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149 results on '"Wang, Ningsheng"'

11. Safety analysis of antineoplastic drugs for lung cancer: a retrospective analysis based on Shaanxi Province in Western China

Author

Lei, Shuang, Wang, Ningsheng, Ren, Biqi, Lin, Shuzhi, and Feng, Bianling

Abstract

ABSTRACTBackgroundChina has the highest proportion of lung cancer-related deaths. Drug therapy is the main tool of comprehensive anticancer treatment. However, most studies to date have focused on certain types of targets or immunotherapeutic modalities for drug safety; few studies have addressed the factors that influence ADRs for each type of drug in patients with lung cancer, and even fewer studies have explored the risk factors for certain types of ADRs. Based on it, we comprehensively evaluate the drug safety of patients and provide a clinical reference with a focus on lung cancer.Research design and methodsWe examined 767 reports of adverse drug reactions (ADRs) in patients with lung cancer and conducted a logistic regression analysis on the risk factors that may cause different types of organ system damage and serious ADRs.ResultsThe logistic regression identified various independent risk factors for system organ damage, and ADRs involving erythrocyte abnormalities (P < 0.001), respiratory system damage (P < 0.001), and leukocyte and reticuloendothelial system abnormalities (P < 0.001) were more likely to be severe.ConclusionsRare adverse reactions and different Clinical medication guidelines for molecular-targeted drugs were identified. These findings had certain practical significance in clinical safe drug use.

Published
2024
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16. Safety analysis of antineoplastic drugs for lung cancer: a retrospective analysis based on Shaanxi Province in Western China

Author

Lei, Shuang, Wang, Ningsheng, Ren, Biqi, Lin, Shuzhi, and Feng, Bianling

Subjects
Pharmacology (medical), General Medicine
Abstract

China has the highest proportion of lung cancer-related deaths. Drug therapy is the main tool of comprehensive anticancer treatment. However, most studies to date have focused on certain types of targets or immunotherapeutic modalities for drug safety; few studies have addressed the factors that influence ADRs for each type of drug in patients with lung cancer, and even fewer studies have explored the risk factors for certain types of ADRs. Based on it, we comprehensively evaluate the drug safety of patients and provide a clinical reference with a focus on lung cancer. We examined 767 reports of adverse drug reactions (ADRs) in patients with lung cancer and conducted a logistic regression analysis on the risk factors that may cause different types of organ system damage and serious ADRs. The logistic regression identified various independent risk factors for system organ damage, and ADRs involving erythrocyte abnormalities (P < 0.001), respiratory system damage (P < 0.001), and leukocyte and reticuloendothelial system abnormalities (P < 0.001) were more likely to be severe. Rare adverse reactions and different Clinical medication guidelines for molecular-targeted drugs were identified. These findings had certain practical significance in clinical safe drug use.

Published
2023
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19. Paleoseismicity of the western Humps fault on the Emu Plain, North Canterbury, New Zealand.

Author

Brough, Thomas, Nicol, Andrew, Stahl, Tim, Pettinga, Jarg R., Dissen, Russ Van, Clark, Dan, Khajavi, Narges, Pedley, Kate, Langridge, Rob, and Wang, Ningsheng

Subjects
PALEOSEISMOLOGY, OPTICALLY stimulated luminescence, RADIOCARBON dating, PLAINS
Abstract

The 2016 MW 7.8 Kaikōura Earthquake nucleated on The Humps fault, which ruptured across the Emu Plain in North Canterbury. The paleoearthquake history of the fault was poorly constrained prior to the 2016 earthquake. To determine the timing and single-event displacements (SED) of earthquakes on the fault we use Optically Stimulated Luminescence (OSL) and radiocarbon dates of faulted stratigraphy and analysis of faulting (i.e. geometry and slip) at the McLean-1 trench site. At the trench the fault trace trends east–west and primarily accommodated right-lateral strike-slip in 2016 (2 ± 0.2 m strike slip and 0.35 ± 0.05 m vertical slip northside downthrow). The Humps fault is more seismically active than previously thought and accrued slip during at least six surface rupturing paleoearthquakes. The timing of these earthquakes was: 9.8–15.3 ka BP (Event 1), 8.6–11.5 ka BP (Event 2), 8.1–10.9 ka BP (Event 3), 6.0–8.6 ka BP (Event 4), 1840 AD to 4.5 ka (Event 5), and 2016 AD (Event 6). These earthquakes have a mean recurrence interval of 1.8–3.4 kyr and could have recurrence intervals up to ~9 kyr. Kaikōura-type ruptures could occur as frequently as every ∼2 kyr and maybe longer if The Humps fault rupture geometries are not characteristic. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Paleoseismology of the Hyde Fault, Otago, New Zealand.

