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Functional group modification is one of the most commonly used modification techniques for graphite-phase carbon nitride. Here, we report a novel approach to synthesize a photocatalyst (P–UCN-NA) via two-step thermal polymerization. By co-modifying the ethanol groups and phosphate groups to the edges and interlayers of graphite-phase carbon nitride (UCN), respectively, carriers could quickly transfer among the layers of P–UCN-NA, leading to a decrease in recombination. The successful of functionalization was confirmed by Fourier transform infrared spectroscopy (FT-IR) characterization. The significant shift of the XPS spectral peak and the appearance of a new peak at a low binding energy of 531 eV indicate that the co-modified photocatalyst has successfully anchored both the ethanol functional group and the phosphate group, forming chemical interactions with them. As the consequence, the co-modified photocatalyst took the advantage of the ethanol group grafted to the edge as an electron donor to accelerate the transfer of electrons to the specific center. Meanwhile, the phosphate group inserted into the middle layer functioned as a carrier transport channel, effectively shortening the charge transfer distance. Under visible light irradiation, the maximum hydrogen evolution rate of P–UCN-NA was 72.17 μmol/h, 13.4 times that of the original g-C 3 N 4 (5.29 μmol/h). This study provides a new idea for the development of functional group-modified photocatalysts. • A graphite-phase carbon nitride photocatalyst co-modified by an ethanol group and a phosphate group was developed. • A new theoretical model of a bifunctional, co-modified carbon nitride photocatalyst was proposed. • Grafted ethanol groups can adjust the band structure and accelerate the electron drive. • The co-functional group functionalization of g-C 3 N 4 enhances the reaction kinetics and promotes H 2 evolution. [ABSTRACT FROM AUTHOR]

The hydrogen evolution reaction (HER) based on water electrolysis represents an ideal approach for hydrogen production. The advancement of highly active non-precious metal catalysts holds paramount importance. This research employed powder metallurgy sintering to prepare Ni–Cr–Fe and Ni–Cr–Fe–Mo porous materials. It investigated the impact of Mo doping and sintering temperature on the catalytic activity and microstructural influence of hydrogen evolution materials. Furthermore, the materials' electrochemical performance and long-term stability in 6 mol/L KOH were examined. In complicated systems, the current work provides a feasible method for producing hydrogen from Ni–Cr–Fe–Mo porous materials in a strong alkali environment. The results exhibited that when Mo content is 5% and the sintering temperature is 800 °C, the porosity of Ni–Cr–Fe–Mo porous materials is up to 39.9% and the catalytic activity is up to 97%. At the same time, the current density decays to 7.1% after 1000 cycles of electrolysis and shows good HER stability after 48 h. The enhanced catalytic activity for hydrogen evolution emanated from the positive synergy among the transition metal elements. • The porous Ni–Cr–Fe–Mo cathodes were sintered through powder metallurgy. • Ni–Cr–Fe–Mo powder provides more active sites and increases the HER performance of the material. • The cathodes exhibited excellent HER activity and stability in 6 mol/L KOH. [ABSTRACT FROM AUTHOR]

In light of the potential for enhancing SrTiO3 (STO)'s photocatalytic efficiency, particularly in the visible light region, a study is conducted on Al, N codoping in STO herein using first‐principles calculations. The effect of oxygen vacancy (VO) is also considered. It is found that AlSr, NO can significantly reduce the bandgap; however, their formation energies are rather high, and the defect levels they brought in may induce recombination centers. Under O‐deficient conditions, VO can facilitate Al, N doping in STO. When Al, N codope in STO, AlTi, NO, and VO would tend to combine, and formation of complex defect AlTi + NO + VO can further enhance N dopability in STO. Moreover, AlTi + NO + VO can simultaneously reduce the bandgap and eliminate the defect levels induced by NO. However, AlTi + NO + VO may not fully realize the potential for the photocatalytic activity due to the low optical absorption and unsuitable band alignment. The work provides a theoretical guidance for the photocatalytic performance of STO in the visible light region. [ABSTRACT FROM AUTHOR]

17β-Estradiol (E2) is the typical endocrine disruptor of steroidal estrogens and is widely used in animal husbandry and dairy processing. In the environment, even lower concentrations of E2 can cause endocrine dysfunction in organisms. Herein, we have developed a novel molecularly imprinted ratiometric fluorescent sensor based on SiO2-coated CdTe quantum dots (CdTe@SiO2) and 7-hydroxycoumarin with a post-imprint mixing strategy. The sensor selectively detected E2 in aqueous environments due to its two fluorescent signals with a self-correction function. The sensor has been successfully used for spiking a wide range of real water and milk samples. The results showed that the sensor exhibited good linearity over the concentration range 0.011–50 μg/L, obtaining satisfactory recoveries of 92.4–110.6% with precisions (RSD) < 2.5%. Moreover, this sensor obtained an ultra-low detection limit of 3.3 ng/L and a higher imprinting factor of 13.66. By using estriol (E3), as a supporting model, it was confirmed that a simple and economical ratiometric fluorescent construction strategy was provided for other hydrophobic substances. [ABSTRACT FROM AUTHOR]

ABSTRACT Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit protein complex which, along with its accessory proteins, resides in almost every eukaryotic cell. It acts as a proton pump and as such is responsible for regulating pH in lysosomes, endosomes, and the extracellular space. Moreover, V‐ATPase has been implicated in receptor‐mediated signaling. Although numerous studies have explored the role of V‐ATPase in cancer, osteoporosis, and neurodegenerative diseases, research on its involvement in vascular disease remains limited. Vascular diseases pose significant challenges to human health. This review aimed to shed light on the role of V‐ATPase in hypertension and atherosclerosis. Furthermore, given that vascular complications are major complications of diabetes, this review also discusses the pathways through which V‐ATPase may contribute to such complications. Beginning with an overview of the structure and function of V‐ATPase in hypertension, atherosclerosis, and diabetes, this review ends by exploring the pharmacological potential of targeting V‐ATPase. [ABSTRACT FROM AUTHOR]

SUMMARY: Upland cotton, the mainly cultivated cotton species in the world, provides over 90% of natural raw materials (fibers) for the textile industry. The development of cotton fibers that are unicellular and highly elongated trichomes on seeds is a delicate and complex process. However, the regulatory mechanism of fiber development is still largely unclear in detail. In this study, we report that a homeodomain‐leucine zipper (HD‐ZIP) IV transcription factor, GhHOX4, plays an important role in fiber elongation. Overexpression of GhHOX4 in cotton resulted in longer fibers, while GhHOX4‐silenced transgenic cotton displayed a "shorter fiber" phenotype compared with wild type. GhHOX4 directly activates two target genes, GhEXLB1D and GhXTH2D, for promoting fiber elongation. On the other hand, phosphatidic acid (PA), which is associated with cell signaling and metabolism, interacts with GhHOX4 to hinder fiber elongation. The basic amino acids KR‐R‐R in START domain of GhHOX4 protein are essential for its binding to PA that could alter the nuclear localization of GhHOX4 protein, thereby suppressing the transcriptional regulation of GhHOX4 to downstream genes in the transition from fiber elongation to secondary cell wall (SCW) thickening during fiber development. Thus, our data revealed that GhHOX4 positively regulates fiber elongation, while PA may function in the phase transition from fiber elongation to SCW formation by negatively modulating GhHOX4 in cotton. Significance Statement: GhHOX4 promotes fiber elongation by directly regulating expressions of GhEXLB1D and GhXTH2D genes in cotton, but phosphatidic acid interacts with GhHOX4 to alter the nuclear localization of GhHOX4, thereby suppressing transcriptional regulation of GhHOX4 to downstream genes in the transition from fiber elongation to secondary cell wall (SCW) thickening. [ABSTRACT FROM AUTHOR]

