseline eosinophil 3.5% was found to be the best cut‐off among all with adjusted OR of 0.138 (95% CI = 0.023–0.822, p‐value = 0.030). Conclusion Baseline eosinophil count of 3.5% might serve as a marker to predict the benefits of ICS on exacerbation risk among patients with non‐CF bronchiectasis.

This study attempted to identify exosomal circular RNAs (circRNAs) as diagnostic and prognostic biomarkers for patients with ST-segment elevation myocardial infarction (STEMI). The differentially expressed exosomal circRNAs (DEECs) were screened from microarray dataset (GSE160717 and GSE197137) and RNA-Seq dataset (GSE208194), and the expression levels of DEECs in patients with STEMI were validated using reverse transcription and quantitative real-time PCR. The diagnostic value of DEECs was assessed using receiver operating characteristic curves. The major adverse cardiovascular event (MACE)-free 1-year survival rate was evaluated using the Kaplan–Meier method, and the factors affecting prognosis were determined using Cox regression model analysis. Results showed that four DEECs were screened including exo-circ-0001490, exo-circ-0020887, exo-circ-0009590, and exo-circ-0055440, and only upregulated exo-circ-0020887 and exo-circ-0009590 expression was validated in patients with STEMI. The exo-circ-0020887 and exo-circ-0009590 expression was positively correlated with hs-CRP, LDL-C, cTnI, and CK-MB. The exo-circ-0020887 and exo-circ-0009590 showed good diagnostic efficacy to distinguish STEMI patients from healthy controls (area under the curves: 0.85 and 0.80). STEMI patients with high levels of exo-circ-0020887 and exo-circ-0009590 had lower MACE-free 1-year survival rate, and exo-circ-0020887 and exo-circ-0009590 expression was independent risk factors for adverse prognosis. In summary, upregulation of plasma exo-circ-0020887 and exo-circ-0009590 might act as potential biomarkers for the diagnosis and prediction of short-term adverse cardiovascular outcomes in patients with STEMI.

The rheumatoid arthritis can contribute to high rate of teratogenicity and disability, which is an internationally recognized major refractory disease. Starting from the current domestic research status, this paper reviewed the studies on effect of paralysis-relieving exercise on the function of the affected limbs in patients with rheumatoid arthritis from five perspectives including biomechanics, Traditional Chinese Medicine five major organs theory, exercise physiology, rehabilitation medicine and sports medicine, and provided reference for expanding treatment options for rheumatoid arthritis. (类风湿关节炎(RA)致畸和致残率高, 是国际公认的重大难治性疾病。本文从目前国内研究现状出发, 从生物力学、中医五脏角度、运动生理、康复医学和运动医学五个维度总结通痹操对RA患者患肢功能的影响, 旨在为进一步拓展RA治疗方案提供参考。)

Abstract Background While there are postulations that asthma is potentially associated with severe coronavirus disease 2019 (COVID-19), there has been conflicting results from studies on the impact mild-to-moderate COVID-19 on asthma control after recovery. Methods A case control study on the association between mild-to-moderate COVID-19 and asthma control post infection was conducted. The primary outcome was a reduction in Asthma Control Test (ACT) score by ≥ 3 points post-COVID infection. The secondary outcomes included the change in ACT score, the proportion of patient with ACT score who dropped to ≤ 15 on enrolment visit and the need for escalation of asthma maintenance therapy. Results Out of the total of 221 adult patients with asthma recruited, 111 had mild-to-moderate COVID-19 within 30 to 270 days prior to study enrolment. The adjusted odds ratio (aOR) for a reduction in ACT score by ≥ 3 points after COVID-19 was 3.105 (95% CI = 1.385–6.959, p = 0.006). The odds of escalation of asthma maintenance therapy by at least 1 Global Initiative for Asthma (GINA) step was 4.733 (95% CI = 1.151–19.467, p = 0.031) and asthma patient are more likely to become uncontrolled after COVID-19 [aOR = 5.509 (95% CI = 1.061–28.600, p = 0.042)]. Conclusion Mild-to-moderate COVID-19 among asthma patients, upon recovery, was associated with worsening of asthma symptom, lower ACT score, a higher need for escalation of asthma maintenance therapy and more uncontrolled asthma.

