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430 results on '"Wang, Zhengjie"'

1. Dynamic Depth Decoding: Faster Speculative Decoding for LLMs

Author

Brown, Oscar, Wang, Zhengjie, Do, Andrea, Mathew, Nikhil, and Yu, Cheng

Subjects
Computer Science - Computation and Language, Computer Science - Artificial Intelligence
Abstract

The acceleration of Large Language Models (LLMs) with speculative decoding provides a significant runtime improvement without any loss of accuracy. Currently, EAGLE-2 is the state-of-the-art speculative decoding method, improving on EAGLE with a dynamic draft tree. We introduce Dynamic Depth Decoding (DDD), which optimises EAGLE-2's tree drafting method using a dynamic depth. This extends the average speedup that EAGLE-2 achieves over EAGLE by $44\%$, giving DDD an average speedup of $3.16$x.

Published
2024

6. Using fine-tuning and min lookahead beam search to improve Whisper

Author

Do, Andrea, Brown, Oscar, Wang, Zhengjie, Mathew, Nikhil, Liu, Zixin, Ahmed, Jawwad, and Yu, Cheng

Subjects
Electrical Engineering and Systems Science - Audio and Speech Processing, Computer Science - Computation and Language, Computer Science - Machine Learning, Computer Science - Sound
Abstract

The performance of Whisper in low-resource languages is still far from perfect. In addition to a lack of training data on low-resource languages, we identify some limitations in the beam search algorithm used in Whisper. To address these issues, we fine-tune Whisper on additional data and propose an improved decoding algorithm. On the Vietnamese language, fine-tuning Whisper-Tiny with LoRA leads to an improvement of 38.49 in WER over the zero-shot Whisper-Tiny setting which is a further reduction of 1.45 compared to full-parameter fine-tuning. Additionally, by using Filter-Ends and Min Lookahead decoding algorithms, the WER reduces by 2.26 on average over a range of languages compared to standard beam search. These results generalise to larger Whisper model sizes. We also prove a theorem that Min Lookahead outperforms the standard beam search algorithm used in Whisper., Comment: 8 pages, submitted to IEEE ICASSP 2024

Published
2023

8. Multichannel full-space coding metasurface with linearly-circularly-polarized wavefront manipulation

Author

Luo Huiling, Gao Huanhuan, Wang Yanzhao, Wang Chaohui, Zhang Fan, Shao Yanzhang, Liu Tong, Wang Zhengjie, and Xu He-Xiu

Subjects
multichannel coding metasurface, full space, wavefront control, shared aperture, linearly-circularly-polarized, Physics, QC1-999
Abstract

Achieving independent multitasked wavefront control by using an ultrathin plate is a challenge to increase information capacity in integration optics and radar applications. Transmission-reflection-integrated metasurface provides an efficient recipe primarily for multifunctional meta-device, however it is challenging to synergize both linear polarization (LP) and circular polarization (CP) using a single meta-plate. Here, a multichannel full-space coding metasurface composed of interleaved shared-aperture meta-atom is proposed to achieve large information capacity by capsulating judiciously engineered high efficiency triple sub-elements (modes) in four-layer scheme. By rotating dual-gap split ring resonator and varying size of “L” type structure insulating by a metallic ring with electrostatic-analogue shielding effect, both Pancharatnam–Berry (PB) and dynamic phases are independently realized under CP and LP waves, respectively. Such an extraordinary insulating strategy completely suppresses crosstalk among three modes and unprecedentedly increases the capability in yielding kaleidoscopic wavefront control. To verify the significance, a proof-of-concept metadevice is devised and experimentally demonstrated with tri-channel wavefront manipulations, exhibiting reflective dual-vortex beam and Bessel beam for forward and backward CP wave, respectively at high frequency, while transmissive polarization beam splitting for 45°-LP wave at low frequency. Our finding in polarization-direction multiplexing is expected to generate great interest in electromagnetic integration with emerging degree of freedoms.

Published
2024
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10. Distributed Control of Multi-unmanned Aerial Vehicle Circumnavigation Formation Based on Partial Differential Equations

Author

Yue, Haoran, Wu, Yanxuan, Tong, Xiaoming, Chen, Hao, Wang, Zhengjie, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, Wang, Qing, editor, Dong, Xiwang, editor, and Song, Peng, editor

Published
2024
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11. Simultaneous Trajectory Tracking and Obstacle Avoidance of a Quadrotor UAV

Author

Du, Hongbao, Wang, Zhengjie, Tang, Lixi, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, El Fadil, Hassan, editor, and Zhang, Weicun, editor

Published
2024
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12. A Game Guidance Law Based on Model Predictive Control

Author

Tang, Lixi, Wang, Zhengjie, Du, Hongbao, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, El Fadil, Hassan, editor, and Zhang, Weicun, editor

Published
2024
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13. Holographic communication using programmable coding metasurface

Author

Zhang Fan, Wang Chaohui, Feng Weike, Liu Tong, Wang Zhengjie, Wang Yanzhao, Wang Mingzhao, and Xu He-Xiu

