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Taking the insulating concrete in thermal insulation materials as a start and from the perspectives of foamed concrete and lightweight aggregate concrete, ceramsite and polystyrene particles are selected as aggregates, with aluminum powder paste used for foaming treatment, a new type of insulating anchor sprayed concrete material is fabricated by orthogonal experiment method, and its insulation performance and compressive strength are measured by the national standard. Consequently, a new formula with thermal conductivity of 0.139 8 W/（ｍ·Ｋ） is chosen, which is only equivalent to 1/12 of ordinary anchor sprayed concrete material. Based on its insulation performance, the Fluent numerical simulation software is utilized to simulate the thermal insulation effect of this new type of concrete under the condition of mine ventilation. The results show that compared with ordinary concrete, the temperature in the center of roadway is reduced by 8.8 ℃, which has a significant effect and good application and development prospect.

In order to study the mechanical properties of inverted cone bottom oil storage tanks under earthquakes when the foundation is uneven, finite element modeling calculation for a 20,000 m3 storage tank is carried out based on ANSYS Workbench. Wind load, hydraulic pressure load, and seismic load are all equalized as distributed loads with varying spatial positions. Considering various combinations of different heterogeneous foundations and seismic loads, and by adjusting the preset foundation bed coefficient, the final foundation bed coefficient and the maximum foundation settlement value when the equivalent stress of the tank floor reaches yield strength under different conditions are calculated. The results show that under the condition of heterogeneous foundation stiffness considering seismic action, when the coefficient of local foundation bed is higher than that of natural silty clay, the requirement for safe use of the inverted cone bottom storage tank can be met. Among the seven simulated heterogeneous foundation forms, the form with high foundation stiffness on the windward side has a great influence on the safety of storage tanks. [ABSTRACT FROM AUTHOR]

Background: Mining gene regulatory network (GRN) is an important avenue for addressing cancer mechanism. Mutations in cancer genome perturb GRN and cause a rewiring in an orchestrated network. Hence, the exploration of gene regulatory network rewiring is significant to discover potential biomarkers and indicators for discriminating cancer phenotypes. Results: Here, we propose a new bioinformatics method of identifying biomarkers based on network rewiring in different states. It firstly reconstructs GRN in different phenotypic conditions from gene expression data with a priori background network. We employ the algorithm based on path consistency algorithm and conditional mutual information to delete false-positive regulatory interactions between independent nodes/genes or not closely related gene pairs. And then a differential gene regulatory network (D-GRN) is constructed from the rewiring parts in the two phenotype-specific GRNs. Community detection technique is then applied for D-GRN to detect functional modules. Finally, we apply logistic regression classifier with recursive feature elimination to select biomarker genes in each module individually. The extracted feature genes result in a gene set of biomarkers with impressing ability to distinguish normal samples from controls. We verify the identified biomarkers in external independent validation datasets. For a proof-of-concept study, we apply the framework to identify diagnostic biomarkers of breast cancer. The identified biomarkers obtain a maximum AUC of 0.985 in the internal sample classification experiments. And these biomarkers achieve a maximum AUC of 0.989 in the external validations. Conclusion: In conclusion, network rewiring reveals significant differences between different phenotypes, which indicating cancer dysfunctional mechanisms. With the development of sequencing technology, the amount and quality of gene expression data become available. Condition-specific gene regulatory networks that are close to the real regulations in different states will be established. Revealing the network rewiring will greatly benefit the discovery of biomarkers or signatures for phenotypes. D-GRN is a general method to meet this demand of deciphering the high-throughput data for biomarker discovery. It is also easy to be extended for identifying biomarkers of other complex diseases beyond breast cancer. [ABSTRACT FROM AUTHOR]

In order to study the stress and deformation distribution characteristics of inverted cone-bottom steel oil tanks with different oil storage capacity, a finite element modeling calculation for a 20 000 m3 storage tank was carried out by ANSYS Workbench software, and the wind load and storage pressure load were equivalently replaced by distributed loads that vary with the spatial position. Considering the multiple combined effects of different storage volumes and wind load,the effect values of the radial deformation of the tank body, the equivalent stress of the tank bottom plate and the vertical settlement deformation of the foundation raft bottom under different working conditions were obtained respectively, and the distribution law of each effect value was analyzed. The results show that the Von-mises equivalent stress on the windward side of the bottom of the storage tank is greatly affected by the wind load, and the equivalent stress in the middle is slightly affected by the wind load. The difference in Von-mises equivalent stress at the edges of the windward and leeward sides of the bottom will be increased by the existence of the static pressure of the storage liquid. The vertical settlement of the raft bottom is reduced by 0-66% on average under the lift of the wind load, but the wind load has a much smaller influence on the settlement distribution than the weight of the storage liquid. [ABSTRACT FROM AUTHOR]

Few-layer and 1T-rich MoS2 is synthesized by a one-step solvothermal process using a rigid segment-containing polysulfide as a concomitant sulfur source and in situ intercalator. The prepared MoS2 displays superior hydrogen evolution reaction activity, providing a facile and mild approach for the development of high performing MoS2 and other two-dimensional lamellar materials. [ABSTRACT FROM AUTHOR]