Gastric cancer is a commonly diagnosed form of cancer, and cisplatin is commonly used as a chemotherapy drug for treating it. However, the side effects of cisplatin may reduce patients’ willingness to use it. Seselin, a derivative of coumarin, has been found to have anticancer properties as well as anticoagulant effects. In this study, we investigated the effect of seselin on promoting cisplatin-induced gastric cancer cell death using the cell proliferation reagent WST-1, BrdU incorporation and lactate dehydrogenase release. The role of seselin and cisplatin in the apoptosis of gastric cancer cells was analyzed using a phospho-kinase array and Western blot analysis. Seselin did not affect G2/M stasis, but it promoted cell death in AGS cells treated with cisplatin. Phospho-kinase array analysis revealed that cisplatin regulates intracellular p53 phosphorylation, while seselin regulates intracellular β-catenin expression by affecting the phosphorylation of glycogen synthase kinase-3 beta (GSK-3β), extracellular-signal-regulated kinase (ERK) and Src tyrosine kinase. Seselin and cisplatin promote the apoptosis of gastric cancer cells by the synergistic effect of two distinct signaling pathways. These findings suggest that seselin may be used as a complementary therapy to reduce the clinical dose of chemotherapy.

Fibrotic remodelling contributes to heart failure in myocardial infarction. MicroRNAs (miRNAs) play a crucial role in myocardial fibrosis. However, current antifibrotic therapeutic strategies using miRNAs are far from effective. In this study, we aim to investigate the effect of miR-96-5p on cardiac fibrosis. Our work reveals a significant upregulation of miR-96-5p level in the ventricular tissues of myocardial infarction mice, as well as in neonatal rat cardiac fibroblasts stimulated with TGF-β or Ang II as shown by qPCR assay. In myocardial infarction mice, miR-96-5p knockdown using antagomir alleviates the aggravated cardiac fibrosis and exacerbated myocardial function caused by myocardial infarction surgery as shown by the echocardiography and Masson’s staining analysis. In contrast, immunofluorescence staining results reveal that miR-96-5p overexpression in neonatal rat cardiac fibroblasts contributes to an increase in the expressions of fibrosis-associated genes and promotes the proliferation and differentiation of cardiac fibroblasts. Conversely, miR-96-5p downregulation using inhibitor presents adverse consequences. Furthermore, Smad7 expression is downregulated in fibrotic cardiac tissues, and the Smad7 gene is identified as a direct target of miR-96-5p by dual luciferase assay. Indeed, Smad7 knockdown weakens the anti-fibrotic effect of the miR-96-5p inhibitor on cardiac fibroblasts. Moreover, Smad3 phosphorylation is elevated in fibrotic cardiac tissues, and interestingly, the Smad3 inhibitor suppresses the profibrotic effect of the miR-96-5p mimic. Taken together, our findings demonstrate that the Smad7/Smad3 signaling pathway mediates the profibrotic effect of miR-96-5p in cardiac fibrosis.

Preventing the penetration of water while allowing it to pass through quickly is the key to achieving waterproof and breathable membranes; it opens up new possibilities for applications in all areas. Herein a novel functional nanofibrous membrane can be prepared via a facile electrospinning strategy, thermal post-treatment and chemical cross-linking, capable of providing excellent mechanical performance. Low-melting-point polyvinyl butyral (PVB) elastomer are added to polyvinylidene fluoride (PVDF) to modify the bonding network structure of the interfiber-adherent membrane, imparting durability and high mechanical properties to the membrane. Subsequently, the blocked isocyanate prepolymer (BIP) is used as the chemical cross-linker with PVDF and polyvinyl butyral (PVB) hybrid system to strengthen the cross-linking structure. Through systematically characterize the morphologies, contact angle, water vapor transmittance rate (WVTR) and hydrostatic pressure, it is studied that the effect of concentrate of PVDF/PVB/BIP and thermal-induced temperature on the waterproofness and breathability. The results indicate that the prepared nanofibrous membranes can maintain highly hydrostatic pressure (93.27kPa) and high WVTR (10.28 kg m−2 d−1); meanwhile, the membranes exhibit the excellent tensile stress (13.07MPa), indicating that it has a broad potential application prospect in the separation process and protective clothing.