Dynamical prediction of monsoon rainfall has been an important topic and a long-standing issue in both research and operational community. This paper provides a comprehensive evaluation of the subseasonal-to-seasonal (S2S) prediction skill of the East Asian summer monsoon (EASM) rainfall using the hindcast record from the Beijing Climate Center Climate System Model, BCC CSM1.1m, during the period 1983–2019. The model exhibits reasonable skills for predicting the EASM rainfall at all lead times with the skill dropping dramatically from the shortest lead time of about 2 weeks (LM0) to 1-month lead (LM1), and then fluctuating remarkably throughout 2-month to 12-month lead times. Over the EASM domain, the rapid decline of the S2S rainfall prediction skill from LM0 to LM1 is mainly caused by the inferior skills over Central China in July and over Northeast China in August. Composite analysis based on hindcast records suggest that these inferior skills are directly tied to the model's difficulties in capturing above-normal precipitation over eastern Central China and Northeast China in the respective months, which are further shown to be associated with anomalous weakening and meridional movement of the Northwestern Pacific subtropical high and the activity of large-scale teleconnection pattern hard to be predicted over northeastern Asia in summer, respectively. These findings inform the intrinsic limits of the S2S predictability of the EASM rainfall by a dynamical model, and strongly suggest that the level of confidence placed upon S2S forecasts should be stratified by large-scale circulation anomalies known to significantly affect the prediction skill, e.g., the subtropical high and high-latitude teleconnection patterns for summer monsoon rainfall prediction in this region. [ABSTRACT FROM AUTHOR]

Background: Metadherin (MTDH) and ubiquitin specific protease 7 (USP7) have been identified to involve in the tumorigenesis of cervical cancer (CC). USP7 is one of the deubiquitinating enzymes. Here, this study aimed to explore whether USP7 affected CC progression via interacting with MTDH and regulating its stability via deubiquitination. Methods: qRT-PCR and western blotting assays detected the levels of genes and proteins. Functional analysis was conducted using 5-ethynyl-2’-deoxyuridine (EdU), flow cytometry, transwell, and tube formation assays, respectively. Proteins between USP7 and MTDH were identified by co-immunoprecipitation assay. A mouse xenograft model was established for in vivo analysis. Results: MTDH was highly expressed in CC tissues and cells, silencing of MTDH suppressed CC cell proliferation, migration, invasion, angiogenesis, and macrophage M2 polarization. Mechanistically, USP7 directly bound to MTDH, and maintained its stability by removing ubiquitination on MTDH. CC tissues and cells showed high USP7 expression, and USP7 knockdown also inhibited CC cell proliferation, migration, invasion, angiogenesis and macrophage M2 polarization, and these effects mediated by USP7 knockdown were reversed by MTDH overexpression. Moreover, USP7 knockdown impeded CC growth in vivo by regulating MTDH. Conclusion: Collectively, USP7 promoted CC cell proliferation, migration, invasion, angiogenesis, and macrophage M2 polarization in vitro, as well as tumor growth in vivo by regulating MTDH. [ABSTRACT FROM AUTHOR]

[Display omitted] Zinc-iodine batteries (ZIBs) have been recognized as a promising energy storage device due to their high energy density, low cost and environmental friendliness. However, the development of ZIBs is hindered by the shuttle effect of polyiodides which results in capacity degradation and poor cycling performance. Inspired by the ability of starch to form inclusion compounds with iodine, we propose to use a starch gel on the cathode to suppress the shuttle of polyiodides. Herein, porous carbon is utilized as a host for iodine species and provides an excellent conductive network, while starch gel is used as another host to suppress polyiodides shuttle, resulting in improved battery performance. The test results demonstrate that the conversion between I−/I 2 /I 3 − in the cathode and the effective inclusion role of starch suppress the shuttle of polyiodides during the charging process. Meanwhile, based on the electrochemical tests and theoretical DFT calculations, it is found that starch has a stronger ability to adsorb polyiodides compared to carbon materials, which enables effective confinement of polyiodides. The ZIBs used the cathode with starch gel exhibit high coulombic efficiency (>95 % at 0.2 A/g) and low self-discharge (86.8 % after resting for 24 h). This strategy is characterized by its simplicity, low cost and high applicability, making it significant for the advancement of high-performance ZIBs. [ABSTRACT FROM AUTHOR]

In the study of singularly perturbed boundary problems with turning points, the solution undergoes sharp changes near these points and exhibits various interior phenomena. We employ the matching asymptotic expansion method to analyze and solve a singularly perturbed boundary and interior layers problem with multiple turning points, resulting in a composite expansion that fits well with the numerical solution. The solution demonstrates a strong association with special functions, which is verified by the theory of differential inequalities. [ABSTRACT FROM AUTHOR]

Diabetic kidney disease (DKD) is a major cause of chronic kidney disease (CKD), and it heightens the risk of cardiovascular incidents. The pathogenesis of DKD is thought to involve hemodynamic, inflammatory, and metabolic factors that converge on the fibrotic pathway. Genetic predisposition and unhealthy lifestyle practices both play a significant role in the development and progression of DKD. In spite of the recent emergence of angiotensin receptors blockers (ARBs)/angiotensin converting enzyme inhibitor (ACEI), sodium-glucose cotransporter 2 (SGLT2) inhibitors, and nonsteroidal mineralocorticoid receptors antagonists (NS-MRAs), current therapies still fail to effectively arrest the progression of DKD. Glucagon-like peptide 1 receptor agonists (GLP-1RAs), a promising class of agents, possess the potential to act as renal protectors, effectively slowing the progression of DKD. Other agents, including pentoxifylline (PTF), selonsertib, and baricitinib hold great promise as potential therapies for DKD due to their anti-inflammatory and antifibrotic properties. Multidisciplinary treatment, encompassing lifestyle modifications and drug therapy, can effectively decelerate the progression of DKD. Based on the treatment of heart failure, it is recommended to use multiple drugs in combination rather than a single-use drug for the treatment of DKD. Unearthing the mechanisms underlying DKD is urgent to optimize the management of DKD. Inflammatory and fibrotic factors (including IL-1, MCP-1, MMP-9, CTGF, TNF-a and TGF-β1), along with lncRNAs, not only serve as diagnostic biomarkers, but also hold promise as therapeutic targets. In this review, we delve into the potential mechanisms and the current therapies of DKD. We also explore the additional value of combing these therapies to develop novel treatment strategies. Drawing from the current understanding of DKD pathogenesis, we propose HIF inhibitors, AGE inhibitors, and epigenetic modifications as promising therapeutic targets for the future. [ABSTRACT FROM AUTHOR]

This paper presents a composite control algorithm for the radio telescope servo control system to address the target tracking and matched/mismatched disturbance suppression problems. The algorithm consists of the equivalent-input-disturbance (EID) approach and the optimal control method. An EID estimator is developed using the difference between the estimated output of the state observer and the measurement output and then the estimate of the EID is fed forward into the control input to reject the disturbance. A cost function with clear physical meaning is selected and the weighting parameters are adjusted for the optimal controller to improve tracking performance. Considering the nonminimum phase characteristics of the radio telescope system, the state observer gain is computed using the linear matrix inequality (LMI) method. The system stability is analyzed using the small gain theorem, and the linear quadratic regulator (LQR) control method is utilized to determine the state feedback gain. Finally, the composite controller is designed for an identified telescope model. Simulation results show that for the tracking performance, the settling time of proposed method is 1.13 s and reduces by about 0.32 s and 0.87 s than that of the ADRC controller and PI controller, respectively. For the antidisturbance performance, the RMS value and the maximum error of the proposed method are 0.0039 and 0.0128, which are 42.86% and 40.38% of the ADRC controller and 30.71% and 27.77% of the PI controller, respectively, which indicates that the proposed method has better control performance. In addition, the proposed controller has certain robustness to systematic parameter perturbations. [ABSTRACT FROM AUTHOR]

