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250 results on '"Wang, Jieh-Neng"'

1. A Global Perspective on PDA Management in the Extremely Premature: Shifting Trend Toward Transcatheter Closure.

Author

Sathanandam, Shyam, McNamara, Patrick, Pedra, Carlos, Toyoshima, Katsuaki, Malekzadeh-Milani, Sophie, Patkai, Juliana, Baspinar, Osman, Uslu, Hasan, Promphan, Worakan, Khorana, Meera, Wang, Jieh-Neng, Lin, Yung-Chieh, Fujii, Takanari, Mainzer, Gur, Salazar-Lizárraga, David, Márquez-Gonzalez, Horacio, Popat, Himanshu, Mervis, Jonathan, Hong, Neoh, Alwi, Mazeni, Wonwandee, Ratthapon, Schranz, Dietmar, Stanimir, Georgiev, Philip, Ranjit, and Ing, Frank

Subjects
global perspective, patent ductus arteriosus, prematurity, transcatheter occlusion
Abstract

Patent ductus arteriosus (PDA) is a frequently encountered defect in infants born extremely premature (≤26 weeks gestation). Historically, closure of the PDA was performed using cyclooxygenase inhibitor medications or by surgical ligations. However, the benefits of PDA closure using these therapies have never been demonstrated, albeit studies have previously not focused on the extremely premature infants. Therefore, there was a worldwide trend toward conservative management of the PDA. With improved survival of extremely premature infants, comorbidities associated with the PDA has increased, resulting in finding alternate treatments such as transcatheter patent ductus arteriosus closure (TCPC) for this population. Currently, there is a renewed interest toward selective treatment of the PDA in this high-risk cohort of small infants. This Comprehensive Review article inspects the globally changing trends in the management of the PDA in premature infants, with a special focus on the rising adoption of TCPC. Moreover, this article compiles data from several neonatal networks worldwide to help understand the problem at hand. Understanding the current management of premature infants and their outcomes is fundamentally essential if pediatric cardiologists are to offer TCPC as a viable therapeutic option for this population. This article aims to serve as a guide for pediatric cardiologists on this topic by compiling the results on landmark clinical trials on PDA management and the controversies that arise from these trials. Comparative outcomes from several countries are presented, including interpretations and opinions of the data from experts globally. This is a step toward coming to a global consensus in PDA management in premature infants.

Published
2023

9. Instructive Nanofiber Scaffolds with VEGF Create a Microenvironment for Arteriogenesis and Cardiac Repair

Author

Lin, Yi-Dong, Luo, Chwan-Yau, Hu, Yu-Ning, Yeh, Ming-Long, Hsueh, Ying-Chang, Chang, Min-Yao, Tsai, Da-Ching, Wang, Jieh-Neng, Tang, Ming-Jer, Wei, Erika IH, Springer, Matthew L, and Hsieh, Patrick CH

Subjects
Bioengineering, Heart Disease - Coronary Heart Disease, Heart Disease, Nanotechnology, Cardiovascular, Regenerative Medicine, Biotechnology, Development of treatments and therapeutic interventions, 5.2 Cellular and gene therapies, 5.1 Pharmaceuticals, Animals, Male, Myocardial Infarction, Myocardium, Nanofibers, Neovascularization, Physiologic, Rats, Tissue Engineering, Tissue Scaffolds, Vascular Endothelial Growth Factor A, Biological Sciences, Medical and Health Sciences
Abstract

Angiogenic therapy is a promising approach for tissue repair and regeneration. However, recent clinical trials with protein delivery or gene therapy to promote angiogenesis have failed to provide therapeutic effects. A key factor for achieving effective revascularization is the durability of the microvasculature and the formation of new arterial vessels. Accordingly, we carried out experiments to test whether intramyocardial injection of self-assembling peptide nanofibers (NFs) combined with vascular endothelial growth factor (VEGF) could create an intramyocardial microenvironment with prolonged VEGF release to improve post-infarct neovascularization in rats. Our data showed that when injected with NF, VEGF delivery was sustained within the myocardium for up to 14 days, and the side effects of systemic edema and proteinuria were significantly reduced to the same level as that of control. NF/VEGF injection significantly improved angiogenesis, arteriogenesis, and cardiac performance 28 days after myocardial infarction. NF/VEGF injection not only allowed controlled local delivery but also transformed the injected site into a favorable microenvironment that recruited endogenous myofibroblasts and helped achieve effective revascularization. The engineered vascular niche further attracted a new population of cardiomyocyte-like cells to home to the injected sites, suggesting cardiomyocyte regeneration. Follow-up studies in pigs also revealed healing benefits consistent with observations in rats. In summary, this study demonstrates a new strategy for cardiovascular repair with potential for future clinical translation.

