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This study assesses the impact of the transition to renewable energy and improved societal well-being on environmentally sustainable economies, concentrating on 20 major CO2-emitting countries from 2000 to 2020. Employing the pooled mean group (PMG) method, the findings indicate that a 1% increase in fossil fuel consumption results in a significant short-term decline of approximately 0.22% and a more substantial long-term decrease of 0.43% in green growth. This decline is attributed to the exacerbation of environmental degradation through notable carbon emissions. Interestingly, a 1% increase in the Human Development Index (HDI) is associated with heightened green growth, indicating an increased awareness of environmental issues. Conversely, a 1% reduction in population has a negative impact on green growth, underscoring the importance of balancing population dynamics with sustainable development. Furthermore, diminished internet penetration, rural electrification, and poverty exert adverse effects on the green growth index. The implementation of practical policies for major CO2 emitters is crucial, encompassing initiatives such as digitalizing the green finance market, promoting ICT diffusion, advancing regional green power generation, adopting eco-friendly practices in petroleum industries, and liberalizing green utilities trade. These measures are essential for fostering green growth, enhancing social prosperity, and mitigating environmental degradation. [ABSTRACT FROM AUTHOR]

The notion of energy digital transformation, considered a groundbreaking and sustainable paradigm, has ignited scholarly debates. This study, covering the period from 2000 to 2021, delves into the intricate interplay among legal efficiency, financial development, and energy digital transformation. Employing the dynamic GMM (Generalized Method of Moments) approach, the research reveals compelling insights. A 1% increase in the good governance index corresponds to an approximate 0.57% rise in the volume of smart grid imports. Similarly, a 1% increase in the financial development index is associated with an approximate 0.26% increase in smart grid imports. Furthermore, a 1% increase in gross domestic product correlates with an approximate 0.17% growth in smart grid imports. Conversely, a 1% increase in energy intensity leads to a nearly 0.14% decrease in smart grid imports. The policy implications derived from this study emphasize the importance of directing funds toward smart grid and renewable energy projects. [ABSTRACT FROM AUTHOR]

Aim: To investigate the impact of family history of type 2 diabetes (T2D) on the clinical phenotypes of patients with idiopathic type 1 diabetes (T1D). Methods: In clinically diagnosed T1D cases, a total of 335 idopathic T1D patients were included in the study, after excluding autoimmune T1D using islet autoantibody testing and monogenic diabetes using a custom monogenic diabetes gene panel obtained from clinically diagnosed T1D cases. A semi‐structured questionnaire was used to collect information on the presence of T2D in first‐degree relatives. The demographic and metabolic markers of idiopathic T1D patients were analysed. Subgroup analysis was performed to investigate potential interactions between T2D family history and human leukocyte antigen (HLA) genotypes. Results: A total of 18.2% of individuals with idiopathic T1D had a T2D family history, and these individuals were more likely to have features associated with T2D, such as older age of onset, higher body mass index at diagnosis, lower insulin dosage and better beta‐cell function, as indicated by higher levels of fasting C‐peptide and 2‐hour postprandial C‐peptide (all P < 0.05). Additionally, regardless of HLA susceptible genotypes, the impact of family history of T2D was consistently observed in idiopathic T1D patients. Multivariable analyses showed that T2D family history was negatively correlated with the risk of beta‐cell function failure in idiopathic T1D patients (P < 0.05). Conclusions: Family history of T2D may be implicated in the heterogeneity of idiopathic T1D patients. [ABSTRACT FROM AUTHOR]

