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A comprehensive understanding of the distribution pattern and driving factors of population aging at the country level in China is fundamental for enhancing the governance capacity of the governing authorities and implementing a national strategy to actively cope with the aging society. On the basis of the 2000, 2010, and 2020 census data on the Chinese population, we determined the distribution pattern of population aging in China over the past 20 years at the county level and adopted a fractional response model to identify the main influencing factors of such spatial distribution from three perspectives: the natural environment, socioeconomic factors, and population migration. The following observations were made: 1) During the past 20 years, most counties in China have entered into an "aging society," some counties have entered into an "aged society," and counties in the Chengdu-Chongqing region, central Inner Mongolia, and peripheral Yangtze River Delta have entered into a "hyper-aged society." 2) The spatial structure of the distribution of population aging exhibited various patterns. Overall, the Hu Line is a clear demarcation for the distribution, with the degree of aging of the counties in the southeastern half of the line being generally higher than that of the counties in the northwestern half and maintaining a certain degree of stability. During the past 20 years, the aging population has shown a gradient diffusion of the characteristics of the Eastern monsoon region―Northwest arid region―Qinghai-Tibet Plateau region. From a local perspective, population aging presents various structural characteristics, such as "homogenization," "reverse core-edge," and "core-edge" spatial structures. 3) Significant regional differences exist in population aging. Vast differences in population aging between different ecological regions, between urban and rural areas, and between ethnic and non-ethnic autonomous regions are obvious, and these differences tend to expand further. 4) Natural factors have laid the macro pattern of the distribution of population aging. Socioeconomic factors are the main driving force of the aging process, and population migration has played an important role in restructuring the aging space pattern. This study provides a scientific basis for optimization of the spatial allocation of pension resources, and different regions can actively respond to the formulation and improvement of differentiated policies for population aging.

Simple Summary: We explored the role of exercise in promoting hippocampal neurogenesis and memory function in T2DM mice through the Irisin/TLR4/MyD88/NF-κB signaling pathway. Ten weeks of exercise training significantly reduced inflammation in the DG region caused by T2DM and promoted hippocampal neurogenesis and memory function. However, these positive effects could be reversed by treatment with Cyclo RGDyk, which blocks irisin receptor signaling. The results suggest that exercise may be an effective strategy for alleviating cognitive decline caused by diabetes by activating the irisin signaling pathway. Neuroinflammation is a major feature of type 2 diabetic mellitus (T2DM), adversely affecting hippocampal neurogenesis. However, the precise mechanism is not fully understood, and therapeutic approaches are currently lacking. Therefore, we determined the effects of exercise on neuroinflammation and hippocampal neurogenesis in T2DM mice, with a specific focus on understanding the role of the irisin and related cascade pathways in modulating the beneficial effects of exercise in these processes. Ten-week exercise significantly decreased T2DM-induced inflammation levels and markedly promoted hippocampal neurogenesis and memory function. However, these positive effects were reversed by 10 weeks of treatment with cyclo RGDyk, an inhibitor of irisin receptor signaling. Additionally, exercise helped reduce the M1 phenotype polarization of hippocampal microglia in diabetic mice; this effect could be reversed with cyclo RGDyk treatment. Moreover, exercise markedly increased the levels of fibronectin type III domain-containing protein 5 (FNDC5)/irisin protein while decreasing the expression of Toll-like receptor 4 (TLR4), myeloid differential protein-88 (MyD88), and nuclear factor kappa-B (NF-κB) in the hippocampus of T2DM mice. However, blocking irisin receptor signaling counteracted the down-regulation of TLR4/MyD88/NF-κB in diabetic mice undergoing exercise intervention. Conclusively, exercise appears to be effective in reducing neuroinflammation and enhancing hippocampal neurogenesis and memory in diabetes mice. The positive effects are involved in the participation of the irisin/TLR4/MyD88/NF-κB signaling pathway, highlighting the potential of exercise in the management of diabetic-induced cognitive decline. [ABSTRACT FROM AUTHOR]

Intratumoral heterogeneity (ITH) is a fundamental property of cancer; however, the origins of ITH remain poorly understood. We performed single-cell transcriptome profiling of peritoneal carcinomatosis (PC) from 15 patients with gastric adenocarcinoma (GAC), constructed a map of 45,048 PC cells, profiled the transcriptome states of tumor cell populations, incisively explored ITH of malignant PC cells and identified significant correlates with patient survival. The links between tumor cell lineage/state compositions and ITH were illustrated at transcriptomic, genotypic, molecular and phenotypic levels. We uncovered the diversity in tumor cell lineage/state compositions in PC specimens and defined it as a key contributor to ITH. Single-cell analysis of ITH classified PC specimens into two subtypes that were prognostically independent of clinical variables, and a 12-gene prognostic signature was derived and validated in multiple large-scale GAC cohorts. The prognostic signature appears fundamental to GAC carcinogenesis and progression and could be practical for patient stratification. Single-cell analysis of gastric cancer samples tracks the cell of origin of metastatic lesions and identifies an independent prognostic signature of the clinical outcome., Author(s): Ruiping Wang [sup.1] , Minghao Dang [sup.1] , Kazuto Harada [sup.2] [sup.12] , Guangchun Han [sup.1] , Fang Wang [sup.3] , Melissa Pool Pizzi [sup.2] , Meina Zhao [sup.2] [...]