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Whether the northern margin of the North China Craton (NCC) was a continental arc or in a lithospheric extensional setting during the Carboniferous is the primary divergence among different tectonic models about the terminal evolutionary history of the southeastern Central Asian Orogenic Belt (CAOB). The Alxa block is the western segment of the northern NCC and contiguous to the southeastern CAOB, and therefore the tectonic setting of the Carboniferous magmatic intrusions in this block can shed light on this controversy. In this contribution, new zircon U–Pb ages, elemental geochemistry, and Sr-Nd isotopes are presented for thirteen Late Carboniferous (~318–300 Ma) magmatic intrusions in the southwestern Alxa block. Among them, seven calc-alkaline I-type granites and one aluminous A2-type granite were probably generated by the partial melting and crystallization differentiation of various crustal sources (perhaps including earlier orogenic materials) under different temperature conditions. Four quartz diorites and one hornblende gabbro may be the partial melts of subduction-modified basaltic lower crust sources and sub-continental lithospheric mantle sources, respectively. According to the integration of the new results and regional geological correlations, the Alxa block and the southeastern CAOB were most likely in a uniform tectonic regime during the Carboniferous. At that time, this region was characterized by the lithospheric extension-related magmatic rock associations, the increasing mantle inputs over time, the clockwise P–T paths of high temperature-low pressure metamorphic rocks, and the transgression sedimentary sequences. All these lines of evidence suggest an intra-continental lithospheric extensional setting rather than a continental arc setting for the southeastern CAOB during the Carboniferous. [ABSTRACT FROM AUTHOR]

