Search

Your search keyword '"Wang, Peichang"' showing total 157 results
Start Over Author "Wang, Peichang"
157 results on '"Wang, Peichang"'

4. Myeloid ectopic viral integration site 2 accelerates the progression of Alzheimer's disease.

Author

Cui, Yuting, Zhang, Xiaomin, Liu, Jing, Hou, Yuli, Song, Qiao, Cao, Min, Zhang, Jingjing, Wang, Xiaoling, Liu, Congcong, Wang, Peichang, and Wang, Yaqi

Subjects
AMYLOID beta-protein precursor, TRANSCRIPTION factors, ALZHEIMER'S disease, AMYLOID plaque, GENETIC transcription
Abstract

Amyloid plaques, a major pathological hallmark of Alzheimer's disease (AD), are caused by an imbalance between the amyloidogenic and non‐amyloidogenic pathways of amyloid precursor protein (APP). BACE1 cleavage of APP is the rate‐limiting step for amyloid‐β production and plaque formation in AD. Although the alteration of BACE1 expression in AD has been investigated, the underlying mechanisms remain unknown. In this study, we determined MEIS2 was notably elevated in AD models and AD patients. Alterations in the expression of MEIS2 can modulate the levels of BACE1. MEIS2 downregulation improved the learning and memory retention of AD mice and decreased the number of amyloid plaques. MEIS2 binds to the BACE1 promoter, positively regulates BACE1 expression, and accelerates APP amyloid degradation in vitro. Therefore, our findings suggest that MEIS2 might be a critical transcription factor in AD, since it regulates BACE1 expression and accelerates BACE1‐mediated APP amyloidogenic cleavage. MEIS2 is a promising early intervention target for AD treatment. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

7. Synaptic Vesicle Glycoprotein 2A in Serum is an Ideal Biomarker for Early Warning and Early Diagnosis of Alzheimer's Disease

Author

Wang, Xiaoling, primary, Zhang, Xiaomin, additional, Liu, Jing, additional, Zhang, Jingjing, additional, Liu, Congcong, additional, Cui, Yuting, additional, Song, Qiao, additional, Hou, Yuli, additional, Wang, Yaqi, additional, Zhang, Qian, additional, Zhang, Yingzhen, additional, Fan, Yujian, additional, Jia, Jianping, additional, and Wang, Peichang, additional

Published
2024
Full Text
View/download PDF

11. Reference intervals for thyroid hormones for the elderly population and their influence on the diagnosis of subclinical hypothyroidism

Author

Jingxuan Fu, Yidan Wang, Yunyi Liu, Qinfei Song, Jingrong Cao, and Wang Peichang

Subjects
Biochemistry (medical), Clinical Biochemistry
Abstract

Background: This study aims to establish reference intervals (RIs) for thyroid hormones in the elderly population and analyze their influence on the prevalence of subclinical hypothyroidism. Methods: Thyroid hormone records of subjects who underwent routine health checkup at our hospital between 2018 and 2020 were analyzed. Thyroid stimulating hormone (TSH), total triiodothyronine, total thyroxine, free triiodothyronine (FT3), and free thyroxine (FT4) levels were compared between young and elderly subjects. Thresholds of these thyroid hormones were established for elderly subjects. Results: A total of 22,207 subjects were included. Of them, 2,254 (10.15%) were aged ≥ 65 years. Elderly subjects had higher TSH, and lower FT3 and FT4 levels when compared with young subjects. In the elderly group, the RIs for TSH, FT3 and FT4 were 0.55-5.14 mIU/L, 3.68-5.47 pmol/L, and 12.00-19.87 pmol/L, respectively. The age and sex specific RIs for TSH were 0.56-5.07 mIU/L for men and 0.51-5.25 mIU/L for women. With whole-group RIs and age and sex-specific RIs for elderly people, the prevalence of subclinical hypothyroidism was 9.83% and 6.29% (p < 0.001), respectively. Conclusions: Elderly individuals had higher TSH levels than young individuals. Our study indicated that establishing specific RIs for elderly individuals is needed. This has implications for the diagnosis and management of subclinical hypothyroidism in the elderly population.

Published
2023
Full Text
View/download PDF

17. Downregulation of KLF14 accelerated cellular senescence and aging

Author

Hou, Yuli, primary, Song, Qiao, additional, Wang, Yaqi, additional, Liu, Jing, additional, Cui, Yuting, additional, Zhang, Xiaomin, additional, Zhang, Jingjing, additional, Fu, Jingxuan, additional, Cao, Min, additional, Zhang, Chi, additional, Liu, Congcong, additional, Wang, Xiaoling, additional, Duan, Huanli, additional, and Wang, Peichang, additional

Published
2023
Full Text
View/download PDF

22. Integrated multi-omics approach revealed cellular senescence landscape

Author

Song, Qiao, primary, Hou, Yuli, additional, Zhang, Yiyin, additional, Liu, Jing, additional, Wang, Yaqi, additional, Fu, Jingxuan, additional, Zhang, Chi, additional, Cao, Min, additional, Cui, Yuting, additional, Zhang, Xiaomin, additional, Wang, Xiaoling, additional, Zhang, Jingjing, additional, Liu, Congcong, additional, Zhang, Yingzhen, additional, and Wang, Peichang, additional

Published
2022
Full Text
View/download PDF

23. The Interpretation of Mirror Pattern Bands During Oligoclonal Immunoglobulin Isoelectric Focusing Electrophoresis: A Retrospective Study.