C22H19ClF3N3O2, triclinic, P1‾$P\overline{1}$ (no. 2), a = 9.8138(7) Å, b = 10.9739(7) Å, c = 11.6878(9) Å, α = 62.633(7)°, β = 67.095(7)°, γ = 68.817(6)°, V = 1003.78(14) Å3, Z = 2, Rgt(F) = 0.0454, wRref(F2) = 0.1158, T = 293 K.

Abstract Accessibility of diagnostic screening and treatment monitoring devices for respiratory diseases is critical in promoting healthcare and reducing sudden complications and mortality. Spirometry is the standard for diagnosing and monitoring several lung diseases. However, it lacks regional assessment capabilities necessary for detecting subtle regional changes in certain diseases. It also requires challenging breathing maneuvers difficult for elderlies, children, and diseased patients. Here, we actualized an affordable, portable, and self-administrable electrical impedance tomography (EIT) system for home-based lung function assessment and telemedicine. Through simultaneous EIT-spirometry trials on healthy subjects, we demonstrated that our device can predict spirometry indicators over a wide range and can provide regional mapping of these indicators. We further developed a close-to-effortless breathing paradigm and tested it by longitudinally monitoring a COVID-19 discharged subject and two healthy controls with results suggesting the paradigm can detect initial deterioration followed by recovery. Overall, the EIT system can be widely applicable for lung function screening and monitoring both at homes and clinics.

Objective: This study focuses on solving the problems of large memory consumption, low recognition accuracy and slow recognition speed in the classification process of peanut quality. Methods: A method for classification of peanut quality based on deep learning and image processing was proposed. The Coordinate Attention module was firstly introduced to encode the obtained feature graph into a pair of direction-aware and position-sensitive attention graph, which improved the ability to obtain the information of the region of interest of the graph. Then, Gradient Centralization was used to improve the optimizer. By modifying the parameters of the last fire layer and the convolution layer. An improved model, CG-SqueezeNet, was applied to peanut pod quality grading. Results: The classical convolutional network models VGG16, AlexNet, DenseNet121, ResNet50, Squeezenet were improved, and five different base classifier models were trained by transfer learning. By comparing with the classic model, it was found that the CG-SqueezeNet model could better learn the features of the region of interest in the image. The detection accuracy of the actual peanut pod image database was 97.83%, and the parameter memory was only 2.52 MB. Conclusion: The method is suitable for deployment on embedded resource-limited devices such as mobile terminals, which helps to realize real-time and accurate identification of peanut pod quality.

This paper introduced the origin of wax therapy technology and its clinical application in cervical spondylosis, osteoarthritis, gynecological diseases, skin diseases, nervous system and digestive system diseases. The clinical application status of wax therapy is summarized as follows, in order to provide more ideas and basis for clinical research. (本文总结了蜡疗技术的起源以及蜡疗技术在颈椎病、骨关节炎、妇科病、皮肤类疾病、神经系统、消化系统疾病中的临床应用, 以期为临床进一步完善蜡疗操作规范提供更多的思路与依据。)

We report a case of pathologically confirmed ALK-rearranged metastatic lung adenocarcinoma with emergence of EGFR L858R mutation on disease progression after two lines of treatment with ALK inhibitors. At initial diagnosis, tumoral ALK expression was detected without EGFR mutation by standard allele-specific polymerase chain reaction. There was sustained partial response to both first-line crizotinib and subsequent brigatinib. On disease progression to brigatinib, result of a liquid biopsy with circulating tumor DNA revealed only EGFR L858R, which was confirmed by tumor rebiopsy on the supraclavicular lymph node. The patient was then treated initially with pemetrexed and carboplatin, and erlotinib was subsequently added after two cycles of chemotherapy. The combination treatment has resulted in very good partial response and mild adverse effects. The overall clinical course would suggest the initial presence of two separate tumor clones, with ALK dominance at diagnosis. The subsequent breakthrough disease progression after initial response to brigatinib was related to uncontrolled growth of the EGFR-mutated tumor subpopulation. The implication on defining molecular mechanism of acquired resistance and treatment strategy would be discussed.

