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【Objective】 Soil salinity is a common abiotic stress most crops experience during their growth. Understanding its spatiotemporal variation and the underlying reasons is impetus to improve agricultural management. We propose a model in this paper to classify soil salinity and analyze the underlying mechanisms. The model is applied to the North of Yellow River in Northern Shandong Plain. 【Method】 The model is based on the two - level fuzzy comprehensive evaluation method. A comprehensive evaluation index system is constructed using soil environment factors, groundwater environmental factors, and physical geographical factors. It considered eight indexes: proportion of land areas affected by salinized soil, degree of soil salinity, soil salt content, lithology of unsaturated zone, depth of groundwater table, groundwater salinity, evaporation-prescription ratio, and topography and landform. The degree of soil quality was divided into excellent, good, moderate, poor, and very poor grades. 【Result】 The areas of soil classified as very poor, poor, moderate, good and excellent based on soil salinization were 5 277.49 km2, 6 564.76 km2, 4 383.79 km2, 5 995.52 km2, and 4 919.29 km2, respectively. Based on their genesis and salinization, the salinized soils in the region can be divided to three areas consisting of eight sub-areas. 【Conclusion】 Soil salinity in the North of Yellow River in Northern Shandong Plain varies in its severity and space. The results presented in this paper can aid in improving soil management practices to promote a healthy agricultural and rural economy in the region.

Loess deposits are widely distributed across the globe and provide detailed records of climatic changes since the Quaternary period. Their geochemical element characteristics are important indicators of paleoenvironmental evolution and provenance. Therefore, four typical loess sections from four different islands of the Miaodao Islands were selected for systematically geochemical analysis of major and trace elements. The geochemical data of major and trace elements are very similar, indicating that the loess of all islands on the Miaodao have a common provenance. The geochemical test results show that t SiO2, Al2O3, Fe2O3 and CaO are the major chemical components of loess, with an average total content of 85–90%. The average Eu/Eu*, ΣLREE/ΣHREE, LaN/YbN, GdN/YbN values of the Miaodao Islands loess range from 0.65 to 0.69, 7.84 to 8.31, 8.02 to 9.99, 1.40 to 1.76. These data are similar to and different from those of the Chinese Loess Plateau, indicating the diversity of Miaodao Islands Loess provenance. The CIA (Chemical Index of Alteration) (50–65) and Na/K results suggest that the loess here had experienced incipient chemical weathering. The A-CN-K (Al2O3-CaO* + Na2O-K2O) diagram indicates that the weathering trend of the loess sections is consistent with that of continental weathering. The local loess data points are close and parallel to the A-CN line, suggesting that the loess dust material on the Miaodao Islands originated from the extensive upper continental crust, and was highly mixed in the process of wind transport and deposition. The relationships of Log[(CaO + Na2O)/K2O] versus Log(SiO2/Al2O3), Na2O/Al2O3 versus K2O/Al2O3, LaN/YbN versus Eu/Eu*, Sc-Th-La and Zr-Sc-Th plots of major and trace elements reveal that the loess sources for the Miaodao Islands are similar to those of the Loess Plateau, which were derived from alluvial fan deposits flanking the Qilian Shan in China, the Gobi Altay and Hangayn Mountains in Mongolia. However, the loess of the Miaodao Islands is coarser in average grain size and contains abundant marine fossils, with gravel layers, indicating it is allochthous and near-source, which suggests it mainly originated from the adjacent exposed sea floor sediments of the Bohai Sea during glacial periods. Finally, we conclude that the loess of the Miaodao Islands is the result of a gradual accumulation process, in which the relative amount of distant-source material decreased and the near-source material increased in response to changes in sea level and paleoclimate. Our findings support that the loess of the Miaodao Islands was formed by mixing material from distant and proximal sources. [ABSTRACT FROM AUTHOR]

In recent years, noticeable subsidence depressions have occurred along the coastal zone of the Yellow River Delta. In some coastal areas, the average annual subsidence varies from tens of millimeters to hundreds of millimeters. Although some studies have discovered a significant land subsidence funnel in the coastal zone of the Yellow River Delta, it has rarely been reported in recent years. Using Sentinel-1A/1B images from the last five years and permanent scatterers interferometric synthetic aperture radar technology, we found a typical subsidence bowl in the northeastern part of the delta, with a cumulative settlement of nearly 1 m over five years. In addition, we used the approach of soil mechanics to simulate the settlement of confined brine layers with different thicknesses under drainage conditions. We found that the 15 m thick confined aquifer can produce 1 m of settlement for every 15% decrease in water content. The simulation results explain the large settlement of the brine industrial area. This study can provide guidance for brine mining in the future. If we continue to overexploit underground brine, there will be more severe land subsidence in the delta in the future. [ABSTRACT FROM AUTHOR]

Establishing a mechanism for realizing the value of ecological products is important for implementing the concept of an ecological society in China. It is a key means of acting upon the idea that green mountains and clear waters are as valuable as gold and silver, and it is a necessary requirement to promote sustainable green development and encourage harmonious coexistence between humans and nature. This article summarizes the connotations of ecological products, the accounting of ecological product value, and the progress made nationally and in Shandong province in promoting the mechanisms for realizing the value of ecological products. Based on the analysis of Shandong's practice in various means of realizing ecological product value, such as the "forest chief system +", "two mountain banks", "mining ecological restoration", "health tourism", "ecological agriculture, culture, and tourism", and "forest ecological compensation", this article summarizes and proposes three types of ecological product value realization paths: government-led, government + market, and market paths. It also proposes four types of ecological product value realization modes: ecological resource indicators and equity exchanges, ecological governance and value enhancement, ecological industrial operations, and ecological protection compensation. Furthermore, this article puts forward targeted suggestions and methods for value realization in four areas: policy, technology, industry, and markets, providing an experiential reference for exploring diversified ecological product value realization in various regions of China. [ABSTRACT FROM AUTHOR]