Author

Griffin, Jonathan D., Stirling, Mark W., Barrell, David J.A., van den Berg, Ella J., Todd, Erin K., Nicolls, Ross, and Wang, Ningsheng

Subjects
PALEOSEISMOLOGY, OPTICALLY stimulated luminescence dating, DIGITAL elevation models, ALLUVIAL fans, GEOMORPHOLOGICAL mapping
Abstract

We present the first paleoseismic investigation of the Hyde Fault, one of a series of north-east striking reverse faults within the Otago range and basin province in southern New Zealand. Surface traces of the fault and associated geomorphology were mapped using a lidar digital elevation model and field investigations. Trenches were excavated at two sites across fault scarps on alluvial fan surfaces. The trenches revealed stratigraphic evidence for four surface-rupturing earthquakes. Optically stimulated luminescence dating constrains the timing of these events to around 47.2 ka (37.5–56.7 ka at 95% confidence), 34.6 ka (24.7–46.4 ka), 23.5 ka (19.7–27.3 ka) and 10.5 ka (7.9–13.1 ka). We obtain a mean inter-event time of 12.4 kyr (2.3–23.9 kyr at 95% confidence) and the slip rate is estimated to be 0.22 mm/yr (0.15–0.3 mm/yr). We do not find evidence to suggest that earthquake recurrence on the Hyde Fault is episodic, in contrast to other well-studied faults within Otago, suggesting diverse recurrence styles may co-exist in the same fault system. This poses challenges for characterising the seismic hazard potential of faults in the region, particularly when paleoearthquake records are limited to the most recent few events. [ABSTRACT FROM AUTHOR]

Published
2022
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33. A rapid sediment pulse induced by glacial melting during the MIS 8/7e transition buried well‐developed karst in the Railton Valley, Tasmania, Australia.

Author

Slee, Adrian, McIntosh, Peter D., Woodward, Craig, Wang, Ningsheng, and Gadd, Patricia

Subjects
GLACIAL melting, KARST, BOULDERS, SEDIMENTS, ALLUVIAL fans
Abstract

Recent catastrophic sinkhole collapse caused by regional water table lowering induced by quarrying has led to the partial exhumation and reactivation of a buried karst cave system in the floor of the Railton Valley in the lowlands of northern Tasmania, Australia, and widespread sinkhole development. Extensive silty sediments exposed in sinkholes, OSL dated to approximately 237 ka, are interpreted to be lacustrine deposits derived from rapidly deposited glacial outwash. The silty sediments have mineralogy consistent with derivation from a source in the upper Mersey catchment rather than locally and are interpreted to be the product of rapid melting of the Mersey Valley glacier during the MIS 8/7e transition. Thick Last Glacial alluvial fan and Holocene flood‐plain deposits mantle the lacustrine sediments. Exposures of glacial erratics and weathered till in streambeds provide further evidence that the valley was impacted by earlier Pleistocene glaciations. [ABSTRACT FROM AUTHOR]

Published
2022
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37. Paleoseismology of the Akatore Fault, Otago, New Zealand.

Author

Taylor-Silva, Briar I., Stirling, Mark W., Litchfield, Nicola J., Griffin, Jonathan D., van den Berg, Ella J., and Wang, Ningsheng

Subjects
PALEOSEISMOLOGY, GROUND penetrating radar, EARTHQUAKE hazard analysis, SEDIMENT analysis, APERIODICITY
Abstract

