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12. Chromatin regulators in the TBX1 network confer risk for conotruncal heart defects in 22q11.2DS.

Author

Zhao, Yingjie, Wang, Yujue, Shi, Lijie, McDonald-McGinn, Donna, Crowley, T, McGinn, Daniel, Tran, Oanh, Miller, Daniella, Lin, Jhih-Rong, Zackai, Elaine, Johnston, H, Chow, Eva, Vorstman, Jacob, Vingerhoets, Claudia, van Amelsvoort, Therese, Gothelf, Doron, Swillen, Ann, Breckpot, Jeroen, Vermeesch, Joris, Eliez, Stephan, Schneider, Maude, van den Bree, Marianne, Owen, Michael, Kates, Wendy, Repetto, Gabriela, Shashi, Vandana, Schoch, Kelly, Digilio, M, Unolt, Marta, Putotto, Carolina, Marino, Bruno, Pontillo, Maria, Armando, Marco, Vicari, Stefano, Angkustsiri, Kathleen, Campbell, Linda, Busa, Tiffany, Heine-Suñer, Damian, Murphy, Kieran, Murphy, Declan, García-Miñaúr, Sixto, Fernández, Luis, Zhang, Zhengdong, Goldmuntz, Elizabeth, Gur, Raquel, Emanuel, Beverly, Zheng, Deyou, Marshall, Christian, Bassett, Anne, Wang, Tao, Morrow, Bernice, and Bearden, Carrie

Abstract

Congenital heart disease (CHD) affecting the conotruncal region of the heart, occurs in 40-50% of patients with 22q11.2 deletion syndrome (22q11.2DS). This syndrome is a rare disorder with relative genetic homogeneity that can facilitate identification of genetic modifiers. Haploinsufficiency of TBX1, encoding a T-box transcription factor, is one of the main genes responsible for the etiology of the syndrome. We suggest that genetic modifiers of conotruncal defects in patients with 22q11.2DS may be in the TBX1 gene network. To identify genetic modifiers, we analyzed rare, predicted damaging variants in whole genome sequence of 456 cases with conotruncal defects and 537 controls, with 22q11.2DS. We then performed gene set approaches and identified chromatin regulatory genes as modifiers. Chromatin genes with recurrent damaging variants include EP400, KAT6A, KMT2C, KMT2D, NSD1, CHD7 and PHF21A. In total, we identified 37 chromatin regulatory genes, that may increase risk for conotruncal heart defects in 8.5% of 22q11.2DS cases. Many of these genes were identified as risk factors for sporadic CHD in the general population. These genes are co-expressed in cardiac progenitor cells with TBX1, suggesting that they may be in the same genetic network. The genes KAT6A, KMT2C, CHD7 and EZH2, have been previously shown to genetically interact with TBX1 in mouse models. Our findings indicate that disturbance of chromatin regulatory genes impact the TBX1 gene network serving as genetic modifiers of 22q11.2DS and sporadic CHD, suggesting that there are some shared mechanisms involving the TBX1 gene network in the etiology of CHD.

Published
2023

13. Compacter networks as a defensive mechanism: How firms clustered during 2015 Financial Crisis in China

Author

Wang, Yujue

Subjects
Economics - General Economics
Abstract

The stock market's reaction to the external risk shock is closely related to the cross-shareholding network structure. This paper takes the public information of listed companies in the A-share securities market as the primary sample to study the relationship between the stock return rate, market performance, and network topology before and after China's stock market crash in 2015. Data visualization and empirical analysis demonstrate that the return rate of stocks is related to the company's traditional business ability and the social capital brought by cross-holding. Several heteroscedasticity tests and endogeneity tests with IV are conducted to support the robustness. The structure of the cross-shareholding network experienced upheaval after the shock, even distorting the effects of market value, and assets holding on the return rate. The enterprises in the entire shareholding network are connected more firmly to overcome systematic external risks. The number of enterprise clusters is significantly reduced during the process. Besides, the number of newly established cross-shareholding relationships shows an outbreak, which may explain the rapid maintenance of stability in the financial system. When stable clustering is formed before and after a stock crash (rather than when it occurs), the clustering coefficient of clear clustering still has an apparent positive influence on the return rate of stocks. To sum up, the compacted network may prevent the firms from pursuing aggressive earning before the financial crisis, but would protect firms from suffering relatively high losses during and after the shock.

Published
2022

14. Short-term shock, long-lasting payment: Evidence from the Lushan Earthquake

Author

Wang, Yujue

Subjects
Economics - General Economics
Abstract

Abrupt catastrophic events bring business risks into firms. The paper introduces the Great Lushan Earthquake in 2013 in China as an unexpected shock to explore the causal effects on public firms in both the long and short term. DID-PSM methods are conducted to examine the robustness of causal inference. The identifications and estimations indicate that catastrophic shock significantly negatively impacts cash flow liquidity and profitability in the short term. Besides, the practical influences on firms' manufacturing and operation emerge in the treated group. Firms increase non-business expenditures and retained earnings as a financial measure to resist series risk during the shock period. As the long-term payment, the decline in production factors, particularly in employment level and the loss in fixed assets, are permanent. The earthquake's comprehensive interactions are also reflected. The recovery from the disaster would benefit the companies by raising the growth rate of R\&D and enhancing competitiveness through increasing market share, though these effects are temporary. PSM-DID and event study methods are implemented to investigate the general effects of specific strong earthquakes on local public firms nationwide. Consistent with the Lushan Earthquake, the ratio of cash flow to sales dropped drastically and recovered in 3 subsequent semesters. The shock on sales was transitory, only in the current semester.

