1. Efficacy of Zengye Chengqi decoction combined with olanzapine in the treatment of schizophrenia of Yangming Fushi syndrome
- Author
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Wang Weili, Deng Li, Wang Hongyu, Yang Shichang, and Cui Guimei
- Subjects
zengye chengqi decoction ,olanzapine ,schizophrenia ,yangming fushi syndrome ,event-related potential p300 ,Psychology ,BF1-990 ,Psychiatry ,RC435-571 - Abstract
BackgroundPatients with schizophrenia of Yangming Fushi syndrome experience more severe symptoms, and a substantial proportion of patients derive inadequate benefit from antipsychotics and suffer from serious adverse effects, yet few studies have been conducted on the treatment of schizophrenia of Yangming Fushi syndrome with Zengye Chengqi decoction.ObjectiveTo explore the efficacy of Zengye Chengqi decoction combined with olanzapine in the treatment of schizophrenia of Yangming Fushi syndrome, in order to provide references for the treatment of schizophrenia with the combination of traditional Chinese and western medicine.MethodsA total of 60 patients attending the Second Affiliated Hospital of Xinxiang Medical College from January 2022 to August 2023 and fulfilling the International Classification of Diseases (ICD-10) diagnostic criteria for schizophrenia were enrolled, and assigned into study group (n=30) and control group (n=30) using random number table methods. All patients were treated with olanzapine, and study group was given Zengye Chengqi decoction on this basis. Treatment for both groups lasted for 4 weeks. All participants were assessed using Positive and Negative Syndrome Scale (PANSS), Montreal Cognitive Assessment (MoCA) and Event-Related Potential P300 at baseline and end of treatment. The occurrence of adverse reactions was recorded at the end of treatment.ResultsStudy group reported a higher treatment effective rate compared with control group (χ2=9.320, P=0.002). After treatment, study group detected a significant reduction in PANSS subscales and total scores (F=10.287, 8.258, 8.844, 20.079, P
- Published
- 2024
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