The interplay between the chiral anomaly and the strong magnetic or vortical fields created in noncentral heavy-ion collisions can lead to various anomalous chiral effects in the quark–gluon plasma, including the chiral magnetic effect (CME), the chiral magnetic wave (CMW), and the chiral vortical effect (CVE). In this proceeding, recent ALICE measurements of these effects are summarized. Utilizing Event Shape Engineering, fractions of CME and CMW signals extracted in Pb–Pb collisions at √SNN = 5.02 TeV are consistent with zero within uncertainties. The CVE is studied using azimuthal correlations between baryon pair Λ–p with Λ–h and h–h as reference. These measurements provide new insights into the experimental search for anomalous chiral effects in heavy-ion collisions.

Based on the theory of Traditional Chinese medicine, the five-element music therapy uses the ancient Chinese five-tone scale, including Gong(do), Shang(rei), Jiao(mi), Zi(sou) and Yu(la), to regulate the five internal organs, so as to regulate Qi and blood, relieve emotional and mental stress and eliminate diseases. At present, five-element music has been widely used, which can play a good effect on pain, anxiety, insomnia and other symptoms. This paper summarized the clinical application of Traditional Chinese Medicine five-element music, in order to provide reference for the further research and clinical practice. (中医五行音乐疗法以中医学理论为基础, 运用“宫、商、角、徵、羽”五个声阶来调节五脏从而调和气血、调节情志以养生祛病。五行音乐疗法在临床应用广泛, 在减轻疼痛、缓解焦虑、改善失眠等方面均取得了良好效果。本文就中医五行音乐疗法临床应用进行总结, 以期为该疗法的进一步研究提供参考。)

Abstract Background Epidermal growth factor receptor‐tyrosine kinase inhibitors (EGFR‐TKIs) are recommended as first‐line treatment in non‐small cell lung cancer (NSCLC) patients with sensitizing EGFR mutations. The sequential use of different EGFR‐TKIs has been reported to demonstrate improvement in overall survival of NSCLC patients with EGFR mutations. There are limited reports on comparisons between regimens with first‐line use of afatinib, gefitinib or erlotinib, followed by osimertinib upon disease progression with acquired T790M mutation. Methods A retrospective cohort study of Chinese patients with metastatic NSCLC harboring EGFR mutations who received first‐line gefitinib, erlotinib or afatinib treatment, followed by osimertinib upon disease progression with acquired T790M mutation, was conducted. The differences in overall survival (OS) and progression‐free survival (PFS) with first‐line EGFR‐TKI (PFS1) and time to second objective disease progression (PFS2) were compared among patients on different first‐line EGFR‐TKIs. Results Among 155 patients, 101 (65.2%), 38 (24.5%) and 16 (10.3%) patients were on first‐line gefitinib, erlotinib or afatinib, respectively. Patients treated with afatinib in the first‐line setting had significantly longer OS compared with those on gefitinib or erlotinib, while the PFS1 and PFS2 were longer for patients on afatinib but did not reach statistical significance. Conclusions First‐line afatinib, followed by osimertinib upon disease progression with T790M mutation, demonstrated significantly longer OS compared to that using other EGFR‐TKI in the first‐line setting.

Objective To investigate the therapeutic effect of deep brain stimulation (DBS) on non⁃motor symptoms of Parkinson's disease (PD). Methods A total of 41 patients with PD who underwent DBS in Tianjin Huanhu Hospital from January 2015 to January 2021 were selected as subjects. The cognitive function was assessed by Mini⁃Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) at 3, 6 and 12 months after operation. Beck Depression Inventory Ⅱ (BDI⁃Ⅱ) and Hamilton Anxiety Rating Scale (HAMA) assessed depression and anxiety, Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) assessed sleep disorders and sleepiness, and Unified Parkinson's Disease Rating Scale Ⅲ (UPDRSⅢ) assessed motor symptoms. Levodopa equivalent daily dose (LEDD) was used to assess postoperative dependence on anti⁃PD drugs. Results The BDI⁃Ⅱscore (P=0.000), HAMA total scores (P=0.000) and its somatic anxiety (P=0.000), mental anxiety (P=0.000), PSQI total scores (P=0.000) and its subjective sleep quality (P=0.000), time to fall asleep (P=0.000), sleep duration (P=0.000), sleep efficiency (P=0.000), sleep disorders (P=0.000), sleep drug use (P=0.015), daytime dysfunction (P=0.000), ESS score (P=0.000), UPDRSⅢ score (P=0.000) and LEDD (P=0.000) had statistically significant differences before and after surgery. The improvement rates of BDI⁃Ⅱ, HAMA, PSQI and ESS were 46.00%, 33.58%, 34.67% and 34.30%, 49.69%, 35.01%, 38.19% and 36.20%, 50.51%, 35.24%, 39.77% and 39.44% at 3, 6 and 12 months after surgery respectively. The scores at different postoperative observation points were significantly different from those before surgery (P＜0.01, for all). However, there were no significant differences in MMSE total scores and its score of orientation, memory, attention and computation, recall ability and language function, as well as MoCA total scores and its score of visual spatial and executive function, naming, attention, language, abstraction, delayed recall and orientation before and after surgery (P＞0.05, for all). Conclusions DBS can significantly improve the motor symptoms, mood and sleep disorder of non⁃motor symptoms (NMS) in PD patients, and reduce the dose of anti⁃PD drugs, but has no effect on cognitive function.