Subjects
holographic communication, spin-decoupled, programmable coding metasurface, near-field communication, Physics, QC1-999
Abstract

With rapid development of holography, metasurface-based holographic communication scheme shows great potential in development of adaptive electromagnetic function. However, conventional passive metasurfaces are severely limited by poor reconfigurability, which makes it difficult to achieve wavefront manipulations in real time. Here, we propose a holographic communication strategy that on-demand target information is firstly acquired and encoded via a depth camera integrated with modified YOLOv5s target detection algorithm, then transmitted by software defined radio modules with long term evolution at 5 GHz, and finally reproduced in the form of holographic images by spin-decoupled programmable coding metasurfaces at 12 GHz after decoding through modified Gerchberg–Saxton algorithm. Experiments are conducted to demonstrate the brand-new concept of optical information conversion to electromagnetic one via above intelligent scheme. Our strategy may open a novel avenue toward applications of near-field communication based on adaptive variation of electric field patterns (i.e. holographic images).

Published
2024
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14. Impact of Large Language Models on Medical Education and Teaching Adaptations

Author

Li Zhui, Nina Yhap, Liu Liping, Wang Zhengjie, Xiong Zhonghao, Yuan Xiaoshu, Cui Hong, Liu Xuexiu, and Ren Wei

Subjects
Computer applications to medicine. Medical informatics, R858-859.7
Abstract

AbstractThis viewpoint article explores the transformative role of large language models (LLMs) in the field of medical education, highlighting their potential to enhance teaching quality, promote personalized learning paths, strengthen clinical skills training, optimize teaching assessment processes, boost the efficiency of medical research, and support continuing medical education. However, the use of LLMs entails certain challenges, such as questions regarding the accuracy of information, the risk of overreliance on technology, a lack of emotional recognition capabilities, and concerns related to ethics, privacy, and data security. This article emphasizes that to maximize the potential of LLMs and overcome these challenges, educators must exhibit leadership in medical education, adjust their teaching strategies flexibly, cultivate students’ critical thinking, and emphasize the importance of practical experience, thus ensuring that students can use LLMs correctly and effectively. By adopting such a comprehensive and balanced approach, educators can train health care professionals who are proficient in the use of advanced technologies and who exhibit solid professional ethics and practical skills, thus laying a strong foundation for these professionals to overcome future challenges in the health care sector.

Published
2024
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22. Machine learning recognition of protein secondary structures based on two-dimensional spectroscopic descriptors

Author

Ren, Hao, Zhang, Qian, Wang, Zhengjie, Zhang, Guozhen, Liu, Hongzhang, Guo, Wenyue, Mukamel, Shaul, and Jiang, Jun

Subjects
Bioengineering, Machine Learning, Neural Networks, Computer, Proteins, Spectrum Analysis, ultrafast spectroscopy, biochemistry, physical chemistry, theoretical chemistry
Abstract

Protein secondary structure discrimination is crucial for understanding their biological function. It is not generally possible to invert spectroscopic data to yield the structure. We present a machine learning protocol which uses two-dimensional UV (2DUV) spectra as pattern recognition descriptors, aiming at automated protein secondary structure determination from spectroscopic features. Accurate secondary structure recognition is obtained for homologous (97%) and nonhomologous (91%) protein segments, randomly selected from simulated model datasets. The advantage of 2DUV descriptors over one-dimensional linear absorption and circular dichroism spectra lies in the cross-peak information that reflects interactions between local regions of the protein. Thanks to their ultrafast (∼200 fs) nature, 2DUV measurements can be used in the future to probe conformational variations in the course of protein dynamics.

Published
2022

27. Research on Adversarial Robustness Properties of Image Classification Networks Based on Deep Vision

Author

Li, Qiaoyi, Wang, Zhengjie, Zhang, Xiaoning, Du, Hongbao, Xu, Bai, Li, Yang, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Jia, Yingmin, editor, Zhang, Weicun, editor, Fu, Yongling, editor, and Wang, Jiqiang, editor

Published
2023
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28. A Centralized Collaborative Monocular SLAM System with Relocalization

Author

Tan, Yunfei, Wang, Zhengjie, Liu, Quanpan, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Fu, Wenxing, editor, Gu, Mancang, editor, and Niu, Yifeng, editor

Published
2023
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29. PDE-ODE Based Consensus and Stability Control of Multi-agent System with Input Delay

Author

Chen, Hao, Wang, Zhengjie, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Ren, Zhang, editor, Wang, Mengyi, editor, and Hua, Yongzhao, editor

Published
2023
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36. Research on Transferable Characteristics of Adversarial Examples Generated Based on Gradient Information

Author

Li, Yang, Zhang, Pengfei, Li, Qiaoyi, Wang, Zhengjie, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Jia, Yingmin, editor, Zhang, Weicun, editor, Fu, Yongling, editor, and Zhao, Shoujun, editor

Published
2022
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37. Application Barrier-Free Deep Reinforcement Learning-Based Navigation in Mapless Environment

Author

Yu, Jin, Wang, Zhengjie, Wu, Yanxuan, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Jia, Yingmin, editor, Zhang, Weicun, editor, Fu, Yongling, editor, Yu, Zhiyuan, editor, and Zheng, Song, editor

Published
2022
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45. MoxRe(1−x)S2‐Based Optoelectronic Synapse for Artificial Neural Visual System Application.