As a fundamental thermodynamic parameter, pressure serves as an effective tool to control the structures and properties of functional materials. To date, numerous pressure‐engineering methods have been introduced to enhance perovskite structures and devices. This paper comprehensively reviews the advances in understanding the effects of pressure on perovskite materials and devices, encompassing both low and high‐pressure influences. These effects are categorized into six distinct groups based on their underlying mechanisms, detailing the evolution of perovskite structures from macroscopic to microscopic levels, and exploring the interplay between these structures and their functional characteristics. Finally, the current challenges and offer insights into the future prospects for harnessing pressure effects to further develop perovskite structures, properties, and devices are assessed. [ABSTRACT FROM AUTHOR]

Purpose: Tegafur (TF) is one of the most important clinical antitumor drugs with poor water solubility, severely reducing its bioavailability. This work develops new cocrystals to improve the solubility of TF and systematically investigates the intermolecular interactions to provide new insights into the formation of cocrystal and changes in physicochemical properties. Method: In this paper, two new 1:1 cocrystals of TF with 2,4 dihydroxybenzoic acid (2,4HBA) and p-nitrophenol (PNP) were synthesized. The cocrystal products were identified and characterized by various solid state analysis techniques. And the high performance liquid chromatography (HPLC) was conducted to determine the solubility and dissolution rate of TF and cocrystals. Moreover, the quantum chemistry calculations of crystal structure provided theoretical support for the results. Result: Compared with pure TF, the solubility and dissolution rate of TF-2,4HBA is significantly increased in a pH 6.8 buffer at 37°C. Under accelerated storage conditions (40°C, 75% RH), all cocrystal exhibits excellent stability over 8 weeks. Hirshfeld surface (HS) analysis, atoms in molecules (AIM) analysis, interaction region indicator (IRI) analysis, molecular electrostatic potential surface (MEPS) analysis and frontier molecular orbital (HOMO–LUMO) analysis were integrated to understand the hydrogen bonding interaction more comprehensively. The simulation results are in good agreement with the experimental data. The results show that the analysis of physical and chemical properties of TF-PNP cocrystal and TF crystal by quantum chemistry method is reliable at molecular level. Conclusion: These results are helpful to provide guiding methods in the cocrystal development and theoretical study of tegafur. [ABSTRACT FROM AUTHOR]

We present a decade of observations of pulse arrival times for 85 pulsars using the Nanshan radio telescope from July 2002 to March 2014. The Cholesky method can accurately estimate the covariance function of the timing residuals, significantly improving the parameter's estimation accuracy when red noise is prominent. We utilize the Cholesky method to determine positions and basic timing parameters of these pulsars, as well as to obtain timing residuals. Most of these sources showed evidence of significant timing irregularities, which are described. The spectral analyses of timing residuals are presented for pulsars showing obvious red noise. Our results show that timing residuals in half of these pulsars are attributed to rotational irregularities. The red noise in normal pulsars may originate from a random walk in spin frequency or spin-down rate. [ABSTRACT FROM AUTHOR]

Left-behind children (LBC; being left behind by one parent or both parents who migrated to a different location over six months) suffered higher peer victimization than did non-left-behind children. However, it is unclear whether intrapersonal (i.e. self-esteem) and environmental factors (i.e. perceived social support) would moderate the effect of LBC status on peer victimization. A total of 1,064 primary school students from rural China participated in this study. They provided demographic information and completed self-report measures on self-esteem, perceived social support, and peer victimization. After controlling for age and gender, multiple regression analysis revealed that LBC experienced higher peer victimization than their non-left-behind counterparts. Self-esteem and perceived social support were negatively associated with peer victimization. Self-esteem moderated the negative impact of being left behind on peer victimization, but perceived social support did not. Furthermore, the moderated moderation model revealed that the buffering role of self-esteem in the relation between being left behind and peer victimization only emerged among children with low perceived social support. These findings suggested that being left behind would increase the risk of peer victimization, but self-esteem could be a protective factor, especially for children with low social support. Intervention programs should pay more attention to LBC in rural China, improve their self-esteem and social support, thus reducing the likelihood of suffering peer victimization. [ABSTRACT FROM AUTHOR]

CsPbI3 possesses three photoactive black phases (α, β, and γ) with perovskite structures and a non-photoactive yellow phase (δ) without a perovskite structure. Among these, α-CsPbI3 exhibits the best performance. However, it only exists at high temperatures and it tends to transform into the δ phase at room temperature, especially in humid environments. Therefore, the phase stability of CsPbI3, especially in humid environments, is the main obstacle to its further development. In this study, we studied the interaction of H2O with α-CsPbI3 and the intrinsic defects within it. It was found that the adsorption energy in the bulk is higher than that on the surface (−1.26 eV in the bulk in comparison with −0.60 eV on the surface); thus, H2O is expected to have a tendency to diffuse into the bulk once it adsorbs on the surface. Moreover, the intrinsic vacancy of VPb0 in the bulk phase can greatly promote H2O insertion due to the rearrangement of two I atoms in the two PbI6 octahedrons nearest to VPb0 and the resultant breaking of the Pb–I bond, which could promote the phase transition of α-CsPbI3 in a humid environment. Moreover, H2O adsorption onto VI+1 contributes to a further distortion in the vicinity of VI+1, which is expected to enhance the effect of VI+1 on the phase transition of α-CsPbI3. Clarifying the interaction of H2O with α-CsPbI3 and the intrinsic defects within it may provide guidance for further improvements in the stability of α-CsPbI3, especially in humid environments. [ABSTRACT FROM AUTHOR]

Introduction: Past research focusing on Western samples has demonstrated that heterosexist harassment, rejection, and discrimination (HHRD) were associated with psychological problems. How and when this relation would occur, however, remains unclear, especially for understudied Chinese sexual minorities. Method: A convenience sample of 1,453 Chinese lesbian, gay, and bisexual (LGB) individuals aged 18–50 participated in this study. They provided demographic information and completed measures of HHRD, internalised homophobia, perceived parental support for sexual orientation, anxiety, and depression. Structural equation modelling was conducted for data analyses. Results: Internalised homophobia partially accounted for the positive relation between HHRD and psychological problems (i.e. anxiety and depression). The indirect effect of HHRD on psychological problems through internalised homophobia was smaller when Chinese LGB persons had higher levels of perceived parental support for sexual orientation. Conclusions: Internalised homophobia might be an underlying mechanism for the relation between HHRD and psychological problems, and perceived parental support for sexual orientation may play a critical role in disrupting the pathway from HHRD to psychological problems through internalised homophobia. [ABSTRACT FROM AUTHOR]

A water soluble diacrylate decorated aggregation induced emission (AIE) fluorophore (tetraphenyl ethylene decorated with diacrylate, TPE‐D) has been synthesized via straight forward synthetical route. The compound displayed promising liquid viscosity sensing capability. Upon increasing the liquid viscosity, the fluorescence emission intensity was observed to enhance. By polymerization with diacrylate‐PEG, a novel mechanical parameter self‐characterizing fluorescent hydrogel has been constructed. Taking advantages of AIE nature of TPE‐D, the viscosity, elastic modulus and viscous modulus, in addition to the liquid viscosity, of the as‐constructed hydrogel can be reflected by fluorescent intensity. We wish this novel hydrogel can be further applied as 3D cell culture to disclose the mechanical influence on disease related cellular behavior. [ABSTRACT FROM AUTHOR]

All crystals are not ideal, and many of their properties are often determined not by the regular arrangement of atoms, but by the irregular arrangement of crystal defects. Many properties of materials can be controlled effectively by proper use of solid defects. By substitution of NH4+ ion of a hexagonal perovskite structure (H2dabco)(NH4)(NO3)3 (dabco=1,4‐diazabicyclo[2.2.2]octane, 1) with Cd2+ ion, we obtained a new metal‐vacancy compound (H2dabco)2Cd(H2O)2(NO3)6 (2). It exhibits a ferroelectric‐paraelectric phase transition at 261 K. A comparison of the various‐temperature single‐crystal structures indicates that the coordination twist of Cd2+ ion leads to instability of the lattices and excellent ferroelectricity. These findings reveal that the vacancy can be utilized as an element to produce ferroelectricity and may start the chemistry of metal‐vacancy coordination compounds. These findings reveals that the vacancy can be utilized as an effective means to tune the symmetry and produce ferroelectricity. [ABSTRACT FROM AUTHOR]