Abstract Neuroinflammation occurs early in Alzheimer’s disease (AD). The initial stage of AD is related to glial dysfunction, which contributes to impairment of Aβ clearance and disruption of synaptic connection. CEBPβ, a member of the CCAAT-enhancer-binding protein (CEBP) family, modulates the expression of inflammation-associated genes, and its expression is elevated in brains undergoing degeneration and injured brains. However, the mechanism underlying CEBPβ-mediated chronic inflammation in AD is unclear. In this study, we observed that increases in the levels of nuclear CEBPβ facilitated the interaction of CEBPβ with the NFκB p65 subunit, increasing the transcription of proinflammatory cytokines in the APP/PS1 mouse brain. Oral administration of nanocarrier-packaged carnosic acid (CA) reduced the aberrant activation of microglia and astrocytes and diminished mature IL-1β, TNFα and IL-6 production in the APP/PS1 mouse brain. CA administration reduced β-amyloid (Aβ) deposition and ameliorated cognitive impairment in APP/PS1 mice. We observed that CA blocked the interaction of CEBPβ with NFκB p65, and chromatin immunoprecipitation revealed that CA reduced the transcription of the NFκB target genes TNFα and IL-6. We confirmed that CA alleviated inflammatory mediator-induced neuronal degeneration and reduced Aβ secretion by inhibiting the CEBPβ-NFκB signalling pathway in vitro. Sulfobutyl ether-beta-cyclodextrin (SBEβCD) was used as the encapsulation agent for the CA-loaded nanocarrier to overcome the poor water solubility and enhance the brain bioavailability of CA. The CA nanoparticles (NPs) had no obvious toxicity. We demonstrated a feasible SBEβCD-based nanodelivery system targeting the brain. Our data provide experimental evidence that CA-loaded NPs are potential therapeutic agents for AD treatment.

Abstract Background Amiodarone is one of the most commonly used anti-arrhythmic agents. Amiodarone pulmonary toxicity is a potentially fatal adverse effect associated with amiodarone use. Previous studies on the epidemiology and risk factors for amiodarone pulmonary toxicity showed diverse results. Methods A multicenter retrospective cohort study was conducted to identify clinic-epidemiologic markers associated with amiodarone pulmonary toxicity for development of a prediction rule. Patients taking amiodarone who were managed in 3 centres in Hong Kong from 2005 to 2015 were included in this study. Penalized logistic regression was used to model the outcome as it is rare. Results A total of 34 cases with amiodarone pulmonary toxicity were identified among 1786 patients taking amiodarone for at least 90 days from 2005 to 2015. The incidence of amiodarone pulmonary toxicity was estimated to be 1.9%. The risk factors for amiodarone pulmonary toxicity included advanced age (OR 1.047, 95% CI 1.010–1.085, p = 0.013), ventricular arrhythmia (OR 2.703, 95% CI 1.053–6.935, p = 0.039), underlying lung disease (OR 2.511, 95% CI 1.146–5.501, p = 0.021) and cumulative dose of amiodarone (OR 4.762, 95% CI 1.310–17.309 p = 0.018). Conclusions The incidence of amiodarone pulmonary toxicity in Chinese patients in Hong Kong is estimated to be 1.9% in this study. Age, underlying lung disease, ventricular arrhythmia and cumulative dose of amiodarone are associated with the development of amiodarone pulmonary toxicity. A prediction rule was developed to inform the risk of developing amiodarone pulmonary toxicity.

