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2,793 results on '"Wang, Peng-Hui"'

1. First-Line Lenvatinib Plus Pembrolizumab Versus Chemotherapy for Advanced Endometrial Cancer: A Randomized, Open-Label, Phase III Trial

Author

Marth, Christian, Moore, Richard G., Bidziński, Mariusz, Pignata, Sandro, Ayhan, Ali, Rubio, M. Jesús, Beiner, Mario, Hall, Marcia, Vulsteke, Christof, Braicu, Elena Ioana, Sonoda, Kenzo, Wu, Xiaohua, Frentzas, Sophia, Mattar, André, Lheureux, Stephanie, Chen, Xiaojun, Hasegawa, Kosei, Magallanes-Maciel, Manuel, Choi, Chel Hun, Shalkova, Mariia, Kaen, Diego, Wang, Peng-Hui, Berger, Regina, Okpara, Chinyere E., McKenzie, Jodi, Yao, Lili, Orlowski, Robert, Khemka, Vivek, Gilbert, Lucy, Makker, Vicky, Kaen, Diego Lucas, Gomez Abuin, Gonzalo, Zamora, Liliana Beatriz, Alfie, Margarita Sonia, Casarini, Ignacio Alfredo, Harrison, Michelle, Ananda, Sumitra, Shannon, Catherine Margaret, Frentzas, Sophia, Friedlander, Michael, Meniawy, Tarek, Gao, Bo, Baron-Hay, Sally, Diakos, Connie, Marth, Christian, Polterauer, Stephan, Petru, Edgar, De Bock, Marlies, Vulsteke, Christof, Baurain, Jean-Francois, Van Gorp, Toon, Altintas, Sevilay, Lima, Joao Paulo da Silveira Nogueira, Mattar, Andre, de Freitas Junior, Ruffo, Santana, Rosane O., de Melo, Andreia Cristina, Franke, Fabio Andre, Zibetti Dal Molin, Graziela, Damian, Fernanda Bronzon, Guedes, João Daniel Cardoso, Ellard, Susan, Tinker, Anna, Samouëlian, Vanessa, Fortin, Suzanne, Bessette, Paul, Kolinsky, Michael, Kumar Tyagi, Nidhi, Ethier, Josee-Lyne, Gilbert, Lucy, Lheureux, Stephanie, MacKay, Helen, Lim, Charles, Wu, Xiaohua, Pan, Lingya, An, Ruifang, Chen, Xiaojun, Zheng, Hong, Wu, Yumei, Zhu, Jianqing, Yao, Shuzhong, Jia, Xuemei, Huang, Yi, Lv, Weiguo, Zhang, Yu, Zhou, Qi, Ma, Cailing, Chekerov, Radoslav, Mach, Pawel, Witteler, Ralf, Marmè, Frederik, Cadoo, Karen, Korach, Jacob, Levy, Talia, Beiner, Mario, Amnon, Amit, Scollo, Paolo, Naglieri, Emanuele, Pignata, Sandro, Zamagni, Claudio, Salutari, Vanda, Usami, Tomoka, Nakamura, Kazuto, Matsumoto, Koji, Yamagami, Wataru, Kobayashi, Yoichi, Takano, Masashi, Kato, Hidenori, Sonoda, Kenzo, Kikuchi, Akira, Katsumata, Noriyuki, Kamiura, Shoji, Horie, Koji, Hasegawa, Kosei, Tsunoda, Takuya, Suzuki, Nao, Yunokawa, Mayu, Nishio, Shin, Kudaka, Wataru, Guerrero Cabrera, Fernando Felix, Gonzalez Mendoza, Rene Lazaro, Magallanes Maciel, Manuel Ernesto, Villalobos Valencia, Ricardo, Escobar Penagos, Jose, Lopez Chuken, Yamil Alonso, Mackowiak-Matejczyk, Beata, Tarnawski, Rafal, Kalinka, Ewa, Bidzinski, Mariusz, Bednarek, Wieslawa, Danska-Bidzinska, Anna, Koralewski, Piotr, Roszak, Andrzej, Kedrova, Anna, Musaeva, Natalia, Urmancheeva, Adiliya Fettekhovna, Vasiliev, Aleksandr Gennadievich, Safina, Sufia Zievna, Lisyanskaya, Alla Sergeevna, Rykov, Ivan V., Rumyantsev, Alexey Alexandrovich, Belonogov, Aleksandr, Makarycheva, Yulia, Kim, Yong Man, Choi, Chel Hun, Kim, Yong Beom, Kim, Hee Seung, Kim, Sang Wun, Quindos Varela, Maria, Casado Herraez, Antonio, Diaz Redondo, Tamara, Rubio Perez, Maria Jesus, Romeo Marin, Margarita, Romero Noguera, Ignacio, Taus Garcia, Alvaro, Lin, Wu-Chou, Chou, Hung-Hsueh, Cheng, Wen-Fang, Lu, Chien-Hsing, Wang, Peng-Hui, Simsek, Tayup, Kose, Fatih, Ayhan, Ali, Vardar, Mehmet Ali, Ozerkan, Kemal, Hughes, Andrew, Stillie, Alison, Eminowicz, Gemma, Khalique, Saira, Shalkova, Mariia, Sukhina, Olena, Piatnytska, Tetiana, Averina, Hanna, Kulyaba, Yaroslav, Kryzhanivska, Anna, Bondarenko, Igor, Svintsitsky, Valentyn, Krasnohrud, Yuliia, Voitko, Nataliia, Buscema, Joseph, Ghamande, Sharad, Lewin, Sharyn, Graham, Deena M., Makker, Vicky, Bell, Maria, Santin, Alessandro, Lee, Christine, Blank, Stephanie, Konecny, Gottfried E., Corr, Bradley, Van Le, Linda, Moore, Richard G., Scalici, Jennifer, Anderson, Charles, Braly, Patricia, Fehniger, Julia, Westhoff, Gina, and Bollinger, Lauren

