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290 results on '"Wang, Zhenpeng"'

9. High Precision and Fast Initial Alignment for Vehicle Mounted Guided Rocket in Erection Process

Author

Wang, Zhenpeng, Chen, Kui, Hu, Zhou, Fan, Shiwei, Jiang, Qi, Zhu, Minghong, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Yan, Liang, editor, and Deng, Yimin, editor

Published
2023
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22. Application of exosomes in tumor immunity: recent progresses

Author

Qiu, Haiyan, primary, Liang, Junting, additional, Yang, Guang, additional, Xie, Zhenyu, additional, Wang, Zhenpeng, additional, Wang, Liyan, additional, Zhang, Jingying, additional, Nanda, Himansu Sekhar, additional, Zhou, Hui, additional, Huang, Yong, additional, Peng, Xinsheng, additional, Lu, Chengyu, additional, Chen, Huizhi, additional, and Zhou, Yubin, additional

Published
2024
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34. Preparation of a novel ginkgolide B niosomal composite drug

Author

Zhou Juntong, Wu Xiao, Zhao Zhanhong, Wang Zhenpeng, Li Shumu, Chen Chang, Yu Shan, Qu Xintong, Li Kexin, Tian Ye, Liu Xiaojing, Zhang Gaoyu, Wang Zhaoxuan, Li Chi, Kang Ning, and Huo Qing

Subjects
ginkgolide b, puerarin, niosome, parkinson’s disease, Chemistry, QD1-999
Abstract

Ginkgolide B (GB) and Puerarin (Pue) are active pharmaceutical ingredients for the treatment of Parkinson’s disease (PD); however, both are poorly water-soluble, which limits their bioavailability. The present study used the niosome vesicle encapsulation technique to prepare a novel GB composite drug. The conditions for GB–Pue niosomal complex preparation were as follows: a hydration temperature of 60°C, a hydrophilic–lipophilic balance of 10.5, a drug–carrier mass ratio of 8:100, and a surfactant–cholesterol mass ratio of 1.5:1. The niosomal complex suspension was uniformly distributed and milky white in color, with no stratification over a duration of 1 month. It had an average particle size of 187.3 nm, a particle-size distribution of 0.237, a GB encapsulation efficiency (EE) of 68.2%, a GB drug-loading rate of 90.1%, a Pue EE of 40.5%, and a Pue drug-loading rate of 83.3%. The optimal storage temperature for the niosomal complex suspension was 4°C. Following an intravenous injection of the niosomal complex suspension into the rat tail, the area under the curve (AUC) from 0 to 4 h was 54.1 h µg mL−1, with a mean residence time (MRT) of 0.96 h, a distribution half-life (T1/2α) of 0.195 h, and a total clearance of 0.003 L h−1 kg−1. The AUC and MRT of the composite prescription were 1.1- and 1.4-times those of the commercial injection, respectively, showing significantly increased sustained release and bioavailability. Moreover, the distribution of GB in the brain tissue was 1.8-times that of the commercial injection. In conclusion, the novel GB niosomal composite drug, with excellent stability, improved pharmacokinetics, and brain tissue distribution, demonstrates great potential for the delivery of GB and Pue for PD therapeutics.

Published
2020
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44. The Optimization and Production of Ginkgolide B Lipid Microemulsion

Author

Wu Xiao, Wang Zhenpeng, Zhao Zhenwen, Chen Lei, Tao Fengyun, Zhang Qian, Zhou Tuo, Cui Junpu, Liu Meng, and Huo Qing

Subjects
ginkgolide b, lipid microemulsion, optimization, Chemistry, QD1-999
Abstract

In this study, we introduce a method to formulate Ginkgolide B lipid microemulsion (GB-LM). We have assessed its general characteristics and pharmacokinetics in animals. Soybean oil (10.0%) and oleic acid (2.4%) were chosen as the oil phase, refined egg yolk lecithin (PC98T) (1.8%) as the surfactant, and glycerol (2.25%) as the co-surfactant. The optimized formulation process resulted in particles with average diameter of 185.9 ± 52.5 nm and the zeta potential of −19.8 ± 1.3 mV. The GB-LM remained steady for three months at room temperature. Giving each dose of 4 mg/kg to rats through the vein, a clearance rate of CL (L/h): 2.594 and C max (ng/mL) was achieved: 353.8 through pharmacokinetic analysis and statistical analysis. The AUC of GB-LM was about 1.57-fold higher than that of the products available in the market. In addition, brain tissue distribution studies show that after 0.5 h administration of GB, the concentration of GB in brain tissue can reach its maximum, and then significantly decrease after 2 hours. Therefore, the improved formulation of GB-LM shows encouraging results compared with present products in several features.

Published
2019
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47. Synthesis of Carboxylic Acids from Saccharides, CO2, and H2

Author

Li, Yang, primary, Wang, Ying, additional, Zhang, Yanru, additional, Wang, Zhenpeng, additional, Xiang, Junfeng, additional, Han, Juanjuan, additional, He, Jun, additional, Zhang, Longbo, additional, Wang, Yanyan, additional, Meng, Qinglei, additional, Qian, Qingli, additional, and Han, Buxing, additional

Published
2023
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