The Yangtze River Economic Belt is a vital ecological security barrier and a focus of China’s economic development. Promoting the construction of urban agglomerations in the Yangtze River Basin is of great significance for accelerating the development of the Yangtze River Economic Belt. Using the five urban agglomerations in the Yangtze River Economic Belt as the research object, we evaluate their environmental carrying capacities and explore the coupling relationship between urban agglomeration development and environmental carrying capacity using a four-quadrant analysis method. We categorize these urban agglomerations into three types. The results show that the urban agglomeration in the Yangtze River Delta belongs to a mature–environmental overload type, the urban agglomerations in Chengdu–Chongqing and the middle reaches of the Yangtze River belong to the high-speed development–environmental overload type, and the urban agglomerations in central Guizhou and central Yunnan belong to the cultivation–environmental non-overload type. Furthermore, we propose strategic suggestions for the development of urban agglomerations in the Yangtze River Economic Belt from the aspects of ecological space control, optimization of land spatial pattern, green development of urban agglomerations, and improvement of human settlement environment. These aim to strengthen the guiding role of environmental carrying capacity in the development of urban agglomerations and provide basic support for promoting the high-quality development of the Yangtze River Economic Belt.

A new type of paste filling material was created using fluorogypsum, a byproduct of hydrofluoric acid, as the raw material to address the issue of the filling material's high cost. The effects of five factors, including gangue, fly ash, fluorogypsum, lime content, and mass concentration on the physical and mechanical properties of filling material were also examined. In addition to analyzing slump and extension changes, the filler's mineral composition and microstructure were examined using SEM and XRD examinations. The results show that the best ratio of the developed filling material was 1000g coal gangue, 300g fly ash, 300g fluorogypsum, and 50g lime and mass concentration is 78%, and its compressive strength can reach 4-5MPa at 28 days. Raw materials such as gangue and fly ash will have a certain influence on the mechanical properties of the filling material. The hydration products of the developed filling material prepared by XRD and SEM were ettringite, calcium sulfate dihydrate, and calcium silicate hydrate gel. The new fluorogypsum-based paste filling material can be used to consolidate loose rock strata and fill goaf. It solves the problem of disposal of industrial waste fluoropgypsum and also solves the problem of coal mine gangue stacking, which has a far-reaching influence on ecological environment management.

C27H20Cl2F2N2O3S, triclinic, P1‾$P‾{1}$ (no. 2), a = 8.7887(4) Å, b = 11.2517(6) Å, c = 13.7609(7) Å, α = 74.962(4)°, β = 81.084(4)°, γ = 71.259(4)°, V = 1240.68(11) Å3, Z = 2, Rgt(F) = 0.0582, wRref(F2) = 0.1543, T = 100.0(1) K.

This paper summarized the effect of hot compress technique with Chinese herbal medicine package in a patient with knee osteoarthritis and related nursing management. Health education, hot compress technique with Chinese herbal medicine package and continuous nursing were carried out to relieve the joint pain symptoms of the. The visual scale of Osteoarthritis Index (WOMAC scale) was used as the evaluation standard. The scores of WOMAC scale decreased, the scores of pain, stiffness and daily activity decreased, and the clinical symptoms improved after intervention. The hot compress technique with Chinese herbal medicine package is potentially effective to alleviate the joint symptoms of patients with knee osteoarthritis, delay the development of the disease and improve the quality of life. (本文回顾1例膝骨关节炎患者应用中药热奄包的治疗效果及护理经验。对患者进行健康教育, 开展中药热奄包技术和延续性护理, 采用骨性关节炎指数可视化量表(WOMAC量表)评价干预效果。干预后WOMAC量表各项评分均降低, 患者疼痛、僵硬、日常活动能力评分降低, 临床症状改善明显。中药热奄包技术能够明显缓解骨痹患者的关节症状, 延缓病情发展, 提高患者的生活质量。)

This paper summarized the nursing measures for a case of gout treated by auricular acupoints sticking-pressing therapy. Key issues of nursing included living care, dietary instruction, psychological intervention, procedure and cautions of auricular acupoints sticking-pressing therapy. Based on the scientific evaluation and acupoints selection by syndrome differentiation, targeted nursing interventions are effective to reduce the pain and improve the quality of life in patients with gout. (本文总结了1例耳穴贴压治疗痛风的护理经验, 包括生活护理、饮食指导、心理干预以及耳穴贴压的操作方法和注意事项。通过科学的评估, 辨证取穴, 开展针对性护理干预, 有助于缓解患者痛风症状, 减轻疼痛, 改善日常生活能力。)