Summary: It is well known that all practical control systems are subject to external disturbances. Therefore, a feedback controller should be designed so that the closed‐loop system has some desired properties such as stability, good tracking performance, at the same time, the impact of external disturbances on the performance of the closed‐loop system is attenuated to some degree. On the other hand, almost all models for real fully actuated systems, which are derived based on the physical laws, are described by a set of high order differential equations. The traditional method for controlling these fully actuated systems is to convert the high order differential equations to first order differential equations, which are called the state equations, and then to design feedback controllers by using the state‐space design methods. Such conversion causes some inconveniences. To overcome such inconveniences, a high‐order fully actuated (HOFA) design method has been proposed to control HOFA systems. The main goal of this paper is to design a weak disturbance decoupling controller for HOFA nonlinear systems to guarantee the stability and desired output tracking performance of the closed‐loop system and to attenuate the impact of disturbances. [ABSTRACT FROM AUTHOR]

The study specifically focused on the Hongliulin mining area, where a total of 40 soil samples were meticulously collected and analyzed from within a 1000 m radius extending from the tailings dam. The findings revealed that soil pH within the 0–1000 m range generally leaned towards the alkaline side. In terms of soil nutrient content, encompassing factors such as soil organic matter (SOM), total nitrogen (TN), total phosphorus (TP), total potassium (TK), alkali nitrogen (AK), available phosphorus (AP), and quick-acting potassium (AK), the variations fell within the following ranges: 2.23–13.58 g/kg, 0.12–0.73 g/kg, 0.18–1.15 g/kg, 9.54–35.82 g/kg, 2.89–6.76 mg/kg, 3.45–11.25 mg/kg, and 5.86–130.9 mg/kg. Collectively, these values indicate relatively low levels of soil nutrients. Within the 0–500 m range of soil samples, the average concentrations of Cd, Hg, Pb, and As were 0.778, 0.198, 24.87, and 17.92 mg/kg, respectively. These concentrations exceeded the established soil background values of Shaanxi Province and emerged as the primary pollutants in the study area. Within this same range, the mean values of eight toxic metals (Pi) were ranked in the following descending order: 1.726 (Hg), 1.400 (As), 1.129 (Cr), 1.109 (Pb), 0.623 (Zn), 0.536 (Cd), 0.309 (Cu), and 0.289 (Ni). With the exception of Hg, As, Cr, and Pb, which exhibited slight pollution, the other toxic metals were found to be within acceptable pollution limits for this sampling range, in line with the results obtained using the geo-accumulation index method. The average potential ecological risk index for the eight toxic metals in the study area stood at 185.0, indicating a moderate overall pollution level. When assessing individual elements, the proportions of ecological risk attributed to Hg, As, Pb, and Cd were 34.57%, 27.44%, 25.11%, and 23.11%, respectively. This suggests that the primary potential ecological risk elements in the study area are Hg and As, followed by Cd and Pb. Notably, toxic metals Hg and Pb, as well as As and Pb, exhibited significant positive correlations within the sampling area, suggesting a common source. An analysis of the relationship between soil physicochemical properties and toxic metals indicated that soil pH, SOM, TN, and TP were closely linked to toxic metal concentrations. The toxic metal elements in the research area's soil exhibit moderate variability (0.16 < CV < 0.36) to high variability (CV > 0.36). Within the range of 0–200 m, the CV values for Cd and Hg exceed 1, indicating a high level of variability. The coefficient of variation for SOM, TP, AP, AK and TK is relatively high with the of 2.93, 2.36, 2.36, 21.01, 7.54. The soil in the sampling area has undergone significant disturbances due to human activities, resulting in toxic metal pollution and nutrient deficiencies. [ABSTRACT FROM AUTHOR]

Obtaining written informed consent from participants before enrolment in a study is essential. A previous study showed that only 50% of the participants in clinical trials understood the components of informed consent, and the methods of participants' understanding of informed consent were controversial. This updated meta-analysis aimed to estimate the proportion of participants in clinical trials who understand the different informed consent components. PubMed, EMBASE, the Cochrane Library, and Scopus were searched till April 2023. Therapeutic misconception, ability to name one risk, knowing that treatments were being compared, and understanding the nature of the study, the purpose of the study, the risks and side-effects, the direct benefits, placebo, randomization, voluntariness, freedom to withdraw, the availability of alternative treatment if withdrawn from the trial, confidentiality, compensation, or comprehension were evaluated. This meta-analysis included 117 studies (155 datasets; 22,118 participants). The understanding of the risks and side-effects was investigated in the largest number of studies (n = 100), whereas comparehension was investigated in the smallest number (n = 11). The highest proportions were 97.5%(95% confidence interval (CI): 97.1–97.9) for confidentiality, 95.9% (95% confidence interval (CI): 95.4–96.4) for compensation, 91.4% (95% CI: 90.7–92.1) for the nature of study, 68.1% (95% CI: 51.6–84.6) for knowing that treatments were being compared, and 67.3% (95% CI: 56.6–78) for voluntary nature of participants. The smallest proportions were the concept of placebo (4.8%, 95%CI: 4.4–5.2) and randomization(39.4%, 95%CI: 38.3–40.4). Our findings suggested that most participants understood the fundamental components of informed consent (study confidentiality, nature, compensation, voluntariness, and freedom to withdraw). The understanding of other components, such as placebo and randomization was less satisfactory. [ABSTRACT FROM AUTHOR]

In this paper, we propose two types of universal characters corresponding to partition shapes π = (3) and π = (2, 1) and construct their vertex operators realizations. It is proved that (3)-type and (2, 1)-type universal characters can be derived by the products of vertex operators acting on the identity. Furthermore, we investigate (3)-type and (2, 1)-type universal characters by means of Hamiltonian and fermions expectation values. In addition, based upon bilinear equations, we present the (3)-type and (2, 1)-type universal characters hierarchies whose τ functions can be derived from (3)-type and (2, 1)-type universal characters. [ABSTRACT FROM AUTHOR]

As a key element in quantum repeaters, entanglement swapping establishes entanglement between two independent entangled states. Besides entanglement, quantum steering has been identified as an essential quantum resource and has broad applications in quantum communication. Although entanglement swapping has been realized experimentally, quantum steering swapping still remains a challenge since the condition of quantum steering is stronger than that of entanglement. In this article, quantum steering swapping between a three‐mode and a two‐mode Gaussian entangled state in a lossy channel is demonstrated. By choosing the optimum gain in the classical channel that corresponds to the maximum transmission distance, the one‐way and two‐way steerabilities in a new three‐mode Gaussian state located in distant nodes are achieved. The obtained collective steerability from two users to one user has potential application in quantum secret sharing. The results make a crucial step toward applications of quantum steering in asymmetric quantum information processing. [ABSTRACT FROM AUTHOR]

For nonlinear discrete systems with dual unknown inputs, there are many limitations regarding previous nonlinear filters. This paper proposes two new, improved square-root cubature Kalman filtering (ISRCKF) algorithms to estimate system states and dual unknown inputs. Improved square-root cubature Kalman filtering 1 (ISRCKF1) introduces an innovation that first obtains the unknown input estimates from the measurement equation, then updates the innovation to derive the unknown input estimates from the state equation, then uses the already obtained estimates of the dual unknown inputs to correct the one-step estimate of the state, and finally the minimum variance unbiased estimate of the state is obtained. Improved square-root cubature Kalman filtering 2 (ISRCKF2) builds a unified innovation feedback model, then applies the minimum variance unbiased estimation (MVUE) criterion to obtain the estimates of system states and dual unknown inputs, refining a more concise recursive filter but requiring stronger assumptions. Finally, simulation results demonstrate that the above two algorithms can achieve the optimal estimates of system states and dual unknown inputs simultaneously, and ISRCKF2 further enhances the accuracy of both state and dual unknown inputs estimation, which verifies the validity of the proposed algorithms. [ABSTRACT FROM AUTHOR]

