Search

Your search keyword '"Wang, Nai-San"' showing total 168 results
Start Over Author "Wang, Nai-San"
168 results on '"Wang, Nai-San"'

2. Compliance and functional residual capacity after staple versus combined staple/holmium laser lung volume reduction surgery in a rabbit emphysema model

Author

Serna, Dan L, Powell, Ledford L, Brenner, Matthew, O’Connor, Shannon M, McKenna, Robert J, Wang, Nai-San, and Chen, John C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Lung, Chronic Obstructive Pulmonary Disease, Animals, Functional Residual Capacity, Laser Therapy, Lung Compliance, Male, Pulmonary Emphysema, Rabbits, Surgical Stapling, Cardiorespiratory Medicine and Haematology, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundThere is some evidence to suggest that laser exposure, when added to standard staple reduction techniques, may result in improved physiologic response to lung volume reduction surgery (LVRS). In this study, we compared physiologic responses of staple LVRS with combined staple/laser in a rabbit emphysema model.MethodsNinety-three New Zealand White rabbits underwent emphysema induction with aerosolized elastase 4 weeks before surgery and were killed 1 week after surgery. Treatment groups were bilateral moderate volume staple LVRS (< or =3 g, n = 39), combined moderate volume staple (< or =3 g)/holmium laser LVRS (n = 18), large-volume staple LVRS (> or =3 g, n = 27), or sham surgery (n = 9).ResultsDecrease in postoperative static respiratory system compliance by combined moderate-volume staple/laser treatment (1.22 cc/cm H2O) was similar to large-volume staple resection (1.40 cc/cm H2O, p = 0.39), and superior to moderate staple resection (0.82 cc/cm H2O, p = 0.01) or sham surgery (0.09 cc/cm H2O, p = 0.0001). Functional residual capacity decrease was greater after combined moderate staple/laser resection (6.46 cc) than large-volume staple resection (4.52 cc, p = 0.33), moderate-volume staple resection (4.59 cc, p = 0.43), or sham surgery (4.10 cc, p = 0.29). Perioperative mortality was highest after laser/staple LVRS (22%, 4/18).ConclusionsIn this rabbit model, combined staple/ holmium laser reduction for emphysema results in significant improvement in compliance and trends toward improvement in functional residual capacity above staple reduction alone, but with higher mortality.

Published
1999

3. Effect of Lung Volume Reduction Surgery in a Rabbit Model of Bullous Lung Disease

Author

Brenner, Matthew, Kafie, Fernando E, Huh, Joseph, Yoong, Benedict, Budd, Michael, Chen, John C, Waite, Teri A, Mukai, David, Wang, Nai-San, McKenna, Robert, Fischel, Rick, Gelb, Arthur, Wilson, Archie F, and Berns, Michael W

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Rare Diseases, Chronic Obstructive Pulmonary Disease, Lung, Respiratory, Animals, Disease Models, Animal, Emphysema, Evaluation Studies as Topic, Forced Expiratory Flow Rates, Forced Expiratory Volume, Humans, Lung Compliance, Lung Diseases, Obstructive, Male, Pneumonectomy, Pressure, Rabbits, Surgery, Clinical sciences
Abstract

Clinical use of staple lung volume reduction surgery (LVRS) has proliferated for treatment of emphysema despite limited data regarding efficacy or optimal techniques. Recent studies in animal models of obstructive lung disease describe the decrease in lung compliance and increase in airway support as mechanisms of an improvement in pulmonary functions analogous to human data. We describe contrasting results in an animal model of bullous lung disease with a mixed but predominantly restrictive pattern of lung disease. Mixed restrictive and bullous lung disease was induced in 17 New Zealand white rabbits with i.v. Sephadex beads and endotracheally instilled carrageenan. Unilateral stapled lung volume reduction surgery was performed at 5 weeks postinduction of emphysema on the right lower lobe by lateral thoracotomy using a pediatric stapler. Static trans-pleural pressures were measured at 60, 40, and 20 cm3 inflation at preinduction (baseline), pre- and postoperatively, and 1 week postoperatively in anesthetized animals. Lungs were then harvested en bloc and examined histopathologically. The effects of volume reduction surgery on static lung compliance, lung conductance, and forced expiratory flows (FEF) were assessed. Five weeks after induction of lung disease, the animals had no significant change in static compliance and forced expiratory volume in 0.5 s (FEV0.5) or lung conductance compared to baseline. Immediately following LVRS, the animals showed a significant decrease in static compliance, FEV0.5, and conductance. One week postoperatively, compliance increased to approximately baseline levels along with a slight increase in FEFs and conductance toward preoperative levels. Histology examination revealed restrictive and bullous lung disease. Thus, we have demonstrated the feasibility of using an animal model for evaluation of volume reduction therapy for restrictive-obstructive lung disease. Physiologically, this model showed decrease conductance and decreased forced expiratory flows following lung volume reduction despite increased recoil. This is in contrast to increased conductance and flows seen in humans with severe emphysema following surgery and suggests that current criteria excluding patients with a significant restrictive component to their lung disease from LVRS surgery may be justified.