Recently, many of the world's major river deltas have been sinking, making them increasingly vulnerable to floods and storm surges, salinization and permanent inundation. For the Yellow River delta, annual subsidence rates of several to dozens of centimeters have been reported in the past few years. The extraction of a considerable amount of groundwater due to continuous pumping is suggested as the main driver of the groundwater depression cone. Despite its scale and severity, methods to quantify subsidence are scarce. We introduce a soil mechanics approach to quantify subsidence due to the compaction of soft soil. The largest reduction in soft soil thickness, which is more than 2.6 m, occurred in the salt field area to the north of the Yellow River. Furthermore, by estimating the primary consolidation of soft soil, the subsidence caused by groundwater exploitation is quantified. In the coastal area of the delta, due to excessive exploitation of shallow underground brine resources, the maximum accumulated subsidence is as high as 2 m. Since the natural consolidation of these deltaic sediments has ended, if the current groundwater exploitation intensity is maintained, major subsidence disasters, such as subsidence depressions and ground fissures, will occur. [ABSTRACT FROM AUTHOR]

Hepatic fibrosis is overly exuberant wound healing in which excessive connective tissue builds up in the liver. The treatment of hepatic fibrosis is still difficult and remains a challenge to the clinician. In recent years, the TGF-β signaling pathway regulator tyrosine kinase Abl has been raised as a new and promising target of hepatic fibrosis therapy. Here, considering that there are numerous drugs and drug-like compounds being approved or under clinical development and experimental investigation, it is expected that some of the existing drugs can be re-exploited as new agents to target Abl with the capability of suppressing hepatic fibrosis. To achieve this, a synthetic protocol that integrated molecular docking, affinity scoring dynamics simulation and free energy analysis was described to systematically profile the inhibitory potency of various drugs and drug-like compounds against the kinase domain of Abl. Consequently, 4 out of 13 tested drug candidates were successfully identified to have high-Abl inhibitory activities. By visually examining the dynamics behavior, structural basis and energetic property of few typical Abl–drug complex cases, a significantly different pattern of non-bonded interactions between the binding of active and inactive drug ligands to Abl receptor was revealed; the former is defined by strong, specific chemical forces, while the latter can only form non-specific hydrophobic contacts with slight atomic collisions. [ABSTRACT FROM PUBLISHER]

Autoimmune thyroid diseases (AITDs) including Graves' disease (GD) and Hashimoto's thyroiditis (HT) are common autoimmune endocrine disorders. Interleukin-4 (IL-4), a cytokine secreted by T cells, plays a critical role in antigen-specific Th2 responses. The IL-4 gene is highly polymorphic and it has been reported that the polymorphism at -590 (T/C, rs2243250) in the promoter region of IL-4 may contribute to the development of AITDs. Recently, several case-control studies have examined the association of genetic variants of IL-4 with AITDs. However, the results of these studies remain conflicting. To systematically study the role of IL-4 in the pathogenesis of AITDs, we conducted a meta-analysis including 11 eligible studies (1847 cases and 2068 healthy controls). Fixed-effect or random-effect models were used to calculate pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs). Our results revealed a significant association between the IL-4 genetic variant (−590, T/C, rs2243250) and the risk of developing AITDs (TC + TT versus TT genotype: OR = 1.83, 95% CI = 1.083-3.091, p = 0.024). These findings demonstrate that the IL-4 rs2243250 genetic variant might play a key role in the development of AITDs. [ABSTRACT FROM AUTHOR]

Phospholipase A2 (PLA2) is potentially an important target for anti-inflammatory therapeutics. Here, we described a systematic scheme that integrated protein docking and peptide redocking, molecular dynamics simulation, and binding affinity analysis to rationally design PLA2 inhibitory peptides based on a solved PLA2 crystal structure. The scheme employed protein docking to sample the interaction modes of PLA2 with its natural inhibitor Clara cell protein, from which a number of peptide fragments, including a pentapeptide LLLGS, were cut off and redocked to serve as the lead entities of PLA2 inhibitory peptides. In addition, a systematic mutation energy map that characterized the binding free energy changes Δ G upon mutations of each position of the putative pentapeptide to 20 amino acids was also profiled, which was subsequently used to guide peptide structure optimization. In order to solidify the computational findings, we performed kinetic and inhibition studies of few designed peptides against human secretory PLA2. Consequently, eight peptides were successfully identified to have potent inhibition potency, in which the LLAYK and AVFRS were found to suppress enzymatic activity significantly ( Ki = 0.75 ± 0.06 and 4.2 ± 0.3 μM, respectively). A further structure examination revealed that the designed peptides can form intensive nonpolar networks of van der Waals contacts and hydrophobic interactions at their complex interfaces with PLA2, conferring considerable stability and affinity for the formed complex systems. [ABSTRACT FROM AUTHOR]