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351 results on '"Wang, Xuefen"'

1. A multicentre, randomised, double-blind, double-dummy, parallel-controlled, phase 3 clinical trial assessing the efficacy and safety of intravenous nemonoxacin malate vs. levofloxacin for community-acquired pneumonia in adult patients

Author

LI, Ying, Zhu, Demei, Sun, Shenghua, Chang, Xiaoyue, Cao, Zhaolong, Yang, Yanping, Fu, Xiuhua, Li, Xiangyang, Xu, Jinfu, Zhu, Yingqun, Hui, Fuxin, Xu, Xingxiang, Chen, Zhang, Peng, Liping, Ma, Zhuang, Mo, Biwen, Li, Chen, Lv, Yuan, Zhao, Li, Zhu, Guangfa, He, Yong, Liu, Hua, Chen, Jichao, Wang, Ying, Liang, Yongjie, Lu, Youjin, Qin, Zhiqiang, Yang, Hongzhong, Zhang, Min, Wu, Shiman, Tong, Zhaohui, Ye, Feng, Xiao, Zuke, Wang, Xuefen, Qiu, Chen, Kuang, Jiulong, Huang, Huaping, Wang, Kai, Ying, Kejing, Jin, Faguang, Lv, Xiaoju, Huang, Yijiang, Liu, Deling, Wang, Wei, and Zhang, Yingyuan

Published
2024
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27. Nanofibrous Polyacrylonitrile Membranes Coated with Nanosheets of Zn-Tetrakis(4-Carboxyphenyl) Porphyrin for Enhanced Pressure Resistance and Dye/Salt Separation.

Author

Wei, Xiaoying, Meng, Zheyi, and Wang, Xuefen

Abstract

Two-dimensional metal–organic framework (MOF) nanosheets have been utilized to fabricate loose nanofiltration membranes, capitalizing on their unique lamellar structure and regular nanopores, which facilitate ultrafast and efficient separations. However, the structural stability of current MOF nanosheet membranes remains suboptimal due to the weak interlayer bonding between nanosheets when a single vacuum-assisted deposition method is employed. To overcome this challenge, poly-(vinyl alcohol) (PVA) and glutaraldehyde (GA) were introduced as cross-linking agents in the vacuum-assisted deposition of zinc-(II)-tetrakis-(4-carboxy-phenyl) porphyrin) (ZnTCPP) nanosheets onto electrospun polyacrylonitrile (PAN) nanofibrous supports. The chemical bonding between nanosheets, PVA and GA, contributed to the superior mechanical performance of the ZnTCPP-PVA-GA/PAN thin-film nanofibrous composite (TFNC) membrane, exhibiting an elongation at break of 62.4%, surpassing that of commercial nanofiltration counterparts by 2.6 times while maintaining a comparable tensile strength of 21.3 MPa. Furthermore, the optimized TFNC demonstrated a high permeance of 49.5 L m–2 h–1 bar–1 and a retention rate of 99.0% for Congo Red (CR) when separating CR from a mixture with NaCl, achieving a CR/NaCl separation factor of 92.9. Simultaneously, this membrane presented excellent compression resistance and was capable of withstanding pressure up to 8 bar without compromising separation performance. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Safety and efficacy of oral nemonoxacin versus levofloxacin in treatment of community-acquired pneumonia: A phase 3, multicenter, randomized, double-blind, double-dummy, active-controlled, non-inferiority trial

Author

Zhao, Li, Wang, Xiongbiao, Wang, Xuefen, Wang, Dexi, Li, Xiangyang, Peng, Yiqiang, Liang, Yongjie, Liu, Hua, Xiao, Zuke, Lv, Xiaoju, Wu, Shiman, Dai, Yuanrong, Huang, Yijiang, Hu, Zhenghong, Qiu, Chen, Li, Xi, Zhang, Suiyang, Li, Wenpu, Liu, Shuang, Shi, Yi, Xiong, Chang, Kuang, Jiulong, Xiu, Qingyu, Cui, Shehuai, Li, Jianguo, Lin, Qichang, Huang, Wenxiang, Wan, Yixin, Qimanguli, Shen, Ce, Xiao, Yi, Wu, Xiaoju, Chuang, Yin Ching, Perng, Wann Cherng, Tsao, Shih-Ming, Hsu, Jeng-Yuan, Wang, Chin-Chou, Wang, Jen-Hsien, Yeh, Pen-Fang, Lin, His-Hsun, Kuo, P.H., Lin, Ming-Shian, Su, Wei-Juin, Yuan, Jinyi, Mo, Biwen, Ma, Zhuang, Lv, Yuan, Cheng, Shih-Lung, Yang, Yanping, Tong, Zhaohui, Wu, Renguang, Sun, Shenghua, Cao, Zhaolong, Wu, Jufang, Zhu, Demei, Chang, Liwen, and Zhang, Yingyuan

Published
2019
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46. 3D stem cell spheroids with urchin-like hydroxyapatite microparticles enhance osteogenesis of stem cells.

Author

Liu, Hongmei, Ye, Jianxin, Hu, Hui, Song, Yuheng, Qiang, Huijun, Wang, Junjun, Zhou, Lei, Wang, Xuefen, Fei, Xiang, and Zhu, Meifang

Abstract

Cell therapy (also known as cell transplantation) has been considered promising as a next-generation living-cell therapy strategy to surpass the effects of traditional drugs. However, their practical clinical uses and product conversion are hampered by the unsatisfied viability and efficacy of the transplanted cells. Herein, we propose a synergistic enhancement strategy to address these issues by constructing 3D stem cell spheroids integrated with urchin-like hydroxyapatite microparticles (uHA). Specifically, cell-sized uHA microparticles were synthesized via a simple hydrothermal method using glutamic acid (Glu, E) as the co-template with good biocompatibility and structural antimicrobial performance (denoted as E-uHA). Combining with a hanging drop method, stem cell spheroids integrated with E-uHA were successfully obtained by culturing bone marrow mesenchymal stem cells (BMSCs) with a low concentration of the E-uHA suspensions (10 μg mL−1). The resulting composite spheroids of BMSCs/E-uHA deliver a high cellular viability, migration activity, and a superior osteogenic property compared to the 2D cultured counterpart or other BMSC spheroids. This work provides an effective strategy for integrating a secondary bio-functional component into stem cell spheroids for designing more cell therapy options with boosted cellular viability and therapeutic effect. [ABSTRACT FROM AUTHOR]

Published
2024
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