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30 results on '"Wang, Zekang"'

24. Obg-like ATPase 1 (OLA1) overexpression predicts poor prognosis and promotes tumor progression by regulating P21/CDK2 in hepatocellular carcinoma

Author

Huang, Shanzhou, primary, Zhang, Chuanzhao, additional, Sun, Chengjun, additional, Hou, Yuchen, additional, Zhang, Yixi, additional, Tam, Nga Lei, additional, Wang, Zekang, additional, Yu, Jia, additional, Huang, Bowen, additional, Zhuang, Hongkai, additional, Zhou, Zixuan, additional, Ma, Zuyi, additional, Sun, Zhonghai, additional, He, Xiaoshun, additional, Zhou, Qi, additional, Hou, Baohua, additional, and Wu, Linwei, additional

Published
2020
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26. Embedding wasted hairs in Ti/PbO2anode for efficient and sustainable electrochemical oxidation of organic wastewater

Author

Shao, Dan, Wang, Zekang, Zhang, Cuiping, Li, Weijia, Xu, Hao, Tan, Guoqiang, and Yan, Wei

Abstract

Despite of the hazardous risk of Pb2+leakage, lead dioxide has been attributed as a quasi-ideal anode material with high oxygen evolution potential, excellent conductivity, good stability and low cost in electrochemical oxidation wastewater treatment technique. In this study, a novel Ti/PbO2anode was fabricated by embedding raw materials that are readily and cheaply available, i.e., hairs. The structure-activity relationship of the new electrode was firstly revealed by material and electrochemical characterizations. Then different levels of pollutants (azo dye, phenol and maleic acid) were used to investigate the electrochemical oxidation performance of the new electrode. Finally, the accelerated electrode lifetime and Pb2+leakage tests were carried out. Results showed that the embedded hairs changed the preferential crystallographic orientation of PbO2and decreased the grain size. Hairs introduced additional roughness and active sites, and decreased the electrode impedance, especially under 5 mg/cm2of embedding amount. The removal efficiencies of different target pollutants were enhanced more or less by embedding appropriate amount of hairs, depending on the current density, but loading excessive hairs had a negative effect. The accumulation of intermediate products during phenol degradation was also changed by the hairs. The new electrode could undergo ∼550 h of harsh electrolysis. It is also relieved that the Pb2+leakage was found to be suppressed during this long-term electrolysis process.

Published
2022
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30. Exosome-related lncRNAs as predictors of HCC patient survival: a prognostic model.

Author

Hou Y, Yu Z, Tam NL, Huang S, Sun C, Wang R, Zhang X, Wang Z, Ma Y, He X, and Wu L

Abstract

Objectives: Accumulating evidence suggests that long non-coding RNA (lncRNA) may affect hepatocellular carcinoma (HCC) progression. However, the mechanism remains unclear. Previous studies have shown that exosomes may promote tumor progression by transporting proteins. Our study aimed to determine the prognostic value of lncRNAs in HCC and the underlying mechanism., Methods: A dataset comprising a HCC cohort of 364 patients from The Cancer Genome Atlas (TCGA) was analyzed to identify lncRNAs with prognostic value. Co-expression and competing endogenous RNA (ceRNA) networks were constructed to investigate the mechanism of exosome-related lncRNAs. To confirm the bioinformatics analysis results, 95 pairs of clinical samples were evaluated by digoxigenin-labeled chromogenic in situ hybridization (CISH)., Results: Five lncRNAs (CTD-2116N20.1, AC012074.2, RP11-538D16.2, LINC00501 and RP11-136I14.5) with significant differences were identified (P<0.001). A prognostic nomogram was constructed with a C-index of 0.701. The co-expression and ceRNA networks showed possible mechanisms for CTD-2116N20.1 and RP11-538D16.2. The CISH results confirmed that CTD-2116N20.1 and RP11-538D16.2 were correlated with a poor prognosis for HCC patients., Conclusion: Our findings provide an independent and effective prognostic model to predict the survival rate of HCC patients. RP11-538D16.2 and CTD-2116N20.1 are highlighted as important exosome-related lncRNAs., Competing Interests: None.

Published
2018

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