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140 results on '"Wang, Yingfan"'

1. Approximate Group Fairness for Clustering

Author

Li, Bo, Li, Lijun, Sun, Ankang, Wang, Chenhao, and Wang, Yingfan

Subjects
Computer Science - Computer Science and Game Theory, Economics - Theoretical Economics
Abstract

We incorporate group fairness into the algorithmic centroid clustering problem, where $k$ centers are to be located to serve $n$ agents distributed in a metric space. We refine the notion of proportional fairness proposed in [Chen et al., ICML 2019] as {\em core fairness}, and $k$-clustering is in the core if no coalition containing at least $n/k$ agents can strictly decrease their total distance by deviating to a new center together. Our solution concept is motivated by the situation where agents are able to coordinate and utilities are transferable. A string of existence, hardness and approximability results is provided. Particularly, we propose two dimensions to relax core requirements: one is on the degree of distance improvement, and the other is on the size of deviating coalition. For both relaxations and their combination, we study the extent to which relaxed core fairness can be satisfied in metric spaces including line, tree and general metric space, and design approximation algorithms accordingly., Comment: Appears in ICML 2021

Published
2022

8. Understanding How Dimension Reduction Tools Work: An Empirical Approach to Deciphering t-SNE, UMAP, TriMAP, and PaCMAP for Data Visualization

Author

Wang, Yingfan, Huang, Haiyang, Rudin, Cynthia, and Shaposhnik, Yaron

Subjects
Computer Science - Machine Learning, Statistics - Machine Learning
Abstract

Dimension reduction (DR) techniques such as t-SNE, UMAP, and TriMAP have demonstrated impressive visualization performance on many real world datasets. One tension that has always faced these methods is the trade-off between preservation of global structure and preservation of local structure: these methods can either handle one or the other, but not both. In this work, our main goal is to understand what aspects of DR methods are important for preserving both local and global structure: it is difficult to design a better method without a true understanding of the choices we make in our algorithms and their empirical impact on the lower-dimensional embeddings they produce. Towards the goal of local structure preservation, we provide several useful design principles for DR loss functions based on our new understanding of the mechanisms behind successful DR methods. Towards the goal of global structure preservation, our analysis illuminates that the choice of which components to preserve is important. We leverage these insights to design a new algorithm for DR, called Pairwise Controlled Manifold Approximation Projection (PaCMAP), which preserves both local and global structure. Our work provides several unexpected insights into what design choices both to make and avoid when constructing DR algorithms.

Published
2020

27. Interictal magnetic signals in new‐onset Rolandic epilepsy may help with timing of treatment selection.

Author

Xu, Fengyuan, Li, Yihan, Wang, Yingfan, Wang, Siyi, Sun, Fangling, and Wang, Xiaoshan

Subjects
FRONTAL lobe, EPILEPSY, TRANSCRANIAL magnetic stimulation, TREATMENT delay (Medicine), MAGNETOENCEPHALOGRAPHY
Abstract

Objective: With research progress on Rolandic epilepsy (RE), its "benign" nature has been phased out. Clinicians are exhibiting an increasing tendency toward a more assertive treatment approach for RE. Nonetheless, in clinical practice, delayed treatment remains common because of the "self‐limiting" nature of RE. Therefore, this study aimed to identify an imaging marker to aid treatment decisions and select a more appropriate time for initiating therapy for RE. Methods: We followed up with children newly diagnosed with RE, classified them into medicated and non‐medicated groups according to the follow‐up results, and compared them with matched healthy controls. Before beginning follow‐up visits, interictal magnetic data were collected using magnetoencephalography in treatment‐naïve recently diagnosed patients. The spectral power of the whole brain during initial diagnosis was determined using minimum normative estimation combined with the Welch technique. Results: A difference was observed in the magnetic source intensity within the left caudal anterior cingulate and precentral and postcentral gyri in the delta band between the medicated and non‐medicated groups. The results revealed good discriminatory ability within the receiver operator characteristic curve. In the medicated group, there was a specific change in the frontotemporal magnetic source intensity, which shifted from high to low frequencies, compared with the healthy control group. Significance: The intensity of the precentral gyrus magnetic source within the delta band showed good specificity. Considering the rigor of initial treatment, the intensity of the precentral gyrus magnetic source can provide some help as an imaging marker for initial RE treatment, particularly for the timing of treatment initiation. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Permittivity Measurement From 40 to 70 GHz Using a DC FPOR With a Fixed Specimen Holder and an Off-Axial Feed