Background & aims: Population aging is a growing phenomenon, with cognitive impairment becoming a prevalent issue among the elderly. This study aimed to investigate the impact of physical activity and depressive symptoms on cognitive function in older adults using a nationally representative data set of U.S. older adults aged ≥ 60 years. Methods: The study comprised 2713 participants aged ≥ 60 from the National Health and Nutrition Examination Survey 2011–2014. Participants were classified into two groups: Cognitive impairment and No-Cognitive impairment, determined by the results of the Digit Symbol Substitution Test (DSST). Physical activity (PA) was assessed using the Global Physical Activity questionnaire (GPAQ), while depressive symptoms were evaluated using the Patient Health Questionnaire (PHQ-9). Logistic regression analysis examined the relationship between physical activity, depressive symptoms and cognitive function. Results: Multifactorial logistic regression analysis showed that high levels of physical activity were found to be significantly associated with a lower risk of cognitive impairment compared to low levels of physical activity [OR = 0.789, 95% CI:0.632 ~ 0.986, P = 0.037]. On the other hand, the presence of major depressive symptoms was significantly associated with a higher risk of cognitive impairment compared to the absence of depressive symptoms [OR = 3.482, 95% CI: 2.278 ~ 5.324, P < 0.001]. Participants in the recreational physical activity group exhibited higher Cognitive scores (P < 0.001), indicating better cognitive functioning. Conclusion: High levels of Physical activity were independently associated with a lower incident cognitive impairment. Additionally, the severity of depression was positively correlated with an increased risk of cognitive impairment. [ABSTRACT FROM AUTHOR]

Background: It has been shown that methylation in the promoter region of eNOS can downregulate eNOS expression resulting in the endothelial dysfunction. However, it is unclear whether low androgen levels and type 1 diabetes cause ED by methylating the promoter region of eNOS in the penile corpus cavernosum. Objective: To clarify the effects of type 1 diabetes and hypo‐androgen status on the methylation level of the promoter region of the eNOS gene in penile cavernous tissue and their relationship with the erectile function. Methods: Fifty‐eight eight‐week‐old male Sprague–Dawley rats were randomly divided into six groups (n = 6): sham operation group, castration group, castration+testosterone (cast+T) group, normoglycemia group, diabetic group, and diabetic+methyltransferase inhibitor (5‐aza‐dc, 1.5 mg/kg) group. The ICPmax/MAP, serum T, the concentration of nitric oxide (NO), the expression of DNMT1, DNMT3a, DNMT3b, and eNOS, and the methylation level of the eNOS promoter region in penile corpus cavernosum of rat were examined 4 weeks after surgery in the sham‐operated group, the castration group, and the castration + testosterone replacement group. Those tests were examined after 6 weeks using of methylation inhibitors in the normoglycemic group, the diabetic group, and the diabetic + methylation inhibitor group. Results: ICPmax/MAP, DNMT1, DNMT3a, DNMT3b, eNOS, and NO levels were significantly lower in castrated rats than in sham and cast+T rats (P < 0.05). ICPmax/MAP, eNOS, and NO levels were lower, and DNMT1, DNMT3a, and DNMT3b expression levels were significantly increased in the diabetic group compared with the normoglycemic and diabetic+methyltransferase inhibitor groups (P < 0.05). There was no significant difference in the methylation level of the promoter region of eNOS in penile cavernous tissue of castrated rats compared with the sham group or the testosterone replacement group. The methylation level of the promoter region of eNOS in penile cavernous tissue was significantly higher in the diabetic group than in the normoglycemic group and diabetic+methyltransferase inhibitor group (P < 0.05). Conclusion: Although low androgen status inhibited the level of methyltransferase in rat penile cavernous tissue, did not affect the level of methylation in the promoter region of eNOS. Hyperglycemia inhibits the NO level in the penile cavernous tissue and the erectile function of rats by upregulating the methyltransferase level in the penile cavernous tissue and the methylation level in the promoter region of eNOS. Methylation inhibitors can partly improve the erectile function in type 1 diabetic rats. [ABSTRACT FROM AUTHOR]

Sarcopenia is associated with NAFLD. It is unknown if the association is explained by shared risk factors. Our study sought to investigate the association between liver fat and sarcopenia in our cohort. Liver fat was measured on CT between 2008 and 2011. We excluded heavy alcohol use and missing covariates. Muscle mass in a subset (n = 485) was measured by 24 h urinary creatinine. Physical function was defined by h strength and walking speed. Sarcopenia was defined as low muscle mass and/or low physical function. We created multivariable-adjusted regression models to evaluate cross-sectional associations between liver fat and low muscle mass, grip strength, and walking speed. The prevalence of hepatic steatosis was 30% (n = 1073; 58.1% women; mean age 65.8 ± 8.6 years). There was a significant positive association between liver fat and muscle mass in linear regression models. The association was not significant after adjusting for BMI. The odds of sarcopenia increased by 28% for each SD in liver fat (OR 1.28; 95% CI 1.02, 1.60) and persisted after accounting for confounders in multivariable-adjusted models (OR 1.30, 95% CI 1.02, 1.67). Further studies are needed to determine if there is a causal relationship between liver fat and sarcopenia and whether treatment of sarcopenia improves liver fat. [ABSTRACT FROM AUTHOR]

Published evidence indicated that the leptin receptor (LEPR) gene polymorphisms are associated with polycystic ovary syndrome (PCOS) risk. However, studies on the association between the polymorphisms of LEPR gene are inconsistent or even controversial. We conducted this meta-analysis to explore the more precise relationship between LEPR polymorphisms and PCOS risk. Relevant articles were searched with five online databases up to March 1 2023. Odds ratios (OR) with 95% confidence intervals (CI) were selected to examine the statistical strength of each genetic model. Moreover, RNA secondary structure and variant effects of these loci were examined with in silico analysis. Overall, 11 publications were analyzed, and the pooled results did not present any significant association between rs1137101 A/G polymorphism and PCOS risk in general population and some subgroup analysis. But the significant association were observed in Asian population (AG vs. AA: OR = 0.51, 95%CI = 0.32–0.81, p =.01, I2=0%; AG + GG vs. AA: OR = 0.41, 95%CI = 0.26–0.65, p <.01, I2=25.9%). Moreover, similar positive associations were also observed in rs1805096 polymorphism with PCOS risk. In summary, our meta-analysis suggested that the LEPR gene polymorphisms might be associated with PCOS susceptibility. Owing to the limited studies and small sample size in our meta-analysis, more well-designed studies from different races were needed to be conducted to verify the current results. [ABSTRACT FROM AUTHOR]

Severe autoimmune hemolytic anemia complicating hereditary spherocytosis is life threatening and has not been described in a case report. Here, we report a case in which this intractable disease was treated successfully with glucocorticoids and cyclosporine. A 25-year-old female patient with hereditary spherocytosis developed severe autoimmune hemolytic anemia after respiratory syncytial virus infection. Her hemoglobin level was 26 g/L and various anti-red blood cell antibodies were detected in her serum, making blood matching difficult. Glucocorticoid monotherapy was ineffective. With the addition of cyclosporine (50 mg/12 h), the patient's hemoglobin level increased significantly and the symptoms associated with anemia were greatly relieved. In patients with severe autoimmune hemolytic anemia, especially when the presence of multiple anti-red blood cell antibodies and alloantibodies interferes with blood matching, a glucocorticoid-cyclosporine regimen may be tried. [ABSTRACT FROM AUTHOR]

