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22. Observation on pathological TDP ⁃ 43 in amygdala of patients with common neurodegenerative diseases

Author

WANG Yuan⁃yuan, WANG Lu⁃ning, and ZHU Ming⁃wei

Subjects
nervous system diseases, tdp ⁃ 43 proteinopathies, dna ⁃ binding proteins, amygdala, pathology, Neurology. Diseases of the nervous system, RC346-429
Abstract

Objective To observe the detection rate, morphological characteristics and deposition degree of pathological trans⁃activation response DNA binding protein 43 (TDP⁃43) in several common neurodegenerative diseases, and to explore its pathological significance. Methods A total of 15 cases with a history of hospitalization in the Second Medical Center, Chinese PLA General Hospital from January 1994 to September 2019 were retrospectively collected, including 5 cases of Alzheimer's disease (AD), 3 cases of Parkinson's disease (PD), 2 cases of progressive supranuclear palsy (PSP), and 5 cases of normal aging brain. HE staining, Lucas fast blue (LFB) staining, Gallyas⁃Braak silver staining, and immunohistochemical staining of β⁃amyloid (Aβ), AT8, phosphorylated TDP⁃43 and α⁃synuclein (α⁃Syn) were performed for amygdala tissue sections. The pathological morphological characteristics of pathological TDP⁃43 protein was observed under a light microscope, and the pathological TDP⁃43 protein was graded by semi⁃quantitative method. Results Phosphorylated TDP⁃43 antibody staining was found in 5/15 of aging brain amygdala tissue, including 2 cases of AD, one case of PD, and 2 cases of normal aging brain. Among them, severe pathological TDP⁃43 protein deposition and mild short neurodystrophy filaments were found in the amygdala of 2/5 cases of AD, mainly neuronal cytoplasmic inclusion bodies. Cytoplasmic inclusions and short neurodystrophy filaments in rare neurons of amygdala in 1/3 cases of PD. Rare or mild neuronal cytoplasmic inclusions and rare short neurodystrophy filaments were found in the amygdala of 2/5 normal aging brain. Two cases of PSP showed negative staining for phosphorylated TDP⁃43 antibody in amygdala. No long amygdala neurodystrophy filaments were found in the 15 patients. No glial cytoplasmic inclusions and neuronal intranuclear inclusions were found in PD, PSP and normal aging brain. Conclusions Pathological TDP⁃43 protein is most severe in the amygdala of AD and may accelerate cognitive decline in AD or lower the threshold of cognitive dysfunction.

Published
2022
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27. Phase change thermostat for all-day temperature-adaptive thermal regulation.

Author

Li, Shuang-Zhu, Wang, Lu-Ning, Wang, Shuai-Peng, Bai, Lu, Yang, Jie, and Yang, Wei

Abstract

The increasing energy consumption in buildings exacerbates the worldwide energy shortage and environmental pollution problems. To reduce the energy consumption, emerging thermal management technologies such as radiative cooling, thermal insulation, and phase change thermal regulation have been used in building envelopes. Most recently, aerogel-based tunable daytime radiative supercoolers have been proved to be an ideal candidate for energy consumption savings. Herein, a phase change material (PCM) enhanced thermostat for energy-efficient buildings is designed to go beyond the limitation of insulating radiative coolers. Compared to cutting-edge aerogel coolers, the proposed phase change thermostat featuring latent heat storage and release is capable of dynamically adjusting its thermal regulation performance along with the change of the environmental temperature, further absorbing the heat during the daylight for cooling and releasing the stored heat at night to suppress overcooling. The phase change thermostat with low thermal conductivity, high solar reflectance, considerable infrared emissivity, and high energy storage density shows great potential for all-day temperature-adaptive thermal management in energy-saving buildings. [ABSTRACT FROM AUTHOR]

Published
2024
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