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To investigate the feasibility and efficacy of combining ultrasound-guided sharp needle technique with percutaneous transluminal angioplasty (PTA) for treating outflow stenosis or dysfunction in arteriovenous fistula (AVF) among hemodialysis patients. From October 2021 to March 2023, patients with occluded or malfunctional fistula veins not amenable to regularly angioplasty were retrospectively enrolled in the study. They underwent ultrasound-guided sharp needle intervention followed by PTA. Data on the location and length between the two veins, technical success, clinical outcomes, and complications were collected. Patency rates post-angioplasty were calculated through Kaplan-Meier analysis. A total of 23 patients were included. The mean length of the reconstructed extraluminal segment was 3.18 cm. The sharp needle opening was performed on the basilic vein (60.9%), brachial vein (26.1%), or upper arm cephalic vein (13%) to create outflow channels. Postoperatively, all cases presented with mild subcutaneous hematomas around the tunneling site and minor diffuse bleeding. The immediate patency rate for the internal fistulas was 100%, with 3-month, 6-month, and 12-month patency rates at 91.3%, 78.3%, and 43.5%, respectively. Sharp needle technology merged with PTA presents an effective and secure minimally invasive method for reconstructing the outflow tract, offering a new solution for recanalizing high-pressure or occluded fistulas. [ABSTRACT FROM AUTHOR]

A method for the simultaneous determination of the 11 strobilurin fungicides (coumoxystrobin, tricyclopyricarb, picoxystrobin, fluoxastrobin, trifloxystrobin, E -metominostrobin, kresoxim-methyl, dimoxystrobin, orysastrobin, pyraoxystrobin and fenaminstrobin) in different vegetation types of soil by QuEChERS-ultra performance liquid chromatography-tandem mass spectrometry was developed. The strobilurin fungicides were extracted with 0.1% (volume percentage) acetic acid-acetonitrile, and cleaned-up with 100 mg primary secondary amine (PSA) and 100 mg C 18 . The separation was performed on a C 18 column with methanol and water as the mobile phases. The strobilurin fungicides were determined in the positive ion mode and multiple reaction monitoring mode. The quantification was carried out by the matrix-matched external standard curve. The results showed good linear relationships for all analytes in the range of 0.1-100 μg/kg with the correlation coefficients of 0.9805-0.9999. The mean recoveries of strobilurin fungicides in the spiked soil samples were 65.1%-103.9% and the relative standard deviations were 0.082%-14% ( n =3) at three spiked levels (5, 10 and 50 μg/kg). The limits of quantitation were 0.005-2.0 μg/kg. This method is suitable for the trace determination of the 11 strobilurin fungicides in different vegetation types of soil (black soil, red soil, sandy soil, moisture soil, desert grey soil, and plateau soil).