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144 results on '"Wang, Yi-Na"'

1. Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial

Author

Lu, Xiao-Ting, Wang, Yi-Na, Mo, Qi-Wan, Huang, Bi-Xia, Wang, Yu-Fang, Huang, Zi-Hui, Luo, Yan, Maierhaba, Wusiman, He, Tong-Tong, Li, Shu-Yi, Huang, Rong-Zhu, Yang, Meng-Tao, Liu, Xiao-Zhan, Liu, Zhao-Yan, Chen, Si, Fang, Ai-Ping, Zhang, Xu-Guang, and Zhu, Hui-Lian

Published
2023
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8. Association of genetic and immuno-characteristics with clinical outcomes in patients with RET-rearranged non-small cell lung cancer: a retrospective multicenter study

Author

Lu, Chang, Dong, Xiao-Rong, Zhao, Jun, Zhang, Xu-Chao, Chen, Hua-Jun, Zhou, Qing, Tu, Hai-Yan, Ai, Xing-Hao, Chen, Xiao-Feng, An, Gai-Li, Bai, Jun, Shan, Jin-Lu, Wang, Yi-Na, Yang, Shuan-Ying, Liu, Xiang, Zhuang, Wu, Wu, Hui-Ta, Zhu, Bo, Xia, Xue-Feng, Chen, Rong-Rong, Gu, De-Jian, Xu, Hua-Min, Wu, Yi-Long, and Yang, Jin-Ji

Published
2020
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22. Comparison of two regimens for patients with thyroid‑associated ophthalmopathy receiving intravenous methyl prednisolone: A single center prospective randomized trial

Author

Mu, Pan-Wei, primary, Tang, Xi-Xiang, additional, Wang, Yi-Na, additional, Lin, Shuo, additional, Wang, Man-Man, additional, Yin, Qiong-Li, additional, Shu, Jiong, additional, Zhu, Bi-Lian, additional, Li, Jing-Ren, additional, Zhou, Li, additional, Zeng, Long-Yi, additional, and Chen, Yan-Ming, additional

Published
2020
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26. Effect of basal insulin supplement therapy on diabetic retinopathy in short‐duration type 2 diabetes: A one‐year randomized parallel‐group trial

Author

Mu, Pan‐Wei, primary, Tang, Xi‐Xiang, additional, Tan, Ying, additional, Wang, Yi‐Na, additional, Lin, Shuo, additional, Wang, Man‐Man, additional, Shu, Jiong, additional, Wang, Jing, additional, Zhang, Yong‐Jun, additional, Liang, Hua, additional, Lin, Bai‐Run, additional, Cai, Meng‐Yin, additional, and Chen, Yan‐Ming, additional

Published
2019
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27. Efficacy of PD-1 monoclonal antibody SHR-1210 plus apatinib in patients with advanced nonsquamous NSCLC with wild‐type EGFR and ALK.

Author

Zhou, Caicun, primary, Gao, Guanghui, additional, Wang, Yi Na, additional, Zhao, Jun, additional, Chen, Gongyan, additional, Liu, Zhihua, additional, Gu, Kangsheng, additional, Huang, Meijuan, additional, He, Jianxing, additional, Chen, Jianhua, additional, Ma, Zhiyong, additional, Feng, Ji Feng, additional, Shi, Jianhua, additional, Wang, Quanren, additional, Yang, Ying, additional, Yu, Xinmin, additional, Cheng, Ying, additional, Yao, Yu, additional, and Ren, Shengxiang, additional

Published
2019
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31. Elevated levels of IL-17A and IL-35 in plasma and bronchoalveolar lavage fluid are associated with checkpoint inhibitor pneumonitis in patients with non-small cell lung cancer.

Author

Wang, Yi Na, Lou, Dan Feng, Li, Dan Yang, Jiang, Wei, Dong, Jing Yin, Gao, Wei, and Chen, Hong Chao

Subjects
*NON-small-cell lung carcinoma, *T helper cells, *SUPPRESSOR cells, *TH1 cells, *IMMUNE checkpoint inhibitors
Abstract

Advances in the immunology have identified that interleukin (IL)-17 and IL-35 are cytokines with diverse functions, serving important roles in autoimmune diseases and chronic inflammation. Checkpoint inhibitor pneumonitis (CIP) is focal or diffuse lung inflammation induced by immune checkpoint inhibitors and the underlying pathogenesis has not been fully explored. The aim of the present study was to investigate the roles of IL-17A and IL-35, and the correlation between their levels and different T cell subsets in CIP. The levels of IL-17A and IL-35 in peripheral blood and bronchoalveolar lavage fluid (BALF) were measured in patients with non-small cell lung cancer (NSCLC) with CIP, and the corresponding controls. The percentages of helper T lymphocyte (Th)1, Th2 and Th17 cells, and regulatory T cells (Tregs) in the peripheral blood were synchronically detected. Serum levels of IL-17A and IL-35 were significantly increased at the time of CIP diagnosis compared with the baseline, and significantly decreased upon clinical recovery or improvement. IL-17A and IL-35 were also increased in the BALF during the development of CIP compared with the baseline. Serum levels of IL-17A were positively correlated with the percentages of Th1 and Th17 cells as well as the ratio of Th17 to Tregs, but negatively associated with the frequency of Tregs in CIP. Serum levels of IL-35 were positively correlated with the percentages of Th1 and Tregs, and with the ratio of Th1 to Th2 cells in CIP. A higher frequency of Th1 and Th17 cells, as well as higher ratios of Th17 to Tregs and Th1 to Th2 cells were detected upon development of CIP comparing with the baseline. These data suggested that the activation of Th1 and Th17 cells, as well as Treg inhibition contributed to the imbalanced ratios of Th1 to Th2 and Th17 to Tregs, which resulted in increased secretion of IL-17A and IL-35 in the plasma and BALF; this may present a valuable index to monitor the development and severity of CIP in patients with NSCLC receiving immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2020
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32. A phase Ib study of SHR-1210 plus apatinib for heavily previously treated advanced non-squamous non-small cell lung cancer (NSCLC) patients.

