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In the context of continuously increasing penetration of new energy sources， flexible resources such as energy storage play a crucial role in constructing a new power system. Based on the current status of the electricity market in Anhui Province， a multi-stage collaborative trading strategy for independent energy storage in the electricity market is proposed. Firstly， a medium-to-long-term transaction settlement model is introduced. Then， to address the uncertainty of electricity price and power forecasting， a day-ahead joint clearing model for electric energy and reserve ancillary services characterized by multiple probability scenarios is established. Furthermore， a separate trading model for intraday deviations is developed. Additionally， an analysis is conducted on the impact of energy storage aging costs on revenue. Finally， simulations are conducted with the objective of maximizing independent energy storage revenue， and the results indicate that the proposed mechanism can effectively enhance market returns for independent energy storage， providing insights for the development of the electricity market.

Under the locational marginal price （LMP） mechanism， there are variations in the congestion cost settlement mechanisms among pilot provinces， requiring a comprehensive analysis. To address this， the paper first delves into the essence of the issue by elucidating the connotations of relevant congestion terms； subsequently， based on a unified connotation， it conducts a comparative analysis of the key similarities and differences in the congestion cost settlement mechanisms among typical spot markets in the pilot provinces. Finally， the paper analyzes issues such as user-side settlement point price calculation， charging of congestion fees for medium to long-term contracts， and the allocation of congestion surplus. In conclusion， it presents relevant recommendations.

Background It is of great importance to standardize labor management for ensuring maternal and neonatal safety. Since the publication of the new stage of labor, the definition of prolonged labor has not been emphasized and it is recommended to minimize interventions during labor, therefore, the number of pregnant women with labor over 24 h is increased compared to the previous. Objective To analyze the risk factors and maternal and neonatal outcomes of pregnant women with labor over 24 h and discuss the labor management under the new stage of labor. Methods The clinical data of pregnant women received maternity examination and delivered at Department of Obstetrics, the First Affiliated Hospital with Nanjing Medical University from January to December 2022 were collected in the retrospective study. A total of 40 single birth pregnant women with normal fetal position and prolonged total labor (more than 24 h) were selected as the observational group, and 95 single birth pregnant women with normal fetal position and normal total labor (less than 24 h) were selected as the control group. The age, BMI, gestational age of delivery, gestational diabetes, gestational hypertension, neonatal body mass, labor condition, analgesic delivery rate and delivery intervention rate of the two groups were compared. Multivariate Logistic regression analysis was used to explore the risk factors for total labor over 24 h. The maternal and neonatal outcomes including intrapartum fever, amniotic fluid contamination, mediolateral episiotomy, vaginal instrumental delivery, cervical laceration, postpartum hemorrhage, manual removal of placenta, fetal distress, neonatal asphyxia and referral to neonatal intensive care unit (NICU) were compared to screen the risk factors and analyse the maternal and neonatal outcomes of pregnant women with labor over 24 h. Results There were no significant differences in age, BMI, gestational age of delivery, gestational hypertension, gestational diabetes mellitus and neonate body mass between the two groups (P>0.05). The first stage of labor, second stage of labor and total labor were longer and the rates of labor analgesia and labor intervention were higher in the observational group than the control group (P0.05). There were no significant differences in the incidence of postpartum hemorrhage, vaginal instrumental delivery and fetal distress between the two groups (P>0.05) ; the incidence of intrapartum fever, amniotic fluid contamination, mediolateral episiotomy, vaginal instrumental delivery, cervical laceration and referral to NICU in the observational group was higher than the control group (P

In pancreatic cancer, KRAS G12D can trigger pancreatic cancer initiation and development. Rapid tumor growth is often accompanied by excess intracellular reactive oxygen species (ROS) production, which is unfavorable to tumor. However, the regulation of intracellular ROS levels in KRAS mutant pancreatic cancer remains unclear. In this study, we establish BxPC3 stable cell strains expressing KRAS wild type (WT) and G12D mutation and find unchanged ROS levels despite higher glycolysis and proliferation viability in KRAS mutant cells than KRAS WT cells. The key hydrogen sulfide (H 2S)-generating enzyme cystathionine-γ-lyase (CSE) is upregulated in KRAS mutant BxPC3 cells, and its knockdown significantly increases intracellular ROS levels and decreases cell glycolysis and proliferation. Nuclear factor erythroid 2-related factor 2 (Nrf2) is activated by KRAS mutation to promote CSE transcription. An Nrf2 binding site (‒47/‒39 bp) in the CSE promoter is verified. CSE overexpression and the addition of NaHS after Nrf2 knockdown or inhibition by brusatol decreases ROS levels and rescues cell proliferation. Our study reveals the regulatory mechanism of intracellular ROS levels in KRAS mutant pancreatic cancer cells, which provides a potential target for pancreatic cancer therapy.