Author

Wu, Changying, Wang, Yingfan, Tu, Limin, Zhang, Yuecheng, and Yashchyshyn, Yevhen

Abstract

This article proposes a double-concave (DC) Fabry–Perot open resonator (FPOR) to measure the complex permittivity of a material under test (MUT) in the band from 40 to 70 GHz. The resonator is fed by waveguides through two feed holes. One of these holes is off-axial and placed at the zero position of the higher order modes fields to suppress the mode coupling from these modes. During the measurement, the MUT is placed on the specimen holder with a fixed position. The fixed sample holder position makes the center of MUT in the resonator change according to its thickness. A method based on the complex-source-point method to calculate the permittivity of the MUT is presented and verified, regardless of whether the MUT is in the center of the resonator. With this method, the motor unit to adjust the position of the MUT to the center of the resonator is no longer needed. A method to measure the exact sample holder position is also given. The validity and accuracy of the proposed DC FPOR and the complex permittivity extraction algorithm are verified by simulation results and by measuring the well-known materials with low, medium, and high permittivity, namely, polytetrafluoroethylene (PTFE), fused silica, and alumina.

Published
2024
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45. MG53 E3 Ligase–Dead Mutant Protects Diabetic Hearts From Acute Ischemic/Reperfusion Injury and Ameliorates Diet-Induced Cardiometabolic Damage

Author

Feng, Han, primary, Shen, Hao, additional, Robeson, Matthew J., additional, Wu, Yue-Han, additional, Wu, Hong-Kun, additional, Chen, Geng-Jia, additional, Zhang, Shuo, additional, Xie, Peng, additional, Jin, Li, additional, He, Yanyun, additional, Wang, Yingfan, additional, Lv, Fengxiang, additional, Hu, Xinli, additional, Zhang, Yan, additional, and Xiao, Rui-Ping, additional

Published
2021
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50. MG53 E3 Ligase-Dead Mutant Protects Diabetic Hearts From Acute Ischemic/Reperfusion Injury and Ameliorates Diet-Induced Cardiometabolic Damage.

Author

Feng, Han, Shen, Hao, Robeson, Matthew J., Wu, Yue-Han, Wu, Hong-Kun, Chen, Geng-Jia, Zhang, Shuo, Xie, Peng, Jin, Li, He, Yanyun, Wang, Yingfan, Lv, Fengxiang, Hu, Xinli, Zhang, Yan, and Xiao, Rui-Ping

Subjects
REPERFUSION injury, MYOCARDIAL injury, HEART metabolism disorders, CARDIOLOGICAL manifestations of general diseases, MYOCARDIAL infarction, CELL metabolism, HEART metabolism, RESEARCH, DIABETIC cardiomyopathy, MYOCARDIUM, CELL culture, HEART, PHARMACOLOGY, ANIMAL experimentation, RESEARCH methodology, DIET, EVALUATION research, MYOCARDIAL reperfusion complications, CELLULAR signal transduction, COMPARATIVE studies, CELLS, MEMBRANE proteins, MICE, DISEASE complications
Abstract

Cardiometabolic diseases, including diabetes and its cardiovascular complications, are the global leading causes of death, highlighting a major unmet medical need. Over the past decade, mitsugumin 53 (MG53), also called TRIM72, has emerged as a powerful agent for myocardial membrane repair and cardioprotection, but its therapeutic value is complicated by its E3 ligase activity, which mediates metabolic disorders. Here, we show that an E3 ligase-dead mutant, MG53-C14A, retains its cardioprotective function without causing metabolic adverse effects. When administered in normal animals, both the recombinant human wild-type MG53 protein (rhMG53-WT) and its E3 ligase-dead mutant (rhMG53-C14A) protected the heart equally from myocardial infarction and ischemia/reperfusion (I/R) injury. However, in diabetic db/db mice, rhMG53-WT treatment markedly aggravated hyperglycemia, cardiac I/R injury, and mortality, whereas acute and chronic treatment with rhMG53-C14A still effectively ameliorated I/R-induced myocardial injury and mortality or diabetic cardiomyopathy, respectively, without metabolic adverse effects. Furthermore, knock-in of MG53-C14A protected the mice from high-fat diet-induced metabolic disorders and cardiac damage. Thus, the E3 ligase-dead mutant MG53-C14A not only protects the heart from acute myocardial injury but also counteracts metabolic stress, providing a potentially important therapy for the treatment of acute myocardial injury in metabolic disorders, including diabetes and obesity. [ABSTRACT FROM AUTHOR]

Published
2022
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