The southeastern Central Asian Orogenic Belt (CAOB) records the assembly process between several micro-continental blocks and the North China Craton (NCC), with the consumption of the Paleo-Asian Ocean (PAO), but whether the S-wards subduction of the PAO beneath the northern NCC was ongoing during Carboniferous–Permian time is still being debated. A key issue to resolve this controversy is whether the Carboniferous magmatism in the northern NCC was continental arc magmatism. The Alxa Block is the western segment of the northern NCC and contiguous to the southeastern CAOB, and their Carboniferous–Permian magmatism could have occurred in similar tectonic settings. In this contribution, new zircon U–Pb ages, elemental geochemistry and Sr–Nd isotopic analyses are presented for three early Carboniferous granitic plutons in the southwestern Alxa Block. Two newly identified aluminous A-type granites, an alkali-feldspar granite (331.6 ± 1.6 Ma) and a monzogranite (331.8 ± 1.7 Ma), exhibit juvenile and radiogenic Sr–Nd isotopic features, respectively. Although a granodiorite (326.2 ± 6.6 Ma) is characterized by high Sr/Y ratios (97.4–139.9), which is generally treated as an adikitic feature, this sample has highly radiogenic Sr–Nd isotopes and displays significantly higher K2O/Na2O ratios than typical adakites. These three granites were probably derived from the partial melting of Precambrian continental crustal sources heated by upwelling asthenosphere in lithospheric extensional setting. Regionally, both the Alxa Block and the southeastern CAOB are characterized by the formation of early Carboniferous extension-related magmatic rocks but lack coeval sedimentary deposits, suggesting a uniform lithospheric extensional setting rather than a simple continental arc. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the molluscicidal effect of the chlorosalicylicamide sustained-release granules (LDS-SRG) on Oncomelania hupensis., Methods: Seven effective concentrations or dosages of LDS-SRG, 0.1, 0.2, 0.4, 0.8, 1.6, 3.2 and 6.4 mg/L （for immersion test） or g/m2（for spraying test）, were prepared from the original 5% and 10% concentrations or dosages in the laboratory. In the immersion test, each concentration of LDS-SRG was incubated with 3 packs of snails（30 snails in each pack）, and each pack was taken for snail counting at 24, 48 and 72 h respectively. In the spraying test, each dosage of LDS-SRG was applied to 200 snails, and the snail mortality was calculated in 50 randmoly collected snails on days 3 and 7, and in the whole on day 14 after administration. In the field immersion test, LDS-SRG at concentrations of 0.4, 0.8 and 1.6 g/m3 was incubated with 6 packs of snails （30 snails in each pack）, and each 2 packs were taken at 24, 48, and 72 h to calculate the snail mortality. In the field spraying test, 0.8, 1.6 and 3.2 g/m2 LDS-SRG was sprayed in 3 snail-positive ditches （～100 m2）, and 10 boxes of snails were selected in each ditch on days 3, 7 and 14 to calculate the snail mortality. The 50% wettable powder of niclosamide ethanolamine salt （WPN） with effective concentrations or dosages of 1.0 mg/L （or g/m2 and g/m3） was used as the positive control. Fresh water served as the blank control., Results: In the labratory immersion test using the original concentration of 5%, both 0.1-6.4 mg/L LDS-SRG for 72 h and 1.6-6.4 mg/L LDS-SRG for 48 h caused 100% mortality; and the concentration lethal to 50% （LC50） at 24, 48 and 72 h was 0.70, 0.01 and 0.01 mg/L respectively. When using the original concentration of 10%, both 0.1-6.4 mg/L LDS-SRG for 72 h and 0.2-6.4 mg/L LDS-SRG for 48 h caused 100% mortality; and the LC50 at 24, 48 and 72 h was 0.15, 0.01 and 0.01 mg/L respectively. The labratory spraying test showed that 7-day administration of 1.6 and 6.4 g/m2 LDS-SRG as well as 14-day administration of 3.2 and 6.4 g/m2 LDS-SRG prepared from 5% dosage, resulted in a snail mortality>95%, with the LD50 on days 3, 7 and 14 being 0.06, 0.16, and 0.18 g/m2; 14-day administration of 1.6 g/m2 LDS-SRG as well as 7-day administration of 6.4 g/m2 LDS-SRG prepared from 10% dosage, resulted in a snail mortality>95%, with the LD50 on days 3, 7 and 14 being 3.29, 0.75, and 0.16 g/m2. The mortality by various dosages of LDS-SRG prepared from 5% dosage was significantly higher than that of the control group (P<0.05). In the field immersion test, the snail mortality by 1.6 g/m3 LDS-SRG prepared from 5% and 10% concentrations for 72 h was 96.43% and 98.21% respectively (P>0.05 versus the control group). In the field spraying test, the snail mortality by 3.2 g/m2 LDS-SRG prepared from 5% dosage for 3, 7 and 14 days was 93.99%, 91.18% and 86.48% respectively, and that from 10% dosage was 94.95%, 93.50% and 85.43%, all significantly higher than that of the control group （82.83%, 72.38% and 48.38%）（P<0.05）; the snail mortality by 0.8 g/m2 LDS-SRG prepared from 5% dosage for 14 days（66.51%） and that by 1.6 g/m2 LDS-SRG prepared from 5% dosage for 3 days（84.61%） were both significantly higher than that by 10% LDS-SRG（20.13% and 43.06%） （P<0.05）., Conclusion: The 5% and 10% LDS-SRG used separately in the immersion test and the spraying test both meet the requirements of the national standard of Efficacy Test Methods and Evaluation of Molluscicide for Pesticide Registration.

