Search

Exploring the evolution of economic spatial correlation and its network effect has theoretical significance of the economic spatial cooperation pattern in the Guangdong-Hong Kong-Macao Greater Bay Area In this paper, the modified gravity model, social network analysis, and OLS regression model were used to examine the evolution characteristics regarding the economic spatial network structure and its effect in the Guangdong-Hong Kong-Macao Greater Bay Area. It is found as follows. 1) The strength of economic connection in the Guangdong-Hong Kong-Macao Greater Bay Area had been continuously increased, driven by four cores in space and economic radiating at the edge became stable. Additionally, the potential energy of economic connection consistently rose, the network density and network relationships of economic network structure fluctuated, but dynamically increased. The network hierarchy varied but increased overall, the network efficiency showed a "V" shaped structure with an initial decline but an overall increase later. 2) The degree centrality of network steadily improved, and the spatial structure gradually transformed from a multi-point agglomeration to a bipolar confrontation. Additionally, the closeness centrality was highly unbalanced and varied greatly, and the betweenness centrality increased significantly. The control force of Shenzhen dominated economic connection role. 3) The augment of the network density and hierarchy as well as the decrease of network efficiency can effectively improve the economic connection intensity of the Guangdong-Hong Kong-Macao Greater Bay Area The degree centrality, betweenness centrality, and closeness centrality are also able to enhance the economic connection strengths in the Greater Bay Area. [ABSTRACT FROM AUTHOR]

With an analysis on the major borehole sealing methods for mine gas drainage in China, it was found that an improper study on the crack development scope of the surrounding rock along the borehole, the irrational selection of the borehole initial sealing depth and borehole sealing length, the low grouting pressure, the polyurethane and cement mortar as well as other sealing material with ineffective sealing of cracks in surrounding coal and rock along the borehole would be the main causes of irrational gas drainage borehole sealing effect in China coal mine. A technical access to improve the borehole sealing effect of the "two sealing and one grouting" pressurized borehole sealing method was provided, including the stud)' on the crack development time effect features of the surrounding rock along the borehole under the condition of the multi damages, the determination on the rational initial sealing depth of the gas drainage borehole and the length of the sealing section between the two ends, the proper grouting material applied and the increase of grouting pressure. [ABSTRACT FROM AUTHOR]

Tm3+ doped β-rhenanite (β-NaCaPO4) series were synthesized by solid-state reaction. The crystalline structure of β-rhenanite was simulated and the photoluminescence properties of NaCa1-x PO4:xTm3+ (0

Distinguishing between N6-methyladenosine (m6A)-associated long noncoding RNAs (lncRNAs) is crucial in non-small-cell lung cancer (NSCLC) patients. In this research, the prognosis and immunotherapeutic response of lncRNAs and m6A in NSCLC were examined. lncRNAs related to m6A were identified using co-expression analyses, and their prognostic impact on patients with NSCLC was assessed using univariate Cox regression analysis. Sixty-three m6A-associated lncRNAs were determined as prognostic lncRNAs, and on this basis, 25 m6A-associated lncRNAs were screened by least absolute shrinkage and selection operator (lasso) Cox regression. Multivariable Cox analysis obtained 14 m6A-associated lncRNAs for the construction of risk model. The NSCLC patients were grouped into different risk subgroups in accordance with the median of the risk fraction in each data, and we evaluated the differences of potential immunotherapeutic characteristics and drug sensitivity prediction between the two subgroups. By using this model to recombine patients, they can be effectively distinguished in terms of the immunotherapy response. Furthermore, candidate compounds for the differentiation of NSCLC subtypes were identified. The model based on 14 m6A-associated lncRNAs is a promising prognostic biomarker, which may help to predict the efficacy of immunotherapy in NSCLC patients and provide a theoretical basis for improving the outcome of patients., Competing Interests: None., (AJTR Copyright © 2022.)

Clarifying the regional natural capital utilization and its spatial effects and influencing factors has important theoretical and practical significance for regional sustainable development. Here, we used a three-dimensional ecological footprint model, exploratory spatial data analysis, a spatial Markov chain, and a spatial panel Durbin model to explore the spatial effects and influencing factors of overall and subcategory natural capital flow and stock occupancy of 112 prefecture-level cities in the Yangtze River Economic Belt from 2008 to 2018. The results showed that the total, per capita, and subcategory natural capital flow and stock occupancy increased during the study period. Most of the regions with low overall and subcategory natural flow occupancy were located in the East, whereas most of the regions with high overall and subcategory natural flow occupancy were mostly located in the Central and Wes-tern area. However, their stock occupancy behaved differently. Except for farmland stock, the overall and subcategory natural capital flow and stock occupancy showed spatial agglomeration. The traditional and spatial Markov chain presented a "Matthew effect" and a "spatial spillover effect" in natural capital flow and stock occupancy. Economic growth and industrial structure positively affected natural capital flow and stock occupancy. Population growth positively affected natural capital flow occupancy. Urbanization rate negatively affected natural capital flow occupancy, and positively impacted natural capital stock occupancy. Government intervention negatively affected the farmland flow and fossil fuels land stock occupancy. Environmental governance negatively affected the natural capital flow occupancy, but positively affected the natural capital stock occupancy. Environmental pollution positively affected natural capital flow and stock occupancy.