Author

Sun, Xiaona, Wang, Zhengjie, Si, Chen, Jiang, Chengbao, and Yang, Shengxue

Subjects
*CHEMICAL vapor deposition, *CHEMICAL systems, *POINT defects, *NOISE control, *TRANSITION metals
Abstract

Optoelectronic synapses, constructed from 2D transition metal dichalcogenides (TMDs) with atomic‐scale thickness, offer substantial benefits for the development of high‐density integrated artificial neural visual systems (ANVSs). Effective charge capture and retention are essential for realizing synaptic memory function. Although charge trapping is realized by gate‐voltage‐regulated three‐terminal devices or interface‐modulated heterostructures, they involve high energy consumption and complex device structures. Another approach is to introduce material defects by post‐processing methods to trap carriers, but this method inevitably damages the pristine materials and requires intricate fabrication processes. In this study, the chemical vapor deposition (CVD) method is employed to directly introduce Re atoms as point defects into MoS2, which act as trap centers for capturing carriers, eliminating the need for complex device structures or post‐processing procedures. The resultant MoxRe(1−x)S2 nanofilms and nanoribbons exhibit excellent optoelectronic synaptic properties and broadband photoresponse characteristics respectively, due to varying doping concentrations. The optoelectronic synapses based on MoxRe(1−x)S2 nanofilms can simulate human color recognition, attributed to their differential response to varying light wavelengths, and possess image preprocessing capabilities for noise reduction and contrast enhancement. The study provides a simple approach for fabricating optoelectronic synapses, thereby facilitating the integration of 2D TMDs into ANVSs. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Efficient generation of 1O2 by activating peroxymonosulfate on graphitic carbon nanoribbons for water remediation.

Author

Tang, Weijiang, Wang, Zhengjie, Guo, Sheng, Chen, Rong, and Chen, Fengxi

Subjects
ELECTRON paramagnetic resonance, REACTIVE oxygen species, POLLUTANTS, ELECTROCHEMICAL analysis, CHARGE exchange
Abstract

Few-layer graphitic carbon nanoribbons (GCN) with rich defective sites were prepared by pyrolysis at 800 oC in N2 of in situ-chelated Fe-polyaniline complexes synthesized via one-pot homogeneous Fenton-like oxidative polymerization of an acidic aniline solution. A minimal amount of iron (0.47 wt%) made a pivotal role in the nanoribbon growth and graphitization of GCN, and deposited highly dispersed iron species on GCN without post-synthesis acid leaching, which greatly simplified the synthesis procedure of GCN with improved yield. GCN exhibited high activity and stability for catalytic degradation of organic pollutants with peroxymonosulfate (PMS) mainly via non-radical pathways. The influences of various operating parameters on the catalytic performance of GCN were investigated. Scavenging tests, spin-trapping electron paramagnetic resonance spectra, electrochemical analyses, and theoretical calculations unveiled that 1O2 was the main reactive oxygen species generated from synergistic activation of PMS on GCN while GCN-mediated electron transfer made a minor contribution to organic degradation. [ABSTRACT FROM AUTHOR]

Published
2024
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47. The Efficient and Sensitive Detection of Serum Dopamine Based on a MOF-199/Ag@Au Composite SERS Sensing Structure.

Author

Peng, Yuyu, Wang, Chunyan, Li, Gen, Cui, Jianguo, Jiang, Yina, Li, Xiwang, Wang, Zhengjie, and Zhou, Xiaofeng

Subjects
SERS spectroscopy, MEDICAL screening, SILVER nanoparticles, NEUROLOGICAL disorders, SUBSTRATES (Materials science)
Abstract

In this study, a MOF-199/Ag@Au SERS sensing structure was successfully synthesized by combining metal–organic frameworks (MOFs) with surface-enhanced Raman scattering (SERS) technology for the efficient detection of dopamine (DA), a biomarker for neurological diseases, in serum. Using electrochemical methods, a copper-based MOF (MOF-199) was synthesized in situ on copper substrates and further deposited with silver nanoparticles (AgNPs). Subsequently, gold nanoshells were encapsulated around these silver cores by in situ chemical deposition. This preparation process is simple, controllable, and inexpensive. Furthermore, a novel Azo reaction-based DA SERS method was proposed to detect 1 pM DA, which represents an improvement in sensitivity by two orders of magnitude compared to previous unlabeled SERS detection methods and by four orders of magnitude compared to another SERS approach proposed in this work. There was an excellent linear relationship (R2 = 0.976) between the SERS signal at 1140 cm−1 and the DA concentration (0.001 M~1 pM). The results indicate that the MOF-199/Ag@Au sensor structure can successfully achieve both the qualitative and quantitative detection of DA in serum, thus providing a robust technical basis for the application of SERS technology in the field of clinical neurological disease screening. [ABSTRACT FROM AUTHOR]

Published
2024
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