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4 results on '"Wang,Zaizhong"'

2. Tumor Suppressor microRNA-138 Suppresses Low-Grade Glioma Development and Metastasis via Regulating IGF2BP2

Author

Yang,Yang, Liu,Xinyu, Cheng,Lulu, Li,Li, Wei,Zhenyu, Wang,Zong, Han,Gang, Wan,Xuefeng, Wang,Zaizhong, Zhang,Jianhua, Chen,Chuanliang, Yang,Yang, Liu,Xinyu, Cheng,Lulu, Li,Li, Wei,Zhenyu, Wang,Zong, Han,Gang, Wan,Xuefeng, Wang,Zaizhong, Zhang,Jianhua, and Chen,Chuanliang

Abstract

Yang Yang,1,2,* Xinyu Liu,3,* Lulu Cheng,2 Li Li,2 Zhenyu Wei,4 Zong Wang,2 Gang Han,2 Xuefeng Wan,2 Zaizhong Wang,2 Jianhua Zhang,5 Chuanliang Chen1 1Henan Key Laboratory for Medical Imaging of Neurological Diseases, People’s Hospital of Zhengzhou University, Zhengzhou 450003, People’s Republic of China; 2Department of Neurosurgery, Zhumadian Central Hospital, Zhumadian 463000, People’s Republic of China; 3School of Intelligent Manufacturing, The Huanghuai University, Zhumadian 463000, People’s Republic of China; 4Department of Neurosurgery, Second Affiliated Hospital of Xinxiang Medical College, Xinxiang 453000, People’s Republic of China; 5Medical Engineering Technology and Data Mining Institute of Zhengzhou University, Zhengzhou 450000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chuanliang ChenHenan Key Laboratory for Medical Imaging of Neurological Diseases, People’s Hospital of Zhengzhou University, Zhengzhou 450003, People’s Republic of ChinaEmail chenchuanliangsy@126.comBackground: Low-grade gliomas (LGG), approximately constitute one-third of all types of gliomas, are prone to relapse and metastasis. MicroRNA-138 (miR-138) is reported to be dysregulated in diverse human tumors and mainly function as a tumor suppressor. In this study, we analyzed the expression profile and function of miR-138 in LGG.Methods: Quantitative PCR (qPCR) and public database bioinformatics analysis were performed to determine the miR-138 levels in LGG. MiR-138 overexpression in LGG cells was achieved by miR-138 mimics transfection. Cell proliferation was assessed by CCK8, EdU and colony formation assays. Cell invasion and migration were analyzed by transwell and wound-healing assays. Xenograft model was employed to study the role of miR-138 in LGG growth in vivo. The target of miR-138 was validated by multiple methods, such as luciferase reporter assay, RT-q

Published
2020

4. Monitoring of acute axonal injury in the swine spinal cord with EAE by diffusion tensor imaging

Author

Chang Ying-juan, Song Feng, Yin Hong, Ge Yali, Liu Ying, Wang ZaiZhong, Zhang Jin-song, Dai XiaoFeng, Zhang Zhou, and Huan Yi

Subjects
Pathology, medicine.medical_specialty, Encephalomyelitis, Autoimmune, Experimental, Swine, Encephalomyelitis, Immunoenzyme Techniques, In vivo, Image Processing, Computer-Assisted, medicine, Animals, Radiology, Nuclear Medicine and imaging, Analysis of Variance, medicine.diagnostic_test, business.industry, Multiple sclerosis, Radial diffusivity, Magnetic resonance imaging, medicine.disease, Spinal cord, Axons, Diffusion Magnetic Resonance Imaging, medicine.anatomical_structure, Spinal Cord, nervous system, Cervical Vertebrae, Disease Progression, Feasibility Studies, Female, Histopathology, business, Diffusion MRI
Abstract

Purpose To evaluate the ability of diffusion tensor imaging (DTI) to detect and monitor acute axonal injury in swine spinal cord with acute experimental allergic encephalomyelitis (EAE). Materials and Methods Magnetic resonance imaging of the cervical spinal cord was performed in vivo at different time points through the onset and progression of EAE using a 3 Tesla clinical scanner. The DTI parameters were calculated in four separate regions of interest at the C2/C3 level. The quantitative DTI-pathology and DTI-clinical correlations were verified. Results In the monophasic acute course of EAE onset and progression, axial diffusivity (AD) decrease correlates with acute axonal injury (r = −0.84; P < 0.001). By contrast, radial diffusivity does not change and no demyelination in histopathology was detected. Moreover, a clear correlation between clinical disease and axial diffusivity was found in two swine EAE models (r = −0.86; P < 0.001 and r = −0.92; P < 0.001). Conclusion AD corresponds with axonal injury in the absence of demyelination and may be a useful noninvasive tool to investigate the underlying pathogenic processes of multiple sclerosis and to monitor the effects of experimental treatments for axonal injury. J. Magn. Reson. Imaging 2009;30:277–285. © 2009 Wiley-Liss, Inc.

Published
2009

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