We present the results of a paleoseismic study of the Akatore Fault in the low seismicity region of Otago, New Zealand. Two trenches reveal at least three reverse fault ruptures that are constrained to have occurred between 13,314 B.C. and 680 A.D. (antepenultimate event), 737 and 960 A.D. (penultimate event) and 1047 and 1278 A.D. (most recent event), with a single-event displacements of 1.6–2.5 m. Ground Penetrating Radar (GPR) profiles and sediment analyses show that a 125 ka marine terrace is likely also only displaced by these three events, suggesting these earthquakes have ended a minimum 110,000 year period of quiescence on the fault. The fault therefore appears to exhibit strong aperiodicity of earthquake occurrence, a characteristic previously suggested for the Akatore Fault and other well-studied Otago faults. Slip rate and recurrence interval for the current active period are 0.3–6.0 mm/yr and 450–5110 years respectively. We suggest that for seismic hazard assessments in nearby Dunedin it is prudent to assume that the high rates of recent earthquakes will continue into the immediate future on the Akatore Fault. [ABSTRACT FROM AUTHOR]

Published
2020
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38. Pharmacokinetic and Pharmacodynamic Properties of Rosmarinic Acid in Rat Cholestatic Liver Injury

Author

Min, Jianbin, primary, Chen, Hao, additional, Gong, Zipeng, additional, Liu, Xian, additional, Wu, Tian, additional, Li, Weirong, additional, Fang, Jiansong, additional, Huang, Tianlai, additional, Zhang, Yingfeng, additional, Zhao, Wei, additional, Zhu, Chenchen, additional, Wang, Qi, additional, Mi, Suiqing, additional, and Wang, Ningsheng, additional

Published
2018
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39. Changes in Ethnic Identity Among Han Immigrants in the Wa Hills from the Seventeenth to Nineteenth Centuries

Author

Wang Ningsheng

Subjects
Cultural Studies, History, Anthropology, media_common.quotation_subject, Long period, Immigration, Ethnic group, Ethnology, media_common
Abstract

The present paper discusses the change in ethnic identity of Han miners who migrated to the Wa Hills during the seventeenth–nineteenth centuries. When the mines closed, the miners did not have the resources to return to their home villages and so settled in the Wa Hills. Only by changing their ethnic identity and becoming Wa could they avoid being attacked and headhunted, as well as gain access to local resources, especially land. Changes in ethnic identity over a long period is evident from the village names, family names, legends and genealogies.1

Published
2010

41. Do Chinese Researchers Conduct Ethical Research and Use Ethics Committee Review in Clinical Trials of Anti-Dementia Drugs? An Analysis of Biomedical Publications Originating from China

Author

Zeng, Lingfeng, primary, Liang, Weixiong, additional, Pan, Jianke, additional, Cao, Ye, additional, Liu, Jun, additional, Wang, Qi, additional, Wang, Lu, additional, Zou, Yuanping, additional, Wang, Kezhu, additional, Kong, Lingshuo, additional, Xie, Hui, additional, Xu, Weihua, additional, Li, Weirong, additional, Zhao, Wei, additional, Mi, Suiqing, additional, Chen, Yunbo, additional, Cheng, Shuyi, additional, Li, Xiaoyan, additional, Cao, Qian, additional, Zeng, Xing, additional, and Wang, Ningsheng, additional

Published
2016
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43. Geniposidic acid protected against ANIT-induced hepatotoxity and acute intrahepatic cholestasis, due to Fxr-mediated regulation of Bsep and Mrp2

Author

Chen, Hao, primary, Huang, Xiaotao, additional, Min, Jianbin, additional, Li, Weirong, additional, Zhang, Rong, additional, Zhao, Wei, additional, Liu, Changhui, additional, Yi, Lang, additional, Mi, Suiqing, additional, Wang, Ningsheng, additional, Wang, Qi, additional, and Zhu, Chenchen, additional

Published
2016
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46. Rabbit Sera Containing Compound Danshen Dripping Pill Attenuate Leukocytes Adhesion to TNF-Alpha–Activated Human Umbilical Vein Endothelial Cells by Suppressing Endothelial ICAM-1 and VCAM-1 Expression Through NF-KappaB Signaling Pathway

Author

Xu, Haibo, primary, Wang, Dejian, additional, Peng, Cheng, additional, Huang, Xiushen, additional, Ou, Ming, additional, Wang, Ningsheng, additional, Wang, Peixun, additional, Zhou, Lijuan, additional, and Ye, Xiaolin, additional

Published
2014
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