Background: Tiam1 has been identified as an oncogene and acts as an activator of GTPase Rac. Tiam1 was reported to be a promoter of cancer progression in various cancer types, while in lung adenocarcinoma, its mechanism of action is poorly understood. Materials and Methods: Immunohistochemistry staining and Western blot assay were used to determine Tiam1 expression in lung adenocarcinoma tissues, and its association with prognosis was determined by statistical analysis. We depleted Tiam1 in both A549 and H1975 cancer cell lines. Carboxyfluorescein diacetate succinimidyl ester staining and colony formation assays were used to evaluate its impact on cell proliferation ability after depletion. Transwell migration assay and wound healing assays were performed to determine its impact on migration ability of both cell lines. Western blot assay and immunofluorescence staining were used to analyze the association between Tiam1 and epithelial–mesenchymal transition (EMT) progression. Tube formation assay and vasculogenic mimicry assay were used to show the impact of Tiam1 depletion on cancer angiogenesis. Results: In this study, we demonstrated that Tiam1 overexpression in lung adenocarcinoma was significantly associated with advanced tumor grade and poor prognosis. In vitro assays indicated that Tiam1 depletion significantly inhibited cell proliferation, colony formation, and migration capacities in A549 and H1975 cells. Further investigations revealed that Tiam1 plays an important role in EMT program enhancement, angiogenesis, and accelerated tumor progression. Notably, Tiam1 depletion in cancer cells strongly inhibited human umbilical vein endothelial cell angiogenesis and vasculogenic mimicry capacities of both cancer cell lines. Conclusion: Tiam1 overexpression is associated with lung adenocarcinoma progression and may indicate poor prognosis. Tiam1 accelerated tumor progression due to EMT and angiogenesis enhancement. Our data may provide a novel therapeutic target for lung adenocarcinoma. [ABSTRACT FROM AUTHOR]

Background:Depression is one of the most prevalent mental disorders among older people. Consistent with the Marital Discord Model of Depression (MDMD), research in Western cultures has found that marital distress is one of the risk factors for depression among older adults. However, the effect of marital distress on depression among older adults has not been examined in a collectivistic society, such as China. Objectives:The purpose of this study was to examine the relationship between marital satisfaction and depressive symptoms in a sample of Chinese older adults. Considering the dyadic nature of the data, the Actor–Partner Interdependence Model was used to test for the actor and partner effects. Methods:The study investigated 139 older couples who were recruited from communities in Beijing, the capital of China. The Lock–Wallace Marital Adjustment and the CES-D scales were administered to the participants. Results:The results indicated that neither of the actor effects was significant. One of the partner effects was significant, with the husbands’ marital satisfaction predicting their wives’ depressive symptoms. Conclusions:The MDMD was only partially supported among older couples in China. An asymmetrical pattern of cross-spouse effects was found, suggesting that the husbands’ perception of marital dissatisfaction could significantly predict their wives’ depressive symptoms. [ABSTRACT FROM PUBLISHER]

Lung cancer has the highest morbidity and mortality of any malignant tumor. To improve efficacy and reduce toxicity in patients with advanced non-small cell lung cancer (NSCLC), it is important to integrate traditional and conventional medicine. Two hundred and forty patients with advanced NSCLC were randomized to tetrandrine plus GP or GP only. We infused gemcitabine on days 1 and 8; cisplatin on day 1. The tetrandrine group received continuous i.v. infusion for 10 days, with treatment repeated every 21 days. After 2 consecutive treatment cycles, we used RECIST criteria to evaluate short-term efficacy. Quality of life (QOL) was assessed according to Karnofsky score (KPS) and body weight change. We used NCI CTC 3.0 to evaluate treatment toxicity. The short-term objective response rate was 36.1% in the tetrandrine group and 24.3% in the controls (P=0.057). The short-term disease control rate was 63.9% in the tetrandrine group and 52.3% in the controls (P=0.081). The 1-year survival rates were 45.7% and 31.3%, respectively (P=0.059). KPS scores improved by 49.1% and 32.4%, respectively (P=0.012). Body weight increased by 28.7% in the tetrandrine group and 16.2% in the controls (P=0.027). The incidence of grade 2-4 leukopenia, thrombocytopenia, nausea, and vomiting in the tetrandrine group was 38.0%, 19.4%, 46.3%, and 16.7%, respectively; the control group figures were 53.2%, 34.2%, 63.0% and 27.9% (P<0.05). Tetrandrine may improve short-term efficacy and survival in patients with advanced NSCLC. Tetrandrine may also mitigate adverse reactions to chemotherapy and improve QOL for patients with NSCLC.