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4. Efficacy observation of clinical medication guided by genetic testing of antipsychotic drugs in patients with schizophrenia

Author

Wang Haiyan, Cao Jianfeng, Fu Liping, Xiang Liangcheng, Tian Tao, Wang Jixiang, Shi Ming, Li Xiaojun, and Tang Chunguang

Subjects
drug genetic testing, schizophrenia, clinical efficacy, medication compliance, social function, Psychology, BF1-990, Psychiatry, RC435-571
Abstract

BackgroundResults of genetic testing for antipsychotic drugs can guide the rational use of drugs in clinical practice and help improve the clinical symptoms of patients with schizophrenia. However， there is currently limited evidence in China regarding the impact of genetic testing results on medication adherence， social function and drug side effects of antipsychotic drug treatment.ObjectiveTo explore the improvement of clinical symptoms， medication adherence and social function in patients with schizophrenia under the guidance of antipsychotic drug gene testing results and examine the safety of drug treatment， so as to provide references for ifor precise treatment of schizophrenia patients.MethodsPatients with acute schizophrenia who received hospitalization at Dazhou Minkang Hospital from July 2019 to August 2021 as well as met the diagnostic criteria of the International Classification of Diseases， tenth edition （ICD-10） were selected as research subjects （n=144）. Based on random number table， subjects were divided into study group and control group， with 72 cases in each group. Control group received drug treatment based on the doctor's clinical experience， while study group received drug treatment based on the results of gene testing for antipsychotic drug. Both treatments lasted for 12 weeks. At baseline as well as 2， 4， 8 and 12 weeks after treatment， Positive and Negative Syndrome Scale （PANSS）， 8-item Morisky Medication Adherence Scale （MMAS-8）， Social Functional Rating Scale （SFRS） and Treatment Emergent Symptom Scale （TESS） were adopted for assessment.ResultTime effect and group effect of the reducing rate of PANSS， MMAS-8 and SFRS scores in the groups were statistically significant （Ftime=95.251， 6.650， 14.101， Fgroup=38.055， 58.175， 128.221， P

Published
2024
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5. Visualization of Irregular Tree Canopy Centerline Data from a Depth Camera Based on an Optimized Spatial Straight-Line Fitting

Author

Gu, Hairong, Wang, Jiale, Hu, Yanhui, Wang, Jixiang, Sun, Lishun, Ahamed, Mostak, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Sheng, Bin, editor, Bi, Lei, editor, Kim, Jinman, editor, Magnenat-Thalmann, Nadia, editor, and Thalmann, Daniel, editor

Published
2024
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6. Study on the Factors Influencing Housing Price Based on the Radiation Effect of Commercial Center

Author

Wang, Jixiang, Wu, Yongxiang, Yu, Lu, Appolloni, Andrea, Series Editor, Caracciolo, Francesco, Series Editor, Ding, Zhuoqi, Series Editor, Gogas, Periklis, Series Editor, Huang, Gordon, Series Editor, Nartea, Gilbert, Series Editor, Ngo, Thanh, Series Editor, Striełkowski, Wadim, Series Editor, Zailani, Suhaiza Hanim Binti Dato Mohamad, editor, Yagapparaj, Kosga, editor, and Zakuan, Norhayati, editor

Published
2024
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7. Polarization effects on fluorescence emission of zebrafish neurons using light-sheet microscopy

Author

Ye, Hong, Xu, Xin, Wang, Jixiang, Wang, Jing, He, Yi, Mu, Yu, and Shi, Guohua

Subjects
Physics - Biological Physics, Quantitative Biology - Neurons and Cognition
Abstract

Light-sheet fluorescence microscopy (LSFM) makes use of a thin plane of light to optically section and image transparent tissues or organisms {\it{in vivo}}, which has the advantages of fast imaging speed and low phototoxicity. In this paper, we have employed light-sheet microscopy to investigate the polarization effects on fluorescence emission of zebrafish neurons via modifying the electric oscillation orientation of the excitation light. The intensity of the fluorescence emission from the excited zebrafish larvae follows a cosine square function with respect to the polarization state of the excitation light and reveals a 40$\%$ higher fluorescence emission when the polarization orientation is orthogonal to the illumination and detection axes. Through registration and subtraction of fluorescence images under different polarization states, we have demonstrated that most of the enhanced fluorescence signals are from the nerve cells rather than the extracellular substance. This provides us a way to distinguish the cell boundaries and observe the organism structures with improved contrast and resolution.

Published
2022

47. Melatonin alleviates high glucose-induced cardiomyocyte injury through suppressing mitochondrial FUNDC1-DRP1 axis.

Author

Zheng, Junyi, Zhao, Lili, Zhang, Yingying, He, Wenbin, Guo, Xukun, and Wang, Jixiang

Subjects
ELECTRON transport, PROTEIN kinases, HYDROGEN bonding, PROTEIN expression, OXIDATIVE stress
Abstract

Objectives To use H9c2 cardiomyocytes to establish a diabetic cardiomyopathic model by exposing these cells to high glucose (HG), followed by treating them with melatonin (MEL) or plasmid vectors overexpressing FUN14 Domain Containing 1 (FUNDC1). Methods We employed quantitative real-time PCR, mitochondrial staining, and biochemical assays to measure the activity of various antioxidant and mitochondrial complex functions under various treatment conditions. Key findings Our results showed that HG induced the expression of FUNDC1 and increased mitochondrial oxidative stress and fragmentation, while MEL treatment reversed most of these pathological effects. Moreover, HG exposure activated dynamin-related protein 1 expression and its translocation to mitochondria. Modulation of AMP-activated protein kinase level was found to be another pathological hallmark. In silico molecular docking, analysis revealed that MEL could directly bind the catalytic groove of FUNDC1 through Van der Waal's force and hydrogen bonding. Finally, MEL ameliorated diabetic cardiomyopathy-induced mitochondrial injury through FUNDC1 in vivo. Conclusions Hyperglycemia induced mitochondrial fragmentation and altered electron transport chain complex functions, which could be ameliorated by MEL treatment, suggesting its potential as a cardiovascular therapeutic. [ABSTRACT FROM AUTHOR]

Published
2024
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