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This article presents the findings of a study on serum globulin levels in patients with systemic lupus erythematosus (SLE). The study identified two distinct trajectories of serum globulin levels and developed a predictive model for the elevated globulin level trajectory. The model included various blood test values and may be useful for monitoring and managing SLE. The study highlights the importance of monitoring globulin levels in SLE patients for disease progression. [Extracted from the article]

An elastohydrodynamic model of ferrofluid‐lubricated involute spur gears was established, and transient thermal elastohydrodynamic lubrication (EHL) analysis was conducted using multigrid method and multigrid integral method. The transient lubricant film thickness, pressure, and friction coefficient characteristics of the spur gears were compared under different carrier fluid ferrofluids. Ester‐based H01 ferrofluid was selected to further examine the lubricant film elastohydrodynamic characteristics of the involute spur gears under different loads and speeds. The results indicated that the film thickness and the inlet area pressure were the largest when hydrocarbon‐based E02 ferrofluid was used for lubrication and were the smallest when ester‐based ferrofluid H01 was used for lubrication. When ester‐based H01 ferrofluid was used, the film thickness, the inlet area pressure, and the second pressure peak increased with the increase of speed, and the second pressure peak shifted toward the inlet area. The friction coefficient and the maximum temperature gradually decreased with the increase of speed, and the second pressure peak, the friction coefficient, and the maximum temperature gradually increased with the increase of load, while the film thickness gradually decreased. [ABSTRACT FROM AUTHOR]

Rheumatoid arthritis (RA) is a chronic inflammatory disorder that can, in severe cases, lead to disability. CC chemokine receptor (CCR), an integral membrane protein, has been suggested to play a key role in the RA developmentThis study is to explore the role of CCR5 silencing in inflammatory response, viability, and apoptosis of synovial cells in RA rats by inactivating the mitogen‐activated protein kinase (MAPK) signaling pathway. Microarray analysis was conducted to screen out differentially expressed genes from RA‐related chips. The rat model was established by injection of siRNA‐CCR5 and PD98059 (inhibitor of mitogen‐activated protein kinase kinase 1) to evaluate the role of CCR5 silencing in RA, with the involvement of inflammatory response, synovial cell viability, apoptosis, and cycle. CCR5 was predicted to participate in RA by regulating the MARK pathway. In animal experiments, reduction was identified in arthritis index (AI), CCR5 positive expression rate, levels of tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), matrix metalloproteinase (MMP)‐1, and MMP‐3 in serum of RA rats after CCR5 siRNA and PD98059 injections. RA rats treated with CCR5 siRNA, and PD98059 presented with inhibition in cell viability, promotion of apoptosis, increase in cell proportion in G0/G1 phase, and shortened the S phase. In addition, the treatment of CCR5 siRNA, and PD98059 resulted in downregulated JNK1, ERK1, p38, Cyclin D1, Cyclin E1, Cyclin B1, and Bcl‐2 and upregulated Bax and Cas3. These findings reveal that CCR5 silencing suppresses inflammatory response, inhibits viability, and promotes apoptosis of synovial cells in RA rats by inhibiting MAPK pathway. Therefore, CCR5 silencing may provide a novel therapeutic target for RA. [ABSTRACT FROM AUTHOR]