Author

Wang, JinLing, Li, Lei, Zhang, YanBing, and Wang, PeiChang

Subjects
BIOMARKERS, STATISTICS, NONPARAMETRIC statistics, ELECTROPHORESIS, RETROSPECTIVE studies, INTER-observer reliability, CHI-squared test, CEREBROSPINAL fluid, DATA analysis software
Abstract

Objective Mirror patterns are incidental types that accompany the analysis of the oligoclonal band (OCB) in cerebrospinal fluid (CSF). However, their interpretation remains controversial. In this study, we analyzed all graphic results of mirror patterns from 86 patients to provide an optimal interpretation scheme for mirror patterns. Methods Matched CSF and serum specimens were obtained from patients with various neurological disorders that required OCB analysis. A total of 86 patients were screened and serum immunofixation electrophoresis (IFE) was performed in all 86. The interobserver agreement for interpreting mirror patterns by visual inspection was tested. The method agreement between the visual inspection and IFE was also evaluated. The CSF/serum albumin quotient (QALB) was calculated to determine the blood-brain barrier integrity of all patients. Results Of the 86 patients with mirror patterns, 19.8% (17/86) had typical mirror bands and most (80.2%) had atypical mirror bands. There was a good agreement between the 2 observers in interpreting typical mirror patterns. However, kappa statistics analysis showed poor agreement regarding the interpretation of atypical mirror bands by visual observation alone (kappa value, −0.026 to 0.314 between 2 observers). The disagreement was pronounced between the visual inspection and validation of IFE (kappa value, −0.0238 to 0.176 between the first observer and IFE; −0.322 to 0.118 between the second observer and IFE). The normal QALB rates in the type V groups were significantly higher than those in the type IV group and the positive QALB rates in the type IV were significantly higher than those in the type V. Conclusion Visual inspection to interpret mirror pattern bands is unreliable. Considering the completely different clinical significance between type IV and type V and high risk of potential misinterpretations, it is necessary to perform IFE on all the atypical mirror types to discriminate atypical type IV from atypical type V. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

38. Chemical screen identifies a geroprotective role of quercetin in premature aging

Author

Geng, Lingling, primary, Liu, Zunpeng, additional, Zhang, Weiqi, additional, Li, Wei, additional, Wu, Zeming, additional, Wang, Wei, additional, Ren, Ruotong, additional, Su, Yao, additional, Wang, Peichang, additional, Sun, Liang, additional, Ju, Zhenyu, additional, Chan, Piu, additional, Song, Moshi, additional, Qu, Jing, additional, and Liu, Guang-Hui, additional

Published
2018
Full Text
View/download PDF

41. Development of a Novel Urine Alzheimer‐Associated Neuronal Thread Protein ELISA Kit and Its Potential Use in the Diagnosis of Alzheimer's Disease

Author

Ma, Lina, Wang, Rong, Han, Ying, Sheng, Shuli, Zhu, Jianan, Ji, Zhijuan, Zhao, Zhiwei, Cao, Ziqing, and Wang, Peichang

Subjects
Male, viruses, Enzyme-Linked Immunosorbent Assay, Nerve Tissue Proteins, Reference Standards, Hippocampus, Immunohistochemistry, Sensitivity and Specificity, Frontal Lobe, Mice, Alzheimer Disease, Animals, Humans, Rabbits, Research Articles
Abstract

BACKGROUND: Alzheimer's disease (AD) is an age‐related chronic degenerative disease that damages the nervous system. A noninvasive and simple method for early detection of AD is extremely important for the diagnosis and prognosis of AD. Thus, we aimed to develop an enzyme‐linked immunosorbent assay (ELISA) kit to detect urine Alzheimer‐associated neuronal thread protein (AD7C‐NTP), and to evaluate its clinical value for the diagnosis of AD. METHODS: Immunogenic AD7C‐NTP peptide fragments were synthesized by the solid‐phase method and used for immunizing mice or rabbits to generate anti‐AD7C‐NTP antibodies. The urine AD7C‐NTP ELISA kit was then established; the generated mouse anti‐AD7C‐NTP antibody was used as a capture antibody, the biotin‐labeled rabbit anti‐AD7C‐NTP antibody was used as a detection antibody, and avidin labeled by horseradish peroxidase was used as a substrate. The first morning urine specimens of 121 AD patients and 118 age‐matched controls were collected, and the urine AD7C‐NTP levels were detected by the above ELISA kit. RESULTS: Mouse and rabbit anti‐AD7C‐NTP antibody ELISA titer was found to be 1:8,000 and 1:32,000, respectively. A single band with a relative molecular mass of 41 kDa was found in human brain specimens by Western blot assay, which was identified as AD7C‐NTP antibody. The urine AD7C‐NTP concentration of the AD patients was higher than that of the age‐matched controls, the sensitivity was 89.3% and the specificity was 84.7%. CONCLUSIONS: Our study demonstrated that our newly developed urine AD7C‐NTP ELISA kit has suggested potential for diagnosing AD in a Chinese population, suggesting it may be a useful diagnostic kit for detecting early AD.

Published
2015

Catalog

Books, media, physical & digital resources
See catalog results