Published
2024
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4. Twin Support Vector Regression and Its Application on Aerodynamic Design

Author

Lu, Pei-Xia, Zhang, Ke-Shi, Wang, Peng-Hui, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Lee, Sangchul, editor, Han, Cheolheui, editor, Choi, Jeong-Yeol, editor, Kim, Seungkeun, editor, and Kim, Jeong Ho, editor

Published
2023
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20. Environmental Heat Stress Decreases Sperm Motility by Disrupting the Diurnal Rhythms of Rumen Microbes and Metabolites in Hu Rams.

Author

Wang, Qiang-Jun, Yi, Huan-Ming, Ou, Jing-Yu, Wang, Ru, Wang, Ming-Ming, Wang, Peng-Hui, He, Xiao-Long, Tang, Wen-Hui, Chen, Jia-Hong, Yu, Yang, Zhang, Chun-Ping, Ren, Chun-Huan, and Zhang, Zi-Jun

Subjects
WEATHER & climate change, CHRONOBIOLOGY disorders, EXTREME weather, SPERM motility, STEROID synthesis
Abstract

Heat stress (HS) has become a common stressor, owing to the increasing frequency of extreme high-temperature weather triggered by global warming, which has seriously affected the reproductive capacity of important livestock such as sheep. However, little is known about whether HS reduces sperm motility by inducing circadian rhythm disorders in rumen microorganisms and metabolites in sheep. In this study, the year-round reproduction of two-year-old Hu rams was selected, and the samples were collected in May and July 2022 at average environmental temperatures between 18.71 °C and 33.58 °C, respectively. The experiment revealed that the mean temperature-humidity index was 86.34 in July, indicating that Hu rams suffered from HS. Our research revealed that HS significantly decreased sperm motility in Hu rams. Microbiome analysis further revealed that HS reshaped the composition and circadian rhythm of rumen microorganisms, leading to the circadian disruption of microorganisms that drive cortisol and testosterone synthesis. Serum indicators further confirmed that HS significantly increased the concentrations of cortisol during the daytime and decreased the testosterone concentration at the highest body temperature. Untargeted metabolomics analysis revealed that the circadian rhythm of rumen fluid metabolites in the HS group was enriched by the cortisol and steroid synthesis pathways. Moreover, HS downregulated metabolites, such as kaempferol and L-tryptophan in rumen fluid and seminal plasma, which are associated with promotion of spermatogenesis and sperm motility; furthermore, these metabolites were found to be strongly positively correlated with Veillonellaceae_UCG_001. Overall, this study revealed the relationship between the HS-induced circadian rhythm disruption of rumen microorganisms and metabolites and sperm motility decline. Our findings provide a new perspective for further interventions in enhancing sheep sperm motility with regard to the circadian time scale. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Safe abortion