Objective: To study the prevalent characteristics and related factors of injuries caused by agricultural machinery in 3 provinces Shandong, Henan and Hebei in China., Methods: A total of 1621 agricultural machinery operators aged between 18 and 60 years old from Shandong, Henan and Hebei provinces were selected by purposive-cluster sampling method in 2009. Demographic characteristics, injury history caused by agricultural machinery in the last year and the related social and psychological factors were collected by self-designed questionnaire. We used statistical description to report the injury prevalence, and adopted the univariate and multivariate analysis to explore the risk factors., Results: The average incidence of injuries caused by agricultural machinery was 13.44% (213/1585) in the three provinces, of which 14.46% (202/1397) in males and 5.85% (11/188) in females (χ(2) = 10.56, P < 0.01). Most of injuries (155 cases, 72.77%) occurred between April and August. Being stuck by rolling starting handles (45 cases, 21.13%), being crushed by running or dropping machineries (32 cases, 15.02%), fall from machines (28 cases, 13.15%) ranked the top three causes of injuries. The main related machines were tractors and motor tricycles (133 cases, 62.44%). The leading types of injuries were scratch (115 cases, 53.99%), strain (68 cases, 31.92%) and fracture (37 cases, 17.37%)., Results: of multivariate logistic regression analysis showed that being male (OR = 3.18, 95%CI:1.65-6.15), educational level above high school(OR = 1.69, 95%CI:1.21-2.34), annual family income <2000 yuan (OR = 1.94, 95%CI:1.13-3.32), operating experience ≤ 5 years (OR = 1.70, 95%CI:1.13-2.55), daytime sleepiness (OR = 2.89, 95%CI:1.66-5.01), smoking during machinery operation (OR = 1.43, 95%CI:1.05-1.96), bearing debts (OR = 1.88, 95%CI:1.35-2.63) and suffering from other diseases (OR = 1.42, 95%CI:1.02-1.98) were risk factors of agricultural machinery injuries., Conclusion: The average incidence of injuries caused by agricultural machinery in the three provinces Shandong, Henan and Hebei, was rather high among agricultural machinery operators, especially in the males. Agricultural machinery injury has been an important issue endangering the health of rural labor force in recent years.

Objective: The aim of the study was to understand the quality of life and the related factors of farmer workers in the countryside of Hubei province., Methods: Purposive sampling was used to select 529 farmer workers and another 326 government workers were served as controls. 'Group investigation' method was used in this study. t-test was used to compare the quality of life among farmer workers and the Chinese norm. SF-36 was used to measure the quality of life. Generalized linear regression model (GLM) and structural equation model (SEM) were applied to test the related factors., Results: Quality of life among farmer workers in Hubei was significantly different from the norm of residents in Hangzhou. The quality of life among migrant workers was significantly lower than the government staff (P(RP) < 0.05, P(BP) < 0.05, P(VT) < 0.05) after controlling the confounding factors. Factors as age (B = -0.33), sex (B = -0.07), marital status (B = -0.10), sleeping habits (B = -0.16), fatigue (B = -0.12), life style (B = -0.05) and social status (B = 0.93) etc. were related to the quality of life., Conclusion: The quality of life among farmer workers was poor, and mainly affected by age, sex, marital status, sleeping habits, fatigue, lifestyle and social status. It is important to reduce the work load and making the work status and life style reasonable to better the quality of life among the farmer workers.

Objective: To investigate the epidemiological condition of the sub-health status of the young and middle-aged persons in urban and rural areas of Hubei province, and to explore the relationships among personality, quality of sleep and sub-health status., Methods: Purposive sampling method and Personal Health Status Questionnaire developed by Chinese Academy of Medical Sciences were used to investigate the sub-healthy status of 3187 subjects aged 18 - 55 and evaluate the relationships among sub-health status, personality and the quality of sleep with structural equation model., Results: Gender, education, marriage, age and occupation were factors influencing the status of sub-health. Among all of the subjects, sub-health status of females were more serious than that of males (P < 0.0001 of all). The divorced, separated and widowed ones were more likely to experience sub-health than other status of marriage (P = 0.0006, P = 0.0102). The sub-health status of the subjects aged 30 - 55 in the urban (P = 0.0197) and low-literacy residents in rural (P = 0.0003) were among the worst. The condition of the sub-health in migrant workers and professional were worse compared to other occupational groups (P = 0.0043). Structural equation model analysis revealed that sub-health status associated with the quality of sleep and the type of characteristics (P < 0.01)., Conclusion: Sub-health status did exist among the young and middle-aged persons and was influenced by the quality of sleep and personality. However, it could be adjusted by improving the quality of sleep and personality to prevent sub-health.