T his paper summarized the Traditional Chinese Medicine (TCM) nursing management for a rheumatoid arthritis patient with knee joint pain. Nursing interventions included TCM characteristic nursing techniques such as TCM wax therapy, auricular point sticking therapy; Health education such as TCM diet treatment, functional exercise, TCM emotional care and other nursing interventions. The TCM characteristic nursing can effectively relieve the knee joint pain of patients with rheumatoid arthritis. The TCM characteristic nursing has advantages of easy-to-use, easy-to-achieve, high cost-effectiveness and high degree of patients' acceptance and tolerance. (本文总结1例尪痹双膝关节疼痛患者的中医特色护理经验, 包括中医特色护理技术如中药蜡疗、耳穴贴压, 中医特色健康教育如中医食疗、功能锻炼、中医情志护理等, 有效改善了尪痹患者双膝关节疼痛症状, 且中医特色护理具有“简、便、验、廉”的优势, 患者更易于接受。)

Abstract Background Considerable experimental and clinical evidences have proved that human umbilical cord mesenchymal stem cells (UC-MSCs) transplantation was powerful in systemic lupus erythematosus (SLE) treatment. MSCs could upregulate regulatory B cells (Bregs) in the mice model of the other immune disease. However, the regulation of MSCs on Bregs in SLE environment remains unclear. Methods To assess the abilities of UC-MSCs to treat SLE, MSCs were transferred intravenously to 17- to 18-week-old MRL/lpr mice. Four weeks later, mice were sacrificed. Survival rates, anti-dsDNA antibodies and renal histology were evaluated. CD4+ T helper (Th) cell subgroups and interleukin (IL)-10+ Bregs (B10) in the spleen were quantitated by flow cytometry. The changes of transforming growth factor (TGF)-β1, IL-6 and indoleamine 2,3-dioxyenase (IDO) mRNAs expressed by MSCs after co-cultured with B cells were detected using real-time polymerase chain reaction (RT-PCR). MSCs were infected by lentivirus carrying TGF-β1 shRNAs, then MSCs with low expression of TGF-β1 were conducted for co-culture in vitro and transplantation experiments in vivo. Results UC-MSCs transplantation could efficiently downregulate 24 h proteinuria and anti-dsDNA antibodies, correct Treg/Th17/Th1 imbalances and increase the frequency of B10 cells. The expression of TGF-β1 in MSCs was significantly increased after co-culture with B cells. Downregulation of TGF-β1 in MSCs could significantly attenuate the upregulation of B10 by MSCs in vitro and in vivo. Downregulation of TGF-β1 also compromised the immunomodulation effects of MSCs on Th17 and Treg cells and the therapeutic effects of MSC transplantation. Conclusions UC-MSCs could protect against SLE in mice and upregulate IL-10+ Bregs via TGF-β1.

The performance of content-based image retrieval(CBIR) system mainly depends on two key technologies:image feature extraction and image feature matching.In this paper,the color features of all the images are extracted,and an appropriate fuzzy algorithm is adopted in the process of color feature extraction to gain the fuzzy color features of image.Image feature ma-tching mainly depends on the similarity between two image feature vectors.In this paper,a novel fuzzy similarity measure method is proposed it adopts the similarity between the query image and its k nearest neighbor images to constitute the k-dimensional fuzzy feature vector of the query imagem,and adopts the similarity between each retrieved image and k nearest neighbor images of the query image to constitute the k-dimensional fuzzy feature vector of each retrieved image.Then it calculates the fuzzy similarity between the k-dimensional fuzzy feature vector of the query image and the k-dimensional fuzzy feature vector of each retrieved image,and the retrieved images are fed back to users in reverse order of the fuzzy similarity.In order to verify the effectiveness of the proposed fuzzy color features,a series of experimental comparison are performed on the WANG dataset.In order to evaluate the performance of the image retrieval system based on different similarities,a series of experimental comparison are performed on WANG,Corel-5k and Corel-10K datasets.Experimental results show that the performance of the image retrieval system based on the maximum and minimum value outperforms that of the image retrieval systems based on the other three commonly used similarities.And the performance of the image retrieval system based on fuzzy similarity outperformsthat of the image retrieval system based on the maximum and minimum value.On the WANG,Corel-5k and Corel-10K datasets,the average precision of top 20 images retrieved by the image retrieval system based on fuzzy similarity is 4.92%,17.11% and 19.48% higher thanthat of top 20 images retrieved by the image retrieval system based on the maximum and minimum value respectively,and the average precision of top 100 images retrieved by the image retrieval system based on fuzzy similarity is 4.94%,22.61% and 33.02% higher that than of top 100 images retrieved by the image retrieval system based on the maximum and minimum value respectively.

