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989 results on '"Wang, Xuelei"'

5. Kinematic Analysis of a 3-DOF Parallel Polishing Manipulator

Author

Bao Xinmian, Wang Xuelei, Zhang Weitao, Wang Lu, and Zhao Dongjie

Subjects
Parallel manipulator, Spiral theory, Kinematics, Virtual prototype, Mechanical engineering and machinery, TJ1-1570
Abstract

A 3-DOF parallel manipulator with X, Y movement and Z rotation for the end-effector is studied in order to meet the requirements of copying and polishing of louver blades. In order to verify the kinematic performance of the manipulator, firstly, the mechanism characteristics are described, and the degree of freedom of the mechanism is analyzed based on the spiral theory. Secondly, the kinematics equations of the mechanism are constructed based on the closed-loop vector method, the forward and inverse position solutions are analyzed, and the analysis results are preliminarily verified by concrete examples. Finally, the numerical simulation model and virtual prototype model of the mechanism are constructed, and the inverse kinematics simulation analysis of the position and velocity is carried out. The simulation results show that the analysis results of the two models are consistent, and the result of inverse solution is reliable. The arm chain can coordinate the movement, the movement process is smooth, and the displacement and velocity curves are smooth and without mutation, and can provide a basis for the size optimization and motion control of the manipulator.

Published
2024
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15. Design and Research on Valve Train of Automobile Engine

Author

Lyu, Shixia, Shi, Guang, Wang, Xuelei, Han, Jianrui, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, You, Peng, editor, Li, Heng, editor, and Chen, Zhenxiang, editor

Published
2023
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18. Practice of Mechanics Experiment Teaching Aimed at Solving Students’ Problem Based on Simulation Technology in Higher Vocational Colleges

Author

Lv, Shixia, Wang, Shang, Wang, Xuelei, Li, Kan, Editor-in-Chief, Li, Qingyong, Associate Editor, Fournier-Viger, Philippe, Series Editor, Hong, Wei-Chiang, Series Editor, Liang, Xun, Series Editor, Wang, Long, Series Editor, Xu, Xuesong, Series Editor, Zhan, Zehui, editor, Zou, Bin, editor, and Yeoh, William, editor

Published
2023
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40. Chinese Drivers’ Preferred Posture for Sedans’ Seat Ergonomic Design

Author

You, Jiaxun, Qin, Lipeng, Zuo, Peiwen, Wang, Xuelei, Zhang, Chao, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Long, Shengzhao, editor, and Dhillon, Balbir S., editor

Published
2020
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44. A Dual-Function LipoAraN-E5 Coloaded with N4-Myristyloxycarbonyl-1-β-d-arabinofuranosylcytosine (AraN) and a CXCR4 Antagonistic Peptide (E5) for Blocking the Dissemination of Acute Myeloid Leukemia

Author

Wang, Xuelei, Wang, Xiaowei, Su, Jiayi, Wang, Dan, Feng, Wenkai, Wang, Xiaobo, Lu, Hongwei, Wang, Apeng, Liu, Mingliang, and Xia, Guimin

Abstract

Acute myeloid leukemia (AML) is a hematological malignancy with a high recurrence rate. The interaction of chemokine receptor 4/chemokine ligand 12 (CXCR4/CXCL12) mediates homing and adhesion of AML cells in bone marrow, leading to minimal residual disease in patients, which brings a hidden danger for future AML recurrence. Ara-C is a nonselective chemotherapeutic agent against AML. Due to its short half-life and severe side effects, a lipid-like Ara-C derivative (AraN) was synthesized and a dual-function LipoAraN-E5 (135 nm, encapsulation efficiency 99%) was developed, which coloaded AraN and E5, a peptide of the CXCR4 antagonist. LipoAraN-E5 effectively improved the uptake, enhanced the inhibition of leukemia cell proliferation, migration, and adhesion to stromal cells in bone marrow, and mobilized the leukemia cells from bone marrow to peripheral blood via interfering with the CXCR4/CXCL12 axis. LipoAraN-E5 prolonged the plasma half-life of AraN (8.31 vs 0.56 h) and was highly enriched in peripheral blood (3.67 vs 0.05 μmol/g at 8 h) and bone marrow (379 vs 148 μmol/g at 24 h). LipoAraN-E5 effectively prevented the infiltration of leukemia cells in peripheral blood, bone marrow, spleen, and liver, prolonged the mice survival, and showed outstanding antineoplastic efficacy with negligible toxicity, which were attributed to the ingenious design of AraN, the use of a liposomal delivery carrier, and the introduction of E5. Our work revealed that LipoAraN-E5 may be a promising nanocandidate against AML.

Published
2024
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