Objective: To understand the epidemiological characteristics and influential factors on internet addiction disorder (IAD) among first-grade junior students in Wuhan city., Methods: An anonymous questionnaire survey was carried out on 1219 first-grade junior students through stratified cluster sampling in 4 middle schools in Wuhan city., Results: The internet use rate (IUR) of first-grade junior students was 96.43%, with the average of primary surfer age as 8.93 +/- 1.95. The internet addiction tendency (IAT) rate and the IAD rate were 10.87% and 7.71% respectively. The IAT and the IAD detection rates among male students were significantly higher than in female students (chi(2) = 13.04, P < 0.01). By ordinal logistic regression analysis, the relative factors mainly involved 6 aspects in IAD, including sex, poor academic performance, the surfer number of times, the surfer time, the surfer place and the surfer expense., Conclusion: The prevalence rates of IAT and IAD were quite high in the first-grade junior students in Wuhan. School authorities, teachers and guardians should collaboratively working together to guide the students in using the network correctly, and to carry out effective interventions to reduce the incidence of internet addiction.

Objective: We developed a scale on opioid addicts' sensitivity to drug-related environments for assessing addicts sensitivity and influential factors, which could provide evidence for psychological interventions on detoxification., Methods: The survey on opioid addicts' sensitivity was administered to 1096 opioid addicts through stratified random cluster sampling in mandatory detoxification centers from 5 cities in China., Results: Patients were more sensitive to environments directly related to drug abuse, social and family environments, especially in those cases that lack of love from family or watching drug use from others, with percentages of persons having strong response reaching 59.40% and 59.05%, respectively. The risk factors of patients' sensitivity to environments directly related to drug abuse would include long period of drug use, high frequency of drug abuse, drug abuse in family members and negative family attitudes (F = 17.10, P < 0.0001). Being female,younger of age, long period of drug use and negative family attitudes increased the extent of patients' sensitivity to social and family environments (F = 8.52, P < 0.0001) while long period of drug use, high frequency of drug abuse, and negative family attitudes increased the extent of patients' sensitivity to environments indirectly related to drug abuse (F = 10.08, P < 0.0001)., Conclusion: Patients were very sensitive to drug-related environments. The extent of patients' sensitivity was influenced by sex, age, years of drug use, the frequency of drug abuse, having drug user in family and the family attitudes towards them.

To explore the role and application of Meta-regression and subgroup analyses to recognize and control the heterogeneity in Meta-analysis, Meta-regression models were established by secondary data to screen the factors resulting heterogeneity, and subgroup analyses were used to compare the change of heterogeneity before and after. The heterogeneity was found in the Meta-analysis (Q = 44.71, df = 27, P = 0.017). Sample size and region were selected (P = 0.012 and P = 0.091, respectively) by Meta-regression from many possible factors such as sample size, year, region and case/ control ratio. The Q values were lowered from 44.71 to 32.11 after subgroup analyses. Thus, Meta-regression method was convenient and reliable to screen the affected factors of heterogeneity, and subgroup analyses based on the hypothesis that could significantly lower the heterogeneity. It was recommended to a combined use when an obvious heterogeneity existed but was in need to get an overall result in Meta-analysis. We could correctly judge and lower the heterogeneity to increase the robustness and rationality of results from Meta-analysis.

Objective: To study the knowledge, attitude and behavior on drugs abuse among junior middle school students., Methods: Junior students of 4 middle schools from 2 cities and 2 small towns were sampled by stratified cluster random sampling method in Xiangfan and Daye respectively, and data was gathered from self-report questionnaires then analyized using SPSS 12.0., Results: Among 1079 junior middle school students, 80.00% of them having good grades for questions about drugs in general while 34.24% ones having poor grades for questions regarding drugs addiction. 54.47% and 41.79% of the students were puzzled on questions related to the harm of drug on brain and body respectively. 30.00% of the students misunderstood the behaviors related to drugs and another 3.20% of them were curious about drugs. 1.58% of the boys and 1.22% of the girls ever having used drugs,with the average age was 9.5 years old when started using drugs. 25.20% of the students ever persuaded their friends to keep away from drugs,while 44.05%-61.29% would refuse the advice from their friends in persuading them to be off from drugs., Conclusion: Junior students had poor knowledge or even wrong ideas about the harm caused by drug, suggesting that it was in urgent need to effectively develop preventive education based on the characteristics of adolescents.