Photothermal therapy using near‐infrared radiation and local heating agents can induce selective tumor ablation with limited harm to the surrounding normal tissue. Graphene sheets are promising local heating agents because of their strong absorbance of near‐infrared radiation. Experimental studies have been conducted to study the heating effect of graphene in photothermal therapy, yet few efforts have been devoted to the quantitative understanding of energy conversion and transport in such systems. Herein, a computational study of cancer photothermal therapy using near‐infrared radiation and graphene is presented using a Monte Carlo approach. A three‐dimensional model was built with a cancer cell inside a cube of healthy tissue. Functionalized graphene nanosheets were randomly distributed on the surface of the cancer cell. The effects of the concentration and morphology of the graphene nanosheets on the thermal behavior of the system were quantitatively investigated. The interfacial thermal resistance around the graphene sheets, which affects the transfer of heat in the nanoscale, was also varied to probe its effect on the temperature increase of the cancer cell and the healthy tissue. The results of this study could guide researchers to optimize photothermal therapy with graphene, while the modeling approach has the potential to be applied for investigating alternative treatment plans. [ABSTRACT FROM AUTHOR]

Head and neck squamous cell carcinoma (HNSC) is one of most common malignancies with high mortality worldwide. Importantly, the molecular heterogeneity of HNSC complicates the clinical diagnosis and treatment, leading to poor overall survival outcomes. To dissect the complex heterogeneity, recent studies have reported multiple molecular subtyping systems. For instance, HNSC can be subdivided to four distinct molecular subtypes: atypical, basal, classical, and mesenchymal, of which the mesenchymal subtype is characterized by upregulated epithelial-mesenchymal transition (EMT) and associated with poorer survival outcomes. Despite a wealth of studies into the complex molecular heterogeneity, the regulatory mechanism specific to this aggressive subtype remain largely unclear. Herein, we developed a network-based bioinformatics framework that integrates lncRNA and mRNA expression profiles to elucidate the subtype-specific regulatory mechanisms. Applying the framework to HNSC, we identified a clinically relevant lncRNA LNCOG as a key master regulator mediating EMT underlying the mesenchymal subtype. Five genes with strong prognostic values, namely ANXA5, ITGA5, CCBE1, P4HA2, and EPHX3 , were predicted to be the putative targets of LNCOG and subsequently validated in other independent datasets. By integrative analysis of the miRNA expression profiles, we found that LNCOG may act as a ceRNA to sponge miR-148a-3p thereby upregulating ITGA5 to promote HNSC progression. Furthermore, our drug sensitivity analysis demonstrated that the five putative targets of LNCOG were also predictive of the sensitivities of multiple FDA-approved drugs. In summary, our bioinformatics framework facilitates the dissection of cancer subtype-specific lncRNA regulatory mechanisms, providing potential novel biomarkers for more optimized treatment of HNSC., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2022 The Author(s).)

Few-layer and 1T-rich MoS 2 is synthesized by a one-step solvothermal process using a rigid segment-containing polysulfide as a concomitant sulfur source and in situ intercalator. The prepared MoS 2 displays superior hydrogen evolution reaction activity, providing a facile and mild approach for the development of high performing MoS 2 and other two-dimensional lamellar materials.

Objective: To evaluate an improving operative procedure and the clinical results of arthroscopically assisted treatment for acute patellar dislocation., Methods: Between April 2006 and March 2009, 22 patients (25 knees) with primary acute complete dislocation of the patella underwent an improving arthroscopic operation, release of lateral retinaculum and suture of medial capsule and retinaculum structure. There were 5 males and 17 females with an average age of 23.6 years (range, 14-34 years). Three patients had bilateral procedure. Eleven left knees and 14 right knees were involved. The disease duration was 1-10 days with an average of 5.9 days. All patients had lateral dislocation; of them, 14 patients showed reduction without treatment, and 8 patients showed dislocation at admission and were given close manipulative reduction. The results were positive for apprehension test in all patients with the limitation of passive motion and for Ballottable Patella Sign in 15 cases. Lysholm score, visual analogue scale (VAS) score, and Insall scale were adopted to evaluate the effect., Results: All incisions healed by first intention. All the patients were followed up 12-36 months (17 months on average). During the first 3 months after operation, sunken skin in the puncture point medial to the patella was observed in 12 knees; 10 knees suffered pain of the soft tissue lateral to the patella; 15 knees felt tense in the soft tissue medial to the patella, however, all these problems disappeared or recovered gradually after rehabilitation and conservative treatment. No recurrence of dislocation was observed during the follow-up. Lysholm score was significantly improved from preoperative 67.3 +/- 5.7 to postoperative 96.6 +/- 4.5 (t = 3.241, P = 0.003) and VAS score from 6.5 +/- 0.5 to 1.8 +/- 0.4 (t = 2.154, P = 0.040). According to Insall scale, the results were excellent in 18 knees, good in 5 knees, and fair in 2 knees at 1 year after operation with an excellent and good rate of 92%., Conclusion: The improving procedure of arthroscopically assisted treatment for acute patellar dislocation is a minimally invasive operation and has a number of benefits. Its short-term clinical outcome was satisfactory.