Author

Chou, Fang-Wei, primary, Chang, Wen-Hsun, additional, and Wang, Peng-Hui, additional

Published
2024
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26. Intrauterine adhesion

Author

Wang, Peng-Hui, primary, Yang, Szu-Ting, additional, Chang, Wen-Hsun, additional, Liu, Chia-Hao, additional, Liu, Hung-Hsien, additional, and Lee, Wen-Ling, additional

Published
2024
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36. Comparative Proteomic Identification of Ram Sperm before and after In Vitro Capacitation.

Author

Chen, Ya-Le, Li, Chun-Yan, Wang, Peng-Hui, Wang, Ru, Zhuo, Xian, Zhang, Yan, Wang, Shi-Jia, Sun, Zhi-Peng, Chen, Jia-Hong, Cheng, Xiao, Zhang, Zi-Jun, Ren, Chun-Huan, and Wang, Qiang-Jun

Subjects
TANDEM mass spectrometry, DATABASES, MASS spectrometry, PROTEOMICS, FUNCTIONAL analysis
Abstract

Simple Summary: Capacitation confers competency to spermatozoa to fertilize the oocyte, yet its regulatory mechanisms are not fully understood. Thus, we aimed to investigate the comparative proteomic profiling in ram spermatozoa under non-capacitating (NC) and capacitating (CAP) conditions in vitro using a liquid chromatography–tandem mass spectrometry (LCMS/MS) combined with tandem mass tag (TMT) labeling strategy. Functional enrichment analysis indicated that the differentially abundant proteins Prune Exopolyphosphatase 1, Galactose-1-Phosphate Uridylyltransferase, and ATP Citrate Lyase were strictly related to energy production and conversion, and Phosphoglycolate phosphatase, Glucosamine-6-Phosphate Deaminase 1 and 2 were related to metabolism, RNA processing, and vesicular transport pathways. Furthermore, the networks of protein–protein interaction indicated a strong interaction among these differential proteins in annotated pathways such as ubiquitin and transport metabolism. Together, our results provided the database for studying the differentially expressed proteins during ram sperm capacitation. Ram sperm undergo a sequence of physiological and biochemical changes collectively termed as capacitation to perform oocyte fertilization. However, the protein changes induced by capacitation remain in need of further exploration. Thus, the present study investigated the comparative proteomic profiling in ram spermatozoa under non-capacitating (NC) and capacitating (CAP) conditions in vitro using a liquid chromatography–tandem mass spectrometry combined with tandem mass tag labeling strategy. As a results, 2050 proteins were identified and quantified; 348 of them were differentially abundant, with 280 of the proteins upregulated and 68 of the proteins downregulated between the CAP and NC spermatozoa, respectively. Functional enrichment analysis indicated that the differentially abundant proteins Prune Exopolyphosphatase 1, Galactose-1-Phosphate Uridylyltransferase, and ATP Citrate Lyase were strictly related to energy production and conversion, and Phosphoglycolate phosphatase, Glucosamine-6-Phosphate Deaminase 1 and 2 were related to metabolism, RNA processing, and vesicular transport pathways. Furthermore, the networks of protein–protein interaction indicated a strong interaction among these differential proteins in annotated pathways such as ubiquitin and transport metabolism. Our findings indicate that capacitation progress might be regulated through different pathways, providing insights into mechanisms involved in ram sperm capacitation and fertility. [ABSTRACT FROM AUTHOR]