Published
2012

31. Congenital heart disease with pulmonary artery hypertension in an Asian cohort-initial report from TACHYON (TAiwan congenital heart disease associated with pulmonarY arterial hypertension) registry

Author

Chiu, Shuenn-Nan, primary, Weng, Ken-Pen, additional, Lin, Ming-Chih, additional, Wang, Jieh-Neng, additional, Hwang, Be-Tau, additional, Dai, Zen-Kong, additional, Lin, Shan-Miao, additional, Chang, Jeng-Sheng, additional, Lin, I-Chun, additional, Wu, Mei-Hwan, additional, Lu, Chun-Wei, additional, Lin, Ming-Tai, additional, Chen, Chun-An, additional, Hua, Yu-Chuan, additional, Wu, Jing-Ming, additional, and Wang, Jou-Kou, additional

Published
2020
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42. Cor Triatriatum in Children

Author

Tsai, Yu-Chien, Wu, Jing-Ming, Yao, Chih-Ta, Yang, Yu-Jen, Lin, Hui-Chen, Lin, Chia-Shiang, and Wang, Jieh-Neng

Published
2003

44. Progenitor Cells Derived from Drain Waste Product of Open-Heart Surgery in Children

Author

Wong, Tak-Wah, primary, Kan, Chung-Dann, additional, Chiu, Wen-Tai, additional, Fok, Kin Lam, additional, Ruan, Ye Chun, additional, Jiang, Xiaohua, additional, Chen, Junjiang, additional, Kao, Chiu-Ching, additional, Chen, I-Yu, additional, Lin, Hui-Chun, additional, Chou, Chia-Hsuan, additional, Lin, Chou-Wen, additional, Yu, Chun-Keung, additional, Tsao, Stephanie, additional, Lee, Yi-Ping, additional, Chan, Hsiao Chang, additional, and Wang, Jieh-Neng, additional

Published
2019
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45. Computer-Assisted Auscultation: Patent Ductus Arteriosus Detection Based on Auditory Time–frequency Analysis

Author

Jhing-Fa Wang, Wang Jieh-Neng, Po-Hsun Sung, William R. Thompson, and Ling Sheng Jang

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, Phonocardiogram, Heart disease, medicine.diagnostic_test, business.industry, Speech recognition, education, Biomedical Engineering, General Medicine, Auscultation, medicine.disease, Time–frequency analysis, Patent ductus arteriosus (PDA), Heart sounds, medicine, Heart murmur, Spectrogram, medicine.symptom, business
Abstract

This study presents a computer-assisted auscultation approach for patent ductus arteriosus (PDA) detection. PDA is a frequent congenital heart disease in neonates. The early detection of the PDA murmur from a neonate’s heart sound is important to avoid the development of severe respiratory diseases in newborns. Computer-assisted auscultation has the potential to become a heart disease screening tool because it can improve the sensitivity and specificity of heart murmur detection. This study proposes an auditory time–frequency representation method (auditory spectrogram) to demonstrate the dynamic and non-stationary characteristics of heart murmurs. The auditory spectrogram is obtained using the proposed cochlear wavelet transform, which mimics the auditory response of the cochlea in the human auditory system. The auditory spectrogram can represent the heart sounds in the time–frequency domain to assist cardiac auscultation. Furthermore, the spectrum flux and spectrum centroid are used to characterize the configuration of the auditory spectrogram. The phonocardiogram data of 18 patients, including normal heart sounds, innocent murmurs, and PDA murmurs, are used in the blind test for algorithm effectiveness assessment. The results demonstrate that the proposed computer-assisted auscultation method can achieve a high sensitivity of 100 % and a specificity of 91.67 % for PDA detection. The developed method is robust, cost-effective, and convenient, making it effective for the enhancement of the accuracy of PDA detection.

Published
2015

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