The low mechanical strength, water deficiency, and oxidative protection of organic membranes impede their use as food-grade packaging materials. Cinnamaldehyde (CIN) tends to lose its activity owing to its instability. In this study, CIN was added to flaxseed gum (FG)/chitosan (CS) films prepared in a "sandwich" structure. The influence of CIN dosage on the properties of the composite films was studied, and the film formation mechanism of the membrane was explored. The elongation at break, water vapor permeability, oxygen permeability, and light transmittance of the composite film with 1.5% CIN were lower than those of the FG/CS/FG film. Supplementation of the composite membrane with CIN generated new hydrogen bonds, electrostatic interactions, and C-O-C bonds, which converted the structure of the composite film into a sheet and increased its crystallinity without markedly affecting its thermal stability. Therefore, CIN is an extremely useful additive for improving the applicability of flaxseed gum/CS membranes as food-grade packaging films. [ABSTRACT FROM AUTHOR]

Background: Various experimental studies demonstrated that atorvastatin exerted additive effects with anticancer drugs to impair tumor growth, delay relapse, and prolong survival time in lung cancer. However, it is indistinct whether there are survival benefits of atorvastatin in the treatment of small-cell lung cancer (SCLC) patients with dyslipidemia. Therefore, this study aimed to evaluate the efficacy and safety of atorvastatin plus first-line standard chemotherapy in SCLC combined dyslipidemia. Methods: This was a retrospective analysis of 91 eligible SCLC patients with dyslipidemia registered at the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from October 2018 to October 2022. SCLC patients with confirmed dyslipidemia were assigned to the treatment group to receive atorvastatin plus first-line standard chemotherapy (n = 45) or to the control group to accept chemotherapy (n = 46) until disease progression or unmanageable toxicity occurred. The clinicopathological parameters and survival data were collected and analyzed. Univariate and multivariate analyses were performed to investigate the prognostic significance of SCLC. The median progression-free survival (mPFS) was considered to be the pivotal symbol as the primary endpoint. The second endpoints were recognized as the median overall survival (mOS) and toxicity. Results: In the total of 91 enrolled patients, the curative effect can be evaluated in all patients. Research results showed that atorvastatin added to first-line standard chemotherapy was associated with a significant improvement in survival (mPFS: 7.4 vs 6.8 months, P = 0.031; mOS: 14.7 vs 13.2 months, P = 0.002). Conclusion: Atorvastatin added to first-line standard chemotherapy achieved prospective efficacy and manageable safety in SCLC combined dyslipidemia. [ABSTRACT FROM AUTHOR]

Purpose: This study aims to identify the novel risk predictors of low medication adherence of cirrhosis patients in a large cohort and construct an applicable predictive model to provide clinicians with a simple and precise personalized prediction tool.Patients and Methods: Patients with cirrhosis were recruited from the inpatient populations at the Department of Infectious Diseases of Tangdu Hospital. Patients who did not meet the inclusion criteria were excluded. The primary outcome was medication adherence, which was analyzed by the medication possession ratio (MPR). Potential predictive factors, including demographics, the severity of cirrhosis, knowledge of disease and medical treatment, social support, self-care agency and pill burdens, were collected by questionnaires. Predictive factors were selected by univariable and multivariable logistic regression analysis. Then, a nomogram was constructed. The decision curve analysis (DCA), clinical application curve analysis, ROC curve analysis, Brier score and mean squared error (MSE) score were utilized to assess the performance of the model. In addition, the bootstrapping method was used for internal validation.Results: Among the enrolled patients (460), most had good or moderate (344, 74.78%) medical adherence. The main risk factors for non-adherence include young age (≤ 50 years), low education level, low income, short duration of disease (< 10 years), low Child-Plush class, poor knowledge of disease and medical treatment, poor social support, low self-care agency and high pill burden. The nomogram comprised these factors showed good calibration and good discrimination (AUC = 0.938, 95% CI = 0.918– 0.956; Brier score = 0.14). In addition, the MSE value was 0.03, indicating no overfitting.Conclusion: This study identified predictive factors regarding low medication adherence among patients with cirrhosis, and a predictive nomogram was constructed. This model could help clinicians identify patients with a high risk of low medication adherence and intervention measures can be taken in time. [ABSTRACT FROM AUTHOR]

In this paper, we construct the 3D Bosonic Fock space, which is isomorphic to the vector space of 3D Young diagrams as graded vector spaces. Then we use 3D Bosons to represent the generators of the affine Yangian of g l (1) and show that the generators ψj in the affine Yangian of g l (1) are the 3D cut-and-join operators. [ABSTRACT FROM AUTHOR]

Non-small cell lung cancer (NSCLC) accounts for more than 80 % of all lung cancers, and its 5-year survival rate can be greatly improved by early diagnosis. However, early diagnosis remains elusive because of the lack of effective biomarkers. In this study, we aimed to develop an effective diagnostic model for NSCLC based on a combination of circulating biomarkers. Tissue-deregulated long noncoding RNAs (lncRNAs) in NSCLC were identified in datasets retrieved from the Gene Expression Omnibus (GEO, n=727) and The Cancer Genome Atlas (TCGA, n=1,135) databases, and their differential expression was verified in paired local plasma and exosome samples from NSCLC patients. Subsequently, LASSO regression was used to screen for biomarkers in a large clinical population, and a logistic regression model was used to establish a multi-marker diagnostic model. The area under the receiver operating characteristic (ROC) curve (AUC), calibration plots, decision curve analysis (DCA), clinical impact curves, and integrated discrimination improvement (IDI) were used to evaluate the efficiency of the diagnostic model. Three lncRNAs-PGM5-AS1, SFTA1P, and CTA-384D8.35 were consistently expressed in online tissue datasets, plasma, and exosomes from local patients. LASSO regression identified nine variables (Plasma CTA-384D8.35, Plasma PGM5-AS1, Exosome CTA-384D8.35, Exosome PGM5-AS1, Exosome SFTA1P, Log10CEA, Log10CA125, SCC, and NSE) in clinical samples that were eventually included in the multi-marker diagnostic model. Logistic regression analysis revealed that Plasma CTA-384D8.35, exosome SFTA1P, Log10CEA, Exosome CTA-384D8.35, SCC, and NSE were independent risk factors for NSCLC (p<0.01), and their results were visualized using a nomogram to obtain personalized prediction outcomes. The constructed diagnostic model demonstrated good NSCLC prediction ability in both the training and validation sets (AUC=0.97). In summary, the constructed circulating lncRNA-based diagnostic model has good NSCLC prediction ability in clinical samples and provides a potential diagnostic tool for NSCLC. [ABSTRACT FROM AUTHOR]

Radio astronomical observations put stringent requirements on the tracking and pointing accuracy of radio telescope antennas. High inertia, low stiffness, underdamped, and multi-resonant frequencies of a large aperture radio telescope's antenna make the high-accuracy control difficult. It is not easy to satisfy control performance using only conventional PID controllers. A low-order Active Disturbance Rejection-based double-loop controller for large antenna is designed in this paper and tested on the Green Bank Telescope model. First, the first-order Linear Active Disturbance Rejecting Controller (LADRC) cascading a first-order low-pass filter and a notch filter is designed for the antenna's velocity loop to achieve the dual-objective optimal velocity tracking. Second, the position loop controller is designed to realize the antenna's position-tracking control by combining the PD controller and a low-pass filter. Further optimization of the position-loop controller helps improve the dynamic performance of the system. The simulation results indicate that the response curves of the proposed PD-LADRC control are smother than those of the Quantitative Feedback Theory (QFT) based controller; the settling time of the PD-LADRC system is 10.1 s and reduces by about 8.2 s than that of the QFT. While using a better position controller reduces settling time to 5 s. The PD-LADRC system also has better wind-disturbance rejection; the worst disturbance response reduces at the gearbox by 68.3% and 60% at the dish, and the recovery time reduces by more than 15 s than the QFT-based controller. In addition, besides easier parameter tuning, the proposed PD-LADRC has better robustness to systematic parameter perturbations and minor tracking error rms in position tracking. [ABSTRACT FROM AUTHOR]