Published
2022

15. A Verifiable Federated Learning Algorithm Supporting Distributed Pseudonym Tracking

Author

Xie, Haoran, Wang, Yujue, Ding, Yong, Yang, Changsong, Wang, Huiyong, Liang, Hai, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Onizuka, Makoto, editor, Lee, Jae-Gil, editor, Tong, Yongxin, editor, Xiao, Chuan, editor, Ishikawa, Yoshiharu, editor, Amer-Yahia, Sihem, editor, Jagadish, H. V., editor, and Lu, Kejing, editor

Published
2024
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16. A Lightweight PUF-Based Group Authentication Scheme for Privacy-Preserving Metering Data Collection in Smart Grid

Author

Cao, Ya-Nan, Wang, Yujue, Ding, Yong, Guo, Zhenwei, Yang, Changsong, Liang, Hai, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin, Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Gao, Honghao, editor, Wang, Xinheng, editor, and Voros, Nikolaos, editor

Published
2024
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17. Secure Traffic Data Sharing in UAV-Assisted VANETs

Author

Liu, Yilin, Wang, Yujue, Yi, Chen, Ding, Yong, Yang, Changsong, Wang, Huiyong, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin, Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Gao, Honghao, editor, Wang, Xinheng, editor, and Voros, Nikolaos, editor

Published
2024
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18. Privacy-Preserving Blockchain Supervision with Responsibility Tracking

Author

Wen, Baodong, Wang, Yujue, Ding, Yong, Zheng, Haibin, Liang, Hai, Yang, Changsong, Liu, Jinyuan, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin, Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Gao, Honghao, editor, Wang, Xinheng, editor, and Voros, Nikolaos, editor

Published
2024
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19. Efficient and Revocable Anonymous Account Guarantee System Based on Blockchain

Author

Liang, Weiyou, Wang, Yujue, Ding, Yong, Liang, Hai, Yang, Changsong, Wang, Huiyong, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin, Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Gao, Honghao, editor, Wang, Xinheng, editor, and Voros, Nikolaos, editor

Published
2024
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21. A UAV Penetration Method Based on the Improved A* Algorithm

Author

Zhang, Shitong, Wang, Qing, Xin, Bin, Wang, Yujue, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Xin, Bin, editor, Kubota, Naoyuki, editor, Chen, Kewei, editor, and Dong, Fangyan, editor

Published
2024
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22. Comprehensive Evaluation of Elasto-Magnetic Parameters for High-Performance Cable Force Monitoring Under the Effect of Temperature

Author

Wang, Yujue, Yan, Shuangsheng, Liu, Xiucheng, Wu, Bin, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Burduk, Anna, editor, Batako, Andre D. L., editor, Machado, José, editor, Wyczółkowski, Ryszrad, editor, Dostatni, Ewa, editor, and Rojek, Izabela, editor

Published
2024
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25. Nebula Graph: An open source distributed graph database

Author

Wu, Min, Yi, Xinglu, Yu, Hui, Liu, Yu, and Wang, Yujue

Subjects
Computer Science - Databases
Abstract

This paper introduces the recent work of Nebula Graph, an open-source, distributed, scalable, and native graph database. We present a system design trade-off and a comprehensive overview of Nebula Graph internals, including graph data models, partitioning strategies, secondary indexes, optimizer rules, storage-side transactions, graph query languages, observability, graph processing frameworks, and visualization tool-kits. In addition, three sets of large-scale graph b

Published
2022

26. Glutamine synthetase limits b-catenin-mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1

Author

Dai, Weiwei, Shen, Jianliang, Yan, Junrong, Bott, Alex J, Maimouni, Sara, Daguplo, Heineken Q, Wang, Yujue, Khayati, Khoosheh, Guo, Jessie Yanxiang, Zhang, Lanjing, Wang, Yongbo, Valvezan, Alexander, Ding, Wen-Xing, Chen, Xin, Su, Xiaoyang, Gao, Shenglan, and Zong, Wei-Xing

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biological Sciences, Cancer, Digestive Diseases, Liver Disease, Rare Diseases, Animals, Mice, Glutamate-Ammonia Ligase, beta Catenin, Mechanistic Target of Rapamycin Complex 1, Ammonia, Nitrogen, Liver Neoplasms, Liver, Glutamine, Homeostasis, Urea, Hepatology, Liver cancer, Metabolism, Medical and Health Sciences, Immunology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Glutamine synthetase (GS) catalyzes de novo synthesis of glutamine that facilitates cancer cell growth. In the liver, GS functions next to the urea cycle to remove ammonia waste. As a dysregulated urea cycle is implicated in cancer development, the impact of GS's ammonia clearance function has not been explored in cancer. Here, we show that oncogenic activation of β-catenin (encoded by CTNNB1) led to a decreased urea cycle and elevated ammonia waste burden. While β-catenin induced the expression of GS, which is thought to be cancer promoting, surprisingly, genetic ablation of hepatic GS accelerated the onset of liver tumors in several mouse models that involved β-catenin activation. Mechanistically, GS ablation exacerbated hyperammonemia and facilitated the production of glutamate-derived nonessential amino acids, which subsequently stimulated mechanistic target of rapamycin complex 1 (mTORC1). Pharmacological and genetic inhibition of mTORC1 and glutamic transaminases suppressed tumorigenesis facilitated by GS ablation. While patients with hepatocellular carcinoma, especially those with CTNNB1 mutations, have an overall defective urea cycle and increased expression of GS, there exists a subset of patients with low GS expression that is associated with mTORC1 hyperactivation. Therefore, GS-mediated ammonia clearance serves as a tumor-suppressing mechanism in livers that harbor β-catenin activation mutations and a compromised urea cycle.

Published
2022

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