Published
1998

6. Anatomy

Author

Wang, Nai-San, Dail, David H., editor, and Hammar, Samuel P., editor

Published
1994
Full Text
View/download PDF

15. Comparison of the effectiveness of tetracycline and minocycline as pleural sclerosing agents in rabbits

Author

Light, Richard W., Wang, Nai-San, Sassoon, Catherine S.H., Gruer, Steve E., and Vargas, Francisco S.

Subjects
Tetracycline -- Physiological aspects -- Evaluation, Sclerotherapy -- Evaluation -- Physiological aspects, Tetracyclines -- Physiological aspects -- Evaluation, Health, Evaluation, Physiological aspects
Abstract

Parenteral tetracycline, one of the most commonly used agents for producing pleurodesis, is no longer available because of stricter regulations governing the manufacturing process. The objective of this project was [...]

Published
1994

18. Anatomy

Author

Wang, Nai-San, Dail, David H., editor, and Hammar, Samuel P., editor

Published
1988
Full Text
View/download PDF

20. Subclinical surface alterations of human pleura: a scanning electron microscopic study

Author

Peng, Ming-Jen, Wang, Nai-San, Vargas, Francisco S., and Light, Richard W.

Subjects
Pleurisy -- Physiological aspects, Scanning electron microscopes -- Physiological aspects, Pleural effusions -- Physiological aspects, Health, Physiological aspects
Abstract

Pleuritis or pleural effusion frequently develops in patients with pneumonia or heart failure. Most of these pleural changes regress without intrapleural intervention. The detailed mechanisms of the regression of the [...]

Published
1994

28. Inhaled Noninfectious Toxicants and Their Effects on the Lung.

Author

Bittar, E. Edward, Schraufnagel, Dean E., Goel, Suman, and Wang, Nai-San

Abstract

The primary function of the respiratory system is to bring in air and allow gas diffusion to the blood through a thin barrier. Our air unfortunately contains more than the desired diffusible gases and nitrogen. Particles and inorganic and organic molecules come in contact with various parts of the respiratory system. Most of these substances are benign and exhaled or readily cleared but some are toxic. The damage done by inhaled toxicants appear in several forms. It may be as predictable as a chemical reaction, or as variable as an idiosyncratic allergic reaction, the injury may be immediate or delayed, and the damage may require large or small amounts of toxicants. An overview of the common inhaled toxicants and their effects on the lungs will be given. Texts of environmental medicine and reviews of individual agents will provide more detailed information. [ABSTRACT FROM AUTHOR]

Published
2004
Full Text
View/download PDF

29. Anatomy and Ultrastructure of the Lung.

Author

Bittar, E. Edward and Wang, Nai-San

Abstract

The lung is unique among all internal organs by the way it exposes itself directly and continuously to the surrounding atmosphere in which hostile agents often abound. For its necessary inspiratory and expiratory movements, the lung has to be durable and efficient in gas exchange. Because gas exchange is essential for life, it has to be protected vigilantly. Although the lung is designed to maintain life with minimum effort, it also needs to respond to urgent needs, increasing its basic rates of function 10-fold or more within seconds in life-threatening situations. [ABSTRACT FROM AUTHOR]

Published
2004
Full Text
View/download PDF

33. An Animal Model for Lung Volume Reduction Therapy of Pulmonary Emphysema

Author

Chen, John C., primary, Brenner, Matthew, additional, Kafie, Fernando E., additional, Yoong, Benedid, additional, Budd, Michael, additional, Gassel, Adam, additional, Waite, Teri A., additional, Millikan, Jeff, additional, Huh, Joe, additional, Wang, Nai-San, additional, McKenna, Robert, additional, Gelb, A., additional, Wilson, Archie F., additional, and Berns, Michael W., additional

Published
1998
Full Text
View/download PDF

34. Comparison of Ho:YAG Versus Nd:YAG Thoracoscopic Laser Treatment of Pulmonary Bullae in a Rabbit Model

Author

BRENNER, MATTHEW, primary, WONG, HUMPHREY, additional, YOONG, BENEDICT, additional, WANG, NAI-SAN, additional, CHEN, JOHN C., additional, BUDD, MICHAEL, additional, HAMILTON, ANN, additional, TADIR, YONA, additional, McKENNA, ROBERT, additional, FISCHEL, RICHARD J., additional, HUH, JOE, additional, TROMBERG, BRUCE, additional, and WILSON, ARCHIE F., additional

Published
1997
Full Text
View/download PDF

37. Doppler Grid Surface Scanning Applications for Pulmonary Subsurface Parenchymal Perfusion Assessment

Author

BRENNER, MATTHEW, primary, MILNER, THOMAS E., additional, WANG, NAI-SAN, additional, CHEN, JOHN C., additional, McKENNA, ROBERT, additional, NORVANG, LILL TOVE, additional, WAITE, TERI A., additional, HAMILTON, ANN, additional, WONG, HUMPHREY, additional, WILSON, ARCHIE F., additional, TADIR, YONA, additional, and BERNS, MICHAEL W., additional

Published
1996
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results