Author

Zhou, Caicun, primary, Gao, Guanghui, additional, Wu, Fengying, additional, Chen, Xiaoxia, additional, Li, Wei, additional, Xiong, Anwen, additional, Su, ChunXia, additional, Cai, Weijing, additional, Ren, Shengxiang, additional, Jiang, Tao, additional, Wang, Yi Na, additional, Kang, Xiaoyan, additional, and Wang, Quanren, additional

Published
2018
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34. Swimming Exercise Improves Skeletal Muscle Dysfunction in Spontaneously Hypertensive Rats via Activating PI3K/Akt Anti-Apoptosis Signaling Pathway.

Author

ZHANG Kun-Ru, WANG Yi-Na, and DUAN Yong-Chang

Abstract

Objectives : To observe the effect of swimming exercise on apoptosis of skeletal muscle cells in spontaneously hypertensive rats, and to explore the role of PI3K/Akt signaling pathway in it. Methods; Four-week-old male WKY rats and SHR were randomly divided into four groups, WKY sedentary group (W), WKY exercise group (WE), SHR sedentary group (S) and SHR exercise group (SE) respectively. Rats in the exercise group underwent 10-week free-loading swimming exercise. Grip strength, apoptosis and the protein expression of p-PI3K, PI3K, p-Akt, Akt, caspase-9, caspase-3, Bcl-2 and Bax in gastrocnemius muscle were determined at the end of exercise. Results; 1. Compared with W group, the grip strength of rats decreased significantly in S group, while that of rats increased significantly in SE group. 2. Compared with W group, gastrocnemius muscle fibers were disordered, cross-sectional area, protein content and weight decreased in S group. Compared with the S group, muscle fibers were arranged neatly, cross-sectional area, protein content and weight increased in SE group. 3. Compared with W group, apoptosis index increased and bcl-2 /Bax decreased significantly in the S group. Compared with S group, apoptosis index decreased, and the bcl-2 /Bax ratio increased significantly in SE group. 4. Compared with W group, p-PI3K /PI3K and p-Akt /Akt levels decreased significantly, and protein expressions of caspase-9 and caspase-3 increased in S group. Compared with the S group, the levels of p-PI3K /PI3K and p-Akt /Akt increased significantly, and protein expressions of caspase-9 and caspase-3 decreased in the SE group. Conclusion; 1. Apoptosis increases, microstructure is damaged as well as muscle strength decreases in skeletal muscle in spontaneously hypertensive rats. 2. Swimming exercise attenuates the skeletal muscle apoptosis, improves the morphology and muscle strength, which may be at least related to the increased p-PI3K and p-Akt levels, the decreased expressions of caspase-9 and caspase-3 of skeletal muscle in spontaneously hypertensive rats, suggesting that swimming exercise is beneficial for skeletal muscle of spontaneously hypertensive rats. [ABSTRACT FROM AUTHOR]

Published
2020
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35. BMP4 facilitates beige fat biogenesis via regulating adipose tissue macrophages.

Author

Qian, Shu-Wen, Wu, Meng-Yuan, Wang, Yi-Na, Zhao, Ya-Xin, Zou, Ying, Pan, Jia-Bao, Tang, Yan, Liu, Yang, Guo, Liang, and Tang, Qi-Qun

Abstract

Thermogenic beige fat improves metabolism and prevents obesity. Emerging evidence shows that the activation of M2 macrophages stimulates beige adipogenesis, whereas the activation of M1 macrophages, which play a major role in inflammation, impedes beige adipogenesis. Thus, the identification of factors that regulate adipose tissue macrophages (ATMs) will help clarify the mechanism involved in beiging. Here, we found that one of the secreted proteins in adipose tissue, namely, BMP4, alters the ATM profile in subcutaneous adipose tissue by activating M2 and inhibiting M1 macrophages. Mechanistically, the BMP4-stimulated p38/MAPK/STAT6/PI3K–AKT signalling pathway is involved. Meanwhile, BMP4 improved the potency of M2 macrophages to induce beige fat biogenesis. Considering that the overexpression of BMP4 in adipose tissue promotes the beiging of subcutaneous adipose tissue and improves insulin sensitivity, these findings provide evidence that BMP4 acts as an activator of beige fat by targeting immuno-metabolic pathways. [ABSTRACT FROM AUTHOR]

Published
2019
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