Electromagnetic interference problems have become an increasing issue with the rapid development of wireless information technologies, which has attracted global attention. The key solution to this challenge is to develop materials that can absorb electromagnetic waves. The ideal absorbing material should be a structural material integrating load bearing, heat protection and strong absorption. The carbon-based, ceramic-based composites and their electromagnetic absorption properties in recent years were summarized in this review. The ultimate goal of these absorbers is to achieve broader effective absorption frequency bandwidth at a thin coating thickness. The synthesis methods, structures and electromagnetic wave loss mechanism of several typical and well-received composites were introduced. The superiorities, research status and main problems of absorbing materials were described. Based on these progresses, the potential development direction of absorbing materials in the future was predicted.

This paper observed the effect of Traditional Chinese Medicine (TCM) exercise therapy on pain relief in a patient with bone arthralgia. Under the guidance of the theory of TCM nursing by syndrome differentiation, the TCM exercise therapy was carried out after implementation of nursing assessment and routine care. The TCM exercise therapy is effective to relieve the pain and improve the activity of daily of life. (本文总结“骨痹操”缓解1例骨关节炎患者疼痛的效果, 总结相关护理措施。在中医辨证施护的理论指导下, 护理人员完善护理评估和常规护理, 并开展“骨痹操”锻炼, 有效缓解疼痛, 提高日常生活活动能力。)

Abstract Background Pseudomonas aeruginosa is one of the commonest bacteria colonizing the airway in patients with non-cystic fibrosis bronchiectasis. Pseudomonas aeruginosa colonization is associated with poor outcomes in patients with bronchiectasis, including rapid decline in lung function, exacerbation frequency and hospitalization. Methods A cross-sectional study in Queen Mary Hospital, Hong Kong that included 350 Chinese patients with non-cystic fibrosis bronchiectasis to investigate the risk factors for Pseudomonas aeruginosa colonization and clinical implications on disease outcomes. Discussions Pseudomonas aeruginosa colonization was more commonly found in patients with longer duration of bronchiectasis and those on proton pump inhibitors (PPIs) with adjusted ORs of 1.066 (95% CI = 1.036–1.096, p

C17H14FNO2, monoclinic, C2/c (no. 15), a = 15.5754(12) Å, b = 7.4828(6) Å, c = 23.0981(18) Å, β = 90.797(7)°, V = 2691.8(4) Å3, Z = 8, Rgt(F) = 0.0442, wRref(F2) = 0.1096, T = 100(1)° K.

The Ti2AlNb alloy and the titanium matrix composites can be joined by direct solid phase diffusion, but the high diffusion temperature causes the base metal to undergo a phase transition, even the joint properties were therefore deteriorated. A method for optimizing the properties of solid phase diffusion joints of Ti2AlNb alloy and Ti matrix composites was proposed by using Ti foil intermediate layer. The results show that after adding 30 μm Ti foil intermediate layer, the diffusion bonding temperature reduces from 950 ℃ to 850 ℃, the deformation rate reduces from 5% to 1.7%, and the decreasing of diffusion bonding temperature can effectively change the structure of the joint interface. The typical interface is Ti2AlNb/B2 phase/α+β dual phase structure/Ti matrix composite, in which the strength of the joint increases by the formation of α+β dual phase structure at the joint interface.When the optimum diffusion bonding parameter is 850 ℃/60 min/5 MPa, the shear strength reaches a maximum value of 399 MPa. The diffusion bonding of Ti2AlNb and Ti based composite at low temperature is realized.