Objective: To establish a model for predicting the disease-specific survival (DSS) of patients with oral squamous cell carcinoma (OSCC). Methods: Patients diagnosed with OSCC from the Surveillance, Epidemiology, and End Results (SEER) database were enrolled and randomly divided into development (n = 14,495) and internal validation cohort (n = 9625). Additionally, a cohort from a hospital located in Southeastern China was utilized for external validation (n = 582). Results: TNM stage, adjuvant treatment, surgery, tumor sites, age, grade, and gender were used for RSF model construction based on the development cohort. The effectiveness of the model was confirmed through time-dependent ROC curves in different cohorts. The risk score exhibited an almost exponential increase in the hazard ratio of death due to OSCC. In development, internal, and external validation cohorts, the prognosis was significantly worse for patients in groups with higher risk scores (all log-rank P < 0.05). Conclusion: Based on RSF, a high-performance prediction model for OSCC prognosis was created and verified in this study. [ABSTRACT FROM AUTHOR]

Assembly of cell division protein FtsZ into the Z‐ring at the division site is a key step in bacterial cell division. The Min proteins can restrict the Z‐ring to the middle of the cell. MinC is the main protein that obstructs Z‐ring formation by inhibiting FtsZ assembly. Its N‐terminal domain (MinCN) regulates the localization of the Z‐ring by inhibiting FtsZ polymerization, while its C‐terminal domain (MinCC) binds to MinD as well as to FtsZ. Previous studies have shown that MinC and MinD form copolymers in vitro. This copolymer may greatly enhance the binding of MinC to FtsZ, and/or prevent FtsZ filaments from diffusing to the ends of the cell. Here, we investigated the assembly properties of MinCC–MinD of Pseudomonas aeruginosa. We found that MinCC is sufficient to form the copolymers. Although MinCC–MinD assembles into larger bundles, most likely because MinCC is spatially more readily bound to MinD, its copolymerization has similar dynamic properties: the concentration of MinD dominates their copolymerization. The critical concentration of MinD is around 3 μm and when MinD concentration is high enough, a low concentration MinCC could still be copolymerized. We also found that MinCC–MinD can still rapidly bind to FtsZ protofilaments, providing direct evidence that MinCC also interacts directly with FtsZ. However, although the presence of minCC can slightly improve the division defect of minC‐knockout strains and shorten the cell length from an average of 12.2 ± 6.7 to 6.6 ± 3.6 μm, it is still insufficient for the normal growth and division of bacteria. [ABSTRACT FROM AUTHOR]

Copper phosphate hybrid nanoflowers (Cu3(PO4)2HNFs) were demonstrated to produce cathodic ECL emission in the presence of potassium persulfate (K2S2O8) and then used as a carrier due to their large specific surface area. AgNPs modified on Cu3(PO4)2HNFs provided more binding sites for immobilizing secondary antibodies and accelerating the electron transfer rate to enhance the ECL signal. In addition, FONDs-Au was used to capture primary antibodies due to its good biocompatibility and large specific surface area. A sandwich electrochemiluminescence (ECL) immunosensor based on copper phosphate hybrid nanoflower/Ag nanoparticle (Cu3(PO4)2HNFs@Ag) composite and Au NPs-functionalized Fe2O3 nanodendrites (FONDs-Au) was constructed to detect prostate-specific antigen (PSA) in real samples. Under optimal conditions, the constructed sandwich ECL immunosensor was sensitive to PSA with a detection limit of 0.037 pg/mL (S/N = 3), a linear detection concentration range of 0.0001–50 ng/mL, and a recovery range of 97.33–102.5%. This immunosensor is expected to provide a method to detect PSA or other biomarkers. [ABSTRACT FROM AUTHOR]

Colorectal cancer is one of the leading causes of cancer deaths worldwide. Currently, chemotherapy is the primary way for colorectal cancer, but with severe side effects. Therefore, it is urgent to find safer and more effective adjuvant treatment methods. At present, natural active substances are promising alternatives, as numerous studies have demonstrated possible synergistic anticancer effects in plant‐active polyphenols. In the present study, the combined effect of procyanidins (PC) (from peanut skin) and resveratrol (RES) (from peanut buds) on the synergistic anticancer potential was investigated. CACO‐2 and HCT‐8 cells were served as colorectal cancer models, and HEPG‐2 and HUH‐7 cells were served as liver cancer models to observe the effects of PC and RES alone or in combination on the growth and proliferation of these four types of cancer cells. The results revealed that both PC and RES could inhibit the cells' proliferation in a manner with concentration‐dependent, but they exerted synergistic anticancer effects only on CACO‐2 cells. PC and RES could synergistically inhibit CACO‐2 cell clone formation, inducing apoptosis of CACO‐2 cells and blocking their cell cycle in G0/G1 phase. Additionally, as observed by the results of Western blot assay, the combined effect of PC and RES also inhibited the phosphorylation of Thr308, Ser473, and ERK and promoted the phosphorylation of IKBα and NF‐κB in CACO‐2 cells. These findings collectively indicate that PC combined with RES might exert synergistic anticancer effects by regulating AKT, ERK, and NF‐κB signaling pathways. [ABSTRACT FROM AUTHOR]

Background: Lung adenocarcinoma (LUAD) is a malignant tumour that seriously threatens the life and health of people worldwide. This research was carried out to investigate the role of Rhotekin 2 (RTKN2) in LUAD progression. Methods and Results: The GEPIA online database was used to analyse abnormally expressed genes in lung adenocarcinoma and RTKN2 expression in various cancers. Cell proliferation was detected with CCK-8 and colony formation assays. Transwell assays were carried out to assess cell migration and invasion. The extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) were evaluated by a Seahorse XFe96 analyser. The interaction between RTKN2 and p65 was confirmed using a coimmunoprecipitation assay. RTKN2 expression was detected with qPCR, immunohistochemistry, and western blot assays. The p65 levels in the cytoplasm and nucleus were determined by western blot assays. RTKN2 levels were prominently decreased in LUAD tissues and cell lines. RTKN2 overexpression suppressed LUAD cell growth, invasion, migration, and glycolysis, while RTKN2 knockdown showed the opposite effects. Additionally, p65 could be negatively regulated by RTKN2. RTKN2 overexpression increased p65 levels in the cytoplasm but decreased p65 levels in the nucleus. Furthermore, blocking the NF-κB signalling pathway neutralized the effect of RTKN2 silencing in LUAD cells. Conclusion: RTKN2 inhibited the malignant behaviour and glycolysis of LUAD cells by blocking the NF-κB signalling pathway, implying that RTKN2 could be a cancer suppressor in LUAD progression. [ABSTRACT FROM AUTHOR]

Background: Nasal eosinophilic inflammation is the therapeutic target for olfactory dysfunction in allergic rhinitis (AR). Intranasal corticosteroids are commonly considered to offer targetable benefit given their immunosuppressive property. However, experimental evidence suggests that continuous corticosteroid exposure may directly cause olfactory damage by disrupting the turnover of olfactory sensory neurons (OSNs). This potentially deleterious effect of corticosteroids calls into question their long‐term topical use for treating olfactory loss related to AR. The aim of this study was to assess the impacts of chronic intranasal corticosteroid treatment on olfactory function and OSN population in mice under normal and pathological conditions. Methods: BALB/c mice were intranasally treated with fluticasone propionate (FP, 0.3 mg/kg) for up to 8 weeks. Additional mice were used to establish an ovalbumin‐induced mouse model of AR, followed by nasal challenge with ovalbumin for 8 weeks in the presence or absence of intranasal FP treatment. The authors examined olfactory function, OSN existence, neuronal turnover, and nasal inflammation using behavioral test, histological analyses, Western blotting, and enzyme‐linked immunosorbent assay. Results: Intranasal treatment with FP for 8 weeks (FP‐wk8) reduced odor sensitivity in normal mice. This reduction was concomitant with loss of OSNs and the axons projecting to the olfactory bulb, primarily resulting from increased neuronal apoptosis. In FP‐wk8 AR mice, intranasal FP treatment attenuated olfactory impairment and eosinophilic inflammation but failed to reconstitute OSN population and axonal projections. Conclusion: These results suggest that chronic intranasal corticosteroid treatment contributes to OSN degeneration that may reduce the therapeutic effectiveness for AR‐related olfactory loss. [ABSTRACT FROM AUTHOR]