Objective: To investigate the role of knowledge, attitude and perceived social norm on the use of New Type of Drugs (NTD) and to construct the mediated model among these factors., Methods: With stratified random group sampling, 3018 students from 3 middle schools, 3 high schools, 3 vocational high schools and a municipal-own university in Wuhan city completed questionnaires under anonymous and voluntary practice. A conceptual model was developed based on Reasoned Behavior Theory. Structural equation modeling (SEM) was used to test the proposed model., Results: The overall prevalent rate of NTD was 3.28%, with 4.81% for males, 1.94% for females,1.80% for middle school students, 2.91% for general high school students, 7.83% for vocational school students and 3.25% for college students. SEM seemed to have been fixed nicely into the model. Adolescent NTD was significantly predicted by knowledge, attitude, perceived social norm which were all directly affecting or medicated by the susceptibility of drugs., Conclusion: Knowledge, attitude, perceived social norm might increase the risks for NTD use among adolescents, suggesting that preventive education on drug use among adolescents should be paid to improve the knowledge on drugs.

Objective: To identify the direct causes of drug relapse and abstainers' demand, and to develop programs for the prevention of drug relapse., Methods: Abstainers in a Compulsive Detoxification Center in Wuhan City, capital of Hubei Province were randomly selected. An investigation on the direct causes of drug relapse and abstainers' demands was conducted with multiple-choice questionnaires and face to face interviews. Data were analyzed with SPSS 12.0., Results: The direct causes leading to drug relapse included: temptation to use drug again by themselves or by their drug mates, seeking pleasure and ecstasy from drug use, relatively well off living, mental stress, irritation, demoralization, family conflicts, unemployment, feeling distrusted by the family, lack of care and love from the family, and discrimination by others. abstainers' demands after detoxification and returning to the society included: care and support from the family, employment assistance, changing living environment, understanding by others, support from the society, and keeping far away from drugs., Conclusions: Environmental factors are the direct causes of drug relapse, and negative irritation is its predisposing causes. Leaving former residence, more care and help given by both the family and the society and raising their overall quality of life are the demands of abstainers.

Objective: To investigate the status on the initial use of illicit drugs among the college students in Wuhan city,and to explore its related risk factors for developing strategies to reduce the rate., Methods: College students were enrolled from universities by stratified randomization, and were asked to answer the self-report questionnaires anonymously. The related risk factors with initial illicit drugs were analyzed by univariate analyses and logistic regression analysis., Results: The rate of initial illicit drugs use reached 2.0 % among 5677 studied college students in Wuhan city including 2.8 % male students ever once used illicitly with the rate as 5.5 % among senior college students. The overall rate of initial illicit drugs use among students who were under the conditions of insomniac, depression, smoking cigarettes, drinking alcohol,lack of parents' care and bad relationship with classmates were seen as 3.3 %, 3.8%, 18.0 %, 16.3%, 12.0%,16.0% respectively. The rate of initial illicit drugs use among those who were with very high or low family income were 4.0% and 3.1% respectively., Conclusion: There was high rate of initial illicit drug use among college students in Wuhan city and the major risk factors of the initial illicit drugs use would include smoke, drink, depression, bad relationship with classmates and being in higher grade. The problem of the initial illicit drugs was very serious among the college students in Wuhan city which called for special attention.