High salinity wastewater is one of the difficulties in the field of wastewater treatment. As a new desalination technology, electrosorption technology has many advantages. This paper studied a new type of carbon-based electrodes, the graphite and activated carbon fiber composite electrodes. And the influencing factors of electrosorption and its desalination effect were investigated. The electrosorption device had optimal desalination effect when the voltage was 1. 6 V, the retention time was 60 min and the plate spacing was 1 cm. The graphite and activated carbon fiber composite electrodes were used to treat the black liquor of refined cotton and sodium copper chlorophyll wastewater to investigate its desalination effect. When the electrodes were used to treat the black liquor of refined cotton after acid treatment, the removal rate of conductivity and COD reached 58. 8% and 75. 6% respectively when 8 pairs of electrodes were used. And when the electrode was used to treat the sodium copper chlorophyll wastewater, the removal rate of conductivity and COD reached higher than 50. 0% and 13. 5% respectively when 6-8 pairs of electrodes were used.

Objective: To explore the protein-tyrosine-phosphatase 1B (PTP1B) expression and its prognostic significance in non-small-cell lung cancer (NSCLC)., Methods: Immunohistochemical method of EnVision was applied to investigate the expression of PTP1B in lung specimens from 63 cases with NSCLC and 9 cases with pneumonia confirmed by pathological examination after surgical removals at Jinling Hospital from June 2000 to October 2010. The data of PTP1B expression in different lung tissues and its relationship with clinicopathological features and prognostic value for survival were analyzed by chi-square test, Kaplan-Meire survival analysis, Log rank test and multivariable Cox regression analysis., Results: The expression of PTP1B was negative in pneumonia group while positive in NSCLC tissues (32/63, 50.8%) (χ(2) = 8.229, P = 0.004). The expression of PTP1B in NSCLC tissue was not correlated with gender, age, smoking history, tumor size, pathological type, lymph node metastasis and chemotherapy, but significantly associated with pTNM staging (χ(2) = 6.426, P = 0.040). Kaplan-Meire survival analysis showed that the expression of PTP1B was significantly correlated with overall survival (Log-rank, P = 0.047). Multivariable Cox regression analysis indicated that both PTP1B (HR = 2.050, P = 0.044) and pTNM staging (HR = 3.631, P = 0.000) were independent prognostic factors for NSCLC., Conclusions: PTP1B may be a biomarker for differential diagnosis of malignant lung disease. And PTP1B and pTNM were independent prognostic factors for NSCLC.

GATA transcription factor family members have been found to involve in the growth and differentiation of mammary gland. Among them GATA-3 is regarded as the most critical regulator involving the tumorigenesis of breast cancer (BC). Recently, trichorhinophalangeal syndrome-1 gene (TRPS-1), a new GATA family member, has been identified to be highly prevalent in breast cancer. Compared with ER-negative breast cancer, the expression of TRPS-1 is higher in ER-positive breast cancer and was significantly correlates with estrogen receptor, progesterone receptor, and GATA-3, indicating it may serve as a ductal epithelial cell-specific regulator in the differentiation of breast ductal epithelial cells. Studies have shown that miR221/222 is able to downregulate the expression of an epithelial cell marker E-cadherin by targeting TRPS-1, resulting in mammary epithelial cells transition to mesenchymal cell (EMT). In addition, it has been well accepted that, and the Science and Technology Bureau of Jiaxing (2012AY1071-2)TRPS-1 plays a role in the differentiation of several other cell types including kidney nephric mesenchymal cells, columnar chondrocytes, and osteoclasts, indicating that TRPS-1 involves in mesenchymal-to-epithelial cell transition (MET). In this article, we summarize the roles of GATA transcription factor TRPS-1 in ductal epithelial cells and the roles of its gene and protein expressions in predicting the prognosis of breast cancer.

The direct asymmetric allylic alkylation of beta,gamma-butenolides with MBH carbonates to access gamma,gamma-disubstituted butenolides containing adjacent quaternary and tertiary chiral centers has been presented in excellent stereoselectivities (86-96% ee, dr >95:5) and moderate to good yield (50-83%). Their synthetic utility has been well demonstrated by the facile construction of bicyclic lactones bearing 4-5 stereogenic centers.