Our objective was to observe the effects of extracorporeal circulation (ECC) with different time on platelet count in patients undergoing cardiac surgery. A total of 427 patients who underwent elective cardiac surgery under ECC in affiliated hospital of north Sichuan medical college from January 1, 2018 to July 31, 2021 were divided into three groups according to ECC time. We concluded that thrombocytopenia was common after ECC, maximum drop of the platelet counts after ECC was usually seen on the second day after ECC, and platelet counts started to recover on the fifth day after ECC. With the extension of ECC time, the drop in platelet counts is more pronounced, the volume of perioperative blood loss and blood products transfusion are more, and the recovery level and speed of platelet counts is lower. [ABSTRACT FROM AUTHOR]

The global supply chain is facing huge uncertainties due to potential emergencies, and the disruption of any link may threaten the security of the supply chain. This paper considers a disruption scenario in which supply disruption and distribution center failure occur simultaneously from the point of view of the manufacturer. A resilient supply chain optimization model is developed based on a combination of proactive and reactive defense strategies, including manufacturer's raw material mitigation inventory, preference for temporary distribution center locations, and product design changes, with the objective of obtaining maximum expected profit. The proposed stochastic planning model with demand uncertainty is approximated as a mixed integer linear programming model using Latin hypercube sampling (LHS), sample average approximation (SAA), and scenario reduction (SR) methods. In addition, an improved genetic algorithm (GA) is also developed to determine the approximate optimal solution. The algorithm ensures the feasibility of the solution and improves the solving efficiency through specific heuristic repair strategies. Numerical experiments are conducted to verify the application and advantages of the proposed disruption recovery model and approach. The experimental results show that the proposed resilient supply chain optimization model can effectively reduce the recovery cost of manufacturers after disruption, and the proposed approach performs well in dealing with related problems. [ABSTRACT FROM AUTHOR]

Background: The relationship between commensal microbiota and lung cancer (LC) has been studied extensively. However, developing replicable microbiological markers for early LC diagnosis across multiple populations has remained challenging. Current studies are limited to a single region, single LC subtype, and small sample size. Therefore, we aimed to perform the first large‐scale meta‐analysis for identifying micro biomarkers for LC screening by integrating gut and respiratory samples from multiple studies and building a machine‐learning classifier. Methods: In total, 712 gut and 393 respiratory samples were assessed via 16 s rRNA amplicon sequencing. After identifying the taxa of differential biomarkers, we established random forest models to distinguish between LC populations and normal controls. We validated the robustness and specificity of the model using external cohorts. Moreover, we also used the KEGG database for the predictive analysis of colony‐related functions. Results: The α and β diversity indices indicated that LC patients' gut microbiota (GM) and lung microbiota (LM) differed significantly from those of the healthy population. Linear discriminant analysis (LDA) of effect size (LEfSe) helped us identify the top‐ranked biomarkers, Enterococcus, Lactobacillus, and Escherichia, in two microbial niches. The area under the curve values of the diagnostic model for the two sites were 0.81 and 0.90, respectively. KEGG enrichment analysis also revealed significant differences in microbiota‐associated functions between cancer‐affected and healthy individuals that were primarily associated with metabolic disturbances. Conclusions: GM and LM profiles were significantly altered in LC patients, compared to healthy individuals. We identified the taxa of biomarkers at the two loci and constructed accurate diagnostic models. This study demonstrates the effectiveness of LC‐specific microbiological markers in multiple populations and contributes to the early diagnosis and screening of LC. [ABSTRACT FROM AUTHOR]

The prevalence of Alzheimer's disease is greater in women, but the underlying mechanisms remain to be elucidated. We herein demonstrated that α-secretase ADAM10 was downregulated and ADAM10 inhibitor sFRP1 was upregulated in 5xFAD mice. While there were no sex effects on ADAM10 protein and sFRP1 mRNA levels, female 5xFAD and age-matched non-transgenic mice exhibited higher levels of sFRP1 protein than corresponding male mice. Importantly, female 5xFAD mice accumulated more Aβ than males, and sFRP1 protein levels were positively associated with Aβ42 levels in 5xFAD mice. Our study suggests that sFRP1 is associated with amyloid pathology in a sex-dependent manner. [ABSTRACT FROM AUTHOR]

Introduction: Psittacosis can cause severe community-acquired pneumonia (CAP). The clinical manifestations of psittacosis range from subclinical to fulminant psittacosis with multi-organ failure. It is essential to summarize the clinical characteristic of patients with severe psittacosis accompanied by acute hypoxic respiratory failure (AHRF). Methods: This retrospective study included patients with severe psittacosis caused CAP accompanied by AHRF from 19 tertiary hospitals of China. We recorded the clinical data, antimicrobial therapy, respiratory support, complications, and outcomes. Chlamydia psittaci was detected on the basis of metagenomic next-generation sequencing performed on bronchoalveolar lavage fluid samples. Patient outcomes were compared between the treatment methods. Results: This study included 45 patients with severe CAP and AHRF caused by psittacosis from April 2018 to May 2021. The highest incidence of these infections was between September and April. There was a history of poultry contact in 64.4% of the patients. The median PaO2/FiO2 of the patients was 119.8 (interquartile range, 73.2 to 183.6) mmHg. Four of 45 patients (8.9%) died in the ICU, and the median ICU duration was 12 days (interquartile range, 8 to 21) days. There were no significant differences between patients treated with fluoroquinolone initially and continued after the diagnosis, fluoroquinolone initially followed by tetracycline, and fluoroquinolone combined with tetracycline. Conclusion: Psittacosis caused severe CAP seems not rare, especially in the patients with the history of exposure to poultry or birds. Empirical treatment that covers atypical pathogens may benefit such patients, which fluoroquinolones might be considered as an alternative. [ABSTRACT FROM AUTHOR]

Introduction: Psittacosis can cause severe community-acquired pneumonia (CAP). The clinical manifestations of psittacosis range from subclinical to fulminant psittacosis with multi-organ failure. It is essential to summarize the clinical characteristic of patients with severe psittacosis accompanied by acute hypoxic respiratory failure (AHRF). Methods: This retrospective study included patients with severe psittacosis caused CAP accompanied by AHRF from 19 tertiary hospitals of China. We recorded the clinical data, antimicrobial therapy, respiratory support, complications, and outcomes. Chlamydia psittaci was detected on the basis of metagenomic next-generation sequencing performed on bronchoalveolar lavage fluid samples. Patient outcomes were compared between the treatment methods. Results: This study included 45 patients with severe CAP and AHRF caused by psittacosis from April 2018 to May 2021. The highest incidence of these infections was between September and April. There was a history of poultry contact in 64.4% of the patients. The median PaO2/FiO2 of the patients was 119.8 (interquartile range, 73.2 to 183.6) mmHg. Four of 45 patients (8.9%) died in the ICU, and the median ICU duration was 12 days (interquartile range, 8 to 21) days. There were no significant differences between patients treated with fluoroquinolone initially and continued after the diagnosis, fluoroquinolone initially followed by tetracycline, and fluoroquinolone combined with tetracycline. Conclusion: Psittacosis caused severe CAP seems not rare, especially in the patients with the history of exposure to poultry or birds. Empirical treatment that covers atypical pathogens may benefit such patients, which fluoroquinolones might be considered as an alternative. [ABSTRACT FROM AUTHOR]

Summary: In this paper, the problem of adaptive stability control for uncertain high‐order fully actuated (HOFA) nonlinear systems with disturbances is solved. The method of almost disturbance decoupling (ADD) is used to cope with unknown disturbances. Meanwhile, the tuning function is applied to design an adaptive update law. According to the full‐actuation feature of HOFA systems and Lyapunov stability theory, a novel adaptive controller is designed. In the end, the effectiveness of the control strategy is validated by a numerical simulation example and the attitude control of a spacecraft. [ABSTRACT FROM AUTHOR]