Objective: To investigate the application of serum glutathione S-transferase (GST) and urinary 8-hydroxy-2-deoxyguanosine (8-OHdG) as the monitoring biomarkers for coke oven workers exposed to polycyclic aromatic hydrocarbons (PAHs)., Methods: 47 male coke oven workers and 31 male control workers were investigated. Urinary 8-OHdG and serum GST were analyzed using high performance liquid chromatography (HPLC) with electrochemical detection and test kit. Urinary 1-hydroxypyrene (1-OHP) as internal exposure of PAHs was also determined simultaneously by alkaline hydrolysis and HPLC., Results: The values of urinary 1-OHP, serum GST and urinary 8-OHdG were reported as median with interquartile range (P(25)-P(75)). Urinary 1-OHP [5.7 (1.4-12.0) micromol/mol Cr], serum GST [22.1 (14.9-31.2) U/ml], and urinary 8-OHdG [1.9 (1.4-15.4) micromol/mol Cr] in coke oven workers were significantly higher than in control workers [3.0 (0.5-6.4) micromol/mol Cr (P < 0.05), 13.1 (9.5-16.7) U/ml (P < 0.01), and 1.3 (1.0-4.0) micromol/mol Cr (P < 0.05) respectively]. Categorizing by smoking status, significant differences in urinary 1-OHP and serum GST were found only in smokers among coke oven workers compared to control workers (P < 0.01), and 8-OHdG levels only in non-smokers (P < 0.01). Additionally, there was significant correlation between urinary 1-OHP and serum GST activity (r(s) = 0.31, P < 0.01, n = 78). The multiple logistic regression analysis showed that coke oven workers were at the higher risk of having GST activities above 16.7 U/ml (OR = 13.2) and 8-OHdG levels above 1.8 micromol/mol creatinine (OR = 4.4). High body mass index was an independent factor to affect urinary 8-OHdG levels., Conclusions: The elevated serum GST activities and increased oxidative DNA damage were found in the coke oven workers. Occupational exposure and smoking interact on each other. Serum GST may be used as a biomarker for assessing the exposure of PAHs. Assay of urinary 8-OHdG may be useful for evaluating the risk of lung cancer in coke oven workers.

Objective: To explore the influence of smoking on chronic diseases among people with various income levels in China., Methods: Cross-sectional study on smoking behavior, chronic disease and income level was performed using database of the Second National Health Service Study (1998) provided by the Ministry of Health in China., Results: Compared to never-smokers, smokers (including current smokers and former smokers) had a higher rate of having chronic diseases, after adjusted in age, income, educational level, employment status and type of jobs with corresponding countryside (OR = 1.185, 95% CI: 1.121 - 1.253 and town OR = 1.083, 95% CI: 1.010 - 1.161). Smoking had a more serious effect on having chronic illness in males from the countryside (former-smoker OR = 2.764, 95% CI: 2.471 - 3.092) than in town (former-smoker OR = 2.112, 95% CI: 1.844 - 2.419). Smokers at the lowest income level had a higher possibility of having chronic illness (town OR = 2.076, 95% CI: 1.551 - 2.780; countryside OR = 2.903, 95% CI: 2.248 - 3.749) than those at the highest income level (town OR = 1.785, 95% CI: 1.285 - 2.479 in the countryside OR = 2.466, 95% CI: 1.941 - 3.134)., Conclusion: Smoking might cause more serious health problems to people at lower income level in China.

Objective: To investigate an effective method to facilitate the physical and mental recovery of drug abusers in detoxification restoration period., Methods: Integrated interventions were adopted to observe the changes in the physical and mental conditions of female drug abusers who had withdrawn drugs., Results: Comparing behavioral changes between the two groups before and after intervention, we found that changes of score in the intervention group were all higher than those in the control group in terms of their physical symptoms or state of anxiety., Conclusion: It is necessary to help drug abusers understand the harm of drug-abuse, build up self-confidence and improve EQ through interventions. It will be beneficial for the drug addicts to refrain from drug-taking and regain a normal life. Our study has proved that positive results can only be obtained from integrated intervention projects.