Published
2024
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37. The left common iliac vein area: Analysis of chronic venous disease patients with and without MTS

Author

Yang Cheng-Hao, Lu Xin-Wu, Huang Xin-Tian, Liu Xiao-Bing, Ye Kai-Chuang, Zhao Zhen, Wang Xu-Hui, Wang Peng-Hui, and Yin Min-Yi

Subjects
chronic venous disease, computer tomography venography, left common iliac vein, may–thurner syndrome, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

OBJECTIVE: To analyze the normal reference left common iliac vein (LCIV) area in chronic venous disease (CVD) patients with or without May–Thurner syndrome (MTS) and its relevant influencing factors. MATERIALS AND METHODS: A prospective analysis of patients with left lower extremity CVD was conducted in a single institution from January to August 2019. A total of 326 patients, 98 with MTS and 228 without MTS after computed tomography (CT) venography, were finally enrolled in this study, and their basic information was recorded. MTS cases were distinguished from non-MTS cases by calculating area stenosis rate with CT three-dimensional reconstruction. The reference area of LCIV was also defined and calculated to analyze its coefficient of variation and relationship with influencing factors in patients with and without MTS. RESULTS: Ninety-eight cases of MTS and 228 cases of non-MTS were finally analyzed. In the MTS group, the mean area of reference LCIV was significantly lower (116.29 ± 53.17 mm2 vs. 160.44 ± 52.99 mm2, P < 0.01) and showed greater variability (0.21 ± 0.13 vs. 0.16 ± 0.08, P = 0.04) compared with non-MTS group. Obesity radio was significantly higher in non-MTS group (28.5% vs. 16.3%, P = 0.03). In both MTS and non-MTS groups, the increase of body mass index (BMI) was generally associated with statistically significant increases in the LCIV area (P = 0.002 and P = 0.005), while other factors showed no statistically significant correlation. CONCLUSIONS: The reference area of LCIV was redefined in this study. We found that the increase of the LCIV area in both MTS and non-MTS groups was correlated with an increase in BMI. Furthermore, a smaller area of reference LCIV and more variability in the LCIV area were found in the MTS group in contrast to the non-MTS group.

Published
2021
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47. Analysis of East Asia Subgroup in Study 309/KEYNOTE-775: Lenvatinib plus pembrolizumab versus treatment of physician’s choice chemotherapy in patients with previously treated advanced or recurrent endometrial cancer

Author

Yonemori, Kan, primary, Fujiwara, Keiichi, additional, Hasegawa, Kosei, additional, Yunokawa, Mayu, additional, Ushijima, Kimio, additional, Suzuki, Shiro, additional, Shikama, Ayumi, additional, Minobe, Shinichiro, additional, Usami, Tomoka, additional, Kim, Jae-Weon, additional, Kim, Byoung-Gie, additional, Wang, Peng-Hui, additional, Chang, Ting-Chang, additional, Yamamoto, Keiko, additional, Han, Shirong, additional, McKenzie, Jodi, additional, Orlowski, Robert J., additional, Miura, Takuma, additional, Makker, Vicky, additional, and Man Kim, Yong, additional

Published
2024
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49. An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma

Author

Wen, Chen-Lei, Huang, Ke, Jiang, Lu-Lu, Lu, Xiong-Xiong, Dai, Yu-Ting, Shi, Min-Min, Tang, Xiao-Mei, Wang, Qing-Bing, Zhang, Xiao-Dan, Wang, Peng-Hui, Li, Hui-Ti, Ruan, Xiao-Xue, Wang, Li-Wen, Wang, Xin-Jing, Wang, Qian, Lu, Wei, Xiang, Xiao-Qiang, Sun, Xun, Xu, Yan-Hui, Lai, Lu-Hua, Zhan, Qian, Li, Hong-Wei, Peng, Cheng-Hong, Chen, Jing, Huang, Jin-Yan, Ye, De-Yong, Chen, Sai-Juan, Chen, Zhu, Li, Min, Fang, Yuan, Shen, Bai-Yong